Donna M. Bouley

Honors and Awards

• Lloyd W. Dinkelspiel Award, Stanford University (June 2007)
• Diplomate, American College of Veterinary Pathologists (1996)

Professional Education

• B.S., U Mass Amherst Animal Science (1976)
• D.V.M, U Tenn Knoxville Veterinary Medicine (1985)
• Ph.D, U Tenn Knoxville Comp. & Exp. Medicine (1995)

Web Site Links

• Stanford Undergraduate Pre-Veterinary Club

Research Interests

My research interests are quite varied. I provide pathology support for several Stanford radiologists using MRI-guided minimally-invasive therapies for the ablation of prostate cancer (focused ultrasound, cryoablation, laser). Histopathological evaluation of induced lesions provides the radiologists with feedback necessary to optimize their procedures, and interpret real-time MR images in order to guarantee the most effective cancer treatment. I also work with several radiation oncologists who study and test hypoxic cytotoxic drugs as cancer treatments. Other interests of mine include phenotypic analysis of transgenic and knockout mice, the use of genetically engineered mice to understand host pathogen interactions, and infectious diseases of frogs.

Publications

• Where's the mouse pathology training? Bouley D,  Meyerholz D, Sellers R, Boyd K, La Perle K.  Vet Pathol.  2009; 46 (6): 1245-7
• MRI-guided cryoablation: In vivo assessment of focal canine prostate cryolesions. Josan S,  Bouley DM, van den Bosch M, Daniel BL, Butts Pauly K.  J Magn Reson Imaging.  2009; 30 (1): 169-76
• Short-term stress enhances cellular immunity and increases early resistance to squamous cell carcinoma. Dhabhar FS,  Saul AN, Daugherty C, Holmes TH, Bouley DM, Oberyszyn TM.  Brain Behav Immun.  2009;
• MR imaging-guided percutaneous cryoablation of the prostate in an animal model: in vivo imaging of cryoablation-induced tissue necrosis with immediate histopathologic correlation. van den Bosch MA,  Josan S, Bouley DM, Chen J, Gill H, Rieke V, Butts-Pauly K, Daniel BL.  J Vasc Interv Radiol.  2009; 20 (2): 252-8
• Transurethral ultrasound applicators with dynamic multi-sector control for prostate thermal therapy: in vivo evaluation under MR guidance. Kinsey AM,  Diederich CJ, Rieke V, Nau WH, Pauly KB, Bouley D, Sommer G.  Med Phys.  2008; 35 (5): 2081-93
• Catheter-based ultrasound devices and MR thermal monitoring for conformal prostate thermal therapy. Diederich CJ,  Nau WH, Kinsey A, Ross T, Wootton J, Juang T, Butts-Pauly K, Rieke V, Chen J, Bouley DM, Sommer G.  Conf Proc IEEE Eng Med Biol Soc.  2008; 2008 3664-8
• Characterization of a novel anthropomorphic plastinated lung phantom. Yoon S,  Henry RW, Bouley DM, Bennett NR, Fahrig R.  Med Phys.  2008; 35 (12): 5934-43
• Monitoring prostate thermal therapy with diffusion-weighted MRI. Chen J,  Daniel BL, Diederich CJ, Bouley DM, van den Bosch MA, Kinsey AM, Sommer G, Pauly KB.  Magn Reson Med.  2008; 59 (6): 1365-72
• Experimental study of intracranial hematoma detection with flat panel detector C-arm CT. Arakawa H,  Marks MP, Do HM, Bouley DM, Strobel N, Moore T, Fahrig R.  AJNR Am J Neuroradiol.  2008; 29 (4): 766-72
• The mouse polyubiquitin gene Ubb is essential for meiotic progression. Ryu KY,  Sinnar SA, Reinholdt LG, Vaccari S, Hall S, Garcia MA, Zaitseva TS, Bouley DM, Boekelheide K, Handel MA, Conti M, Kopito RR.  Mol Cell Biol.  2008; 28 (3): 1136-46
• Host transmission of Salmonella enterica serovar Typhimurium is controlled by virulence factors and indigenous intestinal microbiota. Lawley TD,  Bouley DM, Hoy YE, Gerke C, Relman DA, Monack DM.  Infect Immun.  2008; 76 (1): 403-16
• Determination of 3-dimensional zonal renal volumes using contrast-enhanced computed tomography. Sommer G,  Bouley D, Frisoli J, Pierce L, Sandner-Porkristl D, Fahrig R.  J Comput Assist Tomogr.  2007 Mar-Apr; 31 (2): 209-13
