Key Documents
Gary Steinberg
- Professor, Neurosurgery
- Professor (By courtesy), Neurology & Neurological Sciences
Contact Information
- Clinical Offices
Neurosurgery 300 Pasteur Dr R301A MC 5325 Stanford, CA 94305 Telephone Work (650) 723-5575 Fax (650) 725-0390
- Academic Offices
Personal InformationAdministrative Contact Andrew Kloak Administrative Associate Email akloak@stanford.edu Tel Work 650-725-5562Not for medical emergencies or patient use
Clinical Focus
- Neurological Surgery
- Neurosurgery
- Neurosurgery, Pediatric
Administrative Appointments
- Chair, Stanford University School of Medicine - Neurosurgery , (1995– present )
Professional Education
- Board Certification: Neurological Surgery, American Board of Neurological Surgery (1989)
- SUMC - Graduate Medical Education (1987) CA
- Santa Clara Valley Medical Center (1986) CA USA
- SUMC - Graduate Medical Education (1983) CA
- Institute Of Neurology (1981) England
- Stanford University School of Medicine (1980) CA
- Stanford University School of Medicine (1980) CA
Postdoctoral Advisees
Industry Relationships
Stanford is committed to ethical and transparent interactions with our industry partners. It is our policy to disclose payments of $5,000 or more, equity valued at $5,000 or more in a publicly traded company, or any equity in a privately held company, to physicians and scientists employed by Stanford University from companies or other commercial entities with which they interact as part of their professional activities.
- Consulting: Neurofluidics
Research Interests
Our laboratory is interested in elucidating the pathophysiology of acute cerebral ischemia and in developing neuroprotective treatments, as well as methods to restore neurologic function after stroke. Using rodent wild type, knock out and transgenic models of focal and global ischemia, we are investigating the physiologic processes leading from decreased blood flow after arterial occlusion to irreversible brain injury. A major focus of our work concerns the role of oxidative stress, inflammation and gene expression on necrotic and apoptotic mechnisms of ischemic cell death. Alterations in cerebral blood flow, neuronal metabolic activity, electrophysiology, and gene/protein expression are examined in relation to neurologic behavior. We are also studying the brain microenvironment during recovery after stroke and the effects of stem cell transplantation and enhanced neurogenesis in promoting recovery of function.
We have been successful in attenuating ischemic cerebral damage by inducing mild brain hypothermia (30-33 degrees C) or overexpression of various genes (glucose transporter, bcl-2, hsp70, calbindin, catalase, glutathione peroxidase, SOD) either before or after stroke. Transplantation of human neural stem cells after experimental stroke results in survival, targeted migration and differentiation into appropriate neuronal and glial cell types, while anti-inflammatory treatment enhances native neurogenesis and gliagenesis following stroke.
Methodologies utilized in the laboratory include microsurgery, light and confocal microscopy, stereology, molecular biology techniques, autoradiography, magnetic resonance imaging, electrophysiology, cerebral blood flow measurements and gene transfer therapy.
Our clinical research efforts focus on novel approaches for treating intracranial aneurysms, intracranial and spinal vascular malformations, occlusive cerebrovascular disease such as Moyamoya disease and stroke. These include advances in microsurgery, interventional neuroradiology, stereotactic radiosurgery, 3D imaging, surgical navigation, revascularization techniques, the use of mild brain hypothermia and other clinical neuroprotective agents, and neurotransplantation.
