Key Documents
Paul Buckmaster, DVM, PhD
Administrative Appointments
- Comparative Medicine Review Committee (RIRG-C) Study Section, NCRR, NIH , (2008–
present
)
- Research Council of the Professional Advisory Board, Epilepsy Foundation , (2003–
present
)
- Clinical Neuroplasticity and Neurotransmitter Study Section, NIH Center for Scientific Review , (2004–
2008
)
Honors and Awards
- Career Award in the Biomedical Sciences, Burroughs Wellcome Fund (1996-2000)
Professional Education
-
DVM, University of California, Davis
Veterinary Medicine (1988)
-
PhD, University of Washington
Physiology (1992)
Graduate & Fellowship Program Affiliations
Research Interests
Temporal lobe epilepsy is common, frequently refractory to treatment, and devastating to those affected. Our long-term goal is to better understand the pathophysiological mechanisms of this disease so that rational and effective therapies can be developed. We use electrophysiological, molecular, and anatomical techniques to evaluate neuronal circuitry in normal and in epileptic brains.
Publications
-
Dysfunction of the dentate basket cell circuit in a rat model of temporal lobe epilepsy.
Zhang W,
Buckmaster PS.
J Neurosci.
2009;
29
(24):
7846-56
-
Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy.
Buckmaster PS,
Ingram EA, Wen X.
J Neurosci.
2009;
29
(25):
8259-69
-
Surviving hilar somatostatin interneurons enlarge, sprout axons, and form new synapses with granule cells in a mouse model of temporal lobe epilepsy.
Zhang W,
Yamawaki R, Wen X, Uhl J, Diaz J, Prince DA, Buckmaster PS.
J Neurosci.
2009;
29
(45):
14247-56
-
Synaptic input to dentate granule cell basal dendrites in a rat model of temporal lobe epilepsy.
Thind KK,
Ribak CE, Buckmaster PS.
J Comp Neurol.
2008;
509
(2):
190-202
-
Changes in granule cell firing rates precede locally recorded spontaneous seizures by minutes in an animal model of temporal lobe epilepsy.
Bower MR,
Buckmaster PS.
J Neurophysiol.
2008;
99
(5):
2431-42
-
Recurrent circuits in layer II of medial entorhinal cortex in a model of temporal lobe epilepsy.
Kumar SS,
Jin X, Buckmaster PS, Huguenard JR.
J Neurosci.
2007;
27
(6):
1239-46
-
Hyperexcitability, interneurons, and loss of GABAergic synapses in entorhinal cortex in a model of temporal lobe epilepsy.
Kumar SS,
Buckmaster PS.
J Neurosci.
2006;
26
(17):
4613-23
-
Prolonged infusion of inhibitors of calcineurin or L-type calcium channels does not block mossy fiber sprouting in a model of temporal lobe epilepsy.
Ingram EA,
Toyoda I, Wen X, Buckmaster PS.
Epilepsia.
2009;
50
(1):
56-64
-
Neuron-specific nuclear antigen NeuN is not detectable in gerbil subtantia nigra pars reticulata.
Kumar SS,
Buckmaster PS.
Brain Res.
2007;
1142
54-60
-
GABAA receptor-mediated IPSCs and alpha1 subunit expression are not reduced in the substantia nigra pars reticulata of gerbils with inherited epilepsy.
Kumar SS,
Wen X, Yang Y, Buckmaster PS.
J Neurophysiol.
2006;
95
(4):
2446-55
-
Prolonged infusion of cycloheximide does not block mossy fiber sprouting in a model of temporal lobe epilepsy.
Toyoda I,
Buckmaster PS.
Epilepsia.
2005;
46
(7):
1017-20
-
Does a unique type of CA3 pyramidal cell in primates bypass the dentate gate?
Buckmaster PS,
J Neurophysiol.
2005;
94
(1):
896-900
-
Stereological analysis of forebrain regions in kainate-treated epileptic rats.
Chen S,
Buckmaster PS.
Brain Res.
2005;
1057
(1-2):
141-52
-
Dendritic morphology, local circuitry, and intrinsic electrophysiology of principal neurons in the entorhinal cortex of macaque monkeys.
