Charles A. Taylor

Administrative Appointments

• Founder, Chief Scientist, Cardiovascular Simulation, Inc. , (2007– present )

Honors and Awards

• Fellow, American Institute for Medical and Biological Engineering (2008)
• R.H. Gallagher Young Investigator in Computational Mechanics Award, U.S. Association for Computational Mechanics (2003)
• Young Investigator in Computational Mechanics Award, International Association for Computational Mechanics (2002)
• James F. Clark Fellow, Stanford University (2001)

Professional Education

• Ph.D., Stanford University Mechanical Engineering (1996)
• M.S., Rensselaer Polytechnic Institute Mathematics (1992)
• M.S., Rensselaer Polytechnic Institute Mechanical Engineering (1991)
• B.S., Rensselaer Polytechnic Institute Mechanical Engineering (1987)

Postdoctoral Advisees

• Anamika Prasad

Graduate & Fellowship Program Affiliations

• Bioengineering

Web Site Links

• Cardiovascular Biomechanics Research Lab

Research Interests

Cardiovascular Bioengineering, Simulation-Based Medical Planning, Magnetic Resonance Imaging, Image-Based Geometric Modeling, Computational Fluid and Solid Mechanics.

Clinical Trials

• Abdominal Aortic Aneurysms: Simple Treatment or Prevention (AAA: STOP) Recruiting

