Key Documents

Thomas Quertermous, MD

Professor, Medicine - Cardiovascular Medicine

Contact Information

Clinical Offices

Cardiovascular Medicine Clinic 300 Pasteur Dr A260 MC 5319 Stanford, CA 94305-2200
Telephone Work (650) 723-5012 Fax (650) 725-2178

CVRB #269, MC: 5406 Stanford, CA 94305
Telephone Work (650) 723-5013 Fax (650) 725-2178
Academic Offices

Personal Information
Tel (650) 723-5013

Administrative Contact
Celest Landini Administrative Assistant Email clandini@cvmed.stanford.edu Tel Work 650-723-5013

Postdoctoral Advisees

David Charo, Yoko Kojima, Nicholas Leeper, Azad Raiesdana

Industry Relationships

Stanford is committed to ethical and transparent interactions with our industry partners. It is our policy to disclose payments of $5,000 or more, equity valued at $5,000 or more in a publicly traded company, or any equity in a privately held company, to physicians and scientists employed by Stanford University from companies or other commercial entities with which they interact as part of their professional activities.

Consulting: Aviir, Incorporated, Via Pharmaceuticals
Equity: Via Pharmaceuticals
Service on Board of Directors: Aviir, Incorporated

Research Interests

The Quertermous laboratory employs two basic approaches of study to better understand the genetic basis of atherosclerotic heart disease. One approach uses basic molecular biology methodology, primarily working with cellular and genetic mouse models, and is focused on the recently identified apelin-APJ pathway. A second approach employs the power of modern human genetics. Informative cohorts have been collected that allow investigation of risk factors such as hypertension and insulin resistance as well as coronary heart disease. Initial studies have employed the candidate gene approach, and more recently whole genome association studies, to identify allelic variation that is associated with risk factor and disease susceptibility.

