Stuart Goodman

Clinical Focus

• Adult Reconstruction- Lower Extremity
• Orthopaedic Surgery

Professional Education

• Board Certification: Orthopaedic Surgery, American Board of Orthopaedic Surgery (1987)
• Sunnybrook Medical Center (1985) Canada
• Wellesley Hospital (1985) Canada
• University of Toronto (1984) Canada
• Toronto General Hospital (1979) Canada
• University of Toronto (1978) Canada

Postdoctoral Advisees

• Pei-Gen Ren

Research Interests

As an academic orthopaedic surgeon, my interests center on adult reconstructive surgery including total joint replacement, osteotomies and the fixation of fractures. Both clinical and basic science investigations are ongoing.

My specific research interests include the following:

1. the biological aspects of the interface between orthopaedic implants/biomaterials and bone

2. total joint replacement: prosthesis design, biomechanics, biomaterials, mechanisms of failure

3. the effects of mechanical stimulation on mesenchymal tissue differentiation

4. osteoarthritis: etiology, diagnosis, imaging, treatment, outcomes

Clinical Trials

• Evaluation of E-Poly (tm) and Regenerex (tm) Cementless Acetabular Components: Clinical and Radiographic Outcomes Recruiting

Publications

• Ultrahigh molecular weight polyethylene wear debris inhibits osteoprogenitor proliferation and differentiation in vitro. Chiu R,  Ma T, Smith RL, Goodman SB.  J Biomed Mater Res A.  2009; 89 (1): 242-7
• Efficacy of a p38 mitogen activated protein kinase inhibitor in mitigating an established inflammatory reaction to polyethylene particles in vivo. Ma T,  Ren PG, Larsen DM, Suenaga E, Zilber S, Genovese M, Smith RL, Goodman SB.  J Biomed Mater Res A.  2009; 89 (1): 117-23
• Biocompatibility of poly(ethylene glycol)/poly(acrylic acid) interpenetrating polymer network hydrogel particles in RAW 264.7 macrophage and MG-63 osteoblast cell lines. Yim ES,  Zhao B, Myung D, Kourtis LC, Frank CW, Carter D, Smith RL, Goodman SB.  J Biomed Mater Res A.  2009; 91 (3): 894-902
• Increased expression of toll-like receptors in aseptic loose periprosthetic tissues and septic synovial membranes around total hip implants. Tamaki Y,  Takakubo Y, Goto K, Hirayama T, Sasaki K, Konttinen YT, Goodman SB, Takagi M.  J Rheumatol.  2009; 36 (3): 598-608
• Patellar Management in Revision Total Knee Arthroplasty Is Patellar Resurfacing a Better Option? Patil N,  Lee K, Huddleston JI, Harris AH, Goodman SB.  J Arthroplasty.  2009;
• Third-degree heart block associated with bupivacaine infusion following total knee arthroplasty. A case report. Hay DC,  Mayle RE, Goodman SB.  J Bone Joint Surg Am.  2009; 91 (9): 2238-40
• Bilateral Knee Arthrodesis in a Patient With Common Variable Immunodeficiency. Irani AR,  Graw BP, Goodman SB.  J Arthroplasty.  2009;
• Thrombin-activatable carboxypeptidase B cleavage of osteopontin regulates neutrophil survival and synoviocyte binding in rheumatoid arthritis. Sharif SA,  Du X, Myles T, Song JJ, Price E, Lee DM, Goodman SB, Nagashima M, Morser J, Robinson WH, Leung LL.  Arthritis Rheum.  2009; 60 (10): 2902-12
• Biocompatibility of total joint replacements: A review. Goodman SB,  Gómez Barrena E, Takagi M, Konttinen YT.  J Biomed Mater Res A.  2009; 90 (2): 603-18
• The accuracy of preoperative templating in cementless total hip arthroplasty. Unnanuntana A,  Wagner D, Goodman SB.  J Arthroplasty.  2009; 24 (2): 180-6
• Stem cell-mediated accelerated bone healing observed with in vivo molecular and small animal imaging technologies in a model of skeletal injury. Lee SW,  Padmanabhan P, Ray P, Gambhir SS, Doyle T, Contag C, Goodman SB, Biswal S.  J Orthop Res.  2009; 27 (3): 295-302
• Cell therapy for bone regeneration--bench to bedside. Lee K,  Chan CK, Patil N, Goodman SB.  J Biomed Mater Res B Appl Biomater.  2009; 89 (1): 252-63
• In vivo murine model of continuous intramedullary infusion of particles--a preliminary study. Ma T,  Ortiz SG, Huang Z, Ren P, Smith RL, Goodman SB.  J Biomed Mater Res B Appl Biomater.  2009; 88 (1): 250-3
• Porous tantalum in hip and knee reconstructive surgery. Patil N,  Lee K, Goodman SB.  J Biomed Mater Res B Appl Biomater.  2009; 89 (1): 242-51
• Retroperitoneal hematoma: an unusual cause of pain after total hip arthroplasty. Pouliot MA,  Lee KB, Goodman SB.  J Arthroplasty.  2009; 24 (7): 1144.e9-12
• Aseptic versus septic revision total knee arthroplasty: Patient satisfaction, outcome and quality of life improvement. Patil N,  Lee K, Huddleston JI, Harris AH, Goodman SB.  Knee.  2009;
