Jeffrey A. Feinstein, MD, MPH

Clinical Focus

• Pediatric Cardiology
• Congenital Heart Defects
• Pulmonary Hypertension
• Pulmonary Vascular Disease
• Pulmonary Vascular Abnormalities
• Cardiac Catheterization
• Biomechanical Engineering / Bioengineering

Administrative Appointments

• Director, Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford University Medical Center , (2000– present )
• Associate Director, Pediatric and Congenital Cardiac Catheterization, Stanford University Medical Center , (2001– present )

Professional Education

• Board Certification: Pediatric Cardiology, American Board of Pediatric Cardiology (1998)
• Children's Hospital National Medical Center (1994) DC
• Children's Hospital National Medical Center (1997) DC
• Children's Hospital of Boston (1998) MA
• MS, Duke University Biomedical Engineering (1987)
• New York Medical College (1991) NY
• BS, Duke University Computer Science (1986)
• MPH, George Washington University Health Administration (1994)
• Children's National Medical Center (1992) DC

Graduate & Fellowship Program Affiliations

• Pediatrics
• Bioengineering

Industry Relationships

Stanford is committed to ethical and transparent interactions with our industry partners. It is our policy to disclose payments of $5,000 or more, equity valued at $5,000 or more in a publicly traded company, or any equity in a privately held company, to physicians and scientists employed by Stanford University from companies or other commercial entities with which they interact as part of their professional activities. 

• Consulting: Medtronic

Research Interests

Research interests include (1) computer simulation and modeling of cardiovascular physiology with specific attention paid to congenital heart disease and its treatment, (2) development and testing of transcatheter therapies for the treatment of congenital heart disease, and (3) the evaluation and treatment of pulmonary hypertension/pulmonary vascular disease.

In the area of computational modeling, projects are underway in three areas: (1) examination of alterations in blood flow and vessel mechanics caused by coarctation (narrowing) of the aorta and the use of computational modeling to compare surgical and transcatheter methods of treatment, (2) creation of a computational model of the entire pulmonary vascular tree and computational modeling of various disease states including pulmonary artery stenosis and pulmonary hypertension as a disease stratification tool and better predict responses to therapy, and (3) the use of computational modeling to examine flow characteristics and energy efficiency at rest and varying degrees of exercise in patients who have undergone total cavopulmonary connection.

Dr. Feinstein serves as the local P.I. for two ongoing multi-center clinical trials, one investigating a new oral therapy for the treatment of pediatric pulmonary hypertension and another comparing surgical treatment with balloon angioplasty or stent placement for treatment of coarctation of the aorta. Three additional clinical trials for which Dr. Feinstein will be the local P.I. are scheduled to begin within the next year.

Clinical Trials

• Tracking Outcomes and Practice in Pediatric Pulmonary Hypertension (TOPP) Recruiting