Clinical Trials

Permission to Collect Blood over Time for Research Recruiting

Publications

Apelin prevents aortic aneurysm formation by inhibiting macrophage inflammation. Leeper NJ, Tedesco MM, Kojima Y, Schultz GM, Kundu RK, Ashley EA, Tsao PS, Dalman RL, Quertermous T. Am J Physiol Heart Circ Physiol. 2009; 296 (5): H1329-35
Admixture mapping of quantitative trait loci for blood lipids in African-Americans. Basu A, Tang H, Lewis CE, North K, Curb JD, Quertermous T, Mosley TH, Boerwinkle E, Zhu X, Risch NJ. Hum Mol Genet. 2009; 18 (11): 2091-8
Role of endothelial lipase in plasma HDL levels in a murine model of hypertriglyceridemia. Tanaka H, Ishida T, Johnston TP, Yasuda T, Ueyama T, Kojima Y, Kundu RK, Quertermous T, Ishikawa Y, Hirata K. J Atheroscler Thromb. 2009; 16 (4): 327-38
Insulin resistance independently predicts the progression of coronary artery calcification. Lee KK, Fortmann SP, Fair JM, Iribarren C, Rubin GD, Varady A, Go AS, Quertermous T, Hlatky MA. Am Heart J. 2009; 157 (5): 939-45
Identification of ARIA regulating endothelial apoptosis and angiogenesis by modulating proteasomal degradation of cIAP-1 and cIAP-2. Ikeda K, Nakano R, Uraoka M, Nakagawa Y, Koide M, Katsume A, Minamino K, Yamada E, Yamada H, Quertermous T, Matsubara H. Proc Natl Acad Sci U S A. 2009; 106 (20): 8227-32
Ontogeny of apelin and its receptor in the rodent gastrointestinal tract. Wang G, Kundu R, Han S, Qi X, Englander EW, Quertermous T, Greeley GH. Regul Pept. 2009; 158 (1-3): 32-9
The adhesion molecule esam1 is a novel hematopoietic stem cell marker. Ooi AG, Karsunky H, Majeti R, Butz S, Vestweber D, Ishida T, Quertermous T, Weissman IL, Forsberg EC. Stem Cells. 2009; 27 (3): 653-61
Targeted inactivation of endothelial lipase attenuates lung allergic inflammation through raising plasma HDL level and inhibiting eosinophil infiltration. Otera H, Ishida T, Nishiuma T, Kobayashi K, Kotani Y, Yasuda T, Kundu RK, Quertermous T, Hirata K, Nishimura Y. Am J Physiol Lung Cell Mol Physiol. 2009; 296 (4): L594-602
The negative correlation between plasma adiponectin and blood pressure depends on obesity: a family-based association study in SAPPHIRe. Li HY, Chiu YF, Hwu CM, Sheu WH, Hung YJ, Fujimoto W, Quertermous T, Curb JD, Tai TY, Chuang LM. Am J Hypertens. 2008; 21 (4): 471-6
Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease. Assimes TL, Knowles JW, Priest JR, Basu A, Volcik KA, Southwick A, Tabor HK, Hartiala J, Allayee H, Grove ML, Tabibiazar R, Sidney S, Fortmann SP, Go A, Hlatky M, Iribarren C, Boerwinkle E, Myers R, Risch N, Quertermous T. Hum Genet. 2008; 123 (4): 399-408
A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease. Assimes TL, Knowles JW, Priest JR, Basu A, Borchert A, Volcik KA, Grove ML, Tabor HK, Southwick A, Tabibiazar R, Sidney S, Boerwinkle E, Go AS, Iribarren C, Hlatky MA, Fortmann SP, Myers RM, Kuhn H, Risch N, Quertermous T. Atherosclerosis. 2008; 198 (1): 136-44
In vivo genetic profiling and cellular localization of apelin reveals a hypoxia-sensitive, endothelial-centered pathway activated in ischemic heart failure. Sheikh AY, Chun HJ, Glassford AJ, Kundu RK, Kutschka I, Ardigo D, Hendry SL, Wagner RA, Chen MM, Ali ZA, Yue P, Huynh DT, Connolly AJ, Pelletier MP, Tsao PS, Robbins RC, Quertermous T. Am J Physiol Heart Circ Physiol. 2008; 294 (1): H88-98
Increased rate of hair regrowth in mice with constitutive overexpression of Del1. Hsu GP, Mathy JA, Wang Z, Xia W, Sakamoto G, Kundu R, Longaker MT, Quertermous T, Yang GP. J Surg Res. 2008; 146 (1): 73-80
Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD. Knowles JW, Assimes TL, Boerwinkle E, Fortmann SP, Go A, Grove ML, Hlatky M, Iribarren C, Li J, Myers R, Risch N, Sidney S, Southwick A, Volcik KA, Quertermous T. BMC Med Genet. 2008; 9 23
Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study. Assimes TL, Knowles JW, Basu A, Iribarren C, Southwick A, Tang H, Absher D, Li J, Fair JM, Rubin GD, Sidney S, Fortmann SP, Go AS, Hlatky MA, Myers RM, Risch N, Quertermous T. Hum Mol Genet. 2008; 17 (15): 2320-8
Absence of evidence for an association between resistin gene variants and insulin resistance in an Asian population with low and high blood pressure. Kimbell JL, Koropatnick TA, Grove JS, Huang YH, Chiang FT, Quertermous T, Chen R, Donlon TA, Rodriguez BL, Curb JD. Diabetes Res Clin Pract. 2008; 81 (2): 231-7
A novel platform device for rodent echocardiography. Kutschka I, Sheikh AY, Sista R, Hendry SL, Chun HJ, Hoyt G, Kutschka W, Pelletier MP, Quertermous T, Wu JC, Robbins RC. ILAR J. 2008; 49 E1-7
Molecular and physiological characterization of RV remodeling in a murine model of pulmonary stenosis. Urashima T, Zhao M, Wagner R, Fajardo G, Farahani S, Quertermous T, Bernstein D. Am J Physiol Heart Circ Physiol. 2008; 295 (3): H1351-H1368
Apelin signaling antagonizes Ang II effects in mouse models of atherosclerosis. Chun HJ, Ali ZA, Kojima Y, Kundu RK, Sheikh AY, Agrawal R, Zheng L, Leeper NJ, Pearl NE, Patterson AJ, Anderson JP, Tsao PS, Lenardo MJ, Ashley EA, Quertermous T. J Clin Invest. 2008; 118 (10): 3343-54
Apelin-APJ signaling in retinal angiogenesis. Kojima Y, Quertermous T. Arterioscler Thromb Vasc Biol. 2008; 28 (10): 1687-8
Del-1, an endogenous leukocyte-endothelial adhesion inhibitor, limits inflammatory cell recruitment. Choi EY, Chavakis E, Czabanka MA, Langer HF, Fraemohs L, Economopoulou M, Kundu RK, Orlandi A, Zheng YY, Prieto DA, Ballantyne CM, Constant SL, Aird WC, Papayannopoulou T, Gahmberg CG, Udey MC, Vajkoczy P, Quertermous T, Dimmeler S, Weber C, Chavakis T. Science. 2008; 322 (5904): 1101-4
