Pehr Harbury

Postdoctoral Advisees

• Casey Krusemark

Research Interests

Our lab engineers proteins and small-molecule drugs at atomic resolution through a combination of structural calculations and combinatorial library synthesis. Our goal is to elucidate predictive principles by which novel shapes and catalytic properties can be conferred accurately on designed polypeptides.

Publications

• Remeasuring the double helix. Mathew-Fenn RS,  Das R, Harbury PA.  Science.  2008; 322 (5900): 446-9
• A molecular ruler for measuring quantitative distance distributions. Mathew-Fenn RS,  Das R, Silverman JA, Walker PA, Harbury PA.  PLoS One.  2008; 3 (10): e3229
• Design of protein-ligand binding based on the molecular-mechanics energy model. Boas FE,  Harbury PB.  J Mol Biol.  2008; 380 (2): 415-24
• Potential energy functions for protein design. Boas FE,  Harbury PB.  Curr Opin Struct Biol.  2007; 17 (2): 199-204
• Chemical evolution as a tool for molecular discovery. Wrenn SJ,  Harbury PB.  Annu Rev Biochem.  2007; 76 331-49
• Synthetic ligands discovered by in vitro selection. Wrenn SJ,  Weisinger RM, Halpin DR, Harbury PB.  J Am Chem Soc.  2007; 129 (43): 13137-43
• Misincorporation proton-alkyl exchange (MPAX): engineering cysteine probes into proteins. Burguete AS,  Harbury PB, Pfeffer SR.  Curr Protoc Protein Sci.  2005; Chapter 26 Unit26.1
• DNA display I. Sequence-encoded routing of DNA populations. Halpin DR,  Harbury PB.  PLoS Biol.  2004; 2 (7): E173
• DNA display III. Solid-phase organic synthesis on unprotected DNA. Halpin DR,  Lee JA, Wrenn SJ, Harbury PB.  PLoS Biol.  2004; 2 (7): E175
• DNA display II. Genetic manipulation of combinatorial chemistry libraries for small-molecule evolution. Halpin DR,  Harbury PB.  PLoS Biol.  2004; 2 (7): E174
• In vitro selection and prediction of TIP47 protein-interaction interfaces. Burguete AS,  Harbury PB, Pfeffer SR.  Nat Methods.  2004; 1 (1): 55-60
• Automated design of specificity in molecular recognition. Havranek JJ,  Harbury PB.  Nat Struct Biol.  2003; 10 (1): 45-52
• Rapid mapping of protein structure, interactions, and ligand binding by misincorporation proton-alkyl exchange. Silverman JA,  Harbury PB.  J Biol Chem.  2002; 277 (34): 30968-75
• The equilibrium unfolding pathway of a (beta/alpha)8 barrel. Silverman JA,  Harbury PB.  J Mol Biol.  2002; 324 (5): 1031-40
• Modular enzymes. Khosla C,  Harbury PB.  Nature.  2001; 409 (6817): 247-52
• Reverse engineering the (beta/alpha )8 barrel fold. Silverman JA,  Balakrishnan R, Harbury PB.  Proc Natl Acad Sci U S A.  2001; 98 (6): 3092-7
• Tanford-Kirkwood electrostatics for protein modeling. Havranek JJ,  Harbury PB.  Proc Natl Acad Sci U S A.  1999; 96 (20): 11145-50
• Springs and zippers: coiled coils in SNARE-mediated membrane fusion. Harbury PA,  Structure.  1998; 6 (12): 1487-91