Key Documents

Peter Jackson

Member, Cancer Center
Member, Bio-X

Contact Information

Clinical Offices
Academic Offices

Personal Information
Email pjackson@stanford.edu Tel (650) 302-3581, (650) 498-6872

Research Interests

Cell cycle control of DNA replication in embryonic and somatic cells: cyclins and the cell cycle in Xenopus embryos.

Publications

Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinoma. Gütgemann I, Lehman NL, Jackson PK, Longacre TA. Mod Pathol. 2008; 21 (4): 445-54
The hunt for cyclin. Jackson PK, Cell. 2008; 134 (2): 199-202
Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition. Tang W, Wu JQ, Guo Y, Hansen DV, Perry JA, Freel CD, Nutt L, Jackson PK, Kornbluth S. Mol Biol Cell. 2008; 19 (8): 3536-43
Stopping replication, at the beginning. Jackson PK, Nat Chem Biol. 2008; 4 (6): 331-2
The END network couples spindle pole assembly to inhibition of the anaphase-promoting complex/cyclosome in early mitosis. Ban KH, Torres JZ, Miller JJ, Mikhailov A, Nachury MV, Tung JJ, Rieder CL, Jackson PK. Dev Cell. 2007; 13 (1): 29-42
Oncogenic regulators and substrates of the anaphase promoting complex/cyclosome are frequently overexpressed in malignant tumors. Lehman NL, Tibshirani R, Hsu JY, Natkunam Y, Harris BT, West RB, Masek MA, Montgomery K, van de Rijn M, Jackson PK. Am J Pathol. 2007; 170 (5): 1793-805
Control of Emi2 activity and stability through Mos-mediated recruitment of PP2A. Wu JQ, Hansen DV, Guo Y, Wang MZ, Tang W, Freel CD, Tung JJ, Jackson PK, Kornbluth S. Proc Natl Acad Sci U S A. 2007; 104 (42): 16564-9
Climbing the Greatwall to mitosis. Jackson PK, Mol Cell. 2006; 22 (2): 156-7
CaMKII and polo-like kinase 1 sequentially phosphorylate the cytostatic factor Emi2/XErp1 to trigger its destruction and meiotic exit. Hansen DV, Tung JJ, Jackson PK. Proc Natl Acad Sci U S A. 2006; 103 (3): 608-13
The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1. Eldridge AG, Loktev AV, Hansen DV, Verschuren EW, Reimann JD, Jackson PK. Cell. 2006; 124 (2): 367-80
Dual degradation signals control Gli protein stability and tumor formation. Huntzicker EG, Estay IS, Zhen H, Lokteva LA, Jackson PK, Oro AE. Genes Dev. 2006; 20 (3): 276-81
Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. Miller JJ, Summers MK, Hansen DV, Nachury MV, Lehman NL, Loktev A, Jackson PK. Genes Dev. 2006; 20 (17): 2410-20
Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells. Lehman NL, Verschuren EW, Hsu JY, Cherry AM, Jackson PK. Cell Cycle. 2006; 5 (14): 1569-73
Screening of tissue microarrays for ubiquitin proteasome system components in tumors. Lehman NL, van de Rijn M, Jackson PK. Methods Enzymol. 2005; 399 334-55
A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs. Tung JJ, Hansen DV, Ban KH, Loktev AV, Summers MK, Adler JR, Jackson PK. Proc Natl Acad Sci U S A. 2005; 102 (12): 4318-23
Emi1 class of proteins regulate entry into meiosis and the meiosis I to meiosis II transition in Xenopus oocytes. Tung JJ, Jackson PK. Cell Cycle. 2005; 4 (3): 478-82
Xenopus Cdc14 alpha/beta are localized to the nucleolus and centrosome and are required for embryonic cell division. Kaiser BK, Nachury MV, Gardner BE, Jackson PK. BMC Cell Biol. 2004; 5 27
Linking tumor suppression, DNA damage and the anaphase-promoting complex. Jackson PK, Trends Cell Biol. 2004; 14 (7): 331-4
Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC Inhibitor Emi1. Hansen DV, Loktev AV, Ban KH, Jackson PK. Mol Biol Cell. 2004; 15 (12): 5623-34
Spongiform degeneration in mahoganoid mutant mice. He L, Lu XY, Jolly AF, Eldridge AG, Watson SJ, Jackson PK, Barsh GS, Gunn TM. Science. 2003; 299 (5607): 710-2
Ubiquitinating a phosphorylated Cdk inhibitor on the blades of the Cdc4 beta-propeller. Jackson PK, Cell. 2003; 112 (2): 142-4
Accessory proteins for melanocortin signaling: attractin and mahogunin. He L, Eldridge AG, Jackson PK, Gunn TM, Barsh GS. Ann N Y Acad Sci. 2003; 994 288-98
Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase. Margottin-Goguet F, Hsu JY, Loktev A, Hsieh HM, Reimann JD, Jackson PK. Dev Cell. 2003; 4 (6): 813-26
Control of the centriole and centrosome cycles by ubiquitination enzymes. Hansen DV, Hsu JY, Kaiser BK, Jackson PK, Eldridge AG. Oncogene. 2002; 21 (40): 6209-21
The E3 ubiquitin ligase GREUL1 anteriorizes ectoderm during Xenopus development. Borchers AG, Hufton AL, Eldridge AG, Jackson PK, Harland RM, Baker JC. Dev Biol. 2002; 251 (2): 395-408
Disruption of centrosome structure, chromosome segregation, and cytokinesis by misexpression of human Cdc14A phosphatase. Kaiser BK, Zimmerman ZA, Charbonneau H, Jackson PK. Mol Biol Cell. 2002; 13 (7): 2289-300
The SCF ubiquitin ligase: an extended look. Jackson PK, Eldridge AG. Mol Cell. 2002; 9 (5): 923-5
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). Hsu JY, Reimann JD, Sørensen CS, Lukas J, Jackson PK. Nat Cell Biol. 2002; 4 (5): 358-66
Emi1 is required for cytostatic factor arrest in vertebrate eggs. Reimann JD, Jackson PK. Nature. 2002; 416 (6883): 850-4
Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins. Reimann JD, Gardner BE, Margottin-Goguet F, Jackson PK. Genes Dev. 2001; 15 (24): 3278-85
A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases. Jackson PK, Genes Dev. 2001; 15 (23): 3053-8
Triggering ubiquitination of a CDK inhibitor at origins of DNA replication. Furstenthal L, Swanson C, Kaiser BK, Eldridge AG, Jackson PK. Nat Cell Biol. 2001; 3 (8): 715-22
Emi1 is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Reimann JD, Freed E, Hsu JY, Kramer ER, Peters JM, Jackson PK. Cell. 2001; 105 (5): 645-55
Nuclear accumulation of cyclin E/Cdk2 triggers a concentration-dependent switch for the destruction of p27Xic1. Swanson C, Ross J, Jackson PK. Proc Natl Acad Sci U S A. 2000; 97 (14): 7796-801
The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases. Jackson PK, Eldridge AG, Freed E, Furstenthal L, Hsu JY, Kaiser BK, Reimann JD. Trends Cell Biol. 2000; 10 (10): 429-39
Cyclin-dependent kinase control of centrosome duplication. Lacey KR, Jackson PK, Stearns T. Proc Natl Acad Sci U S A. 1999; 96 (6): 2817-22
Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle. Freed E, Lacey KR, Huie P, Lyapina SA, Deshaies RJ, Stearns T, Jackson PK. Genes Dev. 1999; 13 (17): 2242-57
F-box/WD-repeat proteins pop1p and Sud1p/Pop2p form complexes that bind and direct the proteolysis of cdc18p. Wolf DA, McKeon F, Jackson PK. Curr Biol. 1999; 9 (7): 373-6
Identification of novel F-box proteins in Xenopus laevis. Regan-Reimann JD, Duong QV, Jackson PK. Curr Biol. 1999; 9 (20): R762-3
Cell cycle: oiling the gears of anaphase. Wolf DA, Jackson PK. Curr Biol. 1998; 8 (18): R636-9
Cell cycle: cull and destroy. Jackson PK, Curr Biol. 1996; 6 (10): 1209-12