Transcriptome alteration in the diabetic heart by rosiglitazone: implications for cardiovascular mortality. Wilson KD, Li Z, Wagner R, Yue P, Tsao P, Nestorova G, Huang M, Hirschberg DL, Yock PG, Quertermous T, Wu JC. PLoS One. 2008; 3 (7): e2609
Genetic susceptibility to peripheral arterial disease: a dark corner in vascular biology. Knowles JW, Assimes TL, Li J, Quertermous T, Cooke JP. Arterioscler Thromb Vasc Biol. 2007; 27 (10): 2068-78
HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytes. Glassford AJ, Yue P, Sheikh AY, Chun HJ, Zarafshar S, Chan DA, Reaven GM, Quertermous T, Tsao PS. Am J Physiol Endocrinol Metab. 2007; 293 (6): E1590-6
Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease. Hlatky MA, Quertermous T, Boothroyd DB, Priest JR, Glassford AJ, Myers RM, Fortmann SP, Iribarren C, Tabor HK, Assimes TL, Tibshirani RJ, Go AS. Am Heart J. 2007; 154 (6): 1035-42
Matrix metalloproteinase circulating levels, genetic polymorphisms, and susceptibility to acute myocardial infarction among patients with coronary artery disease. Hlatky MA, Ashley E, Quertermous T, Boothroyd DB, Ridker P, Southwick A, Myers RM, Iribarren C, Fortmann SP, Go AS. Am Heart J. 2007; 154 (6): 1043-51
Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction. Knowles JW, Wang H, Itakura H, Southwick A, Myers RM, Iribarren C, Fortmann SP, Go AS, Quertermous T, Hlatky MA. Am Heart J. 2007; 154 (6): 1052-8
Do plasma biomarkers of coagulation and fibrinolysis differ between patients who have experienced an acute myocardial infarction versus stable exertional angina? Itakura H, Sobel BE, Boothroyd D, Leung LL, Iribarren C, Go AS, Fortmann SP, Quertermous T, Hlatky MA. Am Heart J. 2007; 154 (6): 1059-64
Frontiers in nephrology: genomic approaches to understanding the molecular basis of atherosclerosis. Ashley EA, Spin JM, Tabibiazar R, Quertermous T. J Am Soc Nephrol. 2007; 18 (11): 2853-62
Circulating chemokines accurately identify individuals with clinically significant atherosclerotic heart disease. Ardigo D, Assimes TL, Fortmann SP, Go AS, Hlatky M, Hytopoulos E, Iribarren C, Tsao PS, Tabibiazar R, Quertermous T. Physiol Genomics. 2007; 31 (3): 402-9
Endothelial lipase is increased by inflammation and promotes LDL uptake in macrophages. Yasuda T, Hirata K, Ishida T, Kojima Y, Tanaka H, Okada T, Quertermous T, Yokoyama M. J Atheroscler Thromb. 2007; 14 (4): 192-201
Hepatic proprotein convertases modulate HDL metabolism. Jin W, Wang X, Millar JS, Quertermous T, Rothblat GH, Glick JM, Rader DJ. Cell Metab. 2007; 6 (2): 129-36
Bivariate genome-wide scan for metabolic phenotypes in non-diabetic Chinese individuals from the Stanford, Asia and Pacific Program of Hypertension and Insulin Resistance Family Study. Chiu YF, Chuang LM, Kao HY, Ho LT, Ting CT, Hung YJ, Chen YD, Donlon T, Curb JD, Quertermous T, Hsiung CA. Diabetologia. 2007; 50 (8): 1631-40
Heritability of left ventricular mass in Japanese families living in Hawaii: the SAPPHIRe Study. Assimes TL, Narasimhan B, Seto TB, Yoon S, Curb JD, Olshen RA, Quertermous T. J Hypertens. 2007; 25 (5): 985-92
Apelin and its g protein-coupled receptor regulate cardiac development as well as cardiac function. Quertermous T, Dev Cell. 2007; 12 (3): 319-20
An updated meta-analysis of genome scans for hypertension and blood pressure in the NHLBI Family Blood Pressure Program (FBPP). Wu X, Kan D, Province M, Quertermous T, Rao DC, Chang C, Mosley TH, Curb D, Boerwinkle E, Cooper RS. Am J Hypertens. 2006; 19 (1): 122-7
Statin and beta-blocker therapy and the initial presentation of coronary heart disease. Go AS, Iribarren C, Chandra M, Lathon PV, Fortmann SP, Quertermous T, Hlatky MA. Ann Intern Med. 2006; 144 (4): 229-38
Proteomic profiles of serum inflammatory markers accurately predict atherosclerosis in mice. Tabibiazar R, Wagner RA, Deng A, Tsao PS, Quertermous T. Physiol Genomics. 2006; 25 (2): 194-202
Differences in vascular bed disease susceptibility reflect differences in gene expression response to atherogenic stimuli. Deng DX, Tsalenko A, Vailaya A, Ben-Dor A, Kundu R, Estay I, Tabibiazar R, Kincaid R, Yakhini Z, Bruhn L, Quertermous T. Circ Res. 2006; 98 (2): 200-8
Transcriptional profiling of reporter genes used for molecular imaging of embryonic stem cell transplantation. Wu JC, Spin JM, Cao F, Lin S, Xie X, Gheysens O, Chen IY, Sheikh AY, Robbins RC, Tsalenko A, Gambhir SS, Quertermous T. Physiol Genomics. 2006; 25 (1): 29-38
Dual in vivo magnetic resonance evaluation of magnetically labeled mouse embryonic stem cells and cardiac function at 1.5 t. Arai T, Kofidis T, Bulte JW, de Bruin J, Venook RD, Berry GJ, Mcconnell MV, Quertermous T, Robbins RC, Yang PC. Magn Reson Med. 2006; 55 (1): 203-9
Molecular signatures determining coronary artery and saphenous vein smooth muscle cell phenotypes: distinct responses to stimuli. Deng DX, Spin JM, Tsalenko A, Vailaya A, Ben-Dor A, Yakhini Z, Tsao P, Bruhn L, Quertermous T. Arterioscler Thromb Vasc Biol. 2006; 26 (5): 1058-65
Glia maturation factor-gamma is preferentially expressed in microvascular endothelial and inflammatory cells and modulates actin cytoskeleton reorganization. Ikeda K, Kundu RK, Ikeda S, Kobara M, Matsubara H, Quertermous T. Circ Res. 2006; 99 (4): 424-33
Opposing cardiovascular roles for the angiotensin and apelin signaling pathways. Ashley E, Chun HJ, Quertermous T. J Mol Cell Cardiol. 2006; 41 (5): 778-81
