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Key Documents

Curriculum Vitae available Online

Robert V Rouse

Professor - Med Center Line, Pathology

Contact Information

Clinical Offices

Department of Pathology 300 Pasteur Dr L235 MC 5324 Stanford, CA 94305
Telephone Work (650) 723-7211 Fax (650) 725-7023
Academic Offices

Personal Information
Email rouse@stanford.edu
Not for medical emergencies or patient use

Clinical Focus

Pathology and Laboratory Medicine
Anatomic/Clinical Pathology

Administrative Appointments

Associate Chair for the Pathology Service at VAPAHCS, Stanford University School of Medicine , (2006– present )

Professional Education

Board Certification: Anatomic Pathology, American Board of Pathology (1979)
SUMC - Graduate Medical Education (1979) CA
Stanford University School of Medicine (1975) CA
Washington University School Of Medicine (1974) MO
MD, Washington University Medicine (1974)
BS, Northwestern University Engineering (1970)

Web Site Links

Surgical Pathology Criteria

Research Interests

My recent research efforts are currently focused in the field of applications of immunohistology to the diagnosis of human neoplasms. This work is predominantly aimed at characterizing markers for the identification of non-lymphoid neoplasms and at establishing criteria for their evaluation in diagnostic situations. Examples of these projects have included the identification of CD34 in gastrointestinal stromal tumors and solitary fibrous tumors, studies of the phenotypes of cutaneous tumors such as atypical fibroxanthomas and desmoplastic melanomas and evaluation of markers for types of carcinoma. We have several similar studies currently ongoing.

