Key Documents

Curriculum Vitae available Online

Alan M. Krensky, M.D.

Emeritus Faculty, Acad Council, Pediatrics
Member, Bio-X
Member, Cancer Center

Contact Information

Clinical Offices
Academic Offices

Personal Information
Email krensky@stanford.edu

Administrative Contact
Kim Ross Administrative Associate Email kimross@stanford.edu Tel Work (650) 498-6073

Administrative Appointments

Associate Dean, Children's Health Initiative , (1999– present )
Associate Chair, Stanford University School of Medicine - Pediatrics , (1999– present )
Shelagh Galligan Professor, Stanford University , (1995– present )
Chief, Division of Immunology and Transplantation Biology - Pedaitrics , (1995– present )

Honors and Awards

Young Investigator Award, Society for Pediatric Research (1985)
Young Investigator Award, American Society of Nephrology/American Heart Association (1990)
Joseph A. Shankman Award, National Kidney Foundation of Massachusetts (1983)
Young Investigator Award, American Society for Histocompatibility and Immunogenetics (1985)
Award for Excellence in Pediatric Research, American Academy of Pediatrics (1993)
Scholar in Experimental Therapeutics, Burroughs Wellcome Fund (1994-1999)
Member, American Society of Clinical Investigation (1994)
E. Mead Johnson Award, Society for Pediatric Research (1995)
Novartis Established Investigator Award, American Society of Transplantation (1999)
Member, Association of American Physicians (2002)

Professional Education

B.A., University of Pennsylvania Animal Behavior (1973)
M.D., University of Pennsylvania Medicine (1977)

Graduate & Fellowship Program Affiliations

Research Interests

Research in this laboratory focuses on using knowledge about the basic mechanisms of T lymphocyte biology in order to design novel immunotherapies for use in infectious diseases, transplantation, cancer, and autoimmune diseases. The techniques of cellular immunology, protein chemistry, and molecular biology are used in the following four projects:

1) Immunosuppressive efects of HLA derived peptides. Synthetic peptides corresponding to linear sequences of HLA molecules inhibit T lymphocyte function both in vitro and in vivo. Current studies in the laboratory focus on the mechanism of action of the peptides in signal transduction and transcriptional regulation and identification and characterization of the receptor(s) for peptide. The effect of these peptides in murine models of transplantation, diabetes mellitus, and graft versus host disease is being investigated.

2) Function and transcriptional regulation of expression of the chemokine RANTES. RANTES is a chemoattractant cytokine (chemokine) and HIV suppressor factor first identified in this laboratory. Ongoing studies involve the characterization of novel transcription factors expressed three to five days after T cell activation which are responsible for regulating the RANTES expression in T lymphocytes.

3) The novel cytolyic molecule granulysin. We identified granulysin as a T cell specific gene using subtractive hybridization. It is expressed in CTL and NK cells and kills microbes and tumor cells. Studies in the laboratory are focused on understanding the mechanism of action of granulysin in inducing apoptosis and its target specificity.

4) Role of chemokine lymphotactin in immunologic tolerance.