Network analysis of human in-stent restenosis. Ashley EA, Ferrara R, King JY, Vailaya A, Kuchinsky A, He X, Byers B, Gerckens U, Oblin S, Tsalenko A, Soito A, Spin JM, Tabibiazar R, Connolly AJ, Simpson JB, Grube E, Quertermous T. Circulation. 2006; 114 (24): 2644-54
Metabolic syndrome and early-onset coronary artery disease: is the whole greater than its parts? Iribarren C, Go AS, Husson G, Sidney S, Fair JM, Quertermous T, Hlatky MA, Fortmann SP. J Am Coll Cardiol. 2006; 48 (9): 1800-7
The impact of data quality on the identification of complex disease genes: experience from the Family Blood Pressure Program. Chang YP, Kim JD, Schwander K, Rao DC, Miller MB, Weder AB, Cooper RS, Schork NJ, Province MA, Morrison AC, Kardia SL, Quertermous T, Chakravarti A. Eur J Hum Genet. 2006; 14 (4): 469-77
Genome-wide linkage scans for fasting glucose, insulin, and insulin resistance in the National Heart, Lung, and Blood Institute Family Blood Pressure Program: evidence of linkages to chromosome 7q36 and 19q13 from meta-analysis. An P, Freedman BI, Hanis CL, Chen YD, Weder AB, Schork NJ, Boerwinkle E, Province MA, Hsiung CA, Wu X, Quertermous T, Rao DC. Diabetes. 2005; 54 (3): 909-14
Increased expression of endothelial lipase in rat models of hypertension. Shimokawa Y, Hirata K, Ishida T, Kojima Y, Inoue N, Quertermous T, Yokoyama M. Cardiovasc Res. 2005; 66 (3): 594-600
Overexpression of the Del1 gene causes dendritic branching in the mouse mesentery. Hidai C, Kawana M, Habu K, Kazama H, Kawase Y, Iwata T, Suzuki H, Quertermous T, Kokubun S. Anat Rec A Discov Mol Cell Evol Biol. 2005; 287 (2): 1165-75
Two major QTLs and several others relate to factors of metabolic syndrome in the family blood pressure program. Kraja AT, Rao DC, Weder AB, Cooper R, Curb JD, Hanis CL, Turner ST, de Andrade M, Hsiung CA, Quertermous T, Zhu X, Province MA. Hypertension. 2005; 46 (4): 751-7
Admixture mapping for hypertension loci with genome-scan markers. Zhu X, Luke A, Cooper RS, Quertermous T, Hanis C, Mosley T, Gu CC, Tang H, Rao DC, Risch N, Weder A. Nat Genet. 2005; 37 (2): 177-81
An evaluation of the metabolic syndrome in a large multi-ethnic study: the Family Blood Pressure Program. Kraja AT, Rao DC, Weder AB, Mosley TH, Turner ST, Hsiung CA, Quertermous T, Cooper R, Curb JD, Province MA. Nutr Metab (Lond). 2005; 2 17
Genome-wide expression dynamics during mouse embryonic development reveal similarities to Drosophila development. Wagner RA, Tabibiazar R, Liao A, Quertermous T. Dev Biol. 2005; 288 (2): 595-611
Genetic structure, self-identified race/ethnicity, and confounding in case-control association studies. Tang H, Quertermous T, Rodriguez B, Kardia SL, Zhu X, Brown A, Pankow JS, Province MA, Hunt SC, Boerwinkle E, Schork NJ, Risch NJ. Am J Hum Genet. 2005; 76 (2): 268-75
Signature patterns of gene expression in mouse atherosclerosis and their correlation to human coronary disease. Tabibiazar R, Wagner RA, Ashley EA, King JY, Ferrara R, Spin JM, Sanan DA, Narasimhan B, Tibshirani R, Tsao PS, Efron B, Quertermous T. Physiol Genomics. 2005; 22 (2): 213-26
Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation. Nanda N, Bao M, Lin H, Clauser K, Komuves L, Quertermous T, Conley PB, Phillips DR, Hart MJ. J Biol Chem. 2005; 280 (26): 24680-9
The endogenous peptide apelin potently improves cardiac contractility and reduces cardiac loading in vivo. Ashley EA, Powers J, Chen M, Kundu R, Finsterbach T, Caffarelli A, Deng A, Eichhorn J, Mahajan R, Agrawal R, Greve J, Robbins R, Patterson AJ, Bernstein D, Quertermous T. Cardiovasc Res. 2005; 65 (1): 73-82
Mouse strain-specific differences in vascular wall gene expression and their relationship to vascular disease. Tabibiazar R, Wagner RA, Spin JM, Ashley EA, Narasimhan B, Rubin EM, Efron B, Tsao PS, Tibshirani R, Quertermous T. Arterioscler Thromb Vasc Biol. 2005; 25 (2): 302-8
Myocardial restoration with embryonic stem cell bioartificial tissue transplantation. Kofidis T, de Bruin JL, Hoyt G, Ho Y, Tanaka M, Yamane T, Lebl DR, Swijnenburg RJ, Chang CP, Quertermous T, Robbins RC. J Heart Lung Transplant. 2005; 24 (6): 737-44
Pathway analysis of coronary atherosclerosis. King JY, Ferrara R, Tabibiazar R, Spin JM, Chen MM, Kuchinsky A, Vailaya A, Kincaid R, Tsalenko A, Deng DX, Connolly A, Zhang P, Yang E, Watt C, Yakhini Z, Ben-Dor A, Adler A, Bruhn L, Tsao P, Quertermous T, Ashley EA. Physiol Genomics. 2005; 23 (1): 103-18
An autosomal genome-wide scan for loci linked to pre-diabetic phenotypes in nondiabetic Chinese subjects from the Stanford Asia-Pacific Program of Hypertension and Insulin Resistance Family Study. Chiu YF, Chuang LM, Hsiao CF, Hung YJ, Lin MW, Chen YT, Grove J, Jorgenson E, Quertermous T, Risch N, Hsiung CA. Diabetes. 2005; 54 (4): 1200-6
Transcriptional profiling of in vitro smooth muscle cell differentiation identifies specific patterns of gene and pathway activation. Spin JM, Nallamshetty S, Tabibiazar R, Ashley EA, King JY, Chen M, Tsao PS, Quertermous T. Physiol Genomics. 2004; 19 (3): 292-302
Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice. Ishida T, Choi SY, Kundu RK, Spin J, Yamashita T, Hirata K, Kojima Y, Yokoyama M, Cooper AD, Quertermous T. J Biol Chem. 2004; 279 (43): 45085-92
Endothelial lipase is synthesized by hepatic and aorta endothelial cells and its expression is altered in apoE-deficient mice. Yu KC, David C, Kadambi S, Stahl A, Hirata K, Ishida T, Quertermous T, Cooper AD, Choi SY. J Lipid Res. 2004; 45 (9): 1614-23