Publications

Adenomatoid tumors of the female and male genital tracts: a clinicopathological and immunohistochemical study of 44 cases. Sangoi AR, McKenney JK, Schwartz EJ, Rouse RV, Longacre TA. Mod Pathol. 2009; 22 (9): 1228-35
The transcription factor LMO2 is a robust marker of vascular endothelium and vascular neoplasms and selected other entities. Gratzinger D, Zhao S, West R, Rouse RV, Vogel H, Gil EC, Levy R, Lossos IS, Natkunam Y. Am J Clin Pathol. 2009; 131 (2): 264-78
Ameloblastoma, calcifying epithelial odontogenic tumor, and glandular odontogenic cyst show a distinctive immunophenotype with some myoepithelial antigen expression. Gratzinger D, Salama ME, Poh CF, Rouse RV. J Oral Pathol Med. 2008; 37 (3): 177-84
New models and online calculator for predicting non-sentinel lymph node status in sentinel lymph node positive breast cancer patients. Kohrt HE, Olshen RA, Bermas HR, Goodson WH, Wood DJ, Henry S, Rouse RV, Bailey L, Philben VJ, Dirbas FM, Dunn JJ, Johnson DL, Wapnir IL, Carlson RW, Stockdale FE, Hansen NM, Jeffrey SS. BMC Cancer. 2008; 8 66
Prevalence of nonpolypoid (flat and depressed) colorectal neoplasms in asymptomatic and symptomatic adults. Soetikno RM, Kaltenbach T, Rouse RV, Park W, Maheshwari A, Sato T, Matsui S, Friedland S. JAMA. 2008; 299 (9): 1027-35
High-molecular-weight keratin stain as a complement to Melan A stain. Egbert BM, Rouse RV, Swetter SM. J Cutan Pathol. 2008; 35 (12): 1159
A phase II study of gefitinib, 5-fluorouracil, leucovorin, and oxaliplatin in previously untreated patients with metastatic colorectal cancer. Fisher GA, Kuo T, Ramsey M, Schwartz E, Rouse RV, Cho CD, Halsey J, Sikic BI. Clin Cancer Res. 2008; 14 (21): 7074-9
Short- and long-term outcomes of standardized EMR of nonpolypoid (flat and depressed) colorectal lesions > or = 1 cm (with video). Kaltenbach T, Friedland S, Maheshwari A, Ouyang D, Rouse RV, Wren S, Soetikno R. Gastrointest Endosc. 2007; 65 (6): 857-65
Extragonadal germ cell tumors: a review with emphasis on pathologic features, clinical prognostic variables, and differential diagnostic considerations. McKenney JK, Heerema-McKenney A, Rouse RV. Adv Anat Pathol. 2007; 14 (2): 69-92
Care within a veterans hospital: earlier detection of colon cancer. van Roessel P, Rouse RV, Wren SM. Surg Endosc. 2007; 21 (8): 1434-40
Slow-growing nodule on the thigh. Stewart DB, Egbert BM, Rouse RV, Swetter SM. Arch Dermatol. 2006; 142 (7): 921-6
Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation. 1982. Butcher EC, Rouse RV, Coffman RL, Nottenburg CN, Hardy RR, Weissman IL. J Immunol. 2005; 175 (3): 1363-72
Institutional commitment to rectal cancer screening results in earlier-stage cancers on diagnosis. Battat AC, Rouse RV, Dempsey L, Safadi BY, Wren SM. Ann Surg Oncol. 2004; 11 (11): 970-6
Expression of the B-cell proliferation marker MUM1 by melanocytic lesions and comparison with S100, gp100 (HMB45), and MelanA. Sundram U, Harvell JD, Rouse RV, Natkunam Y. Mod Pathol. 2003; 16 (8): 802-10
Hep par 1 antibody stain for the differential diagnosis of hepatocellular carcinoma: 676 tumors tested using tissue microarrays and conventional tissue sections. Fan Z, van de Rijn M, Montgomery K, Rouse RV. Mod Pathol. 2003; 16 (2): 137-44
Ectopic prostate: case report of a presacral mass presenting with obstructive symptoms. Fulton RS, Rouse RV, Ranheim EA. Arch Pathol Lab Med. 2001; 125 (2): 286-8
Spindle cell lipoma of the foot and the application of CD34 immunohistochemistry to atypical lipomatous tumors in unusual locations. Austin CD, Tiessen JR, Gopalan A, Williams JM, Bangs CD, Cherry AM, Lehnert BA, Rouse RV. Appl Immunohistochem Mol Morphol. 2000; 8 (3): 222-7
Utility of paraffin section immunohistochemistry for C-KIT (CD117) in the differential diagnosis of systemic mast cell disease involving the bone marrow. Natkunam Y, Rouse RV. Am J Surg Pathol. 2000; 24 (1): 81-91
A critical examination of the immunophenotype of pulmonary sclerosing hemangioma. Rodriguez-Soto J, Colby TV, Rouse RV. Am J Surg Pathol. 2000; 24 (3): 442-50
Cytokeratin staining in Merkel cell carcinoma: an immunohistochemical study of cytokeratins 5/6, 7, 17, and 20. Jensen K, Kohler S, Rouse RV. Appl Immunohistochem Mol Morphol. 2000; 8 (4): 310-5