Publications

Messenger RNA expression of IL-8, FOXP3, and IL-12beta differentiates latent tuberculosis infection from disease. Wu B, Huang C, Kato-Maeda M, Hopewell PC, Daley CL, Krensky AM, Clayberger C. J Immunol. 2007; 178 (6): 3688-94
Mechanisms of disease: regulation of RANTES (CCL5) in renal disease. Krensky AM, Ahn YT. Nat Clin Pract Nephrol. 2007; 3 (3): 164-70
Granulysin-mediated tumor rejection in transgenic mice. Huang LP, Lyu SC, Clayberger C, Krensky AM. J Immunol. 2007; 178 (1): 77-84
Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes. Ahn YT, Huang B, McPherson L, Clayberger C, Krensky AM. Mol Cell Biol. 2007; 27 (1): 253-66
Cutting edge: Decreased accumulation and regulatory function of CD4+ CD25(high) T cells in human STAT5b deficiency. Cohen AC, Nadeau KC, Tu W, Hwa V, Dionis K, Bezrodnik L, Teper A, Gaillard M, Heinrich J, Krensky AM, Rosenfeld RG, Lewis DB. J Immunol. 2006; 177 (5): 2770-4
Hemolysis of erythrocytes by granulysin-derived peptides but not by granulysin. Li Q, Dong C, Deng A, Katsumata M, Nakadai A, Kawada T, Okada S, Clayberger C, Krensky AM. Antimicrob Agents Chemother. 2005; 49 (1): 388-97
Granulysin: a novel host defense molecule. Krensky AM, Clayberger C. Am J Transplant. 2005; 5 (8): 1789-92
A novel apoptosis pathway activated by the carboxyl terminus of p21. Dong C, Li Q, Lyu SC, Krensky AM, Clayberger C. Blood. 2005; 105 (3): 1187-94
Granulysin, a cytolytic molecule, is also a chemoattractant and proinflammatory activator. Deng A, Chen S, Li Q, Lyu SC, Clayberger C, Krensky AM. J Immunol. 2005; 174 (9): 5243-8
Glycosylated recombinant human XCL1/lymphotactin exhibits enhanced biologic activity. Dong C, Chua A, Ganguly B, Krensky AM, Clayberger C. J Immunol Methods. 2005; 302 (1-2): 136-44
Gamma delta T cells inhibit in vitro growth of the asexual blood stages of Plasmodium falciparum by a granule exocytosis-dependent cytotoxic pathway that requires granulysin. Farouk SE, Mincheva-Nilsson L, Krensky AM, Dieli F, Troye-Blomberg M. Eur J Immunol. 2004; 34 (8): 2248-56
NK cells use perforin rather than granulysin for anticryptococcal activity. Ma LL, Wang CL, Neely GG, Epelman S, Krensky AM, Mody CH. J Immunol. 2004; 173 (5): 3357-65
Elevated expression of CCL5/RANTES in adult T-cell leukemia cells: possible transactivation of the CCL5 gene by human T-cell leukemia virus type I tax. Mori N, Krensky AM, Ohshima K, Tomita M, Matsuda T, Ohta T, Yamada Y, Tomonaga M, Ikeda S, Yamamoto N. Int J Cancer. 2004; 111 (4): 548-57
Lesional T cells and dermal dendrocytes in psoriasis plaque express increased levels of granulysin. Raychaudhuri SP, Jiang WY, Raychaudhuri SK, Krensky AM. J Am Acad Dermatol. 2004; 51 (6): 1006-8
Granulysin crystal structure and a structure-derived lytic mechanism. Anderson DH, Sawaya MR, Cascio D, Ernst W, Modlin R, Krensky A, Eisenberg D. J Mol Biol. 2003; 325 (2): 355-65
Human NKT cells express granulysin and exhibit antimycobacterial activity. Gansert JL, Kiessler V, Engele M, Wittke F, Röllinghoff M, Krensky AM, Porcelli SA, Modlin RL, Stenger S. J Immunol. 2003; 170 (6): 3154-61
CD40 ligand trimer enhances the response of CD8+ T cells to Mycobacterium tuberculosis. Samten B, Wizel B, Shams H, Weis SE, Klucar P, Wu S, Vankayalapati R, Thomas EK, Okada S, Krensky AM, Barnes PF. J Immunol. 2003; 170 (6): 3180-6
Helicobacter pylori induces RANTES through activation of NF-kappa B. Mori N, Krensky AM, Geleziunas R, Wada A, Hirayama T, Sasakawa C, Yamamoto N. Infect Immun. 2003; 71 (7): 3748-56
Society for Pediatric Research Presidential Address 2002: first principles. Krensky AM, Pediatr Res. 2003; 53 (3): 513-5
Intracellular mediators of granulysin-induced cell death. Okada S, Li Q, Whitin JC, Clayberger C, Krensky AM. J Immunol. 2003; 171 (5): 2556-62
DQ 65-79, a peptide derived from HLA class II, mimics p21 to block T cell proliferation. Dong C, Lyu SC, Krensky AM, Clayberger C. J Immunol. 2003; 171 (10): 5064-70
Granulysin. Clayberger C, Krensky AM. Curr Opin Immunol. 2003; 15 (5): 560-5
A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes. Nikolcheva T, Pyronnet S, Chou SY, Sonenberg N, Song A, Clayberger C, Krensky AM. J Clin Invest. 2002; 110 (1): 119-26
Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes. Song A, Patel A, Thamatrakoln K, Liu C, Feng D, Clayberger C, Krensky AM. J Biol Chem. 2002; 277 (33): 30055-65
DQ 65-79, a peptide derived from HLA class II, induces I kappa B expression. Jiang Y, Chen D, Lyu SC, Ling X, Krensky AM, Clayberger C. J Immunol. 2002; 168 (7): 3323-8
Selective depression of interferon-gamma and granulysin production with increase of proliferative response by Vgamma9/Vdelta2 T cells in children with tuberculosis. Dieli F, Sireci G, Caccamo N, Di Sano C, Titone L, Romano A, Di Carlo P, Barera A, Accardo-Palumbo A, Krensky AM, Salerno A. J Infect Dis. 2002; 186 (12): 1835-9
CD8 T cell-mediated killing of Cryptococcus neoformans requires granulysin and is dependent on CD4 T cells and IL-15. Ma LL, Spurrell JC, Wang JF, Neely GG, Epelman S, Krensky AM, Mody CH. J Immunol. 2002; 169 (10): 5787-95