• The distribution, density and three-dimensional histomorphology of Pacinian corpuscles in the foot of the Asian elephant (Elephas maximus) and their potential role in seismic communication. Bouley DM,  Alarcón CN, Hildebrandt T, O'Connell-Rodwell CE.  J Anat.  2007; 211 (4): 428-35
• The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance. Ryu KY,  Maehr R, Gilchrist CA, Long MA, Bouley DM, Mueller B, Ploegh HL, Kopito RR.  EMBO J.  2007; 26 (11): 2693-706
• Ovarian hyperstimulation syndrome in gonadotropin-treated laboratory South African clawed frogs (Xenopus laevis). Green SL,  Parker J, Davis C, Bouley DM.  J Am Assoc Lab Anim Sci.  2007; 46 (3): 64-7
• Spontaneous murine neuroaxonal dystrophy: a model of infantile neuroaxonal dystrophy. Bouley DM,  McIntire JJ, Harris BT, Tolwani RJ, Otto GM, DeKruyff RH, Hayflick SJ.  J Comp Pathol.  2006 Feb-Apr; 134 (2-3): 161-70
• Magnetic resonance-guided high-intensity ultrasound ablation of the prostate. Pauly KB,  Diederich CJ, Rieke V, Bouley D, Chen J, Nau WH, Ross AB, Kinsey AM, Sommer G.  Top Magn Reson Imaging.  2006; 17 (3): 195-207
• Breakpoints in immunoregulation required for Th1 cells to induce diabetes. Neighbors M,  Hartley SB, Xu X, Castro AG, Bouley DM, O'Garra A.  Eur J Immunol.  2006; 36 (9): 2315-23
• An MRI-compatible semiautomated vacuum-assisted breast biopsy system: initial feasibility study. Daniel BL,  Freeman LJ, Pyzoha JM, McCoy TD, Birdwell RL, Bouley DM, Movius B, Hibner JA.  J Magn Reson Imaging.  2005; 21 (5): 637-44
• The role of antigenic drive and tumor-infiltrating accessory cells in the pathogenesis of helicobacter-induced mucosa-associated lymphoid tissue lymphoma. Mueller A,  O'rourke J, Chu P, Chu A, Dixon MF, Bouley DM, Lee A, Falkow S.  Am J Pathol.  2005; 167 (3): 797-812
• Curvilinear transurethral ultrasound applicator for selective prostate thermal therapy. Ross AB,  Diederich CJ, Nau WH, Rieke V, Butts RK, Sommer G, Gill H, Bouley DM.  Med Phys.  2005; 32 (6): 1555-65
• MRI-guided interstitial ultrasound thermal therapy of the prostate: a feasibility study in the canine model. Nau WH,  Diederich CJ, Ross AB, Butts K, Rieke V, Bouley DM, Gill H, Daniel B, Sommer G.  Med Phys.  2005; 32 (3): 733-43
• Salmonella typhimurium persists within macrophages in the mesenteric lymph nodes of chronically infected Nramp1+/+ mice and can be reactivated by IFNgamma neutralization. Monack DM,  Bouley DM, Falkow S.  J Exp Med.  2004; 199 (2): 231-41
• The antinociceptive effect of transcranial electrostimulation with combined direct and alternating current in freely moving rats. Nekhendzy V,  Fender CP, Davies MF, Lemmens HJ, Kim MS, Bouley DM, Maze M.  Anesth Analg.  2004; 98 (3): 730-7, table of contents
• Diagnosis of tuberculosis in macaques, using whole-blood in vitro interferon-gamma (PRIMAGAM) testing. Garcia MA,  Yee J, Bouley DM, Moorhead R, Lerche NW.  Comp Med.  2004; 54 (1): 86-92
• Topical treatment with inhibitors of the phosphatidylinositol 3'-kinase/Akt and Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways reduces melanoma development in severe combined immunodeficient mice. Bedogni B,  O'Neill MS, Welford SM, Bouley DM, Giaccia AJ, Denko NC, Powell MB.  Cancer Res.  2004; 64 (7): 2552-60
• RabGEF1 is a negative regulator of mast cell activation and skin inflammation. Tam SY,  Tsai M, Snouwaert JN, Kalesnikoff J, Scherrer D, Nakae S, Chatterjea D, Bouley DM, Galli SJ.  Nat Immunol.  2004; 5 (8): 844-52
• Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality. Mazerbourg S,  Bouley DM, Sudo S, Klein CA, Zhang JV, Kawamura K, Goodrich LV, Rayburn H, Tessier-Lavigne M, Hsueh AJ.  Mol Endocrinol.  2004; 18 (9): 2241-54