Immunoblot analysis of CD34 expression in histologically diverse neoplasms. Natkunam Y, Rouse RV, Zhu S, Fisher C, van De Rijn M. Am J Pathol. 2000; 156 (1): 21-7
Basal cell carcinoma with tumor epithelial and stromal giant cells: a variant of pleomorphic basal cell carcinoma. Meehan SA, Egbert BM, Rouse RV. Am J Dermatopathol. 1999; 21 (5): 473-8
Inhibin and CD99 (MIC2) expression in uterine stromal neoplasms with sex-cord-like elements. Baker RJ, Hildebrandt RH, Rouse RV, Hendrickson MR, Longacre TA. Hum Pathol. 1999; 30 (6): 671-9
Intraepidermal cytokeratin 7 expression is not restricted to Paget cells but is also seen in Toker cells and Merkel cells. Lundquist K, Kohler S, Rouse RV. Am J Surg Pathol. 1999; 23 (2): 212-9
Testicular Sertoli cell tumors NOS, the final word? Higgins JP, Rouse RV. Adv Anat Pathol. 1999; 6 (2): 103-13
The differential diagnosis of pagetoid cells in the epidermis. Kohler S, Rouse RV, Smoller BR. Mod Pathol. 1998; 11 (1): 79-92
Menetrier's disease: report of a transient case associated with chylous ascites. Soetikno RM, Tantibhedhyangkul W, Binion D, Rouse RV. Am J Gastroenterol. 1997; 92 (8): 1364-7
Value of inhibin in the identification of granulosa cell tumors of the ovary. Hildebrandt RH, Rouse RV, Longacre TA. Hum Pathol. 1997; 28 (12): 1387-95
Atypical polypoid adenomyofibromas (atypical polypoid adenomyomas) of the uterus. A clinicopathologic study of 55 cases. Longacre TA, Chung MH, Rouse RV, Hendrickson MR. Am J Surg Pathol. 1996; 20 (1): 1-20
Desmoplastic and spindle-cell malignant melanoma. An immunohistochemical study. Longacre TA, Egbert BM, Rouse RV. Am J Surg Pathol. 1996; 20 (12): 1489-500
Transitional cell neoplasms of the ovary and urinary bladder: a comparative immunohistochemical analysis. Soslow RA, Rouse RV, Hendrickson MR, Silva EG, Longacre TA. Int J Gynecol Pathol. 1996; 15 (3): 257-65
Atypical polypoid adenomyofibroma (APA) versus well-differentiated endometrial carcinoma with prominent stromal matrix: an immunohistochemical study. Soslow RA, Chung MH, Rouse RV, Hendrickson MR, Longacre TA. Int J Gynecol Pathol. 1996; 15 (3): 209-16
Esophageal submucosal gland duct adenoma. Rouse RV, Soetikno RM, Baker RJ, Barnard IC, Triadafilopoulos G, Longacre TA. Am J Surg Pathol. 1995; 19 (10): 1191-6
Analyses of homologous rotavirus infection in the mouse model. Burns JW, Krishnaney AA, Vo PT, Rouse RV, Anderson LJ, Greenberg HB. Virology. 1995; 207 (1): 143-53
L-selectin and alpha 4 beta 7 integrin homing receptor pathways mediate peripheral lymphocyte traffic to AKR mouse hyperplastic thymus. Michie SA, Streeter PR, Butcher EC, Rouse RV. Am J Pathol. 1995; 147 (2): 412-21
Expression of CD34 by solitary fibrous tumors of the pleura, mediastinum, and lung. van de Rijn M, Lombard CM, Rouse RV. Am J Surg Pathol. 1994; 18 (8): 814-20
CD34 expression by gastrointestinal tract stromal tumors. van de Rijn M, Hendrickson MR, Rouse RV. Hum Pathol. 1994; 25 (8): 766-71
Detection of immunophenotypic abnormalities in paraffin-embedded B-lineage non-Hodgkin's lymphomas. Gelb AB, Rouse RV, Dorfman RF, Warnke RA. Am J Clin Pathol. 1994; 102 (6): 825-34
A comparative immunohistochemical study of uterine smooth muscle neoplasms with emphasis on the epithelioid variant. Rizeq MN, van de Rijn M, Hendrickson MR, Rouse RV. Hum Pathol. 1994; 25 (7): 671-7
Benign lymphangioendothelioma. Herron GS, Rouse RV, Kosek JC, Smoller BR, Egbert BM. J Am Acad Dermatol. 1994; 31 (2 Pt 2): 362-8
Atypical fibroxanthoma. Multiple immunohistologic profiles. Longacre TA, Smoller BR, Rouse RV. Am J Surg Pathol. 1993; 17 (12): 1199-209
Infantile histiocytoid cardiomyopathy--myocardial or conduction system hamartoma: what is the cell type involved? Gelb AB, Van Meter SH, Billingham ME, Berry GJ, Rouse RV. Hum Pathol. 1993; 24 (11): 1226-31
Traffic of peripheral B and T lymphocytes to hyperplastic, preneoplastic thymuses of AKR mice. Michie SA, Rouse RV. Am J Pathol. 1991; 138 (4): 1015-25
Carcinomas with metaplasia and sarcomas of the breast. Pitts WC, Rojas VA, Gaffey MJ, Rouse RV, Esteban J, Frierson HF, Kempson RL, Weiss LM. Am J Clin Pathol. 1991; 95 (5): 623-32
Heterogeneity of epithelial marker expression in routinely processed, poorly differentiated carcinomas. Kamel OW, Rouse RV, Warnke RA. Arch Pathol Lab Med. 1991; 115 (6): 566-70
Macrophages are the first thymic cells to express polytropic retrovirus in AKR mouse leukemogenesis. Kim SY, Evans LH, Malik FG, Rouse RV. J Virol. 1991; 65 (11): 6238-41
Abnormalities in premigratory granule cells in the weaver cerebellum defined by monoclonal antibody OZ42. Smeyne RJ, Pickford LB, Rouse RV, Napieralski J, Goldowitz D. Anat Embryol (Berl). 1991; 183 (3): 213-9
Grafts of dissociated cerebellar cells containing Purkinje cell precursors organize into zebrin I defined compartments. Rouse RV, Sotelo C. Exp Brain Res. 1990; 82 (2): 401-7
Transiently expressed, neural-specific molecule associated with premigratory granule cells in postnatal mouse cerebellum. Pickford LB, Mayer DN, Bolin LM, Rouse RV. J Neurocytol. 1989; 18 (4): 465-78
Lymphomas presenting as histologically unclassified neoplasms: characteristics and response to treatment. Horning SJ, Carrier EK, Rouse RV, Warnke RA, Michie SA. J Clin Oncol. 1989; 7 (9): 1281-7
Identification of subpopulations of mouse thymic epithelial cells in culture. Small M, Van Ewijk W, Gown AM, Rouse RV. Immunology. 1989; 68 (3): 371-7
The distribution of MHC class I and II antigens on bronchial epithelium. Glanville AR, Tazelaar HD, Theodore J, Imoto E, Rouse RV, Baldwin JC, Robin ED. Am Rev Respir Dis. 1989; 139 (2): 330-4
Traffic of mature lymphocytes into the mouse thymus. Michie SA, Rouse RV. Thymus. 1989; 13 (3-4): 141-8
Human thymomas: evidence of immunohistologically defined normal and abnormal microenvironmental differentiation. Rouse RV, Weiss LM. Cell Immunol. 1988; 111 (1): 94-106
Independent developmental regulation of migratory granule neurons and their cerebellar ligand in the mouse. Bolin LM, Thomas AR, Mayer DN, Rouse RV. Neurosci Lett. 1988; 85 (1): 158-62
The diagnostic utility of the keratin profiles of hepatocellular carcinoma and cholangiocarcinoma. Johnson DE, Herndier BG, Medeiros LJ, Warnke RA, Rouse RV. Am J Surg Pathol. 1988; 12 (3): 187-97
Study of murine T cell migration using the Thy-1 allotypic marker. Demonstration of antigen-specific homing to lymph node germinal centers. Michie SA, Rouse RV. Transplantation. 1988; 46 (1): 98-104
Rare peripheral T cells migrate to and persist in normal mouse thymus. Michie SA, Kirkpatrick EA, Rouse RV. J Exp Med. 1988; 168 (5): 1929-34
Monoclonal antibodies reactive with subsets of mouse and human thymic epithelial cells. Rouse RV, Bolin LM, Bender JR, Kyewski BA. J Histochem Cytochem. 1988; 36 (12): 1511-7
Identification and surface phenotypic characterization of phosphorylcholine-specific idiotype-bearing T cells. Razzeca KJ, Kim SY, Rouse RV. Cell Immunol. 1988; 112 (2): 442-8
Expression of the Leu-8 antigen by B-cell lymphomas. Michie SA, Garcia CF, Strickler JG, Dailey MO, Rouse RV, Warnke RA. Am J Clin Pathol. 1987; 88 (4): 486-90
A panel approach to the evaluation of the sensitivity and specificity of antibodies for the diagnosis of routinely processed histologically undifferentiated human neoplasms. Michie SA, Spagnolo DV, Dunn KA, Warnke RA, Rouse RV. Am J Clin Pathol. 1987; 88 (4): 457-62
Immunohistochemical staining in malignant mesotheliomas. Strickler JG, Herndier BG, Rouse RV. Am J Clin Pathol. 1987; 88 (5): 610-4
Intrathymic presentation of circulating non-MHC antigens by medullary dendritic cells. An antigen-dependent microenvironment for T cell differentiation. Kyewski BA, Fathman CG, Rouse RV. J Exp Med. 1986; 163 (2): 231-46
In situ identification of idiotype-positive cells participating in the immune response to phosphorylcholine. Razzeca KJ, Pillemer E, Weissman IL, Rouse RV. Eur J Immunol. 1986; 16 (4): 393-9
Composition of the lymphoid cell populations from omental milky spots during the immune response in C57BL/Ka mice. Dux K, Rouse RV, Kyewski B. Eur J Immunol. 1986; 16 (8): 1029-32
Localization of Thy-1 expression during postnatal development of the mouse cerebellar cortex. Bolin LM, Rouse RV. J Neurocytol. 1986; 15 (1): 29-36
Monoclonal anti-keratin (AE1) reactivity in routinely processed tissue from 166 human neoplasms. Spagnolo DV, Michie SA, Crabtree GS, Warnke RA, Rouse RV. Am J Clin Pathol. 1985; 84 (6): 697-704