Identification of epitopes of Mycobacterium tuberculosis 16-kDa protein recognized by human leukocyte antigen-A*0201 CD8(+) T lymphocytes. Caccamo N, Milano S, Di Sano C, Cigna D, Ivanyi J, Krensky AM, Dieli F, Salerno A. J Infect Dis. 2002; 186 (7): 991-8
A T cell-specific enhancer of the human CD40 ligand gene. Schubert LA, Cron RQ, Cleary AM, Brunner M, Song A, Lu LS, Jullien P, Krensky AM, Lewis DB. J Biol Chem. 2002; 277 (9): 7386-95
Immunologic tolerance. Krensky AM, Pediatr Nephrol. 2001; 16 (8): 675-9
Granulysin expression is a marker for acute rejection and steroid resistance in human renal transplantation. Sarwal MM, Jani A, Chang S, Huie P, Wang Z, Salvatierra O, Clayberger C, Sibley R, Krensky AM, Pavlakis M. Hum Immunol. 2001; 62 (1): 21-31
A non-peptide functional antagonist of the CCR1 chemokine receptor is effective in rat heart transplant rejection. Horuk R, Clayberger C, Krensky AM, Wang Z, Grone HJ, Weber C, Weber KS, Nelson PJ, May K, Rosser M, Dunning L, Liang M, Buckman B, Ghannam A, Ng HP, Islam I, Bauman JG, Wei GP, Monahan S, Xu W, Snider RM, Morrissey MM, Hesselgesser J, Perez HD. J Biol Chem. 2001; 276 (6): 4199-204
Granulysin: a novel antimicrobial. Kumar J, Okada S, Clayberger C, Krensky AM. Expert Opin Investig Drugs. 2001; 10 (2): 321-9
T-cell release of granulysin contributes to host defense in leprosy. Ochoa MT, Stenger S, Sieling PA, Thoma-Uszynski S, Sabet S, Cho S, Krensky AM, Rollinghoff M, Nunes Sarno E, Burdick AE, Rea TH, Modlin RL. Nat Med. 2001; 7 (2): 174-9
A distinct pathway of cell-mediated apoptosis initiated by granulysin. Kaspar AA, Okada S, Kumar J, Poulain FR, Drouvalakis KA, Kelekar A, Hanson DA, Kluck RM, Hitoshi Y, Johnson DE, Froelich CJ, Thompson CB, Newmeyer DD, Anel A, Clayberger C, Krensky AM. J Immunol. 2001; 167 (1): 350-6
Chemokines, chemokine receptors, and allograft rejection. Nelson PJ, Krensky AM. Immunity. 2001; 14 (4): 377-86
A role of the mitochondrial apoptosis-inducing factor in granulysin-induced apoptosis. Pardo J, Pérez-Galán P, Gamen S, Marzo I, Monleón I, Kaspar AA, Susín SA, Kroemer G, Krensky AM, Naval J, Anel A. J Immunol. 2001; 167 (3): 1222-9
Granulysin-dependent killing of intracellular and extracellular Mycobacterium tuberculosis by Vgamma9/Vdelta2 T lymphocytes. Dieli F, Troye-Blomberg M, Ivanyi J, Fournié JJ, Krensky AM, Bonneville M, Peyrat MA, Caccamo N, Sireci G, Salerno A. J Infect Dis. 2001; 184 (8): 1082-5
Chemokines and allograft rejection: narrowing the list of suspects. Nelson PJ, Krensky AM. Transplantation. 2001; 72 (7): 1195-7
Granulysin blocks replication of varicella-zoster virus and triggers apoptosis of infected cells. Hata A, Zerboni L, Sommer M, Kaspar AA, Clayberger C, Krensky AM, Arvin AM. Viral Immunol. 2001; 14 (2): 125-33
Self-recognition of CD1 by gamma/delta T cells: implications for innate immunity. Spada FM, Grant EP, Peters PJ, Sugita M, Melián A, Leslie DS, Lee HK, van Donselaar E, Hanson DA, Krensky AM, Majdic O, Porcelli SA, Morita CT, Brenner MB. J Exp Med. 2000; 191 (6): 937-48
The immune tolerance network: the "Holy Grail" comes to the clinic. Bluestone JA, Matthews JB, Krensky AM. J Am Soc Nephrol. 2000; 11 (11): 2141-6
Granulysin, a T cell product, kills bacteria by altering membrane permeability. Ernst WA, Thoma-Uszynski S, Teitelbaum R, Ko C, Hanson DA, Clayberger C, Krensky AM, Leippe M, Bloom BR, Ganz T, Modlin RL. J Immunol. 2000; 165 (12): 7102-8
Role of granulysin in immunity to leprosy. Ochoa MT, Thoma-Uszynski S, Sieling PA, Sabet S, Cho S, Krensky AM, Burdick A, Rea TH, Modlin RL. Lepr Rev. 2000; 71 Suppl S115; discussion S115-6
Interleukin-1beta induction of the chemokine RANTES promoter in the human astrocytoma line CH235 requires both constitutive and inducible transcription factors. Miyamoto NG, Medberry PS, Hesselgesser J, Boehlk S, Nelson PJ, Krensky AM, Perez HD. J Neuroimmunol. 2000; 105 (1): 78-90
A human class II MHC-derived peptide antagonizes phosphatidylinositol 3-kinase to block IL-2 signaling. Boytim ML, Lilly P, Drouvalakis K, Lyu SC, Jung R, Krensky AM, Clayberger C. J Clin Invest. 2000; 105 (10): 1447-53
Proliferating cell nuclear antigen as the cell cycle sensor for an HLA-derived peptide blocking T cell proliferation. Ling X, Kamangar S, Boytim ML, Kelman Z, Huie P, Lyu SC, Sibley RK, Hurwitz J, Clayberger C, Krensky AM. J Immunol. 2000; 164 (12): 6188-92
Bactericidal and tumoricidal activities of synthetic peptides derived from granulysin. Wang Z, Choice E, Kaspar A, Hanson D, Okada S, Lyu SC, Krensky AM, Clayberger C. J Immunol. 2000; 165 (3): 1486-90
An immunosuppressive and anti-inflammatory HLA class I-derived peptide binds vascular cell adhesion molecule-1. Ling X, Tamaki T, Xiao Y, Kamangar S, Clayberger C, Lewis DB, Krensky AM. Transplantation. 2000; 70 (4): 662-7
Molecular biology of transplantation. Krensky AM, Nephron. 2000; 86 (3): 260-5
Transcriptional regulation of RANTES expression in T lymphocytes. Song A, Nikolcheva T, Krensky AM. Immunol Rev. 2000; 177 236-45
