Key Documents
Albert Koong
- Associate Professor, Radiation Oncology - Radiation Therapy
- Member, Bio-X
- Member, Cancer Center
Contact Information
- Clinical Offices
Radiation Therapy 875 Blake Wilbur Dr Clinic D Stanford, CA 94305-5847 Telephone Work (650) 723-6171 Fax
Clinical Focus
- Cancer > Radiation Oncology
- Cancer > Radiation Oncology > Radiation Therapy
- Colorectal Cancer
- Colorectal Cancer - Radiation Oncology
- Esophageal Cancer
- Esophageal Cancer - Radiation Oncology
- Liver Cancer
- Liver Cancer - Radiation Oncology
- Pancreatic Cancer
- Pancreatic Cancer - Radiation Oncology
- Radiation Oncology
- Rectal Cancer
- Rectal Cancer - Radiation Oncology
- Stomach Cancer
- Stomach Cancer - Radiation Oncology
Professional Education
- Board Certification: Radiation Oncology, American Board of Radiology (2001)
- SUMC - Graduate Medical Education (2001) CA
- Kaiser Permanente Medical Center (1997) CA
- Northwestern University Medical School (1996) IL
- Stanford University School of Medicine (1994) CA
Postdoctoral Advisees
Graduate & Fellowship Program Affiliations
Web Site Links
Current Research Interests
Hypoxia induces endoplasmic reticulum (ER) stress in solid tumors. Previous studies have indicated that hypoxia is a major determinant of local, regional, and distant recurrence after anticancer therapy. The response of tumor cells to hypoxia depends on the severity and duration of oxygen deprivation. For example, hypoxia induced factor (HIF-1) is activated at physiological levels of oxygen change, whereas the unfolded protein response (UPR) is induced by severe oxygen deprivation. The UPR is an evolutionarily conserved pathway that functions to reduce protein accumulation in the ER resulting in increased capacity to tolerate ER stress. We hypothesize that since the UPR is also activated during hypoxia, it may be a critical regulator of cell survival during hypoxia and is necessary for tumor growth. The focus of my laboratory is to understand the relationship between hypoxia and ER stress, particularly as it relates to tumorigenesis.
Clinical Trials
- Novel Serum Markers for Monitoring Response to Anti-Cancer Therapy Recruiting
- Ph I of FG-3019, Gemcitabine and Erlotinib for Locally Advanced or Metastatic Pancreatic Cancer Recruiting
- Phase II Gemcitabine + Fractionated Stereotactic Radiotherapy for Unresectable Pancreatic Adenocarci Recruiting
- Assessment of Health Related Quality of Life in Patients Treated for Rectal Cancer Recruiting
- PII Combination SBRT with TACE for Unresectable Hepatocellular Carcinoma Recruiting
- Cyberknife Radiosurgery for Locally Advanced Pancreatic Cancer Completed
- Evaluation of Stereotactic Radiosurgery For Liver Malignancies Completed
- Investigate Role of Metabolic Imaging in Predicting Tumor Response/Outcome After Pancreatic CA Tx Completed
- Metabolic Imaging Predict Histopathologic Response to Preop ChemoXRT for Locally Advanced Rectal CA Terminated
- Trilogy Stereotactic Body Radiotherapy for Pancreatic Cancer Completed
- Phase I/II Intratumoral DC Immunotherapy With Gemcitabine & XRT in Unresectable Pancreatic Cancer Completed