• New bone formation by murine osteoprogenitor cells cultured on corticocancellous allograft bone. Nelson ER,  Huang Z, Ma T, Lindsey D, Jacobs C, Smith RL, Goodman SB.  J Orthop Res.  2008; 26 (12): 1660-4
• Continuous intramedullary polymer particle infusion using a murine femoral explant model. Ortiz SG,  Ma T, Regula D, Smith RL, Goodman SB.  J Biomed Mater Res B Appl Biomater.  2008; 87 (2): 440-6
• Systemic trafficking of macrophages induced by bone cement particles in nude mice. Ren PG,  Lee SW, Biswal S, Goodman SB.  Biomaterials.  2008; 29 (36): 4760-5
• Conversion total hip replacement after malunited intertrochanteric fracture: a technical note. Unnanuntana A,  Goodman SB.  Am J Orthop.  2008; 37 (10): 506-9
• Controlled release of growth factors on allograft bone in vitro. Huang Z,  Ryu W, Ren P, Fasching R, Goodman SB.  Clin Orthop Relat Res.  2008; 466 (8): 1905-11
• Validation and quantification of an in vitro model of continuous infusion of submicron-sized particles. Ortiz SG,  Ma T, Epstein NJ, Smith RL, Goodman SB.  J Biomed Mater Res B Appl Biomater.  2008; 84 (2): 328-33
• Histomorphometric analysis of the intramedullary bone response to titanium particles in wild-type and IL-1R1 knock-out mice: a preliminary study. Bragg B,  Epstein NJ, Ma T, Goodman S, Smith RL.  J Biomed Mater Res B Appl Biomater.  2008; 84 (2): 559-70
• An in vivo murine model of continuous intramedullary infusion of polyethylene particles. Ma T,  Huang Z, Ren PG, McCally R, Lindsey D, Smith RL, Goodman SB.  Biomaterials.  2008; 29 (27): 3738-42
• Current state and future of joint replacements in the hip and knee. Lee K,  Goodman SB.  Expert Rev Med Devices.  2008; 5 (3): 383-93
• Early outcome of a modular femoral component in revision total hip arthroplasty. Kang MN,  Huddleston JI, Hwang K, Imrie S, Goodman SB.  J Arthroplasty.  2008; 23 (2): 220-5
• Polymethylmethacrylate particles inhibit osteoblastic differentiation of MC3T3-E1 osteoprogenitor cells. Chiu R,  Ma T, Smith RL, Goodman SB.  J Orthop Res.  2008; 26 (7): 932-6
• Effect of nanofiber-coated surfaces on the proliferation and differentiation of osteoprogenitors in vitro. Huang Z,  Daniels RH, Enzerink RJ, Hardev V, Sahi V, Goodman SB.  Tissue Eng Part A.  2008; 14 (11): 1853-9
• The effects of medications on bone. Goodman SB,  Jiranek W, Petrow E, Yasko AW.  J Am Acad Orthop Surg.  2007; 15 (8): 450-60
• Biodegradable micro-osmotic pump for long-term and controlled release of basic fibroblast growth factor. Ryu W,  Huang Z, Prinz FB, Goodman SB, Fasching R.  J Control Release.  2007; 124 (1-2): 98-105
• Coronal plane stability before and after total knee arthroplasty. Siston RA,  Goodman SB, Delp SL, Giori NJ.  Clin Orthop Relat Res.  2007; 463 43-9
• Dissociation of the femoral head and trunion after constrained conversion total hip arthroplasty for poliomyelitis. Spinnickie A,  Goodman SB.  J Arthroplasty.  2007; 22 (4): 634-7
• Modulation of allograft incorporation by continuous infusion of growth factors over a prolonged duration in vivo. Ma T,  Gutnick J, Salazar B, Larsen MD, Suenaga E, Zilber S, Huang Z, Huddleston J, Smith RL, Goodman S.  Bone.  2007; 41 (3): 386-92
• The sequential expression profiles of growth factors from osteoprogenitors [correction of osteroprogenitors] to osteoblasts in vitro. Huang Z,  Nelson ER, Smith RL, Goodman SB.  Tissue Eng.  2007; 13 (9): 2311-20
• Surgical navigation for total knee arthroplasty: a perspective. Siston RA,  Giori NJ, Goodman SB, Delp SL.  J Biomech.  2007; 40 (4): 728-35
• Deltoid flap combined with fascia lata autograft for rotator cuff defects: a histologic study. McAdams TR,  Knudsen KR, Yalamanchi N, Chang J, Goodman SB.  Knee Surg Sports Traumatol Arthrosc.  2007; 15 (9): 1144-9
• Kinetics of polymethylmethacrylate particle-induced inhibition of osteoprogenitor differentiation and proliferation. Chiu R,  Ma T, Smith RL, Goodman SB.  J Orthop Res.  2007; 25 (4): 450-7
• Effects of a p38 MAP kinase inhibitor on bone ingrowth and tissue differentiation in rabbit chambers. Goodman SB,  Ma T, Spanogle J, Chiu R, Miyanishi K, Oh K, Plouhar P, Wadsworth S, Smith RL.  J Biomed Mater Res A.  2007; 81 (2): 310-6
• Wear particles, periprosthetic osteolysis and the immune system. Goodman SB,  Biomaterials.  2007; 28 (34): 5044-8
• Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis. Paniagua RT,  Sharpe O, Ho PP, Chan SM, Chang A, Higgins JP, Tomooka BH, Thomas FM, Song JJ, Goodman SB, Lee DM, Genovese MC, Utz PJ, Steinman L, Robinson WH.  J Clin Invest.  2006; 116 (10): 2633-42