Granulysin: a novel antimicrobial peptide of cytolytic T lymphocytes and natural killer cells. Krensky AM, Biochem Pharmacol. 2000; 59 (4): 317-20
Granulysin: a lethal weapon of cytolytic T cells. Stenger S, Rosat JP, Bloom BR, Krensky AM, Modlin RL. Immunol Today. 1999; 20 (9): 390-4
HLA-derived peptides as novel immunomodulatory therapeutics. Murphy B, Krensky AM. J Am Soc Nephrol. 1999; 10 (6): 1346-55
The allocation of cadaver kidneys for transplantation in the United States: consensus and controversy. ASN Transplant Advisory Group. American Society of Nephrology. Neylan JF, Sayegh MH, Coffman TM, Danovitch GM, Krensky AM, Strom TB, Turka LA, Harmon WE. J Am Soc Nephrol. 1999; 10 (10): 2237-43
RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes. Song A, Chen YF, Thamatrakoln K, Storm TA, Krensky AM. Immunity. 1999; 10 (1): 93-103
Biosynthesis of granulysin, a novel cytolytic molecule. Hanson DA, Kaspar AA, Poulain FR, Krensky AM. Mol Immunol. 1999; 36 (7): 413-22
Granulysin-induced apoptosis. I. Involvement of at least two distinct pathways. Gamen S, Hanson DA, Kaspar A, Naval J, Krensky AM, Anel A. J Immunol. 1998; 161 (4): 1758-64
An antimicrobial activity of cytolytic T cells mediated by granulysin. Stenger S, Hanson DA, Teitelbaum R, Dewan P, Niazi KR, Froelich CJ, Ganz T, Thoma-Uszynski S, Melián A, Bogdan C, Porcelli SA, Bloom BR, Krensky AM, Modlin RL. Science. 1998; 282 (5386): 121-5
Inhibition of cell cycle progression by a synthetic peptide corresponding to residues 65-79 of an HLA class II sequence: functional similarities but mechanistic differences with the immunosuppressive drug rapamycin. Boytim ML, Lyu SC, Jung R, Krensky AM, Clayberger C. J Immunol. 1998; 160 (5): 2215-22
Chemokines, lymphocytes and viruses: what goes around, comes around. Nelson PJ, Krensky AM. Curr Opin Immunol. 1998; 10 (3): 265-70
Pediatric Transplant Grand Rounds. Pediatric kidney transplantation at Stanford. Salvatierra O, Alexander SR, Krensky AM. Pediatr Transplant. 1998; 2 (2): 165-76
Processing, subcellular localization, and function of 519 (granulysin), a human late T cell activation molecule with homology to small, lytic, granule proteins. Peña SV, Hanson DA, Carr BA, Goralski TJ, Krensky AM. J Immunol. 1997; 158 (6): 2680-8
The HLA system, antigen processing and presentation. Krensky AM, Kidney Int Suppl. 1997; 58 S2-7
New insights into mechanisms of allograft rejection. Pattison JM, Krensky AM. Am J Med Sci. 1997; 313 (5): 257-63
HLA-derived peptides as novel immunosuppressives. Krensky AM, Clayberger C. Nephrol Dial Transplant. 1997; 12 (5): 865-8
SCID mouse models: more than furry flasks. Krensky AM, Nat Biotechnol. 1997; 15 (8): 720-1
Gene expression of RANTES. Nelson PJ, Pattison JM, Krensky AM. Methods Enzymol. 1997; 287 148-62
Switching gears during T-cell maturation: RANTES and late transcription. Ortiz BD, Nelson PJ, Krensky AM. Immunol Today. 1997; 18 (10): 468-71
Granulysin, a new human cytolytic granule-associated protein with possible involvement in cell-mediated cytotoxicity. Peña SV, Krensky AM. Semin Immunol. 1997; 9 (2): 117-25
Expression of chemokine RANTES and production of monoclonal antibodies. Krensky AM, Nelson PJ. Methods Enzymol. 1997; 287 162-74
Stimulus specificity of matrix metalloproteinase dependence of human T cell migration through a model basement membrane. Xia M, Leppert D, Hauser SL, Sreedharan SP, Nelson PJ, Krensky AM, Goetzl EJ. J Immunol. 1996; 156 (1): 160-7
Novel immunotherapeutic strategies using MHC derived peptides. Sayegh MH, Krensky AM. Kidney Int Suppl. 1996; 53 S13-20
Identification of a novel regulatory region critical for expression of the RANTES chemokine in activated T lymphocytes. Nelson PJ, Ortiz BD, Pattison JM, Krensky AM. J Immunol. 1996; 157 (3): 1139-48
Structure of HLA molecules and immunosuppressive effects of HLA derived peptides. Krensky AM, Clayberger C. Int Rev Immunol. 1996; 13 (3): 173-85
Kinetics of transcription factors regulating the RANTES chemokine gene reveal a developmental switch in nuclear events during T-lymphocyte maturation. Ortiz BD, Krensky AM, Nelson PJ. Mol Cell Biol. 1996; 16 (1): 202-10
RANTES chemokine expression in diseased and normal human tissues. von Luettichau I, Nelson PJ, Pattison JM, van de Rijn M, Huie P, Warnke R, Wiedermann CJ, Stahl RA, Sibley RK, Krensky AM. Cytokine. 1996; 8 (1): 89-98
Cytotoxic T lymphocyte recognition of non-Hodgkin's B cell lymphomas. Krensky AM, Immunol Res. 1996; 15 (2): 91-7
HLA-derived peptides which inhibit T cell function bind to members of the heat-shock protein 70 family. Nossner E, Goldberg JE, Naftzger C, Lyu SC, Clayberger C, Krensky AM. J Exp Med. 1996; 183 (2): 339-48
Tumor-specific, cytotoxic T-lymphocyte response after idiotype vaccination for B-cell, non-Hodgkin's lymphoma. Nelson EL, Li X, Hsu FJ, Kwak LW, Levy R, Clayberger C, Krensky AM. Blood. 1996; 88 (2): 580-9
Immunologic tolerance: tailored antigen. Krensky AM, Clayberger C. Transplant Proc. 1996; 28 (4): 2075-7
Immunomodulation by HLA class I-derived peptides. Krensky AM, Clayberger C. Transplant Proc. 1996; 28 (6): 3026-8
