Key Documents
NIH Biosketch available Online
John Boothroyd
- Professor, Microbiology & Immunology
- Member, Bio-X
- Member, Cancer Center
Contact Information
- Clinical Offices
- Academic Offices
Personal Information Email jboothr@stanford.eduAdministrative Contact Bonda Lewis Administrative Assistant Email llewys@stanford.edu Tel Work 650-725-4753
Administrative Appointments
- Associate Vice-Provost for Graduate Education, Stanford University , (2008– present )
- Senior Associate Dean for Research and Training, Stanford University School of Medicine , (2002– 2005 )
- Chair, Dept. Microbiology and Immunology, Stanford University School of Medicine , (1999– 2002 )
- Chair, Burroughs Wellcome Fund Advisory Panel on Molecular Parasitology , (1999– 2001 )
- Chair, Gordon Conference on Parasitism , (1999– 1999 )
- Director, MBL Summer Course on Biology of Parasitism , (1991– 1993 )
Honors and Awards
- Leuckart Medal, German Society for Parasitology (2008)
- Fellow, American Academy of Microbiology (2007)
- Senior Scholar in Global Infectious Diseases, Ellison Medical Foundation (2002-2006)
- Dunlevie Family University Fellow in Undergraduate Education, Stanford University (2002)
- Merit Award, NIH (1994-2004)
- Scholar Award in Molecular Parasitology, Burroughs Wellcome Fund (1986-1991)
- Overseas Research Scholarship, Royal Commission for the Exhibition of 1851 (1976-1979)
Professional Education
- Ph.D., Edinburgh University Molecular Biology (1979)
- B.Sc. (Hons), McGill University Cell, Mol. and Devel. Biology (1975)
Postdoctoral Advisees
Graduate & Fellowship Program Affiliations
Web Site Links
Research Interests
Studies on the cell and molecular biology of parasitic protozoa are critically important for two reasons; first, these organisms are major pathogens of humans and anaimals and, second, they have proven to be a source of some remarkable phenomena that have challenged much of the dogma thought to be universal in eukaryotic biology. We have been studying two of these single-celled eukaryotes, Trypanosoma brucei and Toxoplasma gondii. Each has its own features that make it interesting to the scientist and both are major pathogens, trypanosomes being the cause of sleeping sickness in Africa and Toxoplasma being a major opporunistic pathogen of AIDS patients. As of, 1998, however, we have focused our entire effort on Toxoplasma because of its growing importance and our results developing this system for modern genetic analysis (we now have a full genetic "toolbox" for this intracellular parasite including a genetic map, efficient genetic transformation and gene knock-out).
The major areas where the lab is currently working are:
(i) Intracellular parasitism: how does this parasite attach, invade and reproduce within virtually any nucleated cell.
(ii) Protein trafficking; how are proteins destined for novel organelles specifically targeted.
(iii) Developmental biology; what genes are crucial for asexual development from the actively dividing to the latent form of the parasite and what are the cis- and trans-elements that control that expression.
(iv) Host-pathogen interaction: what changes occur in the host cell in response to infection?
(v) Pathogenesis: what properties make certain strains more virulent than others?
