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Key Documents

NIH Biosketch available Online

Bruce Buckingham

Professor - Med Center Line, Pediatrics - Endocrinology

Contact Information

Clinical Offices

Specialty Center South Bay 14777 Los Gatos Blvd, Suite 200 Los Gatos, CA 95032
Telephone Work (408) 356-0911 Fax (408) 356-7140

Pediatric Endocrinology Clinic 14651 S Bascom Ave Ste 150 Los Gatos, CA 95032
Telephone Work (408) 356-0911 Fax (408) 356-7140
Academic Offices

Personal Information
Email buckingham@stanford.edu
Not for medical emergencies or patient use

Clinical Focus

Endocrinology/Diabetes, Pediatric
Pediatric Endocrinology

Professional Education

Board Certification: Pediatric Endocrinology, American Board of Pediatrics (1978)
UCSD School of Medicine (06/1972) CA
Children's Hospital Los Angeles (06/1976) CA
Children's Hospital Los Angeles (06/1974) CA
Children's Hospital Los Angeles (06/1973) CA
Board Certification: General Pediatrics, American Board of Pediatrics (1977)

Research Interests

My major interest is in type 1 diabetes mellitus, continuous glucose sensor, and the development of an artificial pancreas. Other research interests include using continuous glucose monitoring and algorithms to control blood glucose levels in intensive care units.