Publications

• Patient-specific modeling of cardiovascular mechanics. Taylor CA,  Figueroa CA.  Annu Rev Biomed Eng.  2009; 11 109-34
• Endovascular device design in the future: transformation from trial and error to computational design. Zarins CK,  Taylor CA.  J Endovasc Ther.  2009; 16 Suppl 1 I12-21
• Drug transport in artery walls: a sequential porohyperelastic-transport approach. Feenstra PH,  Taylor CA.  Comput Methods Biomech Biomed Engin.  2009; 12 (3): 263-76
• Methods for quantifying three-dimensional deformation of arteries due to pulsatile and nonpulsatile forces: implications for the design of stents and stent grafts. Choi G,  Cheng CP, Wilson NM, Taylor CA.  Ann Biomed Eng.  2009; 37 (1): 14-33
• Automated Adaptive Cardiovascular Flow Simulations O. Sahni,  K.E. Jansen, C.A. Taylor, M.S. Shephard.  Engineering with Computers.  2009; 25 (1): 25-36
• Effect of curvature on displacement forces acting on aortic endografts: a 3-dimensional computational analysis. Figueroa CA,  Taylor CA, Yeh V, Chiou AJ, Zarins CK.  J Endovasc Ther.  2009; 16 (3): 284-94
• Circumferential and longitudinal cyclic strain of the human thoracic aorta: age-related changes. Morrison TM,  Choi G, Zarins CK, Taylor CA.  J Vasc Surg.  2009; 49 (4): 1029-36
• Magnitude and direction of pulsatile displacement forces acting on thoracic aortic endografts. Figueroa CA,  Taylor CA, Chiou AJ, Yeh V, Zarins CK.  J Endovasc Ther.  2009; 16 (3): 350-8
• On coupling a lumped parameter heart model and a three-dimensional finite element aorta model. Kim HJ,  Vignon-Clementel IE, Figueroa CA, LaDisa JF, Jansen KE, Feinstein JA, Taylor CA.  Ann Biomed Eng.  2009; 37 (11): 2153-69
• Characterization of coherent structures in the cardiovascular system. Shadden SC,  Taylor CA.  Ann Biomed Eng.  2008; 36 (7): 1152-62
• Intracranial and abdominal aortic aneurysms: similarities, differences, and need for a new class of computational models. Humphrey JD,  Taylor CA.  Annu Rev Biomed Eng.  2008; 10 221-46
• Adaptive Boundary Layer Meshing for Viscous Flow Simulations O. Sahni,  K.E. Jansen, M.S. Shephard, C.A. Taylor, M.W. Beall.  Engineering with Computers.  2008; 24 (3): 267-285
• The Simbios National Center: Systems Biology in Motion J.P. Schmidt,  S.L. Delp, M.A. Sherman, C.A. Taylor, V.S. Pande, R.B. Altman.  Proceedings of the IEEE.  2008; 26 (8): 1-15
• The three-dimensional micro- and nanostructure of the aortic medial lamellar unit measured using 3D confocal and electron microscopy imaging. O'Connell MK,  Murthy S, Phan S, Xu C, Buchanan J, Spilker R, Dalman RL, Zarins CK, Denk W, Taylor CA.  Matrix Biol.  2008; 27 (3): 171-81
• Multiscale vascular surface model generation from medical imaging data using hierarchical features. Bekkers EJ,  Taylor CA.  IEEE Trans Med Imaging.  2008; 27 (3): 331-41
• A Computational Framework for Derivative-Free Optimization of Cardiovascular Geometries A.L. Marsden,  J.A. Feinstein, C.A. Taylor.  Computer Methods in Applied Mechanics and Engineering.  2008; 197 (21-24): 1890-1905
• Fractal Network Model for Simulating Abdominal and Lower Extremity Blood Flow During Resting and Exercise Conditions Steele BN,  Olufsen M, Taylor CA.  Computer Methods in Biomechanics and Biomedical Engineering.  2007; 10 (1): 39-51
• Morphometry-based impedance boundary conditions for patient-specific modeling of blood flow in pulmonary arteries. Spilker RL,  Feinstein JA, Parker DW, Reddy VM, Taylor CA.  Ann Biomed Eng.  2007; 35 (4): 546-59
• Increased anterior abdominal aortic wall motion: possible role in aneurysm pathogenesis and design of endovascular devices. Goergen CJ,  Johnson BL, Greve JM, Taylor CA, Zarins CK.  J Endovasc Ther.  2007; 14 (4): 574-84
• Effects of exercise and respiration on hemodynamic efficiency in CFD simulations of the total cavopulmonary connection. Marsden AL,  Vignon-Clementel IE, Chan FP, Feinstein JA, Taylor CA.  Ann Biomed Eng.  2007; 35 (2): 250-63
• Abdominal aortic hemodynamics in young healthy adults at rest and during lower limb exercise: quantification using image-based computer modeling. Tang BT,  Cheng CP, Draney MT, Wilson NM, Tsao PS, Herfkens RJ, Taylor CA.  Am J Physiol Heart Circ Physiol.  2006; 291 (2): H668-76
