NIH Biosketch available OnlineIrving Weissman
- Professor, Pathology - Stem Cell Institute
- Professor, Developmental Biology
- Professor (By courtesy), Biology (School of Humanities and Sciences)
- Member, Bio-X
- Member, Cancer Center
Contact Information
- Clinical Offices
- Academic Offices
Personal Information Email irv@stanford.eduAdministrative Contact Linda Quinn Administrative Associate Email ljquinn@stanford.edu Tel Work 650-723-6520
Administrative Appointments
- Director, Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine , (2003– present )
Honors and Awards
- Passano Award, The Passano Foundation (2009)
- Rosentiel Award, Brandeis University (2009)
- Fellow, American Association for the Advancement of Science (2008)
- Robert Koch Award, Koch Foundation (2008)
- Honoree of the Arthritis Foundation of Northern California Chapter's 2007 Tribute Dinner, Arthritis Foundation (2007)
- I & H Wachter Award, I & H Wachter Foundation (2007)
- Honorary Doctorate, Mount Sinai School of Medicine (2007)
- John Scott Award, City of Philadelphia (2006)
- American-Italian Cancer Foundation Prize for Scientific Excellence in Medicine, American-Italian Cancer Foundation (2006)
- Honorary Doctorate, Columbia University (2006)
- The Commonwealth Club of California 18th Annual Distinguished Citizen Award, Commonwealth Club of California (2006)
- Jeffrey Modell "Dare to Dream" Award, Jeffrey Modell Foundation (2005)
- The Linus Pauling Medal for Outstanding Contributions to Science, Stanford University (2005)
- Rabbi Shai Shacknai Memorial Prize in Immunology and Cancer Research, The Lautenberg Center for General and Tumor Immunology (2004)
- Medal for Distinguished Contributions to Biomedical Research, New York Academy of Medicine (2004)
- Alan Cranston Awardee, Alliance for Aging Research (2004)
- Jessie Stevenson Kovalenko Medal, National Academy of Sciences Council (2004)
- Bass Award, Society of Neurological Surgeons (2003)
- Award for Outstanding Contribution to Cancer Biology, Pasarow Foundation (1989)
- Election to the Institute of Medicine, National Academy of Sciences (1989)
Professional Education
- MD, Stanford University Medicine (1965)
- BS, Montana State College Pre-med (1961)
Postdoctoral Advisees
Graduate & Fellowship Program Affiliations
Industry Relationships
Stanford is committed to ethical and transparent interactions with our industry partners. It is our policy to disclose payments of $5,000 or more, equity valued at $5,000 or more in a publicly traded company, or any equity in a privately held company, to physicians and scientists employed by Stanford University from companies or other commercial entities with which they interact as part of their professional activities.
- Consulting: MPM Capital, Stem cells inc
- Equity: Stem cells inc
- Service on Board of Directors: Stem cells inc
Research Interests
Irving L. Weissman's research encompasses the phylogeny and developmental biology of the cells that make up the blood-forming and immune systems. His laboratory identified and isolated the blood-forming stem cell from mice, and has defined, by lineage analysis, the stages of development between the stem cells and mature progeny (granulocytes, macrophages, etc.). This required developing and cloning stromal cells of the hematolymphoid microenvironments—from the bone marrow for myeloid and B cells, and from the thymus for T cells. While the adhesion molecules and factors from these stromal cells proved important as molecules (and the genes that encode them) for myeloid and B cells, the analysis of T cell development required in vivo studies of thymic development. In addition, the Weissman laboratory has pioneered the study of the genes and proteins involved in cell adhesion events required for lymphocyte homing to lymphoid organs in vivo, either as a normal function or as events involved in malignant leukemic metastases.
The Weissman laboratory also has a small group at Hopkins Marine Station, where they have developed a model organism for laboratory and field study of allorecognition—the invertebrate counterpart of transplantation immunity. Working with the protochordate Botryllus schlosseri (which has a chordate larval stage and an invertebrate adult form) they have identified a single major gene locus that governs rapid allorecognition, and 2-3 other loci involved in delayed allorecognition events. They are using this model to study the genes, proteins, and cells that govern protochordate allorecognition, and the effects of these genes on their population dynamics in the field.