Clinical Trials

Publications

Use of the DirecNet Applied Treatment Algorithm (DATA) for diabetes management with a real-time continuous glucose monitor (the FreeStyle Navigator). Buckingham B, Xing D, Weinzimer S, Fiallo-Scharer R, Kollman C, Mauras N, Tsalikian E, Tamborlane W, Wysocki T, Ruedy K, Beck R. Pediatr Diabetes. 2008; 9 (2): 142-7
Clinical application of emerging sensor technologies in diabetes management: consensus guidelines for continuous glucose monitoring (CGM). Hirsch IB, Armstrong D, Bergenstal RM, Buckingham B, Childs BP, Clarke WL, Peters A, Wolpert H. Diabetes Technol Ther. 2008; 10 (4): 232-44; quiz 245-6
Detection of a meal using continuous glucose monitoring: implications for an artificial beta-cell. Dassau E, Bequette BW, Buckingham BA, Doyle FJ. Diabetes Care. 2008; 31 (2): 295-300
Sensor-augmented insulin pump therapy: results of the first randomized treat-to-target study. Hirsch IB, Abelseth J, Bode BW, Fischer JS, Kaufman FR, Mastrototaro J, Parkin CG, Wolpert HA, Buckingham BA. Diabetes Technol Ther. 2008; 10 (5): 377-83
Continuous glucose monitoring and intensive treatment of type 1 diabetes. Tamborlane WV, Beck RW, Bode BW, Buckingham B, Chase HP, Clemons R, Fiallo-Scharer R, Fox LA, Gilliam LK, Hirsch IB, Huang ES, Kollman C, Kowalski AJ, Laffel L, Lawrence JM, Lee J, Mauras N, O'Grady M, Ruedy KJ, Tansey M, Tsalikian E, Weinzimer S, Wilson DM, Wolpert H, Wysocki T, Xing D. N Engl J Med. 2008; 359 (14): 1464-76
Duration of nocturnal hypoglycemia before seizures. Buckingham B, Wilson DM, Lecher T, Hanas R, Kaiserman K, Cameron F. Diabetes Care. 2008; 31 (11): 2110-2
Increasing the accuracy of oral glucose tolerance testing and extending its application to individuals with normal glucose tolerance for the prediction of type 1 diabetes: the Diabetes Prevention Trial-Type 1. Sosenko JM, Palmer JP, Greenbaum CJ, Mahon J, Cowie C, Krischer JP, Chase HP, White NH, Buckingham B, Herold KC, Cuthbertson D, Skyler JS. Diabetes Care. 2007; 30 (1): 38-42
Real-time continuous glucose monitoring. Buckingham B, Caswell K, Wilson DM. Curr Opin Endocrinol Diabetes Obes. 2007; 14 (4): 288-95
Continuous glucose monitoring in children with type 1 diabetes. Buckingham B, Beck RW, Tamborlane WV, Xing D, Kollman C, Fiallo-Scharer R, Mauras N, Ruedy KJ, Tansey M, Weinzimer SA, Wysocki T. J Pediatr. 2007; 151 (4): 388-93, 393.e1-2
Glucose control in pediatric intensive care unit patients using an insulin-glucose algorithm. Wintergerst KA, Deiss D, Buckingham B, Cantwell M, Kache S, Agarwal S, Wilson DM, Steil G. Diabetes Technol Ther. 2007; 9 (3): 211-22
The Medtronic Minimed Gold continuous glucose monitoring system: an effective means to discover hypo- and hyperglycemia in children under 7 years of age. Gandrud LM, Xing D, Kollman C, Block JM, Kunselman B, Wilson DM, Buckingham BA. Diabetes Technol Ther. 2007; 9 (4): 307-16
Vitamin D deficiency in the San Francisco Bay Area. McAllister JC, Lane AT, Buckingham BA. J Pediatr Endocrinol Metab. 2006; 19 (3): 205-8
Extended use of a new continuous glucose monitoring system with wireless data transmission in children with type 1 diabetes mellitus. Wong LJ, Buckingham BA, Kunselman B, Istoc E, Leach J, Purvis R. Diabetes Technol Ther. 2006; 8 (2): 139-45
Association of hypoglycemia, hyperglycemia, and glucose variability with morbidity and death in the pediatric intensive care unit. Wintergerst KA, Buckingham B, Gandrud L, Wong BJ, Kache S, Wilson DM. Pediatrics. 2006; 118 (1): 173-9