RANTES chemokine expression in transplant-associated accelerated atherosclerosis. Pattison JM, Nelson PJ, Huie P, Sibley RK, Krensky AM. J Heart Lung Transplant. 1996; 15 (12): 1194-9
Gamma delta T cell recognition of tumor Ig peptide. Kim HT, Nelson EL, Clayberger C, Sanjanwala M, Sklar J, Krensky AM. J Immunol. 1995; 154 (4): 1614-23
Novel tumor-associated accessory molecules involved in the gamma/delta cytotoxic T-lymphocyte-Burkitt's lymphoma interaction. Nelson EL, Kim HT, Mar ND, Goralski TJ, McIntyre BW, Clayberger C, Krensky AM. Cancer. 1995; 75 (3): 886-93
Human leukocyte antigen-derived peptides as novel immunosuppressives. Krensky AM, Clayberger C. Proc Assoc Am Physicians. 1995; 107 (1): 81-5
HLA-derived peptides as novel immunotherapeutics. Krensky AM, Clayberger C. Clin Immunol Immunopathol. 1995; 75 (2): 112-6
HLA-derived peptides as novel immunosuppressives. Krensky AM, Pediatr Res. 1995; 38 (3): 275-9
Immunosuppressive peptides corresponding to MHC class I sequences. Clayberger C, Krensky AM. Curr Opin Immunol. 1995; 7 (5): 644-8
Induction of allograft tolerance in rats by an HLA class-I-derived peptide and cyclosporine A. Nisco S, Vriens P, Hoyt G, Lyu SC, Farfan F, Pouletty P, Krensky AM, Clayberger C. J Immunol. 1994; 152 (8): 3786-92
Transplantation immunology. Krensky AM, Clayberger C. Pediatr Clin North Am. 1994; 41 (4): 819-39
The induction of tolerance to alloantigens using HLA-based synthetic peptides. Krensky AM, Clayberger C. Curr Opin Immunol. 1994; 6 (5): 791-6
Prospects for induction of tolerance in renal transplantation. Krensky AM, Clayberger C. Pediatr Nephrol. 1994; 8 (6): 772-9
Peptides corresponding to the CD8 and CD4 binding domains of HLA molecules block T lymphocyte immune responses in vitro. Clayberger C, Lyu SC, DeKruyff R, Parham P, Krensky AM. J Immunol. 1994; 153 (3): 946-51
RANTES chemokine expression in cell-mediated transplant rejection of the kidney. Pattison J, Nelson PJ, Huie P, von Leuttichau I, Farshid G, Sibley RK, Krensky AM. Lancet. 1994; 343 (8891): 209-11
T cells in autoimmunity and allograft rejection. Krensky AM, Kidney Int Suppl. 1994; 44 S50-6
TNF alpha induces expression of the chemoattractant cytokine RANTES in cultured mouse mesangial cells. Wolf G, Aberle S, Thaiss F, Nelson PJ, Krensky AM, Neilson EG, Stahl RA. Kidney Int. 1993; 44 (4): 795-804
Peptides corresponding to T-cell receptor-HLA contact regions inhibit class I-restricted immune responses. Clayberger C, Lyu SC, Pouletty P, Krensky AM. Transplant Proc. 1993; 25 (1 Pt 1): 477-8
Peptides corresponding to the CD8 binding region of HLA class I block the differentiation of cytotoxic T lymphocyte precursors. Krensky AM, Lyu SC, Pouletty P, Benjamin R, Parham P, Clayberger C. Transplant Proc. 1993; 25 (1 Pt 1): 483-4
The CD8 coreceptor interaction with the alpha 3 domain of HLA class I is critical to the differentiation of human cytotoxic T-lymphocytes specific for HLA-A2 and HLA-Cw4. Wesley PK, Clayberger C, Lyu SC, Krensky AM. Hum Immunol. 1993; 36 (3): 149-55
Insulin-like growth factor binding protein-3 protease activity in the urine of children with chronic renal failure. Lee DY, Cohen P, Krensky AM, Rosenfeld RG, Yorgin PD. Pediatr Nephrol. 1993; 7 (4): 416-23
Genomic organization and transcriptional regulation of the RANTES chemokine gene. Nelson PJ, Kim HT, Manning WC, Goralski TJ, Krensky AM. J Immunol. 1993; 151 (5): 2601-12
The nature of allorecognition. Krensky AM, Clayberger C. Curr Opin Nephrol Hypertens. 1993; 2 (6): 898-903
Effect of the substitution of critical residues on the allorecognition of HLA-B27. Ozen S, Clayberger C, Krensky AM, Benjamin R. Clin Exp Rheumatol. 1992 Nov-Dec; 10 (6): 583-7
Interleukin 3 is a growth factor for human follicular B cell lymphoma. Clayberger C, Luna-Fineman S, Lee JE, Pillai A, Campbell M, Levy R, Krensky AM. J Exp Med. 1992; 175 (2): 371-6
Isolation and characterization of cDNA from renal tubular epithelium encoding murine Rantes. Heeger P, Wolf G, Meyers C, Sun MJ, O'Farrell SC, Krensky AM, Neilson EG. Kidney Int. 1992; 41 (1): 220-5
Human cytotoxic T-lymphocytes specific for autologous follicular lymphoma recognize immunoglobulin in a major histocompatibility complex restricted fashion. Luna-Fineman S, Lee JE, Wesley PK, Clayberger C, Krensky AM. Cancer. 1992; 70 (8): 2181-6
Anchoring pockets in human histocompatibility complex leukocyte antigen (HLA) class I molecules: analysis of the conserved B ("45") pocket of HLA-B27. Buxton SE, Benjamin RJ, Clayberger C, Parham P, Krensky AM. J Exp Med. 1992; 175 (3): 809-20
Identification and molecular cloning of tactile. A novel human T cell activation antigen that is a member of the Ig gene superfamily. Wang PL, O'Farrell S, Clayberger C, Krensky AM. J Immunol. 1992; 148 (8): 2600-8
Genomic structure and alternative splicing of 519, a gene expressed late after T cell activation. Manning WC, O'Farrell S, Goralski TJ, Krensky AM. J Immunol. 1992; 148 (12): 4036-42
Generation of monoclonal antibodies against soluble human T cell receptor polypeptides. Devaux B, Bjorkman PJ, Stevenson C, Greif W, Elliott JF, Sagerström C, Clayberger C, Krensky AM, Davis MM. Eur J Immunol. 1991; 21 (9): 2111-9