• Dose- and time-dependent effects of cyclic hydrostatic pressure on transforming growth factor-beta3-induced chondrogenesis by adult human mesenchymal stem cells in vitro. Miyanishi K,  Trindade MC, Lindsey DP, Beaupré GS, Carter DR, Goodman SB, Schurman DJ, Smith RL.  Tissue Eng.  2006; 12 (8): 2253-62
• Effects of orthopaedic wear particles on osteoprogenitor cells. Goodman SB,  Ma T, Chiu R, Ramachandran R, Smith RL.  Biomaterials.  2006; 27 (36): 6096-101
• The high variability of tibial rotational alignment in total knee arthroplasty. Siston RA,  Goodman SB, Patel JJ, Delp SL, Giori NJ.  Clin Orthop Relat Res.  2006; 452 65-9
• Effects of hydrostatic pressure and transforming growth factor-beta 3 on adult human mesenchymal stem cell chondrogenesis in vitro. Miyanishi K,  Trindade MC, Lindsey DP, Beaupré GS, Carter DR, Goodman SB, Schurman DJ, Smith RL.  Tissue Eng.  2006; 12 (6): 1419-28
• Intraoperative passive kinematics of osteoarthritic knees before and after total knee arthroplasty. Siston RA,  Giori NJ, Goodman SB, Delp SL.  J Orthop Res.  2006; 24 (8): 1607-14
• Dose- and Time-Dependent Effects of Cyclic Hydrostatic Pressure on Transforming Growth Factor-beta3-Induced Chondrogenesis by Adult Human Mesenchymal Stem Cells in Vitro. Miyanishi K,  Trindade MC, Lindsey DP, Beaupré GS, Carter DR, Goodman SB, Schurman DJ, Smith RL.  Tissue Eng.  2006;
• Revision total hip arthroplasty in juvenile chronic arthritis: 17 revisions in 11 patients followed for 4-12 years. Goodman SB,  Oh KJ, Imrie S, Hwang K, Shegog M.  Acta Orthop.  2006; 77 (2): 242-50
• Polymethylmethacrylate particles inhibit osteoblastic differentiation of bone marrow osteoprogenitor cells. Chiu R,  Ma T, Smith RL, Goodman SB.  J Biomed Mater Res A.  2006; 77 (4): 850-6
• Comparison of VEGF-producing cells in periprosthetic osteolysis. Spanogle JP,  Miyanishi K, Ma T, Epstein NJ, Smith RL, Goodman SB.  Biomaterials.  2006; 27 (21): 3882-7
• The effects of titanium and polymethylmethacrylate particles on osteoblast phenotypic stability. Ramachandran R,  Goodman SB, Smith RL.  J Biomed Mater Res A.  2006; 77 (3): 512-7
• Effects of local infusion of OP-1 on particle-induced and NSAID-induced inhibition of bone ingrowth in vivo. Ma T,  Nelson ER, Mawatari T, Oh KJ, Larsen DM, Smith RL, Goodman SB.  J Biomed Mater Res A.  2006; 79 (3): 740-6
• Evaluation of methods that locate the center of the ankle for computer-assisted total knee arthroplasty. Siston RA,  Daub AC, Giori NJ, Goodman SB, Delp SL.  Clin Orthop Relat Res.  2005; 439 129-35
• UHMWPE wear debris upregulates mononuclear cell proinflammatory gene expression in a novel murine model of intramedullary particle disease. Epstein NJ,  Bragg WE, Ma T, Spanogle J, Smith RL, Goodman SB.  Acta Orthop.  2005; 76 (3): 412-20
• Wear particulate and osteolysis. Goodman S,  Orthop Clin North Am.  2005; 36 (1): 41-8, vi
• Pharmacologic modulation of periprosthetic osteolysis. Goodman SB,  Trindade M, Ma T, Genovese M, Smith RL.  Clin Orthop Relat Res.  2005; (430): 39-45
• The variability of femoral rotational alignment in total knee arthroplasty. Siston RA,  Patel JJ, Goodman SB, Delp SL, Giori NJ.  J Bone Joint Surg Am.  2005; 87 (10): 2276-80
• Total knee replacement in juvenile rheumatoid arthritis. Rojer DE,  Goodman SB.  Orthopedics.  2005; 28 (1): 39-45; quiz 46-7
• Cemented total knee arthroplasty in patients with juvenile rheumatoid arthritis. Thomas A,  Rojer D, Imrie S, Goodman SB.  Clin Orthop Relat Res.  2005; (433): 140-6
• Interleukin-1 modulates periprosthetic tissue formation in an intramedullary model of particle-induced inflammation. Epstein NJ,  Warme BA, Spanogle J, Ma T, Bragg B, Smith RL, Goodman SB.  J Orthop Res.  2005; 23 (3): 501-10
• Temporal effects of a COX-2-selective NSAID on bone ingrowth. Goodman SB,  Ma T, Mitsunaga L, Miyanishi K, Genovese MC, Smith RL.  J Biomed Mater Res A.  2005; 72 (3): 279-87
• Proinflammatory mediator expression in a novel murine model of titanium-particle-induced intramedullary inflammation. Warme BA,  Epstein NJ, Trindade MC, Miyanishi K, Ma T, Saket RR, Regula D, Goodman SB, Smith RL.  J Biomed Mater Res B Appl Biomater.  2004; 71 (2): 360-6
• Intermittent hydrostatic pressure inhibits matrix metalloproteinase and pro-inflammatory mediator release from human osteoarthritic chondrocytes in vitro. Trindade MC,  Shida J, Ikenoue T, Lee MS, Lin EY, Yaszay B, Yerby S, Goodman SB, Schurman DJ, Smith RL.  Osteoarthritis Cartilage.  2004; 12 (9): 729-35
• Complications of ilioischial reconstruction rings in revision total hip arthroplasty. Goodman S,  Saastamoinen H, Shasha N, Gross A.  J Arthroplasty.  2004; 19 (4): 436-46
• Human interleukin-1-induced murine osteoclastogenesis is dependent on RANKL, but independent of TNF-alpha. Ma T,  Miyanishi K, Suen A, Epstein NJ, Tomita T, Smith RL, Goodman SB.  Cytokine.  2004; 26 (3): 138-44
• Effects of interleukin-10 on titanium particle-induced macrophage transcription factor activation and cytokine expression in vitro. Wong N,  Trindade MC, Patel R, Yaszay B, Goodman SB, Smith RL.  J Biomed Mater Res A.  2004; 69 (1): 40-6
• Modified sliding trochanteric osteotomy in revision total hip arthroplasty. Goodman S,  Pressman A, Saastamoinen H, Gross A.  J Arthroplasty.  2004; 19 (8): 1039-41
• COX-2 selective inhibitors and bone. Goodman SB,  Ma T, Genovese M, Lane Smith R.  Int J Immunopathol Pharmacol.  2003 Sep-Dec; 16 (3): 201-5
• Interleukin 1 receptor antagonist inhibits localized bone formation in vivo. Ma T,  Miyanishi K, Trindade MC, Genovese M, Regula D, Smith RL, Goodman SB.  J Rheumatol.  2003; 30 (12): 2547-52
• Periprosthetic osteolysis: induction of vascular endothelial growth factor from human monocyte/macrophages by orthopaedic biomaterial particles. Miyanishi K,  Trindade MC, Ma T, Goodman SB, Schurman DJ, Smith RL.  J Bone Miner Res.  2003; 18 (9): 1573-83
• Economics of one-stage versus two-stage bilateral total knee arthroplasties. Macario A,  Schilling P, Rubio R, Goodman S.  Clin Orthop Relat Res.  2003; (414): 149-56
• Regulation of nitric oxide and bcl-2 expression by shear stress in human osteoarthritic chondrocytes in vitro. Lee MS,  Trindade MC, Ikenoue T, Goodman SB, Schurman DJ, Smith RL.  J Cell Biochem.  2003; 90 (1): 80-6
• Intermittent hydrostatic pressure inhibits shear stress-induced nitric oxide release in human osteoarthritic chondrocytes in vitro. Lee MS,  Trindade MC, Ikenoue T, Schurman DJ, Goodman SB, Smith RL.  J Rheumatol.  2003; 30 (2): 326-8
• Delayed-onset Mycobacterium tuberculosis infection with staphylococcal superinfection after total knee replacement. Al-Shaikh R,  Goodman SB.  Am J Orthop.  2003; 32 (6): 302-5
• What questions do patients undergoing lower extremity joint replacement surgery have? Macario A,  Schilling P, Rubio R, Bhalla A, Goodman S.  BMC Health Serv Res.  2003; 3 (1): 11
• Local infusion of FGF-2 enhances bone ingrowth in rabbit chambers in the presence of polyethylene particles. Goodman SB,  Song Y, Yoo JY, Fox N, Trindade MC, Kajiyama G, Ma T, Regula D, Brown J, Smith RL.  J Biomed Mater Res A.  2003; 65 (4): 454-61
• Human serum opsonization of orthopedic biomaterial particles: protein-binding and monocyte/macrophage activation in vitro. Sun DH,  Trindade MC, Nakashima Y, Maloney WJ, Goodman SB, Schurman DJ, Smith RL.  J Biomed Mater Res A.  2003; 65 (2): 290-8
• Modulation of bone ingrowth and tissue differentiation by local infusion of interleukin-10 in the presence of ultra-high molecular weight polyethylene (UHMWPE) wear particles. Goodman S,  Trindade M, Ma T, Lee M, Wang N, Ikenou T, Matsuura I, Miyanishi K, Fox N, Regula D, Genovese M, Klein J, Bloch D, Smith RL.  J Biomed Mater Res A.  2003; 65 (1): 43-50
• The role of the TH1 and TH2 immune responses in loosening and osteolysis of cemented total hip replacements. Arora A,  Song Y, Chun L, Huie P, Trindade M, Smith RL, Goodman S.  J Biomed Mater Res A.  2003; 64 (4): 693-7
• Efficacy of intraoperative blood collection and reinfusion in revision total hip arthroplasty. Zarin J,  Grosvenor D, Schurman D, Goodman S.  J Bone Joint Surg Am.  2003; 85-A (11): 2147-51
• Expression of nitric oxide, peroxynitrite, and apoptosis in loose total hip replacements. Puskas BL,  Menke NE, Huie P, Song Y, Ecklund K, Trindade MC, Smith RL, Goodman SB.  J Biomed Mater Res A.  2003; 66 (3): 541-9
• Screw migration from total knee prostheses requiring subsequent surgery. Shah SN,  Schurman DJ, Goodman SB.  J Arthroplasty.  2002; 17 (7): 951-4
• COX-2 selective NSAID decreases bone ingrowth in vivo. Goodman S,  Ma T, Trindade M, Ikenoue T, Matsuura I, Wong N, Fox N, Genovese M, Regula D, Smith RL.  J Orthop Res.  2002; 20 (6): 1164-9
• Revision total knee arthroplasty using large distal femoral augments for severe metaphyseal bone deficiency: a preliminary study. Werle JR,  Goodman SB, Imrie SN.  Orthopedics.  2002; 25 (3): 325-7
• Polyethylene liner dissociation in Harris-Galante acetabular components: a report of 7 cases. Werle J,  Goodman S, Schurman D, Lannin J.  J Arthroplasty.  2002; 17 (1): 78-81
• Measurement of perioperative flexion-extension mechanics of the knee joint. Giori NJ,  Giori KL, Woolson ST, Goodman SB, Lannin JV, Schurman DJ.  J Arthroplasty.  2001; 16 (7): 877-81
• Sliding trochanteric osteotomy preserves favorable abductor biomechanics in revision total hip arthroplasty. Romero AC,  Imrie S, Goodman SB.  J Arthroplasty.  2001; 16 (1): 55-64
• In vitro reaction to orthopaedic biomaterials by macrophages and lymphocytes isolated from patients undergoing revision surgery. Trindade MC,  Lind M, Sun D, Schurman DJ, Goodman SB, Smith RL.  Biomaterials.  2001; 22 (3): 253-9
• Chronic antigen-specific immune-system activation may potentially be involved in the loosening of cemented acetabular components. Farber A,  Chin R, Song Y, Huie P, Goodman S.  J Biomed Mater Res.  2001; 55 (3): 433-41
• Preoperative duplex ultrasonography evaluation for deep venous thrombosis in revision hip arthroplasty patients. Wallace B,  Jeffrey RB, Goodman SB.  Orthopedics.  2001; 24 (6): 577-9
• Interleukin-10 inhibits polymethylmethacrylate particle induced interleukin-6 and tumor necrosis factor-alpha release by human monocyte/macrophages in vitro. Trindade MC,  Lind M, Nakashima Y, Sun D, Goodman SB, Schurman DJ, Smith RL.  Biomaterials.  2001; 22 (15): 2067-73
• Fibroblast expression of C-C chemokines in response to orthopaedic biomaterial particle challenge in vitro. Yaszay B,  Trindade MC, Lind M, Goodman SB, Smith RL.  J Orthop Res.  2001; 19 (5): 970-6
• The effect of a silane coupling agent on the bond strength of bone cement and cobalt-chrome alloy. Yerby SA,  Paal AF, Young PM, Beaupré GS, Ohashi KL, Goodman SB.  J Biomed Mater Res.  2000; 49 (1): 127-33
• Outcome of total hip arthroplasty in small-proportioned patients. Rahimtoola ZO,  Finger S, Imrie S, Goodman SB.  J Arthroplasty.  2000; 15 (1): 27-34
• G-protein activity requirement for polymethylmethacrylate and titanium particle-induced fibroblast interleukin-6 and monocyte chemoattractant protein-1 release in vitro. Trindade MC,  Schurman DJ, Maloney WJ, Goodman SB, Smith RL.  J Biomed Mater Res.  2000; 51 (3): 360-8
• Efficacy of postoperative blood salvage following total hip arthroplasty in patients with and without deposited autologous units. Grosvenor D,  Goyal V, Goodman S.  J Bone Joint Surg Am.  2000; 82-A (7): 951-4
• Use of COX-2 specific inhibitors in operative and nonoperative management of patients with arthritis. Goodman SB,  Orthopedics.  2000; 23 (7 Suppl): S765-8
• Induction of interleukin-6 release in human osteoblast-like cells exposed to titanium particles in vitro. Shida J,  Trindade MC, Goodman SB, Schurman DJ, Smith RL.  Calcif Tissue Int.  2000; 67 (2): 151-5
• Lymphocyte CC chemokine receptor 9 and epithelial thymus-expressed chemokine (TECK) expression distinguish the small intestinal immune compartment: Epithelial expression of tissue-specific chemokines as an organizing principle in regional immunity. Kunkel EJ,  Campbell JJ, Haraldsen G, Pan J, Boisvert J, Roberts AI, Ebert EC, Vierra MA, Goodman SB, Genovese MC, Wardlaw AJ, Greenberg HB, Parker CM, Butcher EC, Andrew DP, Agace WW.  J Exp Med.  2000; 192 (5): 761-8
• Monocyte migration inhibitory factor synthesis and gene expression in particle-activated macrophages. Lind M,  Trindade MC, Schurman DJ, Goodman SB, Smith RL.  Cytokine.  2000; 12 (7): 909-13
• Effects of local infusion of TGFbeta on bone ingrowth in rabbit chambers. Goodman S,  Song Y, Chun L, Aspenberg P, Plouhar P, Glancy T, Regula D, Smith RL.  J Biomed Mater Res.  2000; 53 (5): 475-9
• Interleukin-4 inhibits granulocyte-macrophage colony-stimulating factor, interleukin-6, and tumor necrosis factor-alpha expression by human monocytes in response to polymethylmethacrylate particle challenge in vitro. Trindade MC,  Nakashima Y, Lind M, Sun DH, Goodman SB, Maloney WJ, Schurman DJ, Smith RL.  J Orthop Res.  1999; 17 (6): 797-802
• Effects of TGFbeta on bone ingrowth in the presence of polyethylene particles. Goodman SB,  Song Y, Chun L, Regula D, Aspenberg P.  J Bone Joint Surg Br.  1999; 81 (6): 1069-75
• The characterization of macrophages and osteoclasts in tissues harvested from revised total hip prostheses. Chun L,  Yoon J, Song Y, Huie P, Regula D, Goodman S.  J Biomed Mater Res.  1999; 48 (6): 899-903
• Osseointegration of total hip arthroplasties: studies in humans and animals. Song Y,  Beaupre G, Goodman SB.  J Long Term Eff Med Implants.  1999; 9 (1-2): 77-112
• Induction of macrophage C-C chemokine expression by titanium alloy and bone cement particles. Nakashima Y,  Sun DH, Trindade MC, Chun LE, Song Y, Goodman SB, Schurman DJ, Maloney WJ, Smith RL.  J Bone Joint Surg Br.  1999; 81 (1): 155-62
• Interferon-gamma exacerbates polymethylmethacrylate particle-induced interleukin-6 release by human monocyte/macrophages in vitro. Trindade MC,  Lind M, Goodman SB, Maloney WJ, Schurman DJ, Smith RL.  J Biomed Mater Res.  1999; 47 (1): 1-7
• Chemotaxis and activation of particle-challenged human monocytes in response to monocyte migration inhibitory factor and C-C chemokines. Lind M,  Trindade MC, Nakashima Y, Schurman DJ, Goodman SB, Smith L.  J Biomed Mater Res.  1999; 48 (3): 246-50
• Signaling pathways for tumor necrosis factor-alpha and interleukin-6 expression in human macrophages exposed to titanium-alloy particulate debris in vitro. Nakashima Y,  Sun DH, Trindade MC, Maloney WJ, Goodman SB, Schurman DJ, Smith RL.  J Bone Joint Surg Am.  1999; 81 (5): 603-15
• Proinflammatory mediator release in response to particle challenge: studies using the bone harvest chamber. Trindade MC,  Song Y, Aspenberg P, Smith RL, Goodman SB.  J Biomed Mater Res.  1999; 48 (4): 434-9
• Induction of matrix metalloproteinase expression in human macrophages by orthopaedic particulate debris in vitro. Nakashima Y,  Sun DH, Maloney WJ, Goodman SB, Schurman DJ, Smith RL.  J Bone Joint Surg Br.  1998; 80 (4): 694-700
• Prediction of postoperative knee flexion in Insall-Burstein II total knee arthroplasty. Schurman DJ,  Matityahu A, Goodman SB, Maloney W, Woolson S, Shi H, Bloch DA.  Clin Orthop Relat Res.  1998; (353): 175-84
• Effects of particulate debris on macrophage-dependent fibroblast stimulation in coculture. Lind M,  Trindade MC, Yaszay B, Goodman SB, Smith RL.  J Bone Joint Surg Br.  1998; 80 (5): 924-30
• In vitro, in vivo, and tissue retrieval studies on particulate debris. Goodman SB,  Lind M, Song Y, Smith RL.  Clin Orthop Relat Res.  1998; (352): 25-34
• Composite hip prosthesis design. II. Simulation. Yildiz H,  Chang FK, Goodman S.  J Biomed Mater Res.  1998; 39 (1): 102-19
• Preoperative duplex ultrasonography evaluation for deep vein thrombosis in hip and knee arthroplasty patients. Hartford JM,  Jeffreys B, Goodman SB.  Am J Orthop.  1998; 27 (2): 123-7
• The use of femoral intramedullary nailing as an interim or salvage technique during complicated total hip replacement. Hartford JM,  Goodman SB.  J Arthroplasty.  1998; 13 (4): 467-72
• Complex primary and revision total knee arthroplasty using the condylar constrained prosthesis: an average 5-year follow-up. Hartford JM,  Goodman SB, Schurman DJ, Knoblick G.  J Arthroplasty.  1998; 13 (4): 380-7
• Effects of polyethylene particles on tissue surrounding knee arthroplasties in rabbits. Sacomen D,  Smith RL, Song Y, Fornasier V, Goodman SB.  J Biomed Mater Res.  1998; 43 (2): 123-30
• Cellular profile and cytokine production at prosthetic interfaces. Study of tissues retrieved from revised hip and knee replacements. Goodman SB,  Huie P, Song Y, Schurman D, Maloney W, Woolson S, Sibley R.  J Bone Joint Surg Br.  1998; 80 (3): 531-9
• Total hip arthroplasty in juvenile chronic arthritis: a consecutive series. Haber D,  Goodman SB.  J Arthroplasty.  1998; 13 (3): 259-65
• The effect of a perioperative clinical pathway for knee replacement surgery on hospital costs. Macario A,  Horne M, Goodman S, Vitez T, Dexter F, Heinen R, Brown B.  Anesth Analg.  1998; 86 (5): 978-84
• Inducible nitric oxide synthase messenger RNA levels in hip periprosthetic tissue: a preliminary study. Pearson ML,  Goodman SB, Huie P, Sibley RK.  J Biomed Mater Res.  1998; 40 (3): 419-24
• Norian SRS cement augmentation in hip fracture treatment. Laboratory and initial clinical results. Goodman SB,  Bauer TW, Carter D, Casteleyn PP, Goldstein SA, Kyle RF, Larsson S, Stankewich CJ, Swiontkowski MF, Tencer AF, Yetkinler DN, Poser RD.  Clin Orthop Relat Res.  1998; (348): 42-50
• Design of the femoral component for cementless hip replacement: the surgeon's perspective. Kelsey D,  Goodman SB.  Am J Orthop.  1997; 26 (6): 407-12
• Stability of open-book pelvic fractures using a new biomechanical model of single-limb stance. MacAvoy MC,  McClellan RT, Goodman SB, Chien CR, Allen WA, van der Meulen MC.  J Orthop Trauma.  1997; 11 (8): 590-3
• Loosening and osteolysis of cemented joint arthroplasties. A biologic spectrum. Goodman SB,  Huie P, Song Y, Lee K, Doshi A, Rushdieh B, Woolson S, Maloney W, Schurman D, Sibley R.  Clin Orthop Relat Res.  1997; (337): 149-63
• Early outcome of total hip arthroplasty using the direct lateral vs the posterior surgical approach. Barber TC,  Roger DJ, Goodman SB, Schurman DJ.  Orthopedics.  1996; 19 (10): 873-5
• Tourniquet release: systemic and metabolic effects. Townsend HS,  Goodman SB, Schurman DJ, Hackel A, Brock-Utne JG.  Acta Anaesthesiol Scand.  1996; 40 (10): 1234-7
• Polyethylene and titanium alloy particles reduce bone formation. Dose-dependence in bone harvest chamber experiments in rabbits. Goodman S,  Aspenberg P, Song Y, Regula D, Lidgren L.  Acta Orthop Scand.  1996; 67 (6): 599-605
• Histomorphological reaction of bone to different concentrations of phagocytosable particles of high-density polyethylene and Ti-6Al-4V alloy in vivo. Goodman SB,  Davidson JA, Song Y, Martial N, Fornasier VL.  Biomaterials.  1996; 17 (20): 1943-7
• Does the immune system play a role in loosening and osteolysis of total joint replacements? Goodman SB,  J Long Term Eff Med Implants.  1996; 6 (2): 91-101
• Different effects of phagocytosable particles during bone formation versus remodeling. Goodman S,  Aspenberg P, Song Y, Regula D, Lidgren L.  J Biomed Mater Res.  1996; 33 (3): 153-8
• Biomechanical comparison of posterior internal fixation techniques for unstable pelvic fractures. Comstock CP,  van der Meulen MC, Goodman SB.  J Orthop Trauma.  1996; 10 (8): 517-22
• Effect of size, concentration, surface area, and volume of polymethylmethacrylate particles on human macrophages in vitro. González O,  Smith RL, Goodman SB.  J Biomed Mater Res.  1996; 30 (4): 463-73
• Heterogeneity in cellular and cytokine profiles from multiple samples of tissue surrounding revised hip prostheses. Goodman SB,  Knoblich G, O'Connor M, Song Y, Huie P, Sibley R.  J Biomed Mater Res.  1996; 31 (3): 421-8
• Intermittent micromotion and polyethylene particles inhibit bone ingrowth into titanium chambers in rabbits. Goodman S,  Aspenberg P, Song Y, Regula D, Lidgren L.  J Appl Biomater.  1995; 6 (3): 161-5
• Effects of particulate high-density polyethylene and titanium alloy on tissue ingrowth into bone harvest chamber in rabbits. Goodman S,  Aspenberg P, Song Y, Doshi A, Regula D, Lidgren L.  J Appl Biomater.  1995; 6 (1): 27-33
• Tissue ingrowth and differentiation in the bone-harvest chamber in the presence of cobalt-chromium-alloy and high-density-polyethylene particles. Goodman S,  Aspenberg P, Song Y, Knoblich G, Huie P, Regula D, Lidgren L.  J Bone Joint Surg Am.  1995; 77 (7): 1025-35
• Cessation of strain facilitates bone formation in the micromotion chamber implanted in the rabbit tibia. Goodman SB,  Song Y, Doshi A, Aspenberg P.  Biomaterials.  1994; 15 (11): 889-93
• A clinical and radiographic study of the "safe area" using the direct lateral approach for total hip arthroplasty. Comstock C,  Imrie S, Goodman SB.  J Arthroplasty.  1994; 9 (5): 527-31
• An in vitro study of femoral intramedullary pressures during hip replacement using modern cement technique. Song Y,  Goodman SB, Jaffe RA.  Clin Orthop Relat Res.  1994; (302): 297-304
• Lysosomal enzyme production at the interface surrounding loose and well-fixed cemented tibial hemiarthroplasties in the rabbit knee. Goodman SB,  Kang T, Smith RL.  J Invest Surg.  1993 Sep-Oct; 6 (5): 413-8
• Radiological and histological study of aseptic loosening using a cemented tibial hemiarthroplasty in the rabbit knee. Goodman SB,  Magee FP, Fornasier VL.  Biomaterials.  1993; 14 (7): 522-8
• Effects of mechanical stimulation on the differentiation of hard tissues. Goodman S,  Aspenberg P.  Biomaterials.  1993; 14 (8): 563-9
• Histological reaction to titanium alloy and hydroxyapatite particles in the rabbit tibia. Goodman SB,  Davidson JA, Fornasier VL.  Biomaterials.  1993; 14 (10): 723-8
• The effects of bone cement powder on human adherent monocytes/macrophages in vitro. Davis RG,  Goodman SB, Smith RL, Lerman JA, Williams RJ.  J Biomed Mater Res.  1993; 27 (8): 1039-46
• Segmental wall motion abnormalities in patients undergoing total hip replacement: correlations with intraoperative events. Propst JW,  Siegel LC, Schnittger I, Foppiano L, Goodman SB, Brock-Utne JG.  Anesth Analg.  1993; 77 (4): 743-9
• Bone accretion around polymethylmethacrylate and polyethylene implanted in the rabbit tibia. Goodman SB,  Fornasier VL, Lee J.  Contemp Orthop.  1993; 26 (3): 292-7
• Late rupture of the posterior cruciate ligament after total knee replacement. Montgomery RL,  Goodman SB, Csongradi J.  Iowa Orthop J.  1993; 13 167-70