Publications
- Neurobiol Dis. 2009;
- J Cereb Blood Flow Metab. 2009; (2): 385-97
- J Cereb Blood Flow Metab. 2009; (9): 1589-600
- PLoS One. 2008; (2): e1644
- Stroke. 2008; (4): 1300-6
- Proc Natl Acad Sci U S A. 2007; (24): 10211-6
- Neurosurg Focus. 2009; (4): E5
- Regen Med. 2009; (2): 251-63
- Brain Res. 2009; 256-61
- Stroke. 2009; (1): 270-7
- Neurosurg Focus. 2009; (5): E14
- Neurosurg Focus. 2009; (4): E4
- Neurosurg Focus. 2009; (5): E9
- Neurosurg Focus. 2009; (5): E24
- Neurosurg Focus. 2009; (5): E17
- Mol Ther. 2009; (7): 1282-91
- Neurosurg Focus. 2009; (6): E3
- Brain Inj. 2009; (7): 639-48
- AJNR Am J Neuroradiol. 2008; (2): 242-6
- Regen Med. 2008; (6): 893-905
- Handb Clin Neurol. 2008; 791-808
- J Cereb Blood Flow Metab. 2008; (10): 1722-32
- Neurosci Lett. 2008; (1): 120-4
- Neurosurgery. 2008; (5): 1048-51; discussion 1051-2
- J Neurosurg. 2008; (6): 1152-61
- Neurosurg Focus. 2008; (3-4): E15
- Neurosurg Focus. 2008; (3-4): E16
- Neurosurg Focus. 2008; (2): E16
- Neuroscience. 2008; (4): 1099-103
- Brain Res. 2008; 182-7
- J Neurochem. 2008; (3): 943-55
- J Neurosci Res. 2008; (8): 1659-69
- J Neurosci Res. 2008; (4): 873-82
- J Neurosurg. 2007; (3): 636-41
- Stroke. 2007; (2): 325-9
- Neuroscience. 2007; (4): 804-12
- Neurosci Lett. 2007; (1): 32-6
- J Cereb Blood Flow Metab. 2007; (12): 1879-94
- Brain Res. 2007; 146-55
- J Neurosurg. 2007; (5): 855-65
- Stroke. 2007; (2): 375-80
- Stroke. 2007; (2 Suppl): 817-26
- J Cereb Blood Flow Metab. 2007; (8): 1463-75
- J Stroke Cerebrovasc Dis. 2006 Sep-Oct; (5): 228-31
- Neuroreport. 2006; (16): 1691-5
- Neurosurg Focus. 2006; (6): E3
- Neurosurgery. 2006; (3): 553-60; discussion 553-60
- Curr Neurovasc Res. 2006; (3): 237-45
- J Neurosci Res. 2006; (6): 1004-14
- Neurosurgery. 2006; (4 Suppl 2): ONS-189-201; discussion ONS-201
- J Cereb Blood Flow Metab. 2006; (9): 1114-21
- Cerebrovasc Dis. 2006; (2-3): 109-15
- Mol Neurobiol. 2006; (3): 249-70
- Neurosurg Focus. 2006; (3): E7
- J Neurosci. 2005; (42): 9794-806
- Neurocrit Care. 2005; (2): 212-7
- Skull Base. 2005; (1): 43-62
- Stroke. 2005; (12): 2718-24
- J Cereb Blood Flow Metab. 2005; (9): 1119-29
- Neurosurgery. 2005; (4): 655-67; discussion 655-67
- Cerebrovasc Dis. 2005; (1): 23-7
- AJNR Am J Neuroradiol. 2005; (3): 525-30
- Neurosurgery. 2005; (3): E594; discussion E594
- J Exp Biol. 2004; (Pt 18): 3213-20
- J Neurosci. 2004; (31): 6880-8
- Proc Natl Acad Sci U S A. 2004; (32): 11839-44
- Neurosurgery. 2004; (2): 307-14; discussion 314-5
- Exp Neurol. 2004; (2): 378-86
- J Cereb Blood Flow Metab. 2004; (6): 681-92
- Neuroreport. 2004; (3): 413-6