• Highly directional transurethral ultrasound applicators with rotational control for MRI-guided prostatic thermal therapy. Ross AB,  Diederich CJ, Nau WH, Gill H, Bouley DM, Daniel B, Rieke V, Butts RK, Sommer G.  Phys Med Biol.  2004; 49 (2): 189-204
• Neonatal lethality of LGR5 null mice is associated with ankyloglossia and gastrointestinal distension. Morita H,  Mazerbourg S, Bouley DM, Luo CW, Kawamura K, Kuwabara Y, Baribault H, Tian H, Hsueh AJ.  Mol Cell Biol.  2004; 24 (22): 9736-43
• Outbreak of Mycobacterium bovis in a conditioned colony of rhesus (Macaca mulatta) and cynomolgus (Macaca fascicularis) macaques. Garcia MA,  Bouley DM, Larson MJ, Lifland B, Moorhead R, Simkins MD, Borie DC, Tolwani R, Otto G.  Comp Med.  2004; 54 (5): 578-84
• Magnetic resonance imaging and surgical repair of cleft palate in a four-week-old canine (Canis familiaris): an animal model for cleft palate repair. Tolwani R,  Hagan C, Runstadler J, Lyons H, Green S, Bouley D, Rodriguez L, Schendel S, Moseley M, Daunt D, Otto G, Cork L.  Contemp Top Lab Anim Sci.  2004; 43 (6): 17-21; quiz 58
• Diffusion-weighted MRI after cryosurgery of the canine prostate. Magnetic resonance imaging. Butts K,  Daniel BL, Chen L, Bouley DM, Wansapura J, Maier SE, Dumoulin C, Watkins R.  J Magn Reson Imaging.  2003; 17 (1): 131-5
• Regional vs systemic antivenom administration in the treatment of snake venom poisoning in a rabbit model: a pilot study. Norris RL,  Dery R, Johnson C, Williams S, Rose K, Young L, McDougal IR, Bouley D, Oehlert J, Thompson RC.  Wilderness Environ Med.  2003; 14 (4): 231-5
• Detection of early secretory antigenic target-6 antibody for diagnosis of tuberculosis in non-human primates. Kanaujia GV,  Garcia MA, Bouley DM, Peters R, Gennaro ML.  Comp Med.  2003; 53 (6): 602-6
• Inhibition of delta-protein kinase C protects against reperfusion injury of the ischemic heart in vivo. Inagaki K,  Chen L, Ikeno F, Lee FH, Imahashi K, Bouley DM, Rezaee M, Yock PG, Murphy E, Mochly-Rosen D.  Circulation.  2003; 108 (19): 2304-7
• Cryptosporidiosis associated with emaciation and proliferative gastritis in a laboratory-reared South African clawed frog (Xenopus laevis). Green SL,  Bouley DM, Josling CA, Fayer R.  Comp Med.  2003; 53 (1): 81-4
• Thermal shock in a colony of South African clawed frogs (Xenopus laevis). Green SL,  Moorhead RC, Bouley DM.  Vet Rec.  2003; 152 (11): 336-7
• Measurement of renal volumes with contrast-enhanced MRI. Coulam CH,  Bouley DM, Sommer FG.  J Magn Reson Imaging.  2002; 15 (2): 174-9
• Noninvasive measurement of extraction fraction and single-kidney glomerular filtration rate with MR imaging in swine with surgically created renal arterial stenoses. Coulam CH,  Lee JH, Wedding KL, Spielman DM, Pelc NJ, Kee ST, Hill BB, Bouley DM, Derby GC, Myers BD, Sawyer-Glover AM, Sommer FG.  Radiology.  2002; 223 (1): 76-82
• Canine motor neuron disease: clinicopathologic features and selected indicators of oxidative stress. Green SL,  Bouley DM, Pinter MJ, Cork LC, Vatassery GT.  J Vet Intern Med.  2001 Mar-Apr; 15 (2): 112-9
• Molecular and phenotypic analysis of Attractin mutant mice. Gunn TM,  Inui T, Kitada K, Ito S, Wakamatsu K, He L, Bouley DM, Serikawa T, Barsh GS.  Genetics.  2001; 158 (4): 1683-95
• MRI study of immediate cell viability in focused ultrasound lesions in the rabbit brain. Chen L,  Bouley DM, Harris BT, Butts K.  J Magn Reson Imaging.  2001; 13 (1): 23-30
• Murine cytomegalovirus CC chemokine homolog MCK-2 (m131-129) is a determinant of dissemination that increases inflammation at initial sites of infection. Saederup N,  Aguirre SA, Sparer TE, Bouley DM, Mocarski ES.  J Virol.  2001; 75 (20): 9966-76