• Proximal fibular stress fracture in an aerobic dancer. A case report. Strudwick WJ,  Goodman SB.  Am J Sports Med.  1992 Jul-Aug; 20 (4): 481-2
• A biomechanical study of two methods of internal fixation of unstable fractures of the femoral neck. A preliminary study. Goodman SB,  Davidson JA, Locke L, Novotny S, Jones H, Csongradi JJ.  J Orthop Trauma.  1992; 6 (1): 66-72
• Effect of amplitude of micromotion on bone ingrowth into titanium chambers implanted in the rabbit tibia. Goodman S,  Aspenberg P.  Biomaterials.  1992; 13 (13): 944-8
• Polyethylene wear in knee arthroplasty. A review. Goodman S,  Lidgren L.  Acta Orthop Scand.  1992; 63 (3): 358-64
• Preoperative templating for the equalization of leg lengths in total hip arthroplasty. Goodman SB,  Huene DS, Imrie S.  Contemp Orthop.  1992; 24 (6): 703-10
• Computerized tomographic evaluation of acetabular anatomy. O'Sullivan GS,  Goodman SB, Jones HH.  Clin Orthop Relat Res.  1992; (277): 175-81
• Prostaglandin E2 production by the membrane surrounding loose and fixated cemented tibial hemiarthroplasties in the rabbit knee. Goodman SB,  Chin RC, Magee FP.  Clin Orthop Relat Res.  1992; (284): 283-7
• Suppression of prostaglandin E2 synthesis in the membrane surrounding particulate polymethylmethacrylate in the rabbit tibia. Goodman SB,  Chin RC, Chiou SS, Lee JS.  Clin Orthop Relat Res.  1991; (271): 300-4
• Modulation of the membrane surrounding particulate cement and polyethylene in the rabbit tibia. Goodman SB,  Lee JS, Chin RC, Chiou SS.  Biomaterials.  1991; 12 (2): 194-6
• Quantitative comparison of the histological effects of particulate polymethylmethacrylate versus polyethylene in the rabbit tibia. Goodman SB,  Fornasier VL, Kei J.  Arch Orthop Trauma Surg.  1991; 110 (3): 123-6
• Mechanical overload of a single compartment induces early degenerative changes in the rabbit knee: a preliminary study. Goodman SB,  Lee J, Smith RL, Csongradi JC, Fornasier VL.  J Invest Surg.  1991; 4 (2): 161-70
• Benign versus pathologic compression fractures of vertebral bodies: assessment with conventional spin-echo, chemical-shift, and STIR MR imaging. Baker LL,  Goodman SB, Perkash I, Lane B, Enzmann DR.  Radiology.  1990; 174 (2): 495-502
• Compartment syndrome after intramedullary nailing of the tibia. Tischenko GJ,  Goodman SB.  J Bone Joint Surg Am.  1990; 72 (1): 41-4
• The effects of bulk versus particulate titanium and cobalt chrome alloy implanted into the rabbit tibia. Goodman SB,  Fornasier VL, Lee J, Kei J.  J Biomed Mater Res.  1990; 24 (11): 1539-49
• Prostaglandin E2 levels in the membrane surrounding bulk and particulate polymethylmethacrylate in the rabbit tibia. A preliminary study. Goodman SB,  Chin RC.  Clin Orthop Relat Res.  1990; (257): 305-9
• Comparison of radiographic parameters for analysis of normal and dysplastic hips in the adult. Goodman SB,  Contemp Orthop.  1990; 20 (5): 505-11
• The histological effects of the implantation of different sizes of polyethylene particles in the rabbit tibia. Goodman SB,  Fornasier VL, Lee J, Kei J.  J Biomed Mater Res.  1990; 24 (4): 517-24
• The histology of a failed shelf procedure. Smith JT,  Goodman SB, Fornasier VL.  Orthop Rev.  1989; 18 (10): 1069-72
• Postoperative blood salvage using the Cell Saver after total joint arthroplasty. Semkiw LB,  Schurman DJ, Goodman SB, Woolson ST.  J Bone Joint Surg Am.  1989; 71 (6): 823-7
• A clinical-pathologic-biochemical study of the membrane surrounding loosened and nonloosened total hip arthroplasties. Goodman SB,  Chin RC, Chiou SS, Schurman DJ, Woolson ST, Masada MP.  Clin Orthop Relat Res.  1989; (244): 182-7
• The acetabular teardrop and its relevance to acetabular migration. Goodman SB,  Adler SJ, Fyhrie DP, Schurman DJ.  Clin Orthop Relat Res.  1988; (236): 199-204
• The effects of bulk versus particulate polymethylmethacrylate on bone. Goodman SB,  Fornasier VL, Kei J.  Clin Orthop Relat Res.  1988; (232): 255-62
• The effects of bulk versus particulate ultra-high-molecular-weight polyethylene on bone. Goodman SB,  Fornasier VL, Kei J.  J Arthroplasty.  1988; 3 Suppl S41-6
• Outcome of infected total hip arthroplasty. An inclusive, consecutive series. Goodman SB,  Schurman DJ.  J Arthroplasty.  1988; 3 (2): 97-102
• Hip motion changes in hemophilia. Goodman S,  Gamble JG, Dilley M.  J Pediatr Orthop.  1987 Nov-Dec; 7 (6): 664-6
• Acetabular lucent lines and mechanical stress in total hip arthroplasty. Goodman SB,  Carter DR.  J Arthroplasty.  1987; 2 (3): 219-24