- Stroke. 2004; (2): 572-7
- Stroke. 2003; (10): 2489-94
- Drug News Perspect. 2003; (8): 497-503
- J Neurosurg. 2003; (4): 747-50
- AJNR Am J Neuroradiol. 2003; (4): 585-90
- J Neurochem. 2003; (4): 1026-36
- AJNR Am J Neuroradiol. 2003; (5): 902-7
- AJNR Am J Neuroradiol. 2003; (8): 1520-7
- Ann N Y Acad Sci. 2003; 54-68; discussion 79-81
- Neurosurgery. 2003; (1): 1-11; discussion 11-3
- J Neurosurg. 2003; (6): 1271-6
- J Cereb Blood Flow Metab. 2002; (1): 29-38
- Lancet. 2002; (9309): 863-73
- Ann Neurol. 2002; (2): 160-7
- Neurobiol Dis. 2002; (1): 28-42
- J Cereb Blood Flow Metab. 2002; (1): 21-8
- Brain Res Mol Brain Res. 2001; (1-2): 75-85
- J Cereb Blood Flow Metab. 2001; (11): 1303-9
- J Neurosurg. 2001; (3): 513-7
- J Neurosurg. 2001; (1): 90-6
- Stroke. 2001; (4): 1028-35
- Stud Health Technol Inform. 2001; 177-9
- Neurosurg Clin N Am. 2001; (3): 519-40, viii
- Exp Neurol. 2001; (1): 129-39
- Ann N Y Acad Sci. 2001; 340-57
- Neurol Res. 2001; (5): 543-52
- AJNR Am J Neuroradiol. 2001; (8): 1597-601
- AJNR Am J Neuroradiol. 2001; (7): 1353-6
- Arch Surg. 2000; (8): 939-42
- Muscle Nerve. 2000; (9): 1446
- Muscle Nerve. 2000; (9): 1450-1
- Can J Neurol Sci. 2000; (4): 325-7
- Brain Res. 2000; (2): 208-19
- Neurosurgery. 2000; (2): 260-70; discussion 270-1
- Neurosurgery. 2000; (4): 841-51; discussion 851-2
- Neurosurgery. 2000; (1): 226-30; discussion 230-1
- J Stroke Cerebrovasc Dis. 1999 November - December; (6): 412-422
- Neurosurgery. 1999; (6): 1368-73; discussion 1373-4
- Comput Aided Surg. 1999; (5): 256-63
- Mol Med Today. 1999; (12): 525-31
- Muscle Nerve. 1999; (11): 1538-43
- Pediatrics. 1999; (2): 505-8
- Neurosurgery. 1999; (6): 1174-80; discussion 1180-1
- Neurosurgery. 1999; (5): 1117-20; discussion 1120-1
- Neurosurgery. 1999; (5): 991-6; discussion 996-7
- Stroke. 1999; (5): 1065-9
- J Neurol Neurosurg Psychiatry. 1999; (2): 189-96
- Neurosurgery. 1999; (3): 479-84; discussion 484-6
- Neurology. 1999; (9): 1922-31
- Neurosurgery. 1999; (1): 50-8; discussion 58-60
- J Stroke Cerebrovasc Dis. 1998 May-Jun; (3): 179-86
- Clin Neuropharmacol. 1998 Jan-Feb; (1): 28-34
- J Cardiovasc Nurs. 1998; (1): 34-44
- Exp Neurol. 1998; (2): 223-33
- Ann Neurol. 1998; (4): 584-91
- Brain Dev. 1998; (2): 119-23
- Neurosurgery. 1998; (2): 213-20; discussion 220-1
- Neurosurgery. 1998; (2): 202-11; discussion 211-2
- Neurosurg Clin N Am. 1998; (3): 565-76
- Neurosurgery. 1998; (4): 738-42; discussion 742-3
- Vasc Med. 1998; (4): 315-26
- Neurol Med Chir (Tokyo). 1998; 200-7
- Stroke. 1998; (10): 2171-80
- Clin Neuropathol. 1997 Mar-Apr; (2): 111-6