Clinical Trials
Publications
- Stem Cells Dev. 2009; (2): 205-14
- Ann N Y Acad Sci. 2009; 118-21
- Mol Ther. 2009; (2): 219-30
- Nature. 2009; (7228): 490-4
- Stem Cells. 2009; (3): 653-61
- Proc Natl Acad Sci U S A. 2009; (1): 175-80
- Nature. 2009; (7239): 780-3
- Proc Natl Acad Sci U S A. 2009; (9): 3396-401
- Nat Med. 2009; (6): 701-6
- Lab Chip. 2009; (10): 1365-70
- Proc Natl Acad Sci U S A. 2009; (22): 8953-8
- Magn Reson Med. 2009; (4): 1047-54
- Stem Cells. 2009; (10): 2498-508
- Neurosurgery. 2009; (2): 237-49; discussion 249-50; quiz N6
- Cell. 2009; (2): 286-99
- Cell. 2009; (2): 271-85
- Proc Natl Acad Sci U S A. 2009; (33): 14016-21
- Cell Stem Cell. 2009; (2): 151-3
- Blood. 2009; (4): 807-15
- Mol Biol Cell. 2008; (3): 1210-9
- Mol Cell Biol. 2008; (1): 282-92
- Blood. 2008; (12): 5562-70
- Tissue Eng Part A. 2008;
- Blood. 2008; (12): 4494-502
- Biol Blood Marrow Transplant. 2008; (8): 849-58
- Eur J Immunol. 2008; (8): 2060-7
- PLoS One. 2008; (10): e3474
- Cell Stem Cell. 2008; (4): 456-64
- Cell Stem Cell. 2008; (4): 416-28
- Blood. 2008; (9): 3543-53
- J Thorac Cardiovasc Surg. 2008; (4): 1028-1037.e1
- Cold Spring Harb Symp Quant Biol. 2008; 439-49
- Nat Protoc. 2008; (12): 1932-40
- Tissue Eng Part A. 2008; (6): 995-1006
- Stem Cells Dev. 2008; (1): 11-8
- Cell Stem Cell. 2007; (6): 635-45
- Stem Cells Dev. 2007; (5): 707-17
- Blood. 2007; (10): 4191-9
- FASEB J. 2007; (7): 1335-44
- Exp Gerontol. 2007; (5): 385-90
- Cloning Stem Cells. 2007; (1): 107-17
- Stem Cells. 2007; (7): 1635-44
- Leukemia. 2007; (8): 1783-91
- Proc Natl Acad Sci U S A. 2007; (26): 11008-13
- Nature. 2007; (7145): 725-9
- Proc Natl Acad Sci U S A. 2007; (30): 12371-6
- J Immunol. 2007; (2): 928-38
- Cell Cycle. 2007; (19): 2371-6
- J Immunol. 2007; (10): 6808-19
- Science. 2007; (5854): 1296-9
- Curr Opin Biotechnol. 2007; (5): 460-6
- Methods Mol Biol. 2007; 63-81
- J Exp Med. 2006; (1): 73-85
- Stem Cells. 2006; (4): 1087-94
- Circulation. 2006; (7): 1005-14
- Cell. 2006; (2): 229-31
- Cell Cycle. 2006; (11): 1135-9
- Am J Pathol. 2006; (2): 338-46
- Stem Cell Rev. 2006; (1): 23-30
- Immunity. 2006; (1): 163-73
- Blood. 2006; (4): 1383-90
- Neurosurgery. 2006; (2): 374-82; discussion 374-82
- Cancer Res. 2006; (19): 9339-44
- Dev Cell. 2006; (4): 519-33
- Lab Invest. 2006; (12): 1203-7
- Cell. 2006; (2): 415-26
- J Exp Med. 2005; (10): 1579-89
- Blood. 2005; (6): 2487-94
- Proc Natl Acad Sci U S A. 2005; (9): 3312-7
- Nature. 2005; (7027): 760-4
- Exp Hematol. 2005; (2): 173-81
- Annu Rev Med. 2005; 509-38
- Eur J Cardiothorac Surg. 2005; (3): 461-6
- Proc Natl Acad Sci U S A. 2005; (26): 9194-9