The effects of aerobic exercise on glucose and counterregulatory hormone concentrations in children with type 1 diabetes. Tansey MJ, Tsalikian E, Beck RW, Mauras N, Buckingham BA, Weinzimer SA, Janz KF, Kollman C, Xing D, Ruedy KJ, Steffes MW, Borland TM, Singh RJ, Tamborlane WV. Diabetes Care. 2006; 29 (1): 20-5
Evaluation of factors affecting CGMS calibration. Buckingham BA, Kollman C, Beck R, Kalajian A, Fiallo-Scharer R, Tansey MJ, Fox LA, Wilson DM, Weinzimer SA, Ruedy KJ, Tamborlane WV. Diabetes Technol Ther. 2006; 8 (3): 318-25
Patterns of metabolic progression to type 1 diabetes in the Diabetes Prevention Trial-Type 1. Sosenko JM, Palmer JP, Greenbaum CJ, Mahon J, Cowie C, Krischer JP, Chase HP, White NH, Buckingham B, Herold KC, Cuthbertson D, Skyler JS. Diabetes Care. 2006; 29 (3): 643-9
Patient functional self-assessment in late glenoid component failure at three to eleven years after total shoulder arthroplasty. Buckingham BP, Parsons IM, Campbell B, Titelman RM, Smith KL, Matsen FA. J Shoulder Elbow Surg. 2005 Jul-Aug; 14 (4): 368-74
The extended Kalman filter for continuous glucose monitoring. Knobbe EJ, Buckingham B. Diabetes Technol Ther. 2005; 7 (1): 15-27
Accuracy of the modified Continuous Glucose Monitoring System (CGMS) sensor in an outpatient setting: results from a diabetes research in children network (DirecNet) study. Tansey MJ, Beck RW, Buckingham BA, Mauras N, Fiallo-Scharer R, Xing D, Killman C, Tamborlane WV, Ruedy KJ. Diabetes Technol Ther. 2005; 7 (1): 109-14
Impact of exercise on overnight glycemic control in children with type 1 diabetes mellitus. Tsalikian E, Mauras N, Beck RW, Tamborlane WV, Janz KF, Chase HP, Wysocki T, Weinzimer SA, Buckingham BA, Kollman C, Xing D, Ruedy KJ. J Pediatr. 2005; 147 (4): 528-34
Accuracy of newer-generation home blood glucose meters in a Diabetes Research in Children Network (DirecNet) inpatient exercise study. Weinzimer SA, Beck RW, Chase HP, Fox LA, Buckingham BA, Tamborlane WV, Kollman C, Coffey J, Xing D, Ruedy KJ. Diabetes Technol Ther. 2005; 7 (5): 675-80; discussion 681-3
A two-center randomized controlled feasibility trial of insulin pump therapy in young children with diabetes. Wilson DM, Buckingham BA, Kunselman EL, Sullivan MM, Paguntalan HU, Gitelman SE. Diabetes Care. 2005; 28 (1): 15-9
Hypoglycemia detection, and better yet, prevention, in pediatric patients. Buckingham B, Diabetes Technol Ther. 2005; 7 (5): 792-6
A randomized multicenter trial comparing the GlucoWatch Biographer with standard glucose monitoring in children with type 1 diabetes. Chase HP, Beck R, Tamborlane W, Buckingham B, Mauras N, Tsalikian E, Wysocki T, Weinzimer S, Kollman C, Ruedy K, Xing D. Diabetes Care. 2005; 28 (5): 1101-6
Response to nocturnal alarms using a real-time glucose sensor. Buckingham B, Block J, Burdick J, Kalajian A, Kollman C, Choy M, Wilson DM, Chase P. Diabetes Technol Ther. 2005; 7 (3): 440-7
Lack of accuracy of continuous glucose sensors in healthy, nondiabetic children: results of the Diabetes Research in Children Network (DirecNet) accuracy study. Mauras N, Beck RW, Ruedy KJ, Kollman C, Tamborlane WV, Chase HP, Buckingham BA, Tsalikian E, Weinzimer S, Booth AD, Xing D. J Pediatr. 2004; 144 (6): 770-5
Severe infantile hypercalcemia associated with Williams syndrome successfully treated with intravenously administered pamidronate. Cagle AP, Waguespack SG, Buckingham BA, Shankar RR, Dimeglio LA. Pediatrics. 2004; 114 (4): 1091-5
Use of the Cygnus GlucoWatch biographer at a diabetes camp. Gandrud LM, Paguntalan HU, Van Wyhe MM, Kunselman BL, Leptien AD, Wilson DM, Eastman RC, Buckingham BA. Pediatrics. 2004; 113 (1 Pt 1): 108-11
Initiation of insulin glargine in children and adolescents with type 1 diabetes. Tan CY, Wilson DM, Buckingham B. Pediatr Diabetes. 2004; 5 (2): 80-6
GlucoWatch G2 Biographer alarm reliability during hypoglycemia in children. Tsalikian E, Kollman C, Mauras N, Weinzimer S, Buckingham B, Xing D, Beck R, Ruedy K, Tamborlane W, Fiallo-Scharer R. Diabetes Technol Ther. 2004; 6 (5): 559-66
Analysis: dawn of real-time continuous glucose sensing. Buckingham B, Diabetes Technol Ther. 2003; 5 (3): 381-3
How should we interpret "real life" conditions. Eastman RC, Chase HP, Buckingham B, Hathout E, Tamada J, Ginsberg B. Pediatr Diabetes. 2003; 4 (1): 59
Use of the GlucoWatch biographer in children and adolescents with diabetes. Eastman RC, Chase HP, Buckingham B, Hathout EH, Fuller-Byk L, Leptien A, Van Wyhe MM, Davis TL, Fermi SJ, Pechler H, Sahyun G, Lopatin M, Wang BY, Wei C, Bartkowiak M, Ginsberg BH, Tamada JA, Pitzer KR. Pediatr Diabetes. 2002; 3 (3): 127-34
Type 1 diabetes mellitus and epilepsia partialis continua in a 6-year-old boy with elevated anti-GAD65 antibodies. Olson JA, Olson DM, Sandborg C, Alexander S, Buckingham B. Pediatrics. 2002; 109 (3): E50
Cognitive and behavioral characteristics of turner syndrome: exploring a role for ovarian hormones in female sexual differentiation. Collaer ML, Geffner ME, Kaufman FR, Buckingham B, Hines M. Horm Behav. 2002; 41 (2): 139-55
Intensive diabetes management in pediatric patients. Buckingham B, Bluck B, Wilson DM. Curr Diab Rep. 2001; 1 (1): 11-8
Familial isolated hypoparathyroidism caused by a mutation in the gene for the transcription factor GCMB. Ding C, Buckingham B, Levine MA. J Clin Invest. 2001; 108 (8): 1215-20
Prevention of type 1a diabetes mellitus*. Wilson DM, Buckingham B. Pediatr Diabetes. 2001; 2 (1): 17-24
A randomized trial of methotrexate in newly diagnosed patients with type 1 diabetes mellitus. Buckingham BA, Sandborg CI. Clin Immunol. 2000; 96 (2): 86-90
Decreased IL-4 production in new onset type I insulin-dependent diabetes mellitus. Berman MA, Sandborg CI, Wang Z, Imfeld KL, Zaldivar F, Dadufalza V, Buckingham BA. J Immunol. 1996; 157 (10): 4690-6
Self-care behaviors in insulin-dependent diabetes: evaluative tools and their associations with glycemic control. Hanson CL, De Guire MJ, Schinkel AM, Kolterman OG, Goodman JP, Buckingham BA. J Pediatr Psychol. 1996; 21 (4): 467-82
T-->A transversion 11 bp from a splice acceptor site in the human gene for steroidogenic acute regulatory protein causes congenital lipoid adrenal hyperplasia. Tee MK, Lin D, Sugawara T, Holt JA, Guiguen Y, Buckingham B, Strauss JF, Miller WL. Hum Mol Genet. 1995; 4 (12): 2299-305
IL-4 expression in human T cells is selectively inhibited by IL-1 alpha and IL-1 beta. Sandborg CI, Imfeld KL, Zaldivar F, Wang Z, Buckingham BA, Berman MA. J Immunol. 1995; 155 (11): 5206-12
Biochemical abnormalities in vitreous of humans with proliferative diabetic retinopathy. Sebag J, Buckingham B, Charles MA, Reiser K. Arch Ophthalmol. 1992; 110 (10): 1472-6
A naturally occurring 6-9-kilodalton interleukin-1 (IL-1) inhibitor prevents IL-1-mediated islet cytotoxicity but not IL-1-mediated suppression of insulin secretion. Kawahara DJ, Everts M, Buckingham B, Sandborg C, Berman M. J Immunother (1991). 1991; 10 (3): 182-8
Relationship between the content of lysyl oxidase-dependent cross-links in skin collagen, nonenzymatic glycosylation, and long-term complications in type I diabetes mellitus. Buckingham B, Reiser KM. J Clin Invest. 1990; 86 (4): 1046-54
Heterogeneity in the specificity of the islet cell cytoplasmic antibody response in insulin-dependent diabetes mellitus. Kawahara DJ, Buckingham B, Kershnar A. Pancreas. 1990; 5 (6): 647-51