Developmental endothelial locus-1 (Del-1), a novel angiogenic protein: its role in ischemia. Ho HK, Jang JJ, Kaji S, Spektor G, Fong A, Yang P, Hu BS, Schatzman R, Quertermous T, Cooke JP. Circulation. 2004; 109 (10): 1314-9
Molecular cloning of nonsecreted endothelial cell-derived lipase isoforms. Ishida T, Zheng Z, Dichek HL, Wang H, Moreno I, Yang E, Kundu RK, Talbi S, Hirata K, Leung LL, Quertermous T. Genomics. 2004; 83 (1): 24-33
Genome-wide expression profiling of a cardiac pressure overload model identifies major metabolic and signaling pathway responses. Wagner RA, Tabibiazar R, Powers J, Bernstein D, Quertermous T. J Mol Cell Cardiol. 2004; 37 (6): 1159-70
Molecular isolation and characterization of a soluble isoform of activated leukocyte cell adhesion molecule that modulates endothelial cell function. Ikeda K, Quertermous T. J Biol Chem. 2004; 279 (53): 55315-23
Physical inactivity is an important lifestyle determinant of insulin resistance in hypertensive patients. Hwu CM, Hsiao CF, Kuo SW, Wu KD, Ting CT, Quertermous T, Rodriguez B, Chen I, Grove J, Chen PY, Hoo LT. Blood Press. 2004; 13 (6): 355-61
Biethnic comparisons of autosomal genomic scan for loci linked to plasma adiponectin in populations of Chinese and Japanese origin. Chuang LM, Chiu YF, Sheu WH, Hung YJ, Ho LT, Grove J, Rodriguez B, Quertermous T, Chen YD, Hsiung CA, Tai TY. J Clin Endocrinol Metab. 2004; 89 (11): 5772-8
Endothelial lipase modulates monocyte adhesion to the vessel wall. A potential role in inflammation. Kojma Y, Hirata K, Ishida T, Shimokawa Y, Inoue N, Kawashima S, Quertermous T, Yokoyama M. J Biol Chem. 2004; 279 (52): 54032-8
Tree-structured supervised learning and the genetics of hypertension. Huang J, Lin A, Narasimhan B, Quertermous T, Hsiung CA, Ho LT, Grove JS, Olivier M, Ranade K, Risch NJ, Olshen RA. Proc Natl Acad Sci U S A. 2004; 101 (29): 10529-34
Transcriptional profiling of the heart reveals chamber-specific gene expression patterns. Tabibiazar R, Wagner RA, Liao A, Quertermous T. Circ Res. 2003; 93 (12): 1193-201
Comparison of developmental endothelial locus-1 angiogenic factor with vascular endothelial growth factor in a porcine model of cardiac ischemia. Kown MH, Suzuki T, Koransky ML, Penta K, Sakamoto G, Jahncke CL, Carter AJ, Quertermous T, Robbins RC. Ann Thorac Surg. 2003; 76 (4): 1246-51
Sagittal abdominal diameter is associated with insulin sensitivity in Chinese hypertensive patients and their siblings. Hwu CM, Hsiao CF, Sheu WH, Pei D, Tai TY, Quertermous T, Rodriguez B, Pratt R, Chen YD, Ho LT. J Hum Hypertens. 2003; 17 (3): 193-8
FGF-1 enhanced cardiogenesis in differentiating embryonal carcinoma cell cultures, which was opposite to the effect of FGF-2. Hidai C, Masako O, Ikeda H, Nagashima H, Matsuoka R, Quertermous T, Kasanuki H, Kokubun S, Kawana M. J Mol Cell Cardiol. 2003; 35 (4): 421-5
Immunohistochemical localization of endothelial cell-derived lipase in atherosclerotic human coronary arteries. Azumi H, Hirata K, Ishida T, Kojima Y, Rikitake Y, Takeuchi S, Inoue N, Kawashima S, Hayashi Y, Itoh H, Quertermous T, Yokoyama M. Cardiovasc Res. 2003; 58 (3): 647-54
Genetic epistasis of adiponectin and PPARgamma2 genotypes in modulation of insulin sensitivity: a family-based association study. Yang WS, Hsiung CA, Ho LT, Chen YT, He CT, Curb JD, Grove J, Quertermous T, Chen YD, Kuo SS, Chuang LM. Diabetologia. 2003; 46 (7): 977-83
Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1. Zhong J, Eliceiri B, Stupack D, Penta K, Sakamoto G, Quertermous T, Coleman M, Boudreau N, Varner JA. J Clin Invest. 2003; 112 (1): 30-41
Use of high throughput genomic tools for the study of endothelial cell biology. Tabibiazar R, Quertermous T. Lymphat Res Biol. 2003; 1 (2): 133-45
Endothelial lipase is a major determinant of HDL level. Ishida T, Choi S, Kundu RK, Hirata K, Rubin EM, Cooper AD, Quertermous T. J Clin Invest. 2003; 111 (3): 347-55
Identification of endothelial cell genes by combined database mining and microarray analysis. Ho M, Yang E, Matcuk G, Deng D, Sampas N, Tsalenko A, Tabibiazar R, Zhang Y, Chen M, Talbi S, Ho YD, Wang J, Tsao PS, Ben-Dor A, Yakhini Z, Bruhn L, Quertermous T. Physiol Genomics. 2003; 13 (3): 249-62
Targeted disruption of endothelial cell-selective adhesion molecule inhibits angiogenic processes in vitro and in vivo. Ishida T, Kundu RK, Yang E, Hirata K, Ho YD, Quertermous T. J Biol Chem. 2003; 278 (36): 34598-604
Novel role for the potent endogenous inotrope apelin in human cardiac dysfunction. Chen MM, Ashley EA, Deng DX, Tsalenko A, Deng A, Tabibiazar R, Ben-Dor A, Fenster B, Yang E, King JY, Fowler M, Robbins R, Johnson FL, Bruhn L, McDonagh T, Dargie H, Yakhini Z, Tsao PS, Quertermous T. Circulation. 2003; 108 (12): 1432-9
Del1 mediates VSMC adhesion, migration, and proliferation through interaction with integrin alpha(v)beta(3). Rezaee M, Penta K, Quertermous T. Am J Physiol Heart Circ Physiol. 2002; 282 (5): H1924-32
Inducible and selective transgene expression in murine vascular endothelium. Teng PI, Dichiara MR, Kömüves LG, Abe K, Quertermous T, Topper JN. Physiol Genomics. 2002; 11 (2): 99-107
The embryonic angiogenic factor Del1 accelerates tumor growth by enhancing vascular formation. Aoka Y, Johnson FL, Penta K, Hirata Ki K, Hidai C, Schatzman R, Varner JA, Quertermous T. Microvasc Res. 2002; 64 (1): 148-61