• Dynamic nature of host-pathogen interactions in Mycobacterium marinum granulomas. Bouley DM,  Ghori N, Mercer KL, Falkow S, Ramakrishnan L.  Infect Immun.  2001; 69 (12): 7820-31
• Suspected hypovitaminosis A in a colony of captive green anoles (Anolis carolinensis). Miller EA,  Green SL, Otto GM, Bouley DM.  Contemp Top Lab Anim Sci.  2001; 40 (2): 18-20
• A biochemical function for attractin in agouti-induced pigmentation and obesity. He L,  Gunn TM, Bouley DM, Lu XY, Watson SJ, Schlossman SF, Duke-Cohan JS, Barsh GS.  Nat Genet.  2001; 27 (1): 40-7
• Induction of angiogenesis by implantation of encapsulated primary myoblasts expressing vascular endothelial growth factor. Springer ML,  Hortelano G, Bouley DM, Wong J, Kraft PE, Blau HM.  J Gene Med.  2000 Jul-Aug; 2 (4): 279-88
• Disease attributed to Mycobacterium chelonae in South African clawed frogs (Xenopus laevis). Green SL,  Lifland BD, Bouley DM, Brown BA, Wallace RJ, Ferrell JE.  Comp Med.  2000; 50 (6): 675-9
• Salmonella exploits caspase-1 to colonize Peyer's patches in a murine typhoid model. Monack DM,  Hersh D, Ghori N, Bouley D, Zychlinsky A, Falkow S.  J Exp Med.  2000; 192 (2): 249-58
• mig-14 is a horizontally acquired, host-induced gene required for salmonella enterica lethal infection in the murine model of typhoid fever. Valdivia RH,  Cirillo DM, Lee AK, Bouley DM, Falkow S.  Infect Immun.  2000; 68 (12): 7126-31
• Cryptosporidiosis, coccidiosis, and total colonic mucosal collapse in an immunosuppressed puppy. Willard MD,  Bouley D.  J Am Anim Hosp Assoc.  1999 Sep-Oct; 35 (5): 405-9
• Partial tracheal obstruction due to chondromas in ball pythons (Python regius). Drew ML,  Phalen DN, Berridge BR, Johnson TL, Bouley D, Weeks BR, Miller HA, Walker MA.  J Zoo Wildl Med.  1999; 30 (1): 151-7
• Identification and management of an outbreak of Flavobacterium meningosepticum infection in a colony of South African clawed frogs (Xenopus laevis). Green SL,  Bouley DM, Tolwani RJ, Waggie KS, Lifland BD, Otto GM, Ferrell JE.  J Am Vet Med Assoc.  1999; 214 (12): 1833-8, 1792-3
• Study of focused ultrasound tissue damage using MRI and histology. Chen L,  Bouley D, Yuh E, D'Arceuil H, Butts K.  J Magn Reson Imaging.  1999; 10 (2): 146-53
• Possible antibiotic-associated colitis in a dog. Willard MD,  Berridge B, Braniecki A, Bouley D.  J Am Vet Med Assoc.  1998; 213 (12): 1775-9, 1753-4
• Progressive ataxia, myoclonic epilepsy and cerebellar apoptosis in cystatin B-deficient mice. Pennacchio LA,  Bouley DM, Higgins KM, Scott MP, Noebels JL, Myers RM.  Nat Genet.  1998; 20 (3): 251-8
• Yersinia-induced apoptosis in vivo aids in the establishment of a systemic infection of mice. Monack DM,  Mecsas J, Bouley D, Falkow S.  J Exp Med.  1998; 188 (11): 2127-37
• The role of the innate immune system in the reconstituted SCID mouse model of herpetic stromal keratitis. Bouley DM,  Kanangat S, Rouse BT.  Clin Immunol Immunopathol.  1996; 80 (1): 23-30
• Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness. Banks TA,  Rouse BT, Kerley MK, Blair PJ, Godfrey VL, Kuklin NA, Bouley DM, Thomas J, Kanangat S, Mucenski ML.  J Immunol.  1995; 155 (4): 1685-93
• Characterization of herpes simplex virus type-1 infection and herpetic stromal keratitis development in IFN-gamma knockout mice. Bouley DM,  Kanangat S, Wire W, Rouse BT.  J Immunol.  1995; 155 (8): 3964-71
• Radiographic and scintigraphic evidence of focal pulmonary neoplasia in three cats with hyperthyroidism: diagnostic and therapeutic considerations. Cook SM,  Daniel GB, Walker MA, Maddux JM, Jenkins CC, Klebanow ER, Bouley DM, Dean DF, Petersen MG.  J Vet Intern Med.  1993 Sep-Oct; 7 (5): 303-8
• Herpetic stromal keratitis in the reconstituted scid mouse model. Mercadal CM,  Bouley DM, DeStephano D, Rouse BT.  J Virol.  1993; 67 (6): 3404-8