Daniel V. Madison

Administrative Appointments

• Chair, Admissions Committee, Dept. Molecular and Cellular Physiology , (2005– 2007 )
• Senator at large, Medical School Faculty Senate , (2004– 2006 )
• Director of Admissions, Neurosciences Graduate Program , (1997– 2003 )
• Executive Committee, Neurosciences Graduate Program , (1995– 2003 )
• MSTP Admissions Committee, MSTP , (1995– 1999 )
• Director of Graduate Studies, Dept. Molecular and Cellular Physiology , (1990– 1997 )
• Graduate Admission Committee, Dept. Molecular and Cellular Physiