Key Documents

NIH Biosketch available Online

Rachel Manber

Professor - Med Center Line, Psychiatry & Behavioral Science - Sleep Center

Contact Information

Clinical Offices

Stanford Sleep Medicine Clinic 450 Broadway St Pavilion C, 2nd Flr Redwood City, CA 94063
Telephone Work (650) 723-6601 Fax (650) 721-3465
Academic Offices

Personal Information
Email rmanber@stanford.edu
Not for medical emergencies or patient use

Clinical Focus

non-pharmacological treatments of insomnia
Sleep difficulties in children and teens
Adjustment to CPAP
Sleep Medicine

Professional Education

University of Washington School of Medicine (1993) WA
University of Arizona (1993) AZ USA
PhD, University of Arizona Clinical Psychology (1993)

Postdoctoral Advisees

Rebecca Bernert, Andrea Chambers, Allison Siebern

Research Interests

Comorbid insomnia and depression. Treatment of depression during pregnancy and post partum. Phenomenology and treatment of insomnia. The effects of female gonadal hormones on sleep.

Clinical Trials

TRIAD - Treatment of Insomnia and Depression Recruiting

Publications

Mindfulness meditation and cognitive behavioral therapy for insomnia: a naturalistic 12-month follow-up. Ong JC, Shapiro SL, Manber R. Explore (NY). 2009 Jan-Feb; 5 (1): 30-6
Cognitive behavioral therapy for insomnia enhances depression outcome in patients with comorbid major depressive disorder and insomnia. Manber R, Edinger JD, Gress JL, San Pedro-Salcedo MG, Kuo TF, Kalista T. Sleep. 2008; 31 (4): 489-95
Depression symptoms during pregnancy. Manber R, Blasey C, Allen JJ. Arch Womens Ment Health. 2008; 11 (1): 43-8
Faster remission of chronic depression with combined psychotherapy and medication than with each therapy alone. Manber R, Kraemer HC, Arnow BA, Trivedi MH, Rush AJ, Thase ME, Rothbaum BO, Klein DN, Kocsis JH, Gelenberg AJ, Keller ME. J Consult Clin Psychol. 2008; 76 (3): 459-67
Cardiac vagal control in the severity and course of depression: the importance of symptomatic heterogeneity. Rottenberg J, Chambers AS, Allen JJ, Manber R. J Affect Disord. 2007; 103 (1-3): 173-9
Characteristics of insomniacs with self-reported morning and evening chronotypes. Ong JC, Huang JS, Kuo TF, Manber R. J Clin Sleep Med. 2007; 3 (3): 289-94
Assessing insomnia severity in depression: comparison of depression rating scales and sleep diaries. Manber R, Blasey C, Arnow B, Markowitz JC, Thase ME, Rush AJ, Dowling F, Koscis J, Trivedi M, Keller MB. J Psychiatr Res. 2005; 39 (5): 481-8
Cognitive behavior therapy for chronic insomnia occurring within the context of medical and psychiatric disorders. Smith MT, Huang MI, Manber R. Clin Psychol Rev. 2005; 25 (5): 559-92
Acupuncture: a promising treatment for depression during pregnancy. Manber R, Schnyer RN, Allen JJ, Rush AJ, Blasey CM. J Affect Disord. 2004; 83 (1): 89-95
Patients' perception of their depressive illness. Manber R, Chambers AS, Hitt SK, McGahuey C, Delgado P, Allen JJ. J Psychiatr Res. 2003 Jul-Aug; 37 (4): 335-43
Patient's therapeutic skill acquisition and response to psychotherapy, alone or in combination with medication. Manber R, Arnow B, Blasey C, Vivian D, McCullough JP, Blalock JA, Klein DN, Markowitz JC, Riso LP, Rothbaum B, Rush AJ, Thase ME, Keller MB. Psychol Med. 2003; 33 (4): 693-702
The effects of hormone replacement therapy on sleep-disordered breathing in postmenopausal women: a pilot study. Manber R, Kuo TF, Cataldo N, Colrain IM. Sleep. 2003; 26 (2): 163-8
The effects of psychotherapy, nefazodone, and their combination on subjective assessment of disturbed sleep in chronic depression. Manber R, Rush AJ, Thase ME, Amow B, Klein D, Trivedi MH, Korenstein SG, Markowitz JC, Dunner DL, Munsaka M, Borian FE, Martin, Keller B. Sleep. 2003; 26 (2): 130-6
Cognitive behavioral analysis system of psychotherapy and brief supportive psychotherapy for augmentation of antidepressant nonresponse in chronic depression: the REVAMP Trial. Kocsis JH, Gelenberg AJ, Rothbaum BO, Klein DN, Trivedi MH, Manber R, Keller MB, Leon AC, Wisniewski SR, Arnow BA, Markowitz JC, Thase ME. Arch Gen Psychiatry. 2009; 66 (11): 1178-88
Insomnia and depression: a multifaceted interplay. Manber R, Chambers AS. Curr Psychiatry Rep. 2009; 11 (6): 437-42
Frequency and predictors of obstructive sleep apnea among individuals with major depressive disorder and insomnia. Ong JC, Gress JL, San Pedro-Salcedo MG, Manber R. J Psychosom Res. 2009; 67 (2): 135-41
Early adversity in chronic depression: clinical correlates and response to pharmacotherapy. Klein DN, Arnow BA, Barkin JL, Dowling F, Kocsis JH, Leon AC, Manber R, Rothbaum BO, Trivedi MH, Wisniewski SR. Depress Anxiety. 2009; 26 (8): 701-10
Select comorbid personality disorders and the treatment of chronic depression with nefazodone, targeted psychotherapy, or their combination. Maddux RE, Riso LP, Klein DN, Markowitz JC, Rothbaum BO, Arnow BA, Manber R, Blalock JA, Keitner GI, Thase ME. J Affect Disord. 2009; 117 (3): 174-9
Patient preference as a moderator of outcome for chronic forms of major depressive disorder treated with nefazodone, cognitive behavioral analysis system of psychotherapy, or their combination. Kocsis JH, Leon AC, Markowitz JC, Manber R, Arnow B, Klein DN, Thase ME. J Clin Psychiatry. 2009; 70 (3): 354-61
Chronic forms of major depression are still undertreated in the 21st century: systematic assessment of 801 patients presenting for treatment. Kocsis JH, Gelenberg AJ, Rothbaum B, Klein DN, Trivedi MH, Manber R, Keller MB, Howland R, Thase ME. J Affect Disord. 2008; 110 (1-2): 55-61
Who is at risk for dropout from group cognitive-behavior therapy for insomnia? Ong JC, Kuo TF, Manber R. J Psychosom Res. 2008; 64 (4): 419-25
Therapists' responses to training in brief supportive psychotherapy. Markowitz JC, Manber R, Rosen P. Am J Psychother. 2008; 62 (1): 67-81
Combining mindfulness meditation with cognitive-behavior therapy for insomnia: a treatment-development study. Ong JC, Shapiro SL, Manber R. Behav Ther. 2008; 39 (2): 171-82
Acupuncture for postmenopausal hot flashes. Nir Y, Huang MI, Schnyer R, Chen B, Manber R. Maturitas. 2007; 56 (4): 383-95
Reply of the Authors. Huang MI, Nir Y, Chen B, Manber R, Schnyer RN. Fertil Steril. 2007; 87 (6): 1497-1498
Dropouts versus completers among chronically depressed outpatients. Arnow BA, Blasey C, Manber R, Constantino MJ, Markowitz JC, Klein DN, Thase ME, Kocsis JH, Rush AJ. J Affect Disord. 2007; 97 (1-3): 197-202