Molecular basis of transplant rejection and acceptance. Krensky AM, Pediatr Nephrol. 1991; 5 (4): 422-7
Lymphocyte adhesion molecules in T cell-mediated lysis of human kidney cells. Suranyi MG, Bishop GA, Clayberger C, Krensky AM, Leenaerts P, Aversa G, Hall BM. Kidney Int. 1991; 39 (2): 312-9
The importance of the ICAM-1/LFA-1-dependent pathway in in vitro cytotoxicity against cultured human kidney cells. Suranyi MG, Bishop GA, Clayberger C, Krensky AM, Leenaerts P, Hall BM. Transplant Proc. 1990; 22 (5): 2101-2
Recognition of an HLA public determinant (Bw4) by human allogeneic cytotoxic T lymphocytes. Clayberger C, Rosen M, Parham P, Krensky AM. J Immunol. 1990; 144 (11): 4172-6
A binding site for the T-cell co-receptor CD8 on the alpha 3 domain of HLA-A2. Salter RD, Benjamin RJ, Wesley PK, Buxton SE, Garrett TP, Clayberger C, Krensky AM, Norment AM, Littman DR, Parham P. Nature. 1990; 345 (6270): 41-6
Localization of a human T-cell-specific gene, RANTES (D17S136E), to chromosome 17q11.2-q12. Donlon TA, Krensky AM, Wallace MR, Collins FS, Lovett M, Clayberger C. Genomics. 1990; 6 (3): 548-53
T-lymphocyte-antigen interactions in transplant rejection. Krensky AM, Weiss A, Crabtree G, Davis MM, Parham P. N Engl J Med. 1990; 322 (8): 510-7
Localization of the human T lymphocyte activation gene 519 (D2S69E) to chromosome 2p12----q11. Donlon TA, Krensky AM, Clayberger C. Cytogenet Cell Genet. 1990; 53 (4): 230-1
Treatment of steroid-resistant focal segmental glomerulosclerosis with pulse methylprednisolone and alkylating agents. Mendoza SA, Reznik VM, Griswold WR, Krensky AM, Yorgin PD, Tune BM. Pediatr Nephrol. 1990; 4 (4): 303-7
Molecular cloning and characterization of WP34, a phosphorylated human lymphocyte differentiation and activation antigen. Kadiyala RK, McIntyre BW, Krensky AM. Eur J Immunol. 1990; 20 (11): 2417-23
Continuous venovenous hemofiltration. Yorgin PD, Krensky AM, Tune BM. Pediatr Nephrol. 1990; 4 (6): 640-2
The molecular basis of renal transplant rejection. Krensky AM, Clayberger C. Semin Nephrol. 1989; 9 (1): 116-9
Diversity of class I HLA molecules: functional and evolutionary interactions with T cells. Parham P, Benjamin RJ, Chen BP, Clayberger C, Ennis PD, Krensky AM, Lawlor DA, Littman DR, Norment AM, Orr HT. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 1 529-43
A panel of unique HLA-A2 mutant molecules define epitopes recognized by HLA-A2-specific antibodies and cytotoxic T lymphocytes. Hogan KT, Clayberger C, Bernhard EJ, Walk SF, Ridge JP, Parham P, Krensky AM, Engelhard VH. J Immunol. 1989; 142 (6): 2097-104
Expression of LFA-1 in non-Hodgkin's lymphoma. Medeiros LJ, Weiss LM, Picker LJ, Clayberger C, Horning SJ, Krensky AM, Warnke RA. Cancer. 1989; 63 (2): 255-9
Microvascular destruction in renal transplant rejection. Bishop GA, Waugh JA, Landers DV, Krensky AM, Hall BM. Transplantation. 1989; 48 (3): 408-14
Histamine regulates the generation of human cytolytic T lymphocytes. Khan MM, Keaney KM, Melmon KL, Clayberger C, Krensky AM. Cell Immunol. 1989; 121 (1): 60-73
Cytotoxic T lymphocytes specific for self tumor immunoglobulin express T cell receptor delta chain. Wright A, Lee JE, Link MP, Smith SD, Carroll W, Levy R, Clayberger C, Krensky AM. J Exp Med. 1989; 169 (5): 1557-64
Polymorphism in the alpha 3 domain of HLA-A molecules affects binding to CD8. Salter RD, Norment AM, Chen BP, Clayberger C, Krensky AM, Littman DR, Parham P. Nature. 1989; 338 (6213): 345-7
Identification by site-directed mutagenesis of amino acid residues contributing to serologic and CTL-defined epitope differences between HLA-A2.1 and HLA-A2.3. Hogan KT, Clayberger C, Bernhard EJ, Walk SF, Ridge JP, Parham P, Krensky AM, Engelhard VH. J Immunol. 1988; 141 (7): 2519-25
Cytotoxic T lymphocyte-defined epitope differences between HLA-A2.1 and HLA-A2.2 map to two distinct regions of the molecule. Hogan KT, Clayberger C, Le AX, Walk SF, Ridge JP, Parham P, Krensky AM, Engelhard VH. J Immunol. 1988; 141 (11): 4005-11
Recombinant gamma interferon increases the binding of peripheral blood mononuclear leukocytes and a Leu-3+ T lymphocyte clone to cultured keratinocytes and to a malignant cutaneous squamous carcinoma cell line that is blocked by antibody against the LFA-1 molecule. Nickoloff BJ, Lewinsohn DM, Butcher EC, Krensky AM, Clayberger C. J Invest Dermatol. 1988; 90 (1): 17-22
A human T cell-specific molecule is a member of a new gene family. Schall TJ, Jongstra J, Dyer BJ, Jorgensen J, Clayberger C, Davis MM, Krensky AM. J Immunol. 1988; 141 (3): 1018-25
Rescue of Daudi cell HLA expression by transfection of the mouse beta 2-microglobulin gene. Seong RH, Clayberger CA, Krensky AM, Parnes JR. J Exp Med. 1988; 167 (2): 288-99
Inhibition of alloreactive cytotoxic T lymphocytes by peptides from the alpha 2 domain of HLA-A2. Parham P, Clayberger C, Zorn SL, Ludwig DS, Schoolnik GK, Krensky AM. Nature. 1987 Feb 12-18; 325 (6105): 625-8