- QOL & Functional Outcomes After Combined Modality Tx for Anal CA: Comparison of Conventional vs IMRT Suspended
- Safety Study of Cetuximab in combination with Oxaliplatin, Capecitabine, and Radiation Therapy Followed by Surgery for Locally-advanced Rectal Cancer Completed
- The Role of FDG PET in Radiation Treatment Planning for Head and Neck Cancers Completed
Publications
- J Surg Res. 2010; (2): 209
- Cancer Res. 2010; (1): 78-88
- Cancer Res. 2009; (3): 775-84
- Cancer. 2009; (3): 665-72
- Cancer Cell. 2009; (1): 35-44
- Int J Radiat Oncol Biol Phys. 2009; (2): 553-61
- Am J Clin Oncol. 2009; (4): 405-10
- PLoS One. 2009; (9): e7033
- Radiother Oncol. 2009; (3): 656-7
- Dis Esophagus. 2009;
- Am J Clin Oncol. 2009; (4): 364-8
- J Surg Res. 2009;
- J Vasc Interv Radiol. 2009; (2): 235-9
- Clin Nucl Med. 2009; (5): 312-3
- Transl Oncol. 2009; (1): 31-8
- Colorectal Dis. 2009;
- Mol Imaging. 2008 May-Jun; (3): 139-46
- Clin Chem. 2008; (3): 582-9
- Int J Radiat Oncol Biol Phys. 2008; (2): 599-608
- Int J Radiat Oncol Biol Phys. 2008; (2): 324-5
- Int J Radiat Oncol Biol Phys. 2008; (4): 1151-7
- Int J Radiat Oncol Biol Phys. 2008; (3): 678-86
- Eur J Nucl Med Mol Imaging. 2008; (3): 527-31
- Clin Oncol (R Coll Radiol). 2008; (1): 69-75
- Med Phys. 2007; (9): 3688-95
- Int J Radiat Oncol Biol Phys. 2007; (1): 167-75
- Nat Methods. 2007; (4): 327-9
- Technol Cancer Res Treat. 2007; (1): 31-6
- Eur J Nucl Med Mol Imaging. 2007; (6): 850-8
- Head Neck. 2007; (3): 211-20
- Front Radiat Ther Oncol. 2007; 386-94
- J Clin Oncol. 2006; (33): 5291-7
- Med Phys. 2006; (10): 3825-33
- Med Phys. 2006; (7): 2632-41
- Cancer Biol Ther. 2006; (7): 756-9
- J Thorac Oncol. 2006; (8): 802-9
- Med Dosim. 2006; (2): 91-112
- Cancer. 2006; (9): 1940-9
- Clin Cancer Res. 2006; (5): 1507-14
- Cancer Res. 2006; (11): 5816-27
- Cancer Res. 2005; (14): 6151-8
- Oncogene. 2005; (43): 6555-63
- Int J Radiat Oncol Biol Phys. 2005; (2): 320-3
- Mol Cancer Res. 2005; (11): 597-605
- Mol Cancer Res. 2005; (12): 669-77
- Med Phys. 2005; (12): 3650-60
- J Clin Oncol. 2005; (35): 8932-41
- Cancer Res. 2004; (17): 5943-7
- Cancer Res. 2004; (20): 7302-10
- Clin Cancer Res. 2004; (14): 4806-12
- Bioinformatics. 2004; (17): 3034-44
- Int J Radiat Oncol Biol Phys. 2004; (4): 1017-21
- Int J Radiat Oncol Biol Phys. 2004; (1): 171-7
- Cancer Res. 2004; (20): 7302-10
- Clin Cancer Res. 2003; (1): 59-67
- Int J Radiat Oncol Biol Phys. 2003; (4): 1046-54
- Int J Radiat Oncol Biol Phys. 2003; (1): 132-7
- Int J Radiat Oncol Biol Phys. 2003; (2): 375-83
- Arch Otolaryngol Head Neck Surg. 2002; (6): 698-702
- Clin Cancer Res. 2000; (2): 480-7
- Cancer Res. 2000; (4): 883-7
- Genes Dev. 2000; (4): 391-6
- Int J Radiat Oncol Biol Phys. 2000; (4): 919-22
- Int J Hyperthermia. 1994 May-Jun; (3): 371-9
- J Cell Physiol. 1994; (1): 142-8
- Radiat Res. 1994; (1 Suppl): S60-3
- Cancer Res. 1994; (6): 1425-30
- Int J Radiat Oncol Biol Phys. 1994; (3): 661-6
- Cancer Res. 1994; (20): 5273-9
- Int J Radiat Oncol Biol Phys. 1994; (2): 259-65
- Proc Natl Acad Sci U S A. 1993; (3): 908-12
- J Cell Physiol. 1993; (2): 341-7
- Int J Radiat Oncol Biol Phys. 1992; (4): 891-7
- J Natl Cancer Inst. 1991; (3): 178-85
- Br J Cancer. 1991; (4): 499-502