- J Neuroimaging. 1997; (4): 227-31
- J Cereb Blood Flow Metab. 1997; (4): 401-11
- J Neurosurg. 1997; (4): 699-703
- J Neurol Sci. 1997; (1): 25-31
- J Cereb Blood Flow Metab. 1997; (7): 740-4
- Brain Res. 1996; (1-2): 36-45
- J Child Neurol. 1996; (6): 490-1
- J Neurosurg. 1996; (6): 920-8
- J Neurosurg. 1996; (5): 883-7
- Pediatr Neurosurg. 1996; (3): 145-50
- J Cereb Blood Flow Metab. 1996; (2): 181-5
- AJNR Am J Neuroradiol. 1996; (2): 247-54
- AJNR Am J Neuroradiol. 1996; (2): 205-12; discussion 213-5
- J Neurosci. 1996; (2): 486-96
- J Neurosurg. 1996; (5): 860-6
- Surg Neurol. 1995; (4): 365-9; discussion 369-70
- J Cereb Blood Flow Metab. 1995; (5): 865-76
- J Neurochem. 1995; (2): 652-9
- Neuroscience. 1995; (1): 99-107
- Neurobiol Dis. 1995; (2): 109-18
- Thromb Res. 1995; (5): 475-81
- AJNR Am J Neuroradiol. 1995; (1): 15-8
- J Neurosurg. 1995; (1): 133-7
- J Neurosurg. 1994; (4): 554-9
- N Engl J Med. 1994; (22): 1565-70
- Bioelectromagnetics. 1994; (3): 205-16
- AJNR Am J Neuroradiol. 1994; (5): 821-7
- Neurosurgery. 1994; (5): 809-13; discussion 813-4
- Radiology. 1994; (2): 441-6
- AJNR Am J Neuroradiol. 1993 Mar-Apr; (2): 297-303; discussion 304-5
- AJNR Am J Neuroradiol. 1993 Jul-Aug; (4): 822-6
- Neurol Res. 1993; (4): 281-7
- Arch Pathol Lab Med. 1993; (2): 170-6
- Neurol Res. 1993; (3): 174-80
- J Neurosurg. 1993; (2): 161-73
- Surg Neurol. 1993; (5): 424-8
- Anesthesiology. 1993; (2): 306-12
- Stroke. 1992; (6): 889-93
- Radiology. 1992; (3): 719-24
- Radiology. 1992; (2): 355-60
- Neurosurgery. 1992; (3): 408-11
- Int J Radiat Oncol Biol Phys. 1992; (1): 47-55
- J Neurosci Nurs. 1992; (4): 215-9
- AJNR Am J Neuroradiol. 1991 May-Jun; (3): 489-96
- AJNR Am J Neuroradiol. 1991 Jan-Feb; (1): 89-95
- Rev Infect Dis. 1991 Jan-Feb; (1): 155-9
- J Neurosurg. 1991; (4): 575-82
- Neurosci Lett. 1991; (1): 17-20
- Int J Radiat Oncol Biol Phys. 1991; (4): 689-96
- Stereotact Funct Neurosurg. 1991; (1-2): 64-71
- Stereotact Funct Neurosurg. 1991; (1-2): 36-49
- J Neurosurg. 1991; (4): 642-6
- J Cereb Blood Flow Metab. 1991; (6): 1015-24
- Neurosci Lett. 1991; (2): 225-8
- J Cereb Blood Flow Metab. 1991; (5): 803-9
- Radiology. 1990; (3): 807-13
- Stroke. 1990; (3): 447-50
- N Engl J Med. 1990; (2): 96-101
- Neurosurgery. 1990; (3): 466-70
- Brain Res. 1989; (2): 382-6
- Anesthesiology. 1989; (3): 450-1
- Stroke. 1989; (9): 1247-52
- Stroke. 1989; (4): 519-23
- J Neurosurg. 1989; (4): 649-52
- J Neurosurg. 1989; (1): 132-4
- Brain Res. 1988; (2): 375-9
- Neurosci Lett. 1988; (2): 193-7
- Stroke. 1988; (9): 1112-8
- Anesthesiology. 1988; (1): 145-6