Therapeutic lymphangiogenesis with human recombinant VEGF-C. Szuba A, Skobe M, Karkkainen MJ, Shin WS, Beynet DP, Rockson NB, Dakhil N, Spilman S, Goris ML, Strauss HW, Quertermous T, Alitalo K, Rockson SG. FASEB J. 2002; 16 (14): 1985-7
Endothelial lipase: a new lipase on the block. Choi SY, Hirata K, Ishida T, Quertermous T, Cooper AD. J Lipid Res. 2002; 43 (11): 1763-9
Cloning of an immunoglobulin family adhesion molecule selectively expressed by endothelial cells. Hirata Ki, Ishida T, Penta K, Rezaee M, Yang E, Wohlgemuth J, Quertermous T. J Biol Chem. 2001; 276 (19): 16223-31
Size fractionation using agarose gels. Quertermous T, Curr Protoc Mol Biol. 2001; Chapter 5 Unit5.4
Production of a genomic DNA library. Quertermous T, Curr Protoc Mol Biol. 2001; Chapter 5 Unit5.7
Plating and transferring bacteriophage libraries. Quertermous T, Curr Protoc Mol Biol. 2001; Chapter 6 Unit6.1
Size fractionation using sucrose gradients. Weis JH, Quertermous T. Curr Protoc Mol Biol. 2001; Chapter 5 Unit5.3
Purification of bacteriophage clones. Quertermous T, Curr Protoc Mol Biol. 2001; Chapter 6 Unit6.5
Identification of an octamer element required for in vivo expression of the TIE1 gene in endothelial cells. Boutet SC, Quertermous T, Fadel BM. Biochem J. 2001; 360 (Pt 1): 23-9
NHLBI workshop report: endothelial cell phenotypes in heart, lung, and blood diseases. Stevens T, Rosenberg R, Aird W, Quertermous T, Johnson FL, Garcia JG, Hebbel RP, Tuder RM, Garfinkel S. Am J Physiol Cell Physiol. 2001; 281 (5): C1422-33
Vezf1/DB1 is an endothelial cell-specific transcription factor that regulates expression of the endothelin-1 promoter. Aitsebaomo J, Kingsley-Kallesen ML, Wu Y, Quertermous T, Patterson C. J Biol Chem. 2001; 276 (42): 39197-205
Cardiovascular overexpression of transforming growth factor-beta(1) causes abnormal yolk sac vasculogenesis and early embryonic death. Agah R, Prasad KS, Linnemann R, Firpo MT, Quertermous T, Dichek DA. Circ Res. 2000; 86 (10): 1024-30
Regulated expression of endothelial cell-derived lipase. Hirata K, Ishida T, Matsushita H, Tsao PS, Quertermous T. Biochem Biophys Res Commun. 2000; 272 (1): 90-3
Endothelial cell-specific regulation of the murine endothelin-1 gene. Fadel BM, Boutet SC, Quertermous T. J Cardiovasc Pharmacol. 2000; 35 (4 Suppl 2): S7-11
Cloning of a unique lipase from endothelial cells extends the lipase gene family. Hirata K, Dichek HL, Cioffi JA, Choi SY, Leeper NJ, Quintana L, Kronmal GS, Cooper AD, Quertermous T. J Biol Chem. 1999; 274 (20): 14170-5
Octamer-dependent in vivo expression of the endothelial cell-specific TIE2 gene. Fadel BM, Boutet SC, Quertermous T. J Biol Chem. 1999; 274 (29): 20376-83
Del1 induces integrin signaling and angiogenesis by ligation of alphaVbeta3. Penta K, Varner JA, Liaw L, Hidai C, Schatzman R, Quertermous T. J Biol Chem. 1999; 274 (16): 11101-9
Regional variability in preproEndothelin-1 gene expression in sheep pulmonary artery and lung during the onset of air-induced chronic pulmonary hypertension. Participation Of arterial smooth muscle cells. Tchekneva E, Quertermous T, Christman BW, Lawrence ML, Meyrick B. J Clin Invest. 1998; 101 (6): 1389-97
Cloning of capsulin, a basic helix-loop-helix factor expressed in progenitor cells of the pericardium and the coronary arteries. Hidai H, Bardales R, Goodwin R, Quertermous T, Quertermous EE. Mech Dev. 1998; 73 (1): 33-43
Functional analysis of the endothelial cell-specific Tie2/Tek promoter identifies unique protein-binding elements. Fadel BM, Boutet SC, Quertermous T. Biochem J. 1998; 330 ( Pt 1) 335-43
Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor. Hidai C, Zupancic T, Penta K, Mikhail A, Kawana M, Quertermous EE, Aoka Y, Fukagawa M, Matsui Y, Platika D, Auerbach R, Hogan BL, Snodgrass R, Quertermous T. Genes Dev. 1998; 12 (1): 21-33
Identification of an endothelial cell-specific regulatory region in the murine endothelin-1 gene. Bu X, Quertermous T. J Biol Chem. 1997; 272 (51): 32613-22
Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension. Hocher B, Thöne-Reineke C, Rohmeiss P, Schmager F, Slowinski T, Burst V, Siegmund F, Quertermous T, Bauer C, Neumayer HH, Schleuning WD, Theuring F. J Clin Invest. 1997; 99 (6): 1380-9
Functional activity of the CFTR Cl- channel in human myocardium. Yajima T, Nagashima H, Tsutsumi-Sakai R, Hagiwara N, Hosoda S, Quertermous T, Kasanuki H, Kawana M. Heart Vessels. 1997; 12 (6): 255-61
Role of endothelin in a rabbit model of acute myocardial infarction: effects of receptor antagonists. Vitola JV, Forman MB, Holsinger JP, Kawana M, Atkinson JB, Quertermous T, Jackson EK, Murray JJ. J Cardiovasc Pharmacol. 1996; 28 (6): 774-83
Endogenous endothelin-1 mediates cardiac hypertrophy and switching of myosin heavy chain gene expression in rat ventricular myocardium. Ichikawa KI, Hidai C, Okuda C, Kimata SI, Matsuoka R, Hosoda S, Quertermous T, Kawana M. J Am Coll Cardiol. 1996; 27 (5): 1286-91
Genomic organization and chromosomal localization of the gene TCF15 encoding the early mesodermal basic helix-loop-helix factor bHLH-EC2. Hidai H, Quertermous EE, Espinosa R, LeBeau MM, Quertermous T. Genomics. 1995; 30 (3): 598-601
Mouse Col18a1 is expressed in a tissue-specific manner as three alternative variants and is localized in basement membrane zones. Muragaki Y, Timmons S, Griffith CM, Oh SP, Fadel B, Quertermous T, Olsen BR. Proc Natl Acad Sci U S A. 1995; 92 (19): 8763-7
Regional and maturation-associated expression of endothelin 2 in rat gastrointestinal tract. de la Monte SM, Quertermous T, Hong CC, Bloch KD. J Histochem Cytochem. 1995; 43 (2): 203-9