Publications
- Traffic. 2009; (10): 1458-70
- Nat Rev Microbiol. 2008; (1): 79-88
- Nature. 2007; (7125): 324-7
- Proc Natl Acad Sci U S A. 2006; (27): 10514-9
- PLoS Pathog. 2005; (2): e17
- Science. 2009; (5913): 530-3
- Eukaryot Cell. 2009; (3): 398-409
- Mem Inst Oswaldo Cruz. 2009; (2): 179-84
- Int J Parasitol. 2009; (8): 935-46
- Cell Microbiol. 2009;
- Methods Mol Biol. 2008; 135-46
- Eukaryot Cell. 2008; (8): 1403-14
- Infect Immun. 2008; (12): 5853-61
- Traffic. 2008; (5): 647-56
- Infect Immun. 2008; (6): 2402-10
- Curr Opin Microbiol. 2007; (1): 83-9
- Proc Natl Acad Sci U S A. 2007; (15): 6442-7
- J Immunol. 2007; (8): 5154-65
- Int J Parasitol. 2007; (8-9): 877-85
- Exp Parasitol. 2007; (3): 302-5
- Infect Immun. 2007; (4): 1626-34
- Eukaryot Cell. 2007; (1): 73-83
- Infect Immun. 2007; (2): 634-42
- Cell. 2006; (2): 261-74
- Science. 2006; (5806): 1780-3
- Microbes Infect. 2006; (6): 1623-30
- Eukaryot Cell. 2006; (7): 1169-73
- Nat Biotechnol. 2005; (2): 232-7
- Infect Immun. 2005; (10): 6680-8
- Int J Parasitol. 2005; (3): 285-91
- Infect Immun. 2005; (2): 695-702
- Mol Biochem Parasitol. 2005; (2): 159-66
- Trends Parasitol. 2005; (10): 476-81
- J Biol Chem. 2005; (40): 34245-58
- J Immunol. 2005; (12): 8038-48
- Nucleic Acids Res. 2005; (9): 2980-92
- J Immunol. 2004; (4): 2725-35
- Mol Biochem Parasitol. 2004; (1): 111-20
- Int J Parasitol. 2004; (3): 275-84
- Int J Parasitol. 2004; (3): 361-8
- J Cell Biol. 2004; (5): 653-62
- Trends Parasitol. 2003; (10): 470-6
- J Infect Dis. 2003; (9): 1484-95
- Mol Biochem Parasitol. 2002 Nov-Dec; (1-2): 189-93
- Mol Microbiol. 2002; (3): 721-33
- Nat Struct Biol. 2002; (8): 606-11
- Curr Opin Microbiol. 2002; (4): 438-42
- Eukaryot Cell. 2002; (3): 329-40
- J Biol Chem. 2002; (1): 639-44
- Mol Microbiol. 2002; (5): 1309-18
- Science. 2001; 161-16
- J Clin Microbiol. 2001; (1): 398-400
- Exp Parasitol. 2001; (1): 55-9
- J Biol Chem. 2001; (26): 24223-31
- Mol Biochem Parasitol. 2001; (1): 11-6
- J Infect Dis. 2001; (5): 633-9
- Drug Resist Updat. 2001; (2): 79-84
- Int J Parasitol. 2001; (11): 1177-86
- Mol Biochem Parasitol. 2001; (2): 239-45
- Exp Parasitol. 2001; (4): 206-14
- Int J Parasitol. 2001; (12): 1285-92
- Science. 2001; (5540): 161-5
- Mol Biochem Parasitol. 2000; (1): 1-12
- Microbiol Mol Biol Rev. 2000; (3): 607-23
- Mol Cell Biol. 2000; (24): 9399-408
- Infect Immun. 2000; (12): 7078-86
- Mol Biochem Parasitol. 2000; (1): 199-205
- Exp Parasitol. 2000; (2): 89-96
- J Eukaryot Microbiol. 1999 Sep-Oct; (5): 81S-82S
- Mol Biochem Parasitol. 1999; (1): 103-9
- Exp Parasitol. 1999; (3): 222-30
- J Biol Chem. 1999; (3): 1267-76
- Infect Immun. 1998; (5): 2237-44
- Mol Biochem Parasitol. 1998; (1-2): 37-48
- Parasitol Today. 1998; (12): 490-3