Expression of major histocompatibility complex antigens in the thymuses of chimeric mice. Rouse RV, Ezine S, Weissman IL. Transplantation. 1985; 40 (4): 422-6
Prostatic adenocarcinoma with endometrioid features. Clinical, pathologic, and ultrastructural findings. Bostwick DG, Kindrachuk RW, Rouse RV. Am J Surg Pathol. 1985; 9 (8): 595-609
Limitations encountered in the application of tissue section immunodiagnosis to the study of lymphomas and related disorders. Warnke RA, Rouse RV. Hum Pathol. 1985; 16 (4): 326-31
Morphologic and immunologic characterization of 50 peripheral T-cell lymphomas. Weiss LM, Crabtree GS, Rouse RV, Warnke RA. Am J Pathol. 1985; 118 (2): 316-24
Is Ia antigen expression by thymic epithelial cells constitutive? Rouse RV, Adv Exp Med Biol. 1985; 186 915-9
Thymus homing clonogenic bone marrow cells. Ezine S, Weissman IL, Rouse RV. Adv Exp Med Biol. 1985; 186 223-7
Bone marrow cells give rise to distinct cell clones within the thymus. Ezine S, Weissman IL, Rouse RV. Nature. 1984 Jun 14-20; 309 (5969): 629-31
Localization of lymphocyte subpopulations in peripheral lymphoid organs: directed lymphocyte migration and segregation into specific microenvironments. Rouse RV, Reichert RA, Gallatin WM, Weissman IL, Butcher EC. Am J Anat. 1984; 170 (3): 391-405
The extent of surgery after chemotherapy for advanced germ cell tumors. Freiha FS, Shortliffe LD, Rouse RV, Mark JB, Hannigan JF, Aston D, Spaulding JT, Williams RD, Torti FM. J Urol. 1984; 132 (5): 915-7
Expression of a T-cell antigen (Leu-1) by B-cell lymphomas. Burns BF, Warnke RA, Doggett RS, Rouse RV. Am J Pathol. 1983; 113 (2): 165-71
The principal cells in the thymus expressing MHC antigens are epithelial. Rouse RV, Weissman IL. Adv Exp Med Biol. 1982; 149 401-5
Expression of T cell antigens by cells in mouse and human primary and secondary follicles. Rouse RV, Weissman IL, Ledbetter JA, Warnke RA. Adv Exp Med Biol. 1982; 149 751-6
Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation. Butcher EC, Rouse RV, Coffman RL, Nottenburg CN, Hardy RR, Weissman IL. J Immunol. 1982; 129 (6): 2698-707
Identification of T cell subsets and B lymphocytes in mouse brain experimental allergic encephalitis lesions. Sriram S, Solomon D, Rouse RV, Steinman L. J Immunol. 1982; 129 (4): 1649-51
Thymocyte rosettes: multicellular complexes of lymphocytes and bone marrow-derived stromal cells in the mouse thymus. Kyewski BA, Rouse RV, Kaplan HS. Proc Natl Acad Sci U S A. 1982; 79 (18): 5646-50
Monoclonal antibodies to a human prostate antigen. Frankel AE, Rouse RV, Wang MC, Chu TM, Herzenberg LA. Cancer Res. 1982; 42 (9): 3714-8
Expression of HLA antigens by human thymic epithelial cells. Rouse RV, Parham P, Grumet FC, Weissman IL. Hum Immunol. 1982; 5 (1): 21-34
Mouse lymph node germinal centers contain a selected subset of T cells--the helper phenotype. Rouse RV, Ledbetter JA, Weissman IL. J Immunol. 1982; 128 (5): 2243-6
Human prostate specific and shared differentiation antigens defined by monoclonal antibodies. Frankel AE, Rouse RV, Herzenberg LA. Proc Natl Acad Sci U S A. 1982; 79 (3): 903-7
Human trophoblast cell-surface antigens defined by monoclonal antibodies. Lipinski M, Parks DR, Rouse RV, Herzenberg LA. Proc Natl Acad Sci U S A. 1981; 78 (8): 5147-50
Microanatomy of the thymus: its relationship to T cell differentiation. Rouse RV, Weissman IL. Ciba Found Symp. 1981; 84 161-77
Normal and neoplastic lymphocyte maturation. Weissman IL, McGrath MS, Pillemer E, Hollander N, Rouse RV, Jerabek L, Stevens SK, Scollay RG, Butcher EC. J Supramol Struct Cell Biochem. 1981; 15 (3): 303-14
Distribution of H-2 microenvironments in the mouse thymus. Immunoelectron microscopic identification of I-A and H-2K bearing cells. Van Ewijk W, Rouse RV, Weissman IL. J Histochem Cytochem. 1980; 28 (10): 1089-99
T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views. Ledbetter JA, Rouse RV, Micklem HS, Herzenberg LA. J Exp Med. 1980; 152 (2): 280-95
Expression of MHC antigens by mouse thymic dendritic cells. Rouse RV, van Ewijk W, Jones PP, Weissman IL. J Immunol. 1979; 122 (6): 2508-15
The lymphoid system. Its normal architecture and the potential for understanding the system through the study of lymphoproliferative diseases. Weissman IL, Warnke R, Butcher EC, Rouse R, Levy R. Hum Pathol. 1978; 9 (1): 25-45