Cooperative interaction of GATA-2 and AP1 regulates transcription of the endothelin-1 gene. Kawana M, Lee ME, Quertermous EE, Quertermous T. Mol Cell Biol. 1995; 15 (8): 4225-31
Directed endothelial differentiation of cultured embryonic yolk sac cells in vivo provides a novel cell-based system for gene therapy. Wei Y, Quertermous T, Wagner TE. Stem Cells. 1995; 13 (5): 541-7
The immunoreactive region in a novel autoantigen contains a nuclear localization sequence. Bloch DB, Rabkina D, Quertermous T, Bloch KD. Clin Immunol Immunopathol. 1994; 72 (3): 380-9
Pulmonary hypoxia increases endothelin-1 gene expression in sheep. Donahue DM, Lee ME, Suen HC, Quertermous T, Wain JC. J Surg Res. 1994; 57 (2): 280-3
Cloning and characterization of a basic helix-loop-helix protein expressed in early mesoderm and the developing somites. Quertermous EE, Hidai H, Blanar MA, Quertermous T. Proc Natl Acad Sci U S A. 1994; 91 (15): 7066-70
Cosegregation of the endothelin-3 locus with blood pressure and relative heart weight in inbred Dahl rats. Cicila GT, Rapp JP, Bloch KD, Kurtz TW, Pravenec M, Kren V, Hong CC, Quertermous T, Ng SC. J Hypertens. 1994; 12 (6): 643-51
Effect of heavy chain signal peptide mutations and NH2-terminal chain length on binding of anti-digoxin antibodies. Ping J, Schildbach JF, Shaw SY, Quertermous T, Novotny J, Bruccoleri R, Margolies MN. J Biol Chem. 1993; 268 (31): 23000-7
Structural organization and chromosomal assignment of the gene encoding the human heparin-binding epidermal growth factor-like growth factor/diphtheria toxin receptor. Fen Z, Dhadly MS, Yoshizumi M, Hilkert RJ, Quertermous T, Eddy RL, Shows TB, Lee ME. Biochemistry. 1993; 32 (31): 7932-8
High-level expression of antibody-plasminogen activator fusion proteins in hybridoma cells. Love TW, Quertermous T, Zavodny PJ, Runge MS, Chou CC, Mullins D, Huang PL, Schnee JM, Kestin AS, Savard CE. Thromb Res. 1993; 69 (2): 221-9
Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase. Janssens SP, Shimouchi A, Quertermous T, Bloch DB, Bloch KD. J Biol Chem. 1992; 267 (21): 14519-22
Cloning and expression of a cDNA encoding human endothelium-derived relating factor/nitric oxide synthase. Janssens SP, Simouchi A, Quertermous T, Bloch DB, Bloch KD. J Biol Chem. 1992; 267 (31): 22694
Induction of heparin-binding epidermal growth factor-like growth factor mRNA by phorbol ester and angiotensin II in rat aortic smooth muscle cells. Temizer DH, Yoshizumi M, Perrella MA, Susanni EE, Quertermous T, Lee ME. J Biol Chem. 1992; 267 (34): 24892-6
Tumor necrosis factor increases transcription of the heparin-binding epidermal growth factor-like growth factor gene in vascular endothelial cells. Yoshizumi M, Kourembanas S, Temizer DH, Cambria RP, Quertermous T, Lee ME. J Biol Chem. 1992; 267 (14): 9467-9
Stimulation of endothelin-1 gene expression by insulin in endothelial cells. Oliver FJ, de la Rubia G, Feener EP, Lee ME, Loeken MR, Shiba T, Quertermous T, King GL. J Biol Chem. 1991; 266 (34): 23251-6
A recombinant chimeric plasminogen activator with high affinity for fibrin has increased thrombolytic potency in vitro and in vivo. Runge MS, Quertermous T, Zavodny PJ, Love TW, Bode C, Freitag M, Shaw SY, Huang PL, Chou CC, Mullins D. Proc Natl Acad Sci U S A. 1991; 88 (22): 10337-41
Hybrid molecules: insights into plasminogen activator function. Runge MS, Bode C, Haber E, Quertermous T. Mol Biol Med. 1991; 8 (2): 245-55
cDNA cloning and chromosomal assignment of the endothelin 2 gene: vasoactive intestinal contractor peptide is rat endothelin 2. Bloch KD, Hong CC, Eddy RL, Shows TB, Quertermous T. Genomics. 1991; 10 (1): 236-42
Effect of chemical conjugation of recombinant single-chain urokinase-type plasminogen activator with monoclonal antiplatelet antibodies on platelet aggregation and on plasma clot lysis in vitro and in vivo. Dewerchin M, Lijnen HR, Stassen JM, De Cock F, Quertermous T, Ginsberg MH, Plow EF, Collen D. Blood. 1991; 78 (4): 1005-18
Cloning of the GATA-binding protein that regulates endothelin-1 gene expression in endothelial cells. Lee ME, Temizer DH, Clifford JA, Quertermous T. J Biol Chem. 1991; 266 (24): 16188-92
Regulation of endothelin-1 gene expression by Fos and Jun. Lee ME, Dhadly MS, Temizer DH, Clifford JA, Yoshizumi M, Quertermous T. J Biol Chem. 1991; 266 (28): 19034-9
Expression of the potent vasoconstrictor endothelin in the human central nervous system. Lee ME, de la Monte SM, Ng SC, Bloch KD, Quertermous T. J Clin Invest. 1990; 86 (1): 141-7
Polymerase chain reaction cloning of L-type calcium channel sequences from the heart and the brain. Huang P, Temizer D, Quertermous T. FEBS Lett. 1990; 274 (1-2): 207-13
Binding of tissue-type plasminogen activator with human endothelial cell monolayers. Characterization of the high affinity interaction with plasminogen activator inhibitor-1. Russell ME, Quertermous T, Declerck PJ, Collen D, Haber E, Homcy CJ. J Biol Chem. 1990; 265 (5): 2569-75
Antibody-targeted thrombolytic agents. Haber E, Quertermous T, Matsueda GR, Runge MS, Bode C. Jpn Circ J. 1990; 54 (4): 345-53
Functional analysis of the endothelin-1 gene promoter. Evidence for an endothelial cell-specific cis-acting sequence. Lee ME, Bloch KD, Clifford JA, Quertermous T. J Biol Chem. 1990; 265 (18): 10446-50
Plasminogen activators. The old and the new. Runge MS, Quertermous T, Haber E. Circulation. 1989; 79 (2): 217-24