Beliefs about sleep in disorders characterized by sleep and mood disturbance. Carney CE, Edinger JD, Manber R, Garson C, Segal ZV. J Psychosom Res. 2007; 62 (2): 179-88
Patient expectations and therapeutic alliance as predictors of outcome in group cognitive-behavioral therapy for insomnia. Constantino MJ, Manber R, Ong J, Kuo TF, Huang JS, Arnow BA. Behav Sleep Med. 2007; 5 (3): 210-28
A randomized controlled pilot study of acupuncture for postmenopausal hot flashes: effect on nocturnal hot flashes and sleep quality. Huang MI, Nir Y, Chen B, Schnyer R, Manber R. Fertil Steril. 2006; 86 (3): 700-10
Acupuncture for depression: a randomized controlled trial. Allen JJ, Schnyer RN, Chambers AS, Hitt SK, Moreno FA, Manber R. J Clin Psychiatry. 2006; 67 (11): 1665-73
Historical perspective and future directions in Cognitive Behavioral Therapy for insomnia and behavioral sleep medicine. Manber R, Harvey A. Clin Psychol Rev. 2005; 25 (5): 535-8
Chronic depression: medication (nefazodone) or psychotherapy (CBASP) is effective when the other is not. Schatzberg AF, Rush AJ, Arnow BA, Banks PL, Blalock JA, Borian FE, Howland R, Klein DN, Kocsis JH, Kornstein SG, Manber R, Markowitz JC, Miller I, Ninan PT, Rothbaum BO, Thase ME, Trivedi MH, Keller MB. Arch Gen Psychiatry. 2005; 62 (5): 513-20
Self-reported depressive symptom measures: sensitivity to detecting change in a randomized, controlled trial of chronically depressed, nonpsychotic outpatients. Rush AJ, Trivedi MH, Carmody TJ, Ibrahim HM, Markowitz JC, Keitner GI, Kornstein SG, Arnow B, Klein DN, Manber R, Dunner DL, Gelenberg AJ, Kocsis JH, Nemeroff CB, Fawcett J, Thase ME, Russell JM, Jody DN, Borian FE, Keller MB. Neuropsychopharmacology. 2005; 30 (2): 405-16
Management of bipolar disorder during pregnancy and the postpartum period. Yonkers KA, Wisner KL, Stowe Z, Leibenluft E, Cohen L, Miller L, Manber R, Viguera A, Suppes T, Altshuler L. Am J Psychiatry. 2004; 161 (4): 608-20
Cognitive-behavioral analysis system of psychotherapy as a maintenance treatment for chronic depression. Klein DN, Santiago NJ, Vivian D, Blalock JA, Kocsis JH, Markowitz JC, McCullough Jr JP, Rush AJ, Trivedi MH, Arnow BA, Dunner DL, Manber R, Rothbaum B, Thase ME, Keitner GI, Miller IW, Keller MB. J Consult Clin Psychol. 2004; 72 (4): 681-8
Randomized, placebo-controlled trial of nefazodone maintenance treatment in preventing recurrence in chronic depression. Gelenberg AJ, Trivedi MH, Rush AJ, Thase ME, Howland R, Klein DN, Kornstein SG, Dunner DL, Markowitz JC, Hirschfeld RM, Keitner GI, Zajecka J, Kocsis JH, Russell JM, Miller I, Manber R, Arnow B, Rothbaum B, Munsaka M, Banks P, Borian FE, Keller MB. Biol Psychiatry. 2003; 54 (8): 806-17
The 16-Item Quick Inventory of Depressive Symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression. Rush AJ, Trivedi MH, Ibrahim HM, Carmody TJ, Arnow B, Klein DN, Markowitz JC, Ninan PT, Kornstein S, Manber R, Thase ME, Kocsis JH, Keller MB. Biol Psychiatry. 2003; 54 (5): 573-83