HLA-A2 peptides can regulate cytolysis by human allogeneic T lymphocytes. Clayberger C, Parham P, Rothbard J, Ludwig DS, Schoolnik GK, Krensky AM. Nature. 1987 Dec 24-31; 330 (6150): 763-5
Rhabdomyolysis complicating doxylamine overdose. Mendoza FS, Atiba JO, Krensky AM, Scannell LM. Clin Pediatr (Phila). 1987; 26 (11): 595-7
Absence of cell surface LFA-1 as a mechanism of escape from immunosurveillance. Clayberger C, Wright A, Medeiros LJ, Koller TD, Link MP, Smith SD, Warnke RA, Krensky AM. Lancet. 1987; 2 (8558): 533-6
In vitro mutagenesis at a single residue introduces B and T cell epitopes into a class I HLA molecule. Salter RD, Clayberger C, Lomen CE, Krensky AM, Parham P. J Exp Med. 1987; 166 (1): 283-8
Human allospecific cytolytic T lymphocyte lysis of a murine cell transfected with HLA-A2. Koller TD, Clayberger C, Maryanski JL, Krensky AM. J Immunol. 1987; 138 (7): 2044-9
Expression of Leu-19 (NKH-1) antigen on IL 2-dependent cytotoxic and non-cytotoxic T cell lines. Lanier LL, Le AM, Ding A, Evans EL, Krensky AM, Clayberger C, Phillips JH. J Immunol. 1987; 138 (7): 2019-23
Identification and characterization of two novel lymphocyte function-associated antigens, L24 and L25. Clayberger C, Krensky AM, McIntyre BW, Koller TD, Parham P, Brodsky F, Linn DJ, Evans EL. J Immunol. 1987; 138 (5): 1510-4
The isolation and sequence of a novel gene from a human functional T cell line. Jongstra J, Schall TJ, Dyer BJ, Clayberger C, Jorgensen J, Davis MM, Krensky AM. J Exp Med. 1987; 165 (3): 601-14
Mapping functional epitopes of the human LFA-1 glycoprotein: monoclonal antibody inhibition of NK and CTL effectors. Mentzer SJ, Krensky AM, Burakoff SJ. Hum Immunol. 1986; 17 (3): 288-96
The modulation of generation/function of human cytotoxic lymphocytes by autacoids: unusually compartmentalized cAMP? Khan MM, Keaney KM, Krensky AM, Melmon KL. Proc West Pharmacol Soc. 1986; 29 31-4
Function and cell distribution of KC-1, a novel natural killer cell-associated antigen. Clayberger C, Dyer B, McIntyre B, Koller TD, Hardy B, Parham P, Lanier LL, Krensky AM. J Immunol. 1986; 136 (5): 1537-41
Phytohaemagglutinin activation of T cells through the sheep red blood cell receptor. O'Flynn K, Krensky AM, Beverley PC, Burakoff SJ, Linch DC. Nature. 1985 Feb 21-27; 313 (6004): 686-7
Diagnostic and therapeutic implications of T cell surface antigens. Krensky AM, Clayberger C. Transplantation. 1985; 39 (4): 339-48
Target specificity and cell surface structures involved in the human cytolytic T lymphocyte response to endothelial cells. Clayberger C, Uyehara T, Hardy B, Eaton J, Karasek M, Krensky AM. J Immunol. 1985; 135 (1): 12-8
LFA-1 membrane molecule in the regulation of homotypic adhesions of human B lymphocytes. Mentzer SJ, Gromkowski SH, Krensky AM, Burakoff SJ, Martz E. J Immunol. 1985; 135 (1): 9-11
Human T cell clones express functional homing receptors required for normal lymphocyte trafficking. Navarro RF, Jalkanen ST, Hsu M, Søenderstrup-Hansen G, Goronzy J, Weyand C, Fathman CG, Clayberger C, Krensky AM, Butcher EC. J Exp Med. 1985; 162 (3): 1075-80
The human cytolytic T lymphocyte response to transplantation antigens. Krensky AM, Pediatr Res. 1985; 19 (12): 1231-4
Heritable lymphocyte function-associated antigen-1 deficiency: abnormalities of cytotoxicity and proliferation associated with abnormal expression of LFA-1. Krensky AM, Mentzer SJ, Clayberger C, Anderson DC, Schmalstieg FC, Burakoff SJ, Springer TA. J Immunol. 1985; 135 (5): 3102-8
MHC-unrestricted cytolytic T lymphocytes. Krensky AM, Clayberger C. Surv Immunol Res. 1985; 4 (4): 297-302
The function of LFA-1 in cell-mediated killing and adhesion: studies on heritable LFA-1, Mac-1 deficiency and on lymphoid cell self-aggregation. Springer TA, Rothlein R, Anderson DC, Burakoff SJ, Krensky AM. Adv Exp Med Biol. 1985; 184 311-22
Determinants recognized by human cytotoxic T cells on a natural hybrid class I HLA molecule. Clayberger C, Holmes N, Wang PL, Koller TD, Parham P, Krensky AM. J Exp Med. 1985; 162 (5): 1709-14
Lymphocyte subsets and surface molecules in man. Krensky AM, Lanier LL, Engleman EG. Clin Immunol Rev. 1985; 4 (1): 95-138
Functional distinctions between the LFA-1, LFA-2, and LFA-3 membrane proteins on human CTL are revealed with trypsin-pretreated target cells. Gromkowski SH, Krensky AM, Martz E, Burakoff SJ. J Immunol. 1985; 134 (1): 244-9
Experimental evidence for the potential usefulness of permanent IL-3-dependent multipotential hematopoietic progenitor cell lines in transfusion granulocyte support therapy: need for expansion of early passage cells. Greenberger JS, Sakakeeny MA, Krensky A, Burakoff S, Reid D, Novak T, Boggs SS. Kroc Found Ser. 1984; 18 255-69
A molecular analysis of the cytolytic T lymphocyte response. Burakoff SJ, Weinberger O, Krensky AM, Reiss CS. Adv Immunol. 1984; 36 45-85
Human lymphocyte function-associated antigens. Krensky AM, Sanchez-Madrid F, Springer TA, Burakoff SJ. Surv Immunol Res. 1984; 3 (1): 39-44
LFA-1, LFA-2, and LFA-3 antigens are involved in CTL-target conjugation. Krensky AM, Robbins E, Springer TA, Burakoff SJ. J Immunol. 1984; 132 (5): 2180-2