- Genome Res. 1998; (1): 18-28
- J Cell Sci. 1998; 23-9
- Infect Immun. 1998; (4): 1632-7
- Int J Parasitol. 1998; (1): 3-9
- J Biol Chem. 1998; (7): 3972-9
- Mol Cell Biol. 1998; (2): 807-14
- Mol Biochem Parasitol. 1998; (1-2): 1-11
- Methods. 1997; (2): 89-102
- Mol Biochem Parasitol. 1997; (2): 271-82
- Philos Trans R Soc Lond B Biol Sci. 1997; (1359): 1347-54
- Antimicrob Agents Chemother. 1997; (9): 1849-53
- Mol Biochem Parasitol. 1996; (2): 119-26
- J Mol Evol. 1996; (5): 500-11
- Mol Microbiol. 1996; (1): 53-63
- Gene. 1996; (1): 39-45
- Mol Biochem Parasitol. 1995; (1): 55-63
- Mol Biochem Parasitol. 1995; (1): 131-4
- Exp Parasitol. 1995; (1): 46-53
- Exp Parasitol. 1995; (3): 313-20
- Int J Parasitol. 1995; (11): 1293-9
- Mol Cell Biol. 1995; (1): 87-93
- Mol Biochem Parasitol. 1995; (1): 87-97
- J Eukaryot Microbiol. 1994 Sep-Oct; (5): 19S-21S
- Infect Immun. 1994; (1): 203-9
- Res Immunol. 1993; (1): 14-6
- Parasitol Today. 1993; (10): 392-5
- Mol Biochem Parasitol. 1993; (1): 143-8
- Science. 1993; (5135): 911-4
- J Cell Sci. 1993; 1101-13
- Infect Agents Dis. 1993; (2): 100-2
- Science. 1993; (5106): 349-52
- Nature. 1992; (6390): 82-5
- Genetics. 1992; (4): 1003-15
- J Immunol. 1992; (5): 1493-8
- Mol Biochem Parasitol. 1992; (1): 1-15
- Mol Biochem Parasitol. 1992; (2): 291-300
- J Mol Biol. 1992; (4): 961-71
- J Mol Biol. 1992; (4): 973-83
- EMBO J. 1992; (11): 4187-95
- J Biol Chem. 1992; (14): 9805-15
- Mol Biochem Parasitol. 1991; (1): 133-9
- Parasitol Today. 1991; (12): 327-8
- J Mol Biol. 1991; (3): 525-36
- J Immunol. 1991; (10): 3496-500
- Mol Cell Biol. 1990; (6): 3284-8
- J Clin Microbiol. 1990; (10): 2297-301
- Mol Biochem Parasitol. 1990; (1): 1-16
- Gene. 1989; (1): 169-75
- J Biol Chem. 1989; (13): 7107-10
- Mol Biochem Parasitol. 1989; (1): 3-13
- J Clin Microbiol. 1989; (8): 1787-92
- J Biol Chem. 1989; (10): 5569-74
- Biochemistry. 1989; (15): 6440-6
- Mol Biochem Parasitol. 1988; (2-3): 261-73
- Mol Cell Biol. 1988; (1): 494-6
- EMBO J. 1988; (5): 1431-7
- Mol Cell Biol. 1988; (9): 3837-46
- J Immunol. 1988; (10): 3584-91
- J Mol Biol. 1987; (1): 113-24
- Nucleic Acids Res. 1987; (10): 4065-84
- Cell. 1986; (4): 527-35
- Annu Rev Microbiol. 1985; 475-502
- Nature. 1984 Sep 27-Oct 3; (5984): 350-5
- Nucleic Acids Res. 1984; (6): 2759-74
- Nucleic Acids Res. 1982; (24): 8285-95
- J Mol Biol. 1982; (3): 547-56
- Gene. 1982; (2): 153-61
- Gene. 1982; (2): 281-9
- Cell. 1981; (3 Pt 2): 497-505
- Nucleic Acids Res. 1981; (18): 4745-53
- Nature. 1981; (5809): 800-2
- Nucleic Acids Res. 1981; (18): 4735-43
- Nature. 1980; (5791): 624-6
- Am J Trop Med Hyg. 1980; (5 Suppl): 1027-32
- Nucleic Acids Res. 1979; (7): 1931-43
- Plant Physiol. 1976; (4): 497-503