Stanford School of Medicine
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Key Documents

David Prince

Contact Information

  • Clinical Offices
    Neurology 300 Pasteur Dr A301 MC 5325 Stanford, CA 94305
    Telephone Work (650) 723-6469 Fax (650) 725-0390
  • Academic Offices
    Personal Information
    Email daprince@stanford.edu
    Administrative Contact
    Myrna Canizares Administrative Assistant Tel Work 650-723-5522

Administrative Appointments

  • Chairman, Department of Neurology and Neurological Sciences, Stanford Univ. School of Medicine , (1970– 1989 )

Honors and Awards

  • Special Lecturer, Society for Neuroscience (2008)
  • Lothman Lecturer, University of Virginia (2007)
  • The Larry Benardo Research and Education Fund Lecturer ., SUNY Downstate Medical Center, New York (2006)
  • Servier Lecturer, University of Montreal (2002)
  • Bronte Lecturer, University of California, Davis (2001)
  • Peter Kellaway Lecturer, Baylor College of Medicine, Houston, Texas (1998)
  • George Bishop Lecturer, Washington University, St. Louis (1997)
  • Sachs Lecturer, Child Neurology Society (1994)
  • Lennox Lecturer, American Epilepsy Society (1987)
  • Herbert Jasper Lecture, Montreal Neurological Institute, Montreal, Quebec, Canada. (1984)
  • First Morris B. Bender Memorial Lectureship., Mount Sinai Medical School, New York, New York. (1984)
  • Arthur Bloomfield Award for excellence in clinical teaching., Stanford Univ. School of Medicine (1986)
  • Javits Neuroscience Investigator Award, NINDS, National Institute of Neurological Disorders and Stroke (1987-1995; 1995-2001)
  • Research Recognition Award in Basic Neuroscience, Americal Epilepsy Society (1991)
  • Lennox Award for contributions in the field of epilepsy., American Epilepsy Society (1978)
  • Principal Investigator, USPHS Research Grant NS 06477 "Cellular mechanisms in focal epileptogenesis", National Institute of Neurological Diseases and Stroke (1966-current)
  • Program Director,Principal Investigator Epilepsy Program Project Grant NS 12151, National Institute of Neurological Diseases and Stroke (1975-present)
  • Program Director, NIH Training Grant NS07280 "Epilepsy Training Program", National Institute of Neurological Diseases and Stroke (1985-2003)
  • Program Director, Dana Fellowship Program in Neuroscience, Dana Foundation (1988-1995)
  • Principal Investigator, NS39579 Modulation of Neocortical Interneuronal Functionƒ°, NINDS (7/00-current)

Professional Education

  • B.S., Univ. of Vermont Psychology (1953)
  • M.D., Univ. of Pennsylvania Medicine (1956)

Postdoctoral Advisees

Graduate & Fellowship Program Affiliations

Research Interests

My work deals with regulation of excitability in neurons of mammalian cerebral cortex and thalamus and mechanisms underlying development of epilepsy. Long-term goals are to understand how injury produces changes in structure and function of neurons and neuronal networks that lead to hyperexcitability and epileptogenesis, and approaches to prevention of epilepsy after cortical injury. Areas of interest include regulation of voltage dependent membrane properties, neuropharmacology of transmitters and modulators including neuropeptides, synaptic mechanisms, and intrinsic properties of single, anatomically identified neurons. Techniques include use of in vivo mammalian preparations as well as in vitro slices and acutely dissociated neurons for recordings of synaptic activities and membrane properties, using patch-clamp techniques to study whole cell currents and membrane channels. Electrophysiological approaches are combined with intracellular labeling and immunocytochemistry to identify types of neurons and responses to injury.

Current studies include:
i) Reorganization of neocortical neuronal synaptic activities,and intrinsic neuronal properties after cortical trauma.
ii) Electrophysiologic and neuroanatomic studies of axonal sprouting following chronic neocortical injury.
iii) Anatomy and pathophysiology of neocortical developmental malformations.
iv) Effects of neuropeptides and GABAergic inhibition on intrinsic, synaptic and network properties of thalamic neurons; and generation of normal and pathophysiologic rhythms.
v) Modulation of neocortical inhibitory interneuronal activities by neurotransmitters and injury.

Publications