Publications

• Use of magnetic resonance imaging and computed tomography. Feinstein JA,  Gatzoulis MA.  Cardiol Young.  2009; 19 Suppl 1 16-22
• Angina associated with left main coronary artery compression in pulmonary hypertension. de Jesus Perez VA,  Haddad F, Vagelos RH, Fearon W, Feinstein J, Zamanian RT.  J Heart Lung Transplant.  2009; 28 (5): 527-30
• Short- and long-term outcomes of necrotizing enterocolitis in infants with congenital heart disease. Pickard SS,  Feinstein JA, Popat RA, Huang L, Dutta S.  Pediatrics.  2009; 123 (5): e901-6
• Evaluation, risk stratification, and management of pulmonary hypertension in patients with congenital heart disease. Feinstein JA,  Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu.  2009; 106-11
• A novel non-invasive method of estimating pulmonary vascular resistance in patients with pulmonary arterial hypertension. Haddad F,  Zamanian R, Beraud AS, Schnittger I, Feinstein J, Peterson T, Yang P, Doyle R, Rosenthal D.  J Am Soc Echocardiogr.  2009; 22 (5): 523-9
• On coupling a lumped parameter heart model and a three-dimensional finite element aorta model. Kim HJ,  Vignon-Clementel IE, Figueroa CA, LaDisa JF, Jansen KE, Feinstein JA, Taylor CA.  Ann Biomed Eng.  2009; 37 (11): 2153-69
• Extension of Doppler-derived echocardiographic measures of pulmonary vascular resistance to patients with moderate or severe pulmonary vascular disease. Vlahos AP,  Feinstein JA, Schiller NB, Silverman NH.  J Am Soc Echocardiogr.  2008; 21 (6): 711-4
• Noninherited risk factors and congenital cardiovascular defects: current knowledge: a scientific statement from the American Heart Association Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics. Jenkins KJ,  Correa A, Feinstein JA, Botto L, Britt AE, Daniels SR, Elixson M, Warnes CA, Webb CL.  Circulation.  2007; 115 (23): 2995-3014
• Noninvasive assessment of pulmonary arterial capacitance by echocardiography. Friedberg MK,  Feinstein JA, Rosenthal DN.  J Am Soc Echocardiogr.  2007; 20 (2): 186-90
• Morphometry-based impedance boundary conditions for patient-specific modeling of blood flow in pulmonary arteries. Spilker RL,  Feinstein JA, Parker DW, Reddy VM, Taylor CA.  Ann Biomed Eng.  2007; 35 (4): 546-59
• Effects of exercise and respiration on hemodynamic efficiency in CFD simulations of the total cavopulmonary connection. Marsden AL,  Vignon-Clementel IE, Chan FP, Feinstein JA, Taylor CA.  Ann Biomed Eng.  2007; 35 (2): 250-63
• Ketamine does not increase pulmonary vascular resistance in children with pulmonary hypertension undergoing sevoflurane anesthesia and spontaneous ventilation. Williams GD,  Philip BM, Chu LF, Boltz MG, Kamra K, Terwey H, Hammer GB, Perry SB, Feinstein JA, Ramamoorthy C.  Anesth Analg.  2007; 105 (6): 1578-84, table of contents
• Percutaneous pulmonary valve placement in a 10-month-old patient using a hand crafted stent-mounted porcine valve. Feinstein JA,  Kim N, Reddy VM, Perry SB.  Catheter Cardiovasc Interv.  2006; 67 (4): 644-9
• Relative lung perfusion distribution in normal lung scans: observations and clinical implications. Cheng CP,  Taur AS, Lee GS, Goris ML, Feinstein JA.  Congenit Heart Dis.  2006; 1 (5): 210-6
• Percutaneous transluminal coronary angioplasty in a two-month old with coronary stenosis presenting as congenital cardiomyopathy: acute results and intermediate follow-up. Cheng CW,  Lee DP, Rosenthal DN, Feinstein JA.  Catheter Cardiovasc Interv.  2006; 68 (4): 632-6
• Unifocalization of major aortopulmonary collaterals in single-ventricle patients. Reinhartz O,  Reddy VM, Petrossian E, Suleman S, Mainwaring RD, Rosenthal DN, Feinstein JA, Gulati R, Hanley FL.  Ann Thorac Surg.  2006; 82 (3): 934-8; discussion 938-9
• A novel echocardiographic Doppler method for estimation of pulmonary arterial pressures. Friedberg MK,  Feinstein JA, Rosenthal DN.  J Am Soc Echocardiogr.  2006; 19 (5): 559-62
• Surgical and interventional therapies for pulmonary arterial hypertension. Olsson JK,  Zamanian RT, Feinstein JA, Doyle RL.  Semin Respir Crit Care Med.  2005; 26 (4): 417-28
• Experience of percutaneous coronary intervention in the management of pediatric cardiac allograft vasculopathy. Tham EB,  Yeung AC, Cheng CW, Bernstein D, Chin C, Feinstein JA.  J Heart Lung Transplant.  2005; 24 (6): 769-73
• Proximal pulmonary artery blood flow characteristics in healthy subjects measured in an upright posture using MRI: the effects of exercise and age. Cheng CP,  Herfkens RJ, Taylor CA, Feinstein JA.  J Magn Reson Imaging.  2005; 21 (6): 752-8
• Angiojet catheter-based thrombectomy in a neonate with postoperative pulmonary embolism. Feldman JP,  Feinstein JA, Lamberti JJ, Perry SB.  Catheter Cardiovasc Interv.  2005; 66 (3): 442-5
• Regression of severe pulmonary arteriovenous malformations after Fontan revision and "hepatic factor" rerouting. Pike NA,  Vricella LA, Feinstein JA, Black MD, Reitz BA.  Ann Thorac Surg.  2004; 78 (2): 697-9
• Identifying cardiac transplant rejection in children: diagnostic utility of echocardiography, right heart catheterization and endomyocardial biopsy data. Rosenthal DN,  Chin C, Nishimura K, Perry SB, Robbins RC, Reitz B, Bernstein D, Feinstein JA.  J Heart Lung Transplant.  2004; 23 (3): 323-9
• Blood flow conditions in the proximal pulmonary arteries and vena cavae: healthy children during upright cycling exercise. Cheng CP,  Herfkens RJ, Lightner AL, Taylor CA, Feinstein JA.  Am J Physiol Heart Circ Physiol.  2004; 287 (2): H921-6
• Usefulness of epoprostenol therapy in the severely ill adolescent/adult with Eisenmenger physiology. Fernandes SM,  Newburger JW, Lang P, Pearson DD, Feinstein JA, Gauvreau K, Landzberg MJ.  Am J Cardiol.  2003; 91 (5): 632-5
• Electrical resynchronization: a novel therapy for the failing right ventricle. Dubin AM,  Feinstein JA, Reddy VM, Hanley FL, Van Hare GF, Rosenthal DN.  Circulation.  2003; 107 (18): 2287-9
• Comparison of contrast echocardiography versus cardiac catheterization for detection of pulmonary arteriovenous malformations. Feinstein JA,  Moore P, Rosenthal DN, Puchalski M, Brook MM.  Am J Cardiol.  2002; 89 (3): 281-5
• Temporary IVC filtration before patent foramen ovale closure in a patient with paradoxic embolism. Lewis-Carey MB,  Kee ST, Feinstein JA.  J Vasc Interv Radiol.  2002; 13 (12): 1275-8
• A technique for maintenance of airway access in infants with a difficult airway following tracheal extubation. Hammer GB,  Funck N, Rosenthal DN, Feinstein JA.  Paediatr Anaesth.  2001; 11 (5): 622-5
• Balloon pulmonary angioplasty for treatment of chronic thromboembolic pulmonary hypertension. Feinstein JA,  Goldhaber SZ, Lock JE, Ferndandes SM, Landzberg MJ.  Circulation.  2001; 103 (1): 10-3
• Preoperative management of pulmonary venous hypertension in hypoplastic left heart syndrome with restrictive atrial septal defect. Atz AM,  Feinstein JA, Jonas RA, Perry SB, Wessel DL.  Am J Cardiol.  1999; 83 (8): 1224-8
• Using cardiac phase to order reconstruction (CAPTOR): a method to improve diastolic images. Feinstein JA,  Epstein FH, Arai AE, Foo TK, Hartley MR, Balaban RS, Wolff SD.  J Magn Reson Imaging.  1997 Sep-Oct; 7 (5): 794-8