Therapeutic reactance as a predictor of outcome in the treatment of chronic depression. Arnow BA, Manber R, Blasey C, Klein DN, Blalock JA, Markowitz JC, Rothbaum BO, Rush AJ, Thase ME, Riso LP, Vivian D, McCullough JP, Keller MB. J Consult Clin Psychol. 2003; 71 (6): 1025-35
Therapeutic alliance in depression treatment: controlling for prior change and patient characteristics. Klein DN, Schwartz JE, Santiago NJ, Vivian D, Vocisano C, Castonguay LG, Arnow B, Blalock JA, Manber R, Markowitz JC, Riso LP, Rothbaum B, McCullough JP, Thase ME, Borian FE, Miller IW, Keller MB. J Consult Clin Psychol. 2003; 71 (6): 997-1006
Sexual function and satisfaction in the treatment of chronic major depression with nefazodone, psychotherapy, and their combination. Zajecka J, Dunner DL, Gelenberg AJ, Hirschfeld RM, Kornstein SG, Ninan PT, Rush AJ, Thase ME, Trivedi MH, Arnow BA, Borian FE, Manber R, Keller MB. J Clin Psychiatry. 2002; 63 (8): 709-16
Emotional blunting associated with SSRI-induced sexual dysfunction. Do SSRIs inhibit emotional responses? Opbroek A, Delgado PL, Laukes C, McGahuey C, Katsanis J, Moreno FA, Manber R. Int J Neuropsychopharmacol. 2002; 5 (2): 147-51
Symptomatic and syndromal anxiety in chronic forms of major depression: effect of nefazodone, cognitive behavioral analysis system of psychotherapy, and their combination. Ninan PT, Rush AJ, Crits-Christoph P, Kornstein SG, Manber R, Thase ME, Trivedi MH, Rothbaum BO, Zajecka J, Borian FE, Keller MB. J Clin Psychiatry. 2002; 63 (5): 434-41
Differential effects of nefazodone and cognitive behavioral analysis system of psychotherapy on insomnia associated with chronic forms of major depression. Thase ME, Rush AJ, Manber R, Kornstein SG, Klein DN, Markowitz JC, Ninan PT, Friedman ES, Dunner DL, Schatzberg AF, Borian FE, Trivedi MH, Keller MB. J Clin Psychiatry. 2002; 63 (6): 493-500
Alternative treatments for depression: empirical support and relevance to women. Manber R, Allen JJ, Morris ME, Morris MM. J Clin Psychiatry. 2002; 63 (7): 628-40
Six-month depression relapse rates among women treated with acupuncture. Gallagher SM, Allen JJ, Hitt SK, Schnyer RN, Manber R. Complement Ther Med. 2001; 9 (4): 216-8
The Arizona Sexual Experience Scale (ASEX): reliability and validity. McGahuey CA, Gelenberg AJ, Laukes CA, Moreno FA, Delgado PL, McKnight KM, Manber R. J Sex Marital Ther. 2000 Jan-Mar; 26 (1): 25-40
Valence-dependent modulation of psychophysiological measures: is there consistency across repeated testing? Manber R, Allen JJ, Burton K, Kaszniak AW. Psychophysiology. 2000; 37 (5): 683-92
Sex, steroids, and sleep: a review. Manber R, Armitage R. Sleep. 1999; 22 (5): 540-55
Sleep Disorders. In: Comprehensive Clinical Psychology Manber, R, Bootzin, R.R., & Lowey, D.. A. Bellack & M. Hersen (Eds.) Oxford, England: Elsevier Science LTD.. 1998; 505-527.
Sleep and the menstrual cycle. Manber R, Bootzin RR. Health Psychol. 1997; 16 (3): 209-14
The effects of regularizing sleep-wake schedules on daytime sleepiness. Manber R, Bootzin RR, Acebo C, Carskadon MA. Sleep. 1996; 19 (5): 432-41
Sleep disorders. In: P.B. Sutker & H.E. Adams (Eds), Comprehensive Handbook of Psychopathology, 2nd Edition. Bootzin, R.R., Manber, R., Perlis, , Salvio, M., & Wyatt, J.K.. New York: Plenum Press.. 1993; 531-561