Andrew J. Patterson, M.D., Ph.D.

Clinical Focus

• Anesthesia
• Critical Care Medicine

Administrative Appointments

• Chair, Pharmacy and Therapeutics Committee, Stanford University Medical Center , (2009– present )

Honors and Awards

• Presidential Citation, Society of Critical Care Medicine (2008 and 2009)
• H. Barrie Fairley Excellence in Teaching Award, Stanford University (2001)

Professional Education

• Massachusetts General Hospital (1995) MA
• Board Certification: Anesthesia, American Board of Anesthesiology (1996)
• Board Certification: Critical Care Medicine, American Board of Anesthesiology (1999)
• Massachusetts General Hospital (1996) MA
• Emory University School of Medicine (1992) GA
• Emory University School of Medicine (1991) GA
• B.S., University of Michigan History & Chemistry (1987)
• M.D. & Internship, Emory University Medicine 1991; Internship in Internal Medicine 1992 (1992)
• Residency & Chief Residency, Massachusetts General Hospital Anesthesiology (1995)
• Fellowship, Massachusetts General Hospital Critical Care Medicine (1996)
• Ph.D., Stanford University Neurosciences (2002)

Graduate & Fellowship Program Affiliations

• Anesthesia

Community & International Work

• Hospital de la Familia, Nuevo Progreso, Guatemala More »
• Medical Missions for Children, Gitwe Rwanda, Cusco Peru More »
• Interplast, La Ceiba Honduras, Loja Ecuador, Santa Cruz Bolivia More »

Research Interests

Critical Care Medicine,
Cardiovascular Pharmacology,
Adrenergic Receptors,
Congestive Heart Failure,
Vascular Biology,
Cardiopulmonary Physiology,
Sepsis

Publications

• Postischemic brain injury is attenuated in mice lacking the beta2-adrenergic receptor. Han RQ,  Ouyang YB, Xu L, Agrawal R, Patterson AJ, Giffard RG.  Anesth Analg.  2009; 108 (1): 280-7
• Genetic polymorphisms in sepsis. Namath A,  Patterson AJ.  Crit Care Clin.  2009; 25 (4): 835-56, x
• Gene expression profiling: Classification of mice with left ventricle systolic dysfunction using microarray analysis* Wong J,  Chang C, Agrawal R, Walton GB, Chen C, Murthy A, Patterson AJ.  Crit Care Med.  2009;
• Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. Chun HJ,  Ali ZA, Kojima Y, Kundu RK, Sheikh AY, Agrawal R, Zheng L, Leeper NJ, Pearl NE, Patterson AJ, Anderson JP, Tsao PS, Lenardo MJ, Ashley EA, Quertermous T.  J Clin Invest.  2008; 118 (10): 3343-54
• Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4. Richter W,  Day P, Agrawal R, Bruss MD, Granier S, Wang YL, Rasmussen SG, Horner K, Wang P, Lei T, Patterson AJ, Kobilka B, Conti M.  EMBO J.  2008; 27 (2): 384-93
• Ushering in the Era of Nuclear Terrorism Patterson AJ,  Critical Care Medicine.  2007; 35 (3): 953-954
• Impact of Phosphodiesterase 4D on Cardiac beta2 Adrenergic Receptor Signaling Patterson AJ,  Pearl N, Chang C.  Seminars in Anesthesia, Perioperative Medicine, and Pain.  2007; 26 (1): 22-27
• beta1 and beta2 Adrenergic Receptor Polymorphisms: Their Impact on Cardiovascular Physiology, Disease States, and Response to Therapeutic Agents Namath A,  Chen C, Agrawal R, Patterson AJ.  Seminars in Anesthesia, Perioperative Medicine, and Pain.  2007; 26 (1): 2-9
• Fiberoptic light source-induced surgical fires -- the contribution of forced-air warming blankets. Williams DM,  Littwin S, Patterson AJ, Brock-Utne JG.  Acta Anaesthesiol Scand.  2006; 50 (4): 505-8
• Overexpression of dimethylarginine dimethylaminohydrolase reduces tissue asymmetric dimethylarginine levels and enhances angiogenesis. Jacobi J,  Sydow K, von Degenfeld G, Zhang Y, Dayoub H, Wang B, Patterson AJ, Kimoto M, Blau HM, Cooke JP.  Circulation.  2005; 111 (11): 1431-8
• The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo. Ashley EA,  Powers J, Chen M, Kundu R, Finsterbach T, Caffarelli A, Deng A, Eichhorn J, Mahajan R, Agrawal R, Greve J, Robbins R, Patterson AJ, Bernstein D, Quertermous T.  Cardiovasc Res.  2005; 65 (1): 73-82
• Protecting the myocardium: a role for the beta2 adrenergic receptor in the heart. Patterson AJ,  Zhu W, Chow A, Agrawal R, Kosek J, Xiao RP, Kobilka B.  Crit Care Med.  2004; 32 (4): 1041-8
• Thrombin activatable fibrinolysis inhibitor, a potential regulator of vascular inflammation. Myles T,  Nishimura T, Yun TH, Nagashima M, Morser J, Patterson AJ, Pearl RG, Leung LL.  J Biol Chem.  2003; 278 (51): 51059-67
• Dimethylarginine dimethylaminohydrolase regulates nitric oxide synthesis: genetic and physiological evidence. Dayoub H,  Achan V, Adimoolam S, Jacobi J, Stuehlinger MC, Wang BY, Tsao PS, Kimoto M, Vallance P, Patterson AJ, Cooke JP.  Circulation.  2003; 108 (24): 3042-7
• Vasoregulation at the molecular level: a role for the beta1 subunit of the calcium-activated potassium (BK) channel. Patterson AJ,  Henrie-Olson J, Brenner R.  Trends Cardiovasc Med.  2002; 12 (2): 78-82
• Abnormal Cardiac Function Associated with Sympathetic Nervous System Hyperactivity in Mice Patrcia C. Brum,  Jon Kosek, Andrew Patterson, Daniel Bernstein, Brian Kobilka.  Am J Physiol Heart Circ Physiol.  2002; 283 H1838-H1845
• Vasoregulation by the beta1 subunit of the calcium-activated potassium channel. Brenner R,  Peréz GJ, Bonev AD, Eckman DM, Kosek JC, Wiler SW, Patterson AJ, Nelson MT, Aldrich RW.  Nature.  2000; 407 (6806): 870-6
• Nitrous oxide produces antinociceptive response via alpha2B and/or alpha2C adrenoceptor subtypes in mice. Guo TZ,  Davies MF, Kingery WS, Patterson AJ, Limbird LE, Maze M.  Anesthesiology.  1999; 90 (2): 470-6
• Airway obstruction caused by an oleothorax. Patterson AJ,  Leong MS, Brodsky JB, Mark JB.  J Cardiothorac Vasc Anesth.  1998; 12 (2): 189-91