Innovative approaches to plasminogen activator therapy. Haber E, Quertermous T, Matsueda GR, Runge MS. Science. 1989; 243 (4887): 51-6
Variability in messenger RNA levels in human umbilical vein endothelial cells of different lineage and time in culture. Dichek D, Quertermous T. In Vitro Cell Dev Biol. 1989; 25 (3 Pt 1): 289-92
Structural organization and chromosomal assignment of the gene encoding endothelin. Bloch KD, Friedrich SP, Lee ME, Eddy RL, Shows TB, Quertermous T. J Biol Chem. 1989; 264 (18): 10851-7
Thrombin regulation of mRNA levels of tissue plasminogen activator and plasminogen activator inhibitor-1 in cultured human umbilical vein endothelial cells. Dichek D, Quertermous T. Blood. 1989; 74 (1): 222-8
Modulation of mRNA levels for urinary- and tissue-type plasminogen activator and plasminogen activator inhibitors 1 and 2 in human fibroblasts by interleukin 1. Michel JB, Quertermous T. J Immunol. 1989; 143 (3): 890-5
cDNA cloning and chromosomal assignment of the gene encoding endothelin 3. Bloch KD, Eddy RL, Shows TB, Quertermous T. J Biol Chem. 1989; 264 (30): 18156-61
Recombinant antibodies possessing novel effector functions. Love TW, Runge MS, Haber E, Quertermous T. Methods Enzymol. 1989; 178 515-27
Structural integrity of the glycoprotein IIb and IIIa genes in Glanzmann thrombasthenia patients from Israel. Russell ME, Seligsohn U, Coller BS, Ginsberg MH, Skoglund P, Quertermous T. Blood. 1988; 72 (5): 1833-6
Nonlinkage of the T cell receptor alpha, beta, and gamma genes to systemic lupus erythematosus in multiplex families. Wong DW, Bentwich Z, Martinez-Tarquino C, Seidman JG, Duby AD, Quertermous T, Schur PH. Arthritis Rheum. 1988; 31 (11): 1371-6
Increasing selectivity of plasminogen activators with antibodies. Runge MS, Quertermous T, Matsueda GR, Haber E. Clin Res. 1988; 36 (5): 501-6
Left ventricular ejection fraction. Physician estimates compared with gated blood pool scan measurements. Eagle KA, Quertermous T, Singer DE, Mulley AG, Reder VA, Boucher CA, Strauss HW, Thibault GE. Arch Intern Med. 1988; 148 (4): 882-5
T-cell receptor gene rearrangement and expression in human natural killer cells: natural killer activity is not dependent on the rearrangement and expression of T-cell receptor alpha, beta, or gamma genes. Leiden JM, Gottesdiener KM, Quertermous T, Coury L, Bray RA, Gottschalk L, Gebel H, Seidman JG, Strominger JL, Landay AL. Immunogenetics. 1988; 27 (4): 231-8
Construction and expression of a recombinant antibody-targeted plasminogen activator. Schnee JM, Runge MS, Matsueda GR, Hudson NW, Seidman JG, Haber E, Quertermous T. Proc Natl Acad Sci U S A. 1987; 84 (19): 6904-8
T cell receptor-CD3 complex during early T cell differentiation. Analysis of immature T cell acute lymphoblastic leukemias (T-ALL) at DNA, RNA, and cell membrane level. van Dongen JJ, Quertermous T, Bartram CR, Gold DP, Wolvers-Tettero IL, Comans-Bitter WM, Hooijkaas H, Adriaansen HJ, de Klein A, Raghavachar A. J Immunol. 1987; 138 (4): 1260-9
Comparison of T cell receptor gene rearrangements in patients with large granular T cell leukemia and Felty's syndrome. Freimark B, Lanier L, Phillips J, Quertermous T, Fox R. J Immunol. 1987; 138 (6): 1724-9
Human T cell gamma chain joining regions and T cell development. Quertermous T, Strauss WM, Van Dongen JJ, Seidman JG. J Immunol. 1987; 138 (8): 2687-90
Provocative pattern of rearrangements of the genes for the gamma and beta chains of the T-cell receptor in human leukemias. Goorha R, Bunin N, Mirro J, Murphy SB, Cross AH, Behm FG, Quertermous T, Seidman J, Kitchingman GR. Proc Natl Acad Sci U S A. 1987; 84 (13): 4547-51
Measuring the human T cell receptor gamma-chain locus. Strauss WM, Quertermous T, Seidman JG. Science. 1987; 237 (4819): 1217-9
Human T-cell gamma genes contain N segments and have marked junctional variability. Quertermous T, Strauss W, Murre C, Dialynas DP, Strominger JL, Seidman JG. Nature. 1986 Jul 10-16; 322 (6075): 184-7
Spectrum of conditions initially suggesting acute aortic dissection but with negative aortograms. Eagle KA, Quertermous T, Kritzer GA, Newell JB, Dinsmore R, Feldman L, DeSanctis RW. Am J Cardiol. 1986; 57 (4): 322-6
Human T-cell gamma chain genes: organization, diversity, and rearrangement. Quertermous T, Murre C, Dialynas D, Duby AD, Strominger JL, Waldman TA, Seidman JG. Science. 1986; 231 (4735): 252-5
Immunoglobulin and T-cell receptor gene rearrangement and expression in human lymphoid leukemia cells at different stages of maturation. Davey MP, Bongiovanni KF, Kaulfersch W, Quertermous T, Seidman JG, Hershfield MS, Kurtzberg J, Haynes BF, Davis MM, Waldmann TA. Proc Natl Acad Sci U S A. 1986; 83 (22): 8759-63
Human T cell gamma-chain gene rearrangements in acute lymphoid and nonlymphoid leukemia: comparison with the T cell receptor beta-chain gene. Greenberg JM, Quertermous T, Seidman JG, Kersey JH. J Immunol. 1986; 137 (6): 2043-9
T cell receptor gene rearrangements define a monoclonal T cell proliferation in patients with T cell lymphocytosis and cytopenia. Berliner N, Duby AD, Linch DC, Murre C, Quertermous T, Knott LJ, Azin T, Newland AC, Lewis DL, Galvin MC. Blood. 1986; 67 (4): 914-8
Cloning and sequence analysis of complementary DNA encoding an aberrantly rearranged human T-cell gamma chain. Dialynas DP, Murre C, Quertermous T, Boss JM, Leiden JM, Seidman JG, Strominger JL. Proc Natl Acad Sci U S A. 1986; 83 (8): 2619-23
Pacemaker failure resulting from radiation damage. Quertermous T, Megahy MS, Das Gupta DS, Griem ML. Radiology. 1983; 148 (1): 257-8