Buckmaster PS,
Alonso A, Canfield DR, Amaral DG.
J Comp Neurol.
2004;
470
(3):
317-29
-
Recurrent excitation of granule cells with basal dendrites and low interneuron density and inhibitory postsynaptic current frequency in the dentate gyrus of macaque monkeys.
Austin JE,
Buckmaster PS.
J Comp Neurol.
2004;
476
(3):
205-18
-
Prolonged infusion of tetrodotoxin does not block mossy fiber sprouting in pilocarpine-treated rats.
Buckmaster PS,
Epilepsia.
2004;
45
(5):
452-8
-
Laboratory animal models of temporal lobe epilepsy.
Buckmaster PS,
Comp Med.
2004;
54
(5):
473-85
-
Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy.
Kobayashi M,
Buckmaster PS.
J Neurosci.
2003;
23
(6):
2440-52
-
Reduced inhibition and increased output of layer II neurons in the medial entorhinal cortex in a model of temporal lobe epilepsy.
Kobayashi M,
Wen X, Buckmaster PS.
J Neurosci.
2003;
23
(24):
8471-9
-
Absence of temporal lobe epilepsy pathology in dogs with medically intractable epilepsy.
Buckmaster PS,
Smith MO, Buckmaster CL, LeCouteur RA, Dudek FE.
J Vet Intern Med.
2002 Jan-Feb;
16
(1):
95-9
-
BDNF overexpression increases dendrite complexity in hippocampal dentate gyrus.
Tolwani RJ,
Buckmaster PS, Varma S, Cosgaya JM, Wu Y, Suri C, Shooter EM.
Neuroscience.
2002;
114
(3):
795-805
-
Heightened seizure severity in somatostatin knockout mice.
Buckmaster PS,
Otero-Corchón V, Rubinstein M, Low MJ.
Epilepsy Res.
2002;
48
(1-2):
43-56
-
Axon arbors and synaptic connections of a vulnerable population of interneurons in the dentate gyrus in vivo.
Buckmaster PS,
Yamawaki R, Zhang GF.
J Comp Neurol.
2002;
445
(4):
360-73
-
Evoked responses of the dentate gyrus during seizures in developing gerbils with inherited epilepsy.
Buckmaster PS,
Wong EH.
J Neurophysiol.
2002;
88
(2):
783-93
-
Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuit.
Buckmaster PS,
Zhang GF, Yamawaki R.
J Neurosci.
2002;
22
(15):
6650-8
-
Somatostatin-immunoreactive interneurons contribute to lateral inhibitory circuits in the dentate gyrus of control and epileptic rats.
Boyett JM,
Buckmaster PS.
Hippocampus.
2001;
11
(4):
418-22
-
Intracellular recording and labeling of mossy cells and proximal CA3 pyramidal cells in macaque monkeys.
Buckmaster PS,
Amaral DG.
J Comp Neurol.
2001;
430
(2):
264-81
-
Testing the disinhibition hypothesis of epileptogenesis in vivo and during spontaneous seizures.
Buckmaster PS,
Jongen-Rêlo AL, Davari SB, Wong EH.
J Neurosci.
2000;
20
(16):
6232-40
-
Neuron loss and axon reorganization in the dentate gyrus of cats infected with the feline immunodeficiency virus.
Mitchell TW,
Buckmaster PS, Hoover EA, Whalen LR, Dudek FE.
J Comp Neurol.
1999;
411
(4):
563-77
-
Highly specific neuron loss preserves lateral inhibitory circuits in the dentate gyrus of kainate-induced epileptic rats.
Buckmaster PS,
Jongen-Rêlo AL.
J Neurosci.
1999;
19
(21):
9519-29
-
In vivo intracellular analysis of granule cell axon reorganization in epileptic rats.
Buckmaster PS,
Dudek FE.
J Neurophysiol.
1999;
81
(2):
712-21
-
Axonal sprouting in hippocampus of cats infected with feline immunodeficiency virus (FIV).
Mitchell TW,
Buckmaster PS, Hoover EA, Whalen LR, Dudek FE.
J Acquir Immune Defic Syndr Hum Retrovirol.
1998;
17
(1):
1-8
-
Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy.
Hellier JL,
Patrylo PR, Buckmaster PS, Dudek FE.
Epilepsy Res.
1998;
31
(1):
73-84
-
Ultrastructural localization of neurotransmitter immunoreactivity in mossy cell axons and their synaptic targets in the rat dentate gyrus.
Wenzel HJ,
Buckmaster PS, Anderson NL, Wenzel ME, Schwartzkroin PA.
Hippocampus.
1997;
7
(5):
559-70
-
Network properties of the dentate gyrus in epileptic rats with hilar neuron loss and granule cell axon reorganization.
Buckmaster PS,
Dudek FE.
J Neurophysiol.
1997;
77
(5):
2685-96
-
Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainate-treated rats.
Buckmaster PS,
Dudek FE.
J Comp Neurol.
1997;
385
(3):
385-404
-
Possible mechanisms of seizure-related cell damage in the dentate hilus.
Schwartzkroin PA,
Buckmaster PS, Strowbridge BW, Kunkel DD, Owens J, Pokorný J.
Epilepsy Res Suppl.
1996;
12
317-24
-
Electrophysiological correlates of seizure sensitivity in the dentate gyrus of epileptic juvenile and adult gerbils.
Buckmaster PS,
Tam E, Schwartzkroin PA.
J Neurophysiol.
1996;
76
(4):
2169-80
-
Axon arbors and synaptic connections of hippocampal mossy cells in the rat in vivo.
Buckmaster PS,
Wenzel HJ, Kunkel DD, Schwartzkroin PA.
J Comp Neurol.
1996;
366
(2):
271-92
-
Neurobiology of hippocampal interneurons: a workshop review.
Buckmaster PS,
Soltesz I.
Hippocampus.
1996;
6
(3):
330-9
-
Physiological and morphological heterogeneity of dentate gyrus-hilus interneurons in the gerbil hippocampus in vivo.
Buckmaster PS,
Schwartzkroin PA.
Eur J Neurosci.
1995;
7
(6):
1393-402
-
Interneurons and inhibition in the dentate gyrus of the rat in vivo.
Buckmaster PS,
Schwartzkroin PA.
J Neurosci.
1995;
15
(1 Pt 2):
774-89
-
Physiological and morphological heterogeneity of dentate gyrus-hilus interneurons in the gerbil hippocampus in vivo.
Buckmaster PS,
Schwartzkroin PA.
Eur J Neurosci.
1995;
7
(10):
1393-402
-
Somatostatin-immunoreactivity in the hippocampus of mouse, rat, guinea pig, and rabbit.
Buckmaster PS,
Kunkel DD, Robbins RJ, Schwartzkroin PA.
Hippocampus.
1994;
4
(2):
167-80
-
Hyperexcitability in the dentate gyrus of the epileptic Mongolian gerbil.
Buckmaster PS,
Schwartzkroin PA.
Epilepsy Res.
1994;
18
(1):
23-8
-
Hippocampal mossy cell function: a speculative view.
Buckmaster PS,
Schwartzkroin PA.
Hippocampus.
1994;
4
(4):
393-402
-
Brainstem auditory evoked potential interwave intervals are prolonged in vitamin B-6-deficient cats.
Buckmaster PS,
Holliday TA, Bai SC, Rogers QR.
J Nutr.
1993;
123
(1):
20-6
-
A comparison of rat hippocampal mossy cells and CA3c pyramidal cells.
Buckmaster PS,
Strowbridge BW, Schwartzkroin PA.
J Neurophysiol.
1993;
70
(4):
1281-99
-
Mossy cell axonal projections to the dentate gyrus molecular layer in the rat hippocampal slice.
Buckmaster PS,
Strowbridge BW, Kunkel DD, Schmiege DL, Schwartzkroin PA.
Hippocampus.
1992;
2
(4):
349-62
-
Potentiation of spontaneous synaptic activity in rat mossy cells.
Strowbridge BW,
Buckmaster PS, Schwartzkroin PA.
Neurosci Lett.
1992;
142
(2):
205-10
-
Fastigial nucleus activity in the alert monkey during slow eye and head movements.
Büttner U,
Fuchs AF, Markert-Schwab G, Buckmaster P.
J Neurophysiol.
1991;
65
(6):
1360-71