Glycoproteins of 210,000 and 130,000 m.w. on activated T cells: cell distribution and antigenic relation to components on resting cells and T cell lines. Hemler ME, Sanchez-Madrid F, Flotte TJ, Krensky AM, Burakoff SJ, Bhan AK, Springer TA, Strominger JL. J Immunol. 1984; 132 (6): 3011-8
Production of colony-stimulating factor(s) for granulocyte-macrophage and multipotential (granulocyte/erythroid/megakaryocyte/macrophage) hematopoietic progenitor cells (CFU-GEMM) by clonal lines of human IL-2-dependent T-lymphocytes. Greenberger JS, Krensky AM, Messner H, Burakoff SJ, Wandl U, Sakakeeny MA. Exp Hematol. 1984; 12 (9): 720-7
Human cytolytic T lymphocyte interactions with vascular endothelium and fibroblasts: role of effector and target cell molecules. Collins T, Krensky AM, Clayberger C, Fiers W, Gimbrone MA, Burakoff SJ, Pober JS. J Immunol. 1984; 133 (4): 1878-84
Interactions of T lymphocytes with human vascular endothelial cells: role of endothelial cells surface antigens. Pober JS, Gimbrone MA, Collins T, Cotran RS, Ault KA, Fiers W, Krensky AM, Clayberger C, Reiss CS, Burakoff SJ. Immunobiology. 1984; 168 (3-5): 483-94
Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon. Pober JS, Collins T, Gimbrone MA, Cotran RS, Gitlin JD, Fiers W, Clayberger C, Krensky AM, Burakoff SJ, Reiss CS. Nature. 1983 Oct 20-26; 305 (5936): 726-9
Causes of increased renal echogenicity in pediatric patients. Krensky AM, Reddish JM, Teele RL. Pediatrics. 1983; 72 (6): 840-6
Human lymphocyte function associated antigen-1 (LFA-1): identification of multiple antigenic epitopes and their relationship to CTL-mediated cytotoxicity. Ware CF, Sanchez-Madrid F, Krensky AM, Burakoff SJ, Strominger JL, Springer TA. J Immunol. 1983; 131 (3): 1182-8
Basic science seminar: cytotoxic T-lymphocyte response to HLA antigens. Krensky AM, Burakoff SJ. J Pediatr. 1983; 102 (6): 814-9
Cytotoxic T cells directed against HLA-DR antigens and their surface proteins. Burakoff SJ, Clayberger C, Hemler M, Krensky AM, Reiss CS, Robbins E, Sanchez-Madrid F, Springer TA, Strominger JL, Ware CF. Diagn Immunol. 1983; 1 (3): 116-9
Epidemic and endemic HLA-B and DR associations in mucocutaneous lymph node syndrome. Krensky AM, Grady S, Shanley KM, Berenberg W, Yunis EJ. Hum Immunol. 1983; 6 (2): 75-7
Hemolytic uremic syndrome and crescentic glomerulonephritis complicating childhood nephrosis. Krensky AM, Ingelfinger JR, Grupe WE, Rosen S. Clin Nephrol. 1983; 19 (2): 99-106
Tubulo-interstitial nephritis associated with polyomavirus (BK type) infection. Rosen S, Harmon W, Krensky AM, Edelson PJ, Padgett BL, Grinnell BW, Rubino MJ, Walker DL. N Engl J Med. 1983; 308 (20): 1192-6
The functional significance, distribution, and structure of LFA-1, LFA-2, and LFA-3: cell surface antigens associated with CTL-target interactions. Krensky AM, Sanchez-Madrid F, Robbins E, Nagy JA, Springer TA, Burakoff SJ. J Immunol. 1983; 131 (2): 611-6
A DC-specific cytolytic T lymphocyte line is OKT8+1. Krensky AM, Clayberger C, Greenstein JL, Crimmins M, Burakoff SJ. J Immunol. 1983; 131 (6): 2777-80
Technique for infrequent arterial blood gas monitoring in the newborn. Krensky AM, Clin Pediatr (Phila). 1982; 21 (1): 57
Long-term human cytolytic T-cell lines allospecific for HLA-DR6 antigen are OKT4+. Krensky AM, Reiss CS, Mier JW, Strominger JL, Burakoff SJ. Proc Natl Acad Sci U S A. 1982; 79 (7): 2365-9
Generation of long-term human cytolytic cell lines with persistent natural killer activity. Krensky AM, Ault KA, Reiss CS, Strominger JL, Burakoff SJ. J Immunol. 1982; 129 (4): 1748-51
Peritonitis in childhood nephrotic syndrome: 1970-1980. Krensky AM, Ingelfinger JR, Grupe WE. Am J Dis Child. 1982; 136 (8): 732-6
Immunoregulatory abnormalities in mucocutaneous lymph node syndrome. Leung DY, Siegel RL, Grady S, Krensky A, Meade R, Reinherz EL, Geha RS. Clin Immunol Immunopathol. 1982; 23 (1): 100-12
Specificity of OKT4+ cytotoxic T lymphocyte clones. Krensky AM, Clayberger C, Reiss CS, Strominger JL, Burakoff SJ. J Immunol. 1982; 129 (5): 2001-3
Three distinct antigens associated with human T-lymphocyte-mediated cytolysis: LFA-1, LFA-2, and LFA-3. Sanchez-Madrid F, Krensky AM, Ware CF, Robbins E, Strominger JL, Burakoff SJ, Springer TA. Proc Natl Acad Sci U S A. 1982; 79 (23): 7489-93
HLA antigens in mucocutaneous lymph node syndrome in New England. Krensky AM, Berenberg W, Shanley K, Yunis EJ. Pediatrics. 1981; 67 (5): 741-3
Elevated nephrogenous cyclic adenosine monophosphate to monitor early renal osteodystrophy. Krensky AM, Harmon WE, Ingelfinger JR, Kirkpatrick JA, Grupe WE. Clin Nephrol. 1981; 16 (5): 245-50
Mucocutaneous lymph node syndrome and hydropic gallbladders. Krensky AM, Pediatrics. 1980; 66 (5): 814
Streptococcal antigenicity in mucocutaneous lymph node syndrome and hydropic gallbladders. Krensky AM, Teele R, Watkins J, Bates J. Pediatrics. 1979; 64 (6): 979-80
Identification of heterozygote carriers of congenital adrenal hyperplasia by radioimmunoassay of serum 17-OH progesterone. Krensky AM, Bongiovanni AM, Marino J, Parks J, Tenore A. J Pediatr. 1977; 90 (6): 930-3