Interferon responsiveness of natural killer cells in type I human diabetes. Negishi K, Gupta S, Chandy KG, Waldeck N, Kershnar A, Buckingham B, Charles MA. Diabetes Res. 1988; 7 (1): 49-52
The surgical management of hyperinsulinism in infancy due to nesidioblastosis. Warden MJ, German JC, Buckingham BA. J Pediatr Surg. 1988; 23 (5): 462-5
Natural killer cell and islet killer cell activities in human type 1 diabetes. Negishi K, Waldeck N, Chandy G, Buckingham B, Kershnar A, Fisher L, Gupta S, Charles AM. Exp Clin Endocrinol. 1987; 89 (3): 345-53
Multiparameter immunologic studies in patients with newly diagnosed type 1 insulin-dependent diabetes mellitus. Gupta S, Charles MA, Waldeck N, Kershnar A, Buckingham B. Diabetes Res. 1986; 3 (5): 225-9
Skin, joint, and pulmonary changes in type I diabetes mellitus. Buckingham B, Perejda AJ, Sandborg C, Kershnar AK, Uitto J. Am J Dis Child. 1986; 140 (5): 420-3
Natural killer cell and islet killer cell activities in type 1 (insulin-dependent) diabetes. Negishi K, Waldeck N, Chandy G, Buckingham B, Kershnar A, Fisher L, Gupta S, Charles MA. Diabetologia. 1986; 29 (6): 352-7
Complement activation in type 1 human diabetes. Sundsmo JS, Papin RA, Wood L, Hirani S, Waldeck N, Buckingham B, Kershnar A, Ascher M, Charles MA. Clin Immunol Immunopathol. 1985; 35 (2): 211-25
Scleroderma-like changes in insulin-dependent diabetes mellitus: clinical and biochemical studies. Buckingham BA, Uitto J, Sandborg C, Keens T, Roe T, Costin G, Kaufman F, Bernstein B, Landing B, Castellano A. Diabetes Care. 1984 Mar-Apr; 7 (2): 163-9
Autologous mixed lymphocyte reaction in man: XV. Cellular and molecular basis of deficient autologous mixed lymphocyte response in insulin-dependent diabetes mellitus. Chandy KG, Charles AM, Kershnar A, Buckingham B, Waldeck N, Gupta S. J Clin Immunol. 1984; 4 (6): 424-8
Deficiency of monoclonal antibody (Leu 7) defined NK cells in newly diagnosed insulin-dependent diabetes mellitus. Chandy KG, Charles MA, Buckingham B, Waldeck N, Kershnar A, Gupta S. Immunol Lett. 1984; 8 (2): 89-91
Immunological events in new onset diabetes. Charles M, Suzuki M, Sundsmo J, Waldeck N, Negishi K, Slater L, Ong K, Buckingham B, Kershnar A. Biomed Biochim Acta. 1984; 43 (5): 615-9
Immune islet killing mechanisms associated with insulin-dependent diabetes: in vitro expression of cellular and antibody-mediated islet cell cytotoxicity in humans. Charles MA, Suzuki M, Waldeck N, Dodson LE, Slater L, Ong K, Kershnar A, Buckingham B, Golden M. J Immunol. 1983; 130 (3): 1189-94
Rhabdomyolysis in diabetic ketoacidosis. Buckingham BA, Roe TF, Yoon JW. Am J Dis Child. 1981; 135 (4): 352-4
Hyperthyroidism in children. A reevaluation of treatment. Buckingham BA, Costin G, Roe TF, Weitzman JJ, Kogut MD. Am J Dis Child. 1981; 135 (2): 112-7
Studies of immune-complex glomerulonephritis mediated by human thyroglobulin. Jordan SC, Buckingham B, Sakai R, Olson D. N Engl J Med. 1981; 304 (20): 1212-5
Thyroidectomy for hyperthyroidism in children. Andrassy RJ, Buckingham BA, Weitzman JJ. J Pediatr Surg. 1980; 15 (4): 501-4
Surgical treatment of hyperthyroidism in children. Wesley JR, Buckingham BA, Gahr JA, Isaacs H, Kogut MD, Weitzman JJ. Surg Gynecol Obstet. 1977; 145 (3): 343-6
Thyroid function in children with chronic renal failure. Wassner SJ, Buckingham BA, Kershnar AJ, Malekzadeh MH, Pennisi AJ, Fine RN. Nephron. 1977; 19 (4): 236-41
Pathologic and immune factors in thyroid disease. Buckingham BA, Costin G, Kogut MD, Isaacs H, Landing BH. J Pediatr. 1977; 91 (5): 728-33