• A Coupled Momentum Method For Modeling Blood Flow In Three-Dimensional Deformable Arteries Figueroa CA,  Vignon-Clementel IE, Jansen KE, Hughes TJR, Taylor CA.  Computer Methods in Applied Mechanics and Engineering.  2006; 195 (41-43): 5685-5706
• Aortoiliac hemodynamic and morphologic adaptation to chronic spinal cord injury. Yeung JJ,  Kim HJ, Abbruzzese TA, Vignon-Clementel IE, Draney-Blomme MT, Yeung KK, Perkash I, Herfkens RJ, Taylor CA, Dalman RL.  J Vasc Surg.  2006; 44 (6): 1254-1265
• Efficient Anisotropic Adaptive Discretization of the Cardiovascular System Sahni O,  Müller J, Jansen KE, Shephard MS, Taylor CA.  Computer Methods in Applied Mechanics and Engineering.  2006; 195 (41-43): 5634-5655
• AAA disease: mechanism, stratification, and treatment. Dalman RL,  Tedesco MM, Myers J, Taylor CA.  Ann N Y Acad Sci.  2006; 1085 92-109
• Allometric scaling of wall shear stress from mice to humans: quantification using cine phase-contrast MRI and computational fluid dynamics. Greve JM,  Les AS, Tang BT, Draney Blomme MT, Wilson NM, Dalman RL, Pelc NJ, Taylor CA.  Am J Physiol Heart Circ Physiol.  2006; 291 (4): H1700-8
• In vivo MR angiographic quantification of axial and twisting deformations of the superficial femoral artery resulting from maximum hip and knee flexion. Cheng CP,  Wilson NM, Hallett RL, Herfkens RJ, Taylor CA.  J Vasc Interv Radiol.  2006; 17 (6): 979-87
• Outflow Boundary Conditions for Three-Dimensional Finite Element Modeling of Blood Flow and Pressure in Arteries Vignon-Clementel IE,  Figueroa CA, Jansen KE, Taylor CA.  Computer Methods in Applied Mechanics and Engineering.  2006; 195 (29-32): 3776-3796
• Three-dimensional analysis of renal artery bending motion during respiration. Draney MT,  Zarins CK, Taylor CA.  J Endovasc Ther.  2005; 12 (3): 380-6
• Anisotropic adaptive finite element method for modelling blood flow. Müller J,  Sahni O, Li X, Jansen KE, Shephard MS, Taylor CA.  Comput Methods Biomech Biomed Engin.  2005; 8 (5): 295-305
• Predicting changes in blood flow in patient-specific operative plans for treating aortoiliac occlusive disease. Wilson NM,  Arko FR, Taylor CA.  Comput Aided Surg.  2005; 10 (4): 257-77
• Flow imaging and computing: large artery hemodynamics. Steinman DA,  Taylor CA.  Ann Biomed Eng.  2005; 33 (12): 1704-9
• Increased aortic stiffness in the insulin-resistant Zucker fa/fa rat. Sista AK,  O'Connell MK, Hinohara T, Oommen SS, Fenster BE, Glassford AJ, Schwartz EA, Taylor CA, Reaven GM, Tsao PS.  Am J Physiol Heart Circ Physiol.  2005; 289 (2): H845-51
• Comparison of CFD and MRI flow and velocities in an in vitro large artery bypass graft model. Ku JP,  Elkins CJ, Taylor CA.  Ann Biomed Eng.  2005; 33 (3): 257-69
• Proximal pulmonary artery blood flow characteristics in healthy subjects measured in an upright posture using MRI: the effects of exercise and age. Cheng CP,  Herfkens RJ, Taylor CA, Feinstein JA.  J Magn Reson Imaging.  2005; 21 (6): 752-8
• Patient-Specific Operative Planning for Aorto-Femoral Reconstruction Procedures Wilson NM,  Arko F, Taylor CA.  Lecture Notes in Computer Science.  2004; 3217 422-429
• Outflow Boundary Conditions for One-dimensional Finite Element Modeling of Blood Flow and Pressure Waves in Arteries Vignon IE,  Taylor CA.  Wave Motion.  2004; 39 361-374
• Experimental and Computational Methods in Cardiovascular Fluid Mechanics Taylor CA,  Draney MT.  Annual Review of Fluid Mechanics.  2004; 36 197-231
• Quantification of vessel wall motion and cyclic strain using cine phase contrast MRI: in vivo validation in the porcine aorta. Draney MT,  Arko FR, Alley MT, Markl M, Herfkens RJ, Pelc NJ, Zarins CK, Taylor CA.  Magn Reson Med.  2004; 52 (2): 286-95
• Blood flow conditions in the proximal pulmonary arteries and vena cavae: healthy children during upright cycling exercise. Cheng CP,  Herfkens RJ, Lightner AL, Taylor CA, Feinstein JA.  Am J Physiol Heart Circ Physiol.  2004; 287 (2): H921-6
• Internet-based system for simulation-based medical planning for cardiovascular disease. Steele BN,  Draney MT, Ku JP, Taylor CA.  IEEE Trans Inf Technol Biomed.  2003; 7 (2): 123-9