- Proc Natl Acad Sci U S A. 2005; (32): 11408-13
- Novartis Found Symp. 2005; 35-50; discussion 50-4, 92-7
- PLoS Genet. 2005; (3): e28
- JAMA. 2005; (11): 1359-66
- Dev Dyn. 2005; (4): 997-1005
- J Exp Med. 2005; (11): 1599-611
- Nature. 2005; (7067): 454-9
- Stem Cells Dev. 2005; (5): 478-86
- J Neurosurg. 2005; (5 Suppl): 446-50
- Cell. 2005; (7): 1351-60
- Clin Neurosurg. 2005; 384-8
- J Immunol. 2005; (7): 4363-73
- Circulation. 2005; (19): 2486-93
- Microcirculation. 2004; (8): 699-708
- Dev Comp Immunol. 2004; (3): 201-9
- Stem Cells. 2004; (7): 1292-304
- Stem Cells. 2004; (7): 1239-45
- Cell. 2004; (4): 543-54
- Cell. 2004; (3): 431-43
- Dev Biol. 2004; (2): 185-94
- N Engl J Med. 2004; (7): 657-67
- Proc Natl Acad Sci U S A. 2004; (32): 11839-44
- Proc Natl Acad Sci U S A. 2004; (29): 10792-7
- Nat Med. 2004; (5): 510-7
- Blood. 2004; (8): 3192-9
- Nature. 2004; (6983): 668-73
- PLoS Biol. 2004; (3): E75
- Cell. 2004; (5): 639-48
- Science. 2004; (5660): 977
- Proc Natl Acad Sci U S A. 2004; (1): 221-6
- Cancer Cell. 2004; (6): 531-3
- Mar Biotechnol (NY). 2003 Mar-Apr; (2): 103-15
- Genes Dev. 2003; (24): 3029-35
- Immunogenetics. 2003; (7): 480-90
- Proc Natl Acad Sci U S A. 2003; 11842-9
- Proc Natl Acad Sci U S A. 2003; (17): 10002-7
- J Exp Med. 2003; (2): 305-13
- J Immunol. 2003; (3): 1207-15
- Nature. 2003; (6938): 448-52
- Blood. 2003; (2): 517-20
- Blood. 2003; (2): 421-8
- Blood. 2003; (1): 94-101
- Cancer Cell. 2003; (2): 161-71
- Diabetes. 2003; (1): 59-68
- Proc Natl Acad Sci U S A. 2003; (1): 205-10
- Blood. 2002; (13): 4660-7
- Semin Immunol. 2002; (6): 377-84
- Proc Natl Acad Sci U S A. 2002; (18): 11872-7
- Immunol Rev. 2002; 159-74
- Dev Cell. 2002; (1): 137-47
- J Exp Med. 2002; (11): 1427-33
- Exp Hematol. 2002; (2): 176-85
- Proc Natl Acad Sci U S A. 2002; (7): 4508-13
- J Exp Med. 2002; (9): 1145-54
- N Engl J Med. 2002; (20): 1576-9
- Gene Ther. 2002; (10): 606-12
- Oncogene. 2002; (21): 3270-3
- J Clin Invest. 2002; (12): 1579-85
- Nat Immunol. 2002; (12): 1135-41
- Science. 2002; (5590): 2256-9
- Curr Opin Immunol. 2001; (4): 451-7
- Curr Opin Genet Dev. 2001; (5): 520-6
- Annu Rev Cell Dev Biol. 2001; 387-403
- Nature. 2001; (6859): 105-11
- Proc Natl Acad Sci U S A. 2001; (25): 14541-6
- Science. 2001; (5548): 1933-6
- Blood. 2001; (3): 627-35
- Ann N Y Acad Sci. 2001; 167-73; discussion 173-4
- Proc Natl Acad Sci U S A. 2001; (14): 7934-9
- Blood. 2001; (11): 3333-41
- J Exp Med. 2001; (8): 917-24
- Blood. 2001; (8): 2278-85
- Proc Natl Acad Sci U S A. 2001; (7): 3976-81
- Blood. 2001; (3): 618-26
- Biol Blood Marrow Transplant. 2000; (3): 262-71
- Blood. 2000; (3): 894-901
- Proc Natl Acad Sci U S A. 2000; (17): 9555-60
- Nature. 2000; (6802): 383-6
- Curr Top Microbiol Immunol. 2000; 59-65
- Science. 2000; (5496): 1585-8
- Science. 2000; (5499): 2152-4
- J Exp Med. 2000; (12): 1707-18
- J Exp Med. 2000; (2): 253-64
- Cell. 2000; (1): 157-68
- Science. 2000; (5457): 1442-6
- Curr Opin Immunol. 2000; (2): 144-50
- Nature. 2000; (6774): 193-7
- Proc Natl Acad Sci U S A. 2000; (13): 7521-6
- Proc Natl Acad Sci U S A. 2000; (13): 6924-6
- J Immunol. 2000; (10): 5221-6
- Immunol Rev. 1999; 69-79
- Mol Med Today. 1999; (5): 201-8
- Int J Hematol. 1999; (4): 217-26
- Proc Natl Acad Sci U S A. 1999; (16): 9148-53
- Immunity. 1999; (5): 579-90
- Cold Spring Harb Symp Quant Biol. 1999; 1-12
- Proc Natl Acad Sci U S A. 1999; (6): 3120-5
- Proc Natl Acad Sci U S A. 1999; (6): 3006-11
- Genetics. 1998; (1): 277-87
- J Exp Med. 1998; (11): 1813-23
- Immunogenetics. 1998; (6): 468-76
- Immunity. 1998; (1): 47-57
- Mol Mar Biol Biotechnol. 1998; (3): 204-13
- Immunol Rev. 1998; 13-28
- Blood. 1998; (7): 2272-82
- Proc Natl Acad Sci U S A. 1998; (2): 657-62
- Stem Cells. 1998; (1): 38-48
- Transplantation. 1998; (3): 295-304
- Proc Natl Acad Sci U S A. 1998; (5): 2486-91
- Hereditas. 1997; (1-2): 25-35
- Cell. 1997; (5): 661-72
- Mol Mar Biol Biotechnol. 1997; (3): 163-71
- Immunity. 1997; (1): 155-62
- Proc Natl Acad Sci U S A. 1997; (5): 1908-13
- Development. 1997; (10): 1929-39
- Blood. 1997; (10): 3596-606
- Immunol Rev. 1997; 13-40
- Cell. 1997; (7): 1021-31
- Cell. 1997; (7): 1033-41
- Proc Natl Acad Sci U S A. 1996; (26): 15254-9
- J Immunol Methods. 1996; (1-2): 139-50
- Proc Natl Acad Sci U S A. 1996; (20): 11019-24
- Immunity. 1996; (3): 207-16
- Nat Med. 1996; (9): 1011-6
- Immunity. 1996; (2): 147-61
- Microsc Res Tech. 1996; (3): 259-66
- Blood. 1996; (10): 4057-67
- Exp Hematol. 1996; (5): 649-59
- J Immunol. 1996; (6): 2019-25
- Blood. 1996; (4): 1225-31
- Biol Blood Marrow Transplant. 1996; (1): 3-14
- Immunogenetics. 1996; (2): 134-42
- Blood. 1995; (9): 3493-9
- Annu Rev Cell Dev Biol. 1995; 35-71
- Proc Assoc Am Physicians. 1995; (2): 187-94
- Biol Bull. 1995; (1): 36-41
- J Immunol. 1995; (7): 3338-44
- Proc Natl Acad Sci U S A. 1995; (22): 10192-6
- Proc Natl Acad Sci U S A. 1995; (22): 10302-6
- Arthritis Rheum. 1994; (7): 1046-54
- Blood. 1994; (12): 3758-79
- Blood. 1994; (12): 3480-90
- Am J Pathol. 1994; (6): 1247-56
- J Biol Chem. 1994; (20): 14411-8
- Cell. 1994; (3): 335-47
- Ann N Y Acad Sci. 1994; 346-9
- Eur J Immunol. 1994; (3): 781-4
- J Exp Med. 1994; (3): 1047-52
- J Virol. 1994; (2): 1165-72
- Trends Microbiol. 1994; (7): 250-4
- J Immunol. 1994; (4): 1581-92
- Immunity. 1994; (7): 529-31
- Jpn J Cancer Res. 1994; (10): inside front cover
- Immunity. 1994; (8): 661-73
- Biotechniques. 1994; (2): 246-8, 250
- Cell. 1994; (2): 207-18
- Proc Natl Acad Sci U S A. 1994; (1): 262-6
- Biological Bulletin. 1993;
- Curr Biol. 1993; (11): 766-9
- Curr Top Microbiol Immunol. 1993; 125-38
- Transplantation. 1993; (1): 146-53
- Curr Opin Immunol. 1993; (2): 177-84
- Proc Natl Acad Sci U S A. 1993; (8): 3760-4
- Genes Dev. 1993; (5): 735-48
- Blood. 1993; (1): 247-61
- J Exp Med. 1993; (1): 265-77
- Proc Natl Acad Sci U S A. 1993; (14): 6815-9
- Cell. 1993; (1): 185-95
- J Cell Biol. 1993; (4): 897-902
- Sci Am. 1993; (3): 64-71
- Mol Cell Biol. 1993; (11): 7000-5
- Exp Hematol. 1993; (13): 1673-9
- Science. 1992; (5090): 1955-7
- Blood. 1992; (12): 3144-56
- Proc Natl Acad Sci U S A. 1992; (2): 549-53
- Curr Top Microbiol Immunol. 1992; 95-105
- J Exp Med. 1992; (1): 175-84
- Cold Spring Harb Symp Quant Biol. 1992; 291-308
- Proc Natl Acad Sci U S A. 1992; (4): 1502-6
- Blood. 1992; (8): 1907-15
- Ann N Y Acad Sci. 1992; 21-32
- Int Immunol. 1992; (7): 821-4
- J Exp Med. 1992; (2): 399-405
- J Biol Chem. 1992; (35): 25488-93
- Proc Natl Acad Sci U S A. 1991; (7): 2788-92
- Eur J Immunol. 1991; (3): 687-93
- J Exp Med. 1991; (2): 373-81
- Blood. 1991; (10): 2650-65
- Curr Top Dev Biol. 1991; 155-75
- J Exp Med. 1991; (5): 1279-82
- Int J Cell Cloning. 1991; (5): 451-60
- Cell. 1991; (4): 799-806
- J Exp Med. 1991; (1): 139-49
- J Cell Biol. 1991; (4): 1149-58
- Cell. 1990; (4): 611-22
- Arthritis Rheum. 1990; (5): 702-10
- J Immunol. 1990; (9): 3473-7
- Immunol Rev. 1990; 227-41
- J Immunol. 1990; (1): 111-21
- Int Immunol. 1990; (9): 795-802
- Int Immunol. 1990; (5): 399-406
- Cell. 1990; (5): 863-74
- J Immunol. 1990; (5): 1477-82
- J Exp Med. 1990; (3): 835-45
- Harvey Lect. 1989-1990; 43-69
- Proc Natl Acad Sci U S A. 1989; (19): 7542-6
- Immunol Rev. 1989; 45-61
- J Exp Med. 1989; (5): 1703-19
- Mol Cell Biol. 1989; (6): 2665-71
- J Autoimmun. 1989; 141-53
- Proc Natl Acad Sci U S A. 1989; (12): 4634-8
- EMBO J. 1989; (6): 1735-41
- J Immunol. 1989; (11): 3773-80
- Proc Natl Acad Sci U S A. 1989; (14): 5562-6
- J Immunol Methods. 1989; (1): 79-90
- Cell. 1989; (1): 37-46
- Cold Spring Harb Symp Quant Biol. 1989; 75-85
- J Immunol. 1989; (2): 425-30
- Science. 1989; (4895): 1165-72
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- Transplant Proc. 1988; (2): 251-3
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- Science. 1988; (4886): 1684-6
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- Ann N Y Acad Sci. 1988; 367-79
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