• In vivo validation of a one-dimensional finite-element method for predicting blood flow in cardiovascular bypass grafts. Steele BN,  Wan J, Ku JP, Hughes TJ, Taylor CA.  IEEE Trans Biomed Eng.  2003; 50 (6): 649-56
• Abdominal aortic hemodynamic conditions in healthy subjects aged 50-70 at rest and during lower limb exercise: in vivo quantification using MRI. Cheng CP,  Herfkens RJ, Taylor CA.  Atherosclerosis.  2003; 168 (2): 323-31
• Time-resolved three-dimensional phase-contrast MRI. Markl M,  Chan FP, Alley MT, Wedding KL, Draney MT, Elkins CJ, Parker DW, Wicker R, Taylor CA, Herfkens RJ, Pelc NJ.  J Magn Reson Imaging.  2003; 17 (4): 499-506
• Inferior vena caval hemodynamics quantified in vivo at rest and during cycling exercise using magnetic resonance imaging. Cheng CP,  Herfkens RJ, Taylor CA.  Am J Physiol Heart Circ Physiol.  2003; 284 (4): H1161-7
• Dynamic exercise imaging with an MR-compatible stationary cycle within the general electric open magnet. Cheng CP,  Schwandt DF, Topp EL, Anderson JH, Herfkens RJ, Taylor CA.  Magn Reson Med.  2003; 49 (3): 581-5
• Comparison of abdominal aortic hemodynamics between men and women at rest and during lower limb exercise. Cheng CP,  Herfkens RJ, Taylor CA.  J Vasc Surg.  2003; 37 (1): 118-23
• A one-dimensional finite element method for simulation-based medical planning for cardiovascular disease. Wan J,  Steele B, Spicer SA, Strohband S, Feijóo GR, Hughes TJ, Taylor CA.  Comput Methods Biomech Biomed Engin.  2002; 5 (3): 195-206
• Quantification of vessel wall cyclic strain using cine phase contrast magnetic resonance imaging. Draney MT,  Herfkens RJ, Hughes TJ, Pelc NJ, Wedding KL, Zarins CK, Taylor CA.  Ann Biomed Eng.  2002; 30 (8): 1033-45
• Quantification of wall shear stress in large blood vessels using Lagrangian interpolation functions with cine phase-contrast magnetic resonance imaging. Cheng CP,  Parker D, Taylor CA.  Ann Biomed Eng.  2002; 30 (8): 1020-32
• In vivo validation of numerical prediction of blood flow in arterial bypass grafts. Ku JP,  Draney MT, Arko FR, Lee WA, Chan FP, Pelc NJ, Zarins CK, Taylor CA.  Ann Biomed Eng.  2002; 30 (6): 743-52
• In vivo quantification of blood flow and wall shear stress in the human abdominal aorta during lower limb exercise. Taylor CA,  Cheng CP, Espinosa LA, Tang BT, Parker D, Herfkens RJ.  Ann Biomed Eng.  2002; 30 (3): 402-8
• Measurement of vessel wall strain using cine phase contrast MRI. Wedding KL,  Draney MT, Herfkens RJ, Zarins CK, Taylor CA, Pelc NJ.  J Magn Reson Imaging.  2002; 15 (4): 418-28
• A Software Framework for Creating Patient Specific Geometric Models from Medical Imaging Data for Simulation Based Medical Planning of Vascular Surgery Wilson N,  Wang K, Dutton R, Taylor CA.  Lecture Notes in Computer Science.  2001; 2208 449-456
• Simulation-based medical planning for cardiovascular disease: visualization system foundations. Spicer SA,  Taylor CA.  Comput Aided Surg.  2000; 5 (2): 82-9
• Improving geometric model construction for blood flow modeling. Wang KC,  Dutton RW, Taylor CA.  IEEE Eng Med Biol Mag.  1999 Nov-Dec; 18 (6): 33-9
• Predictive medicine: computational techniques in therapeutic decision-making. Taylor CA,  Draney MT, Ku JP, Parker D, Steele BN, Wang K, Zarins CK.  Comput Aided Surg.  1999; 4 (5): 231-47
• Effect of exercise on hemodynamic conditions in the abdominal aorta. Taylor CA,  Hughes TJ, Zarins CK.  J Vasc Surg.  1999; 29 (6): 1077-89
• Finite element modeling of three-dimensional pulsatile flow in the abdominal aorta: relevance to atherosclerosis. Taylor CA,  Hughes TJ, Zarins CK.  Ann Biomed Eng.  1998 Nov-Dec; 26 (6): 975-87
• Finite Element Modeling of Blood Flow in Arteries Taylor CA,  Hughes TJR, Zarins CK.  Computer Methods in Applied Mechanics and Engineering.  1998; 158 (1-2): 155-196
• Computational Investigations in Vascular Disease Taylor CA,  Hughes TJR, Zarins CK.  Computers in Physics.  1996; 10 (3): 224-232
• Stable and Time-Dissipative Finite Element Methods for the Incompressible Navier-Stokes Equations Simo JC,  Armero FA, Taylor CA.  International Journal for Numerical Methods in Engineering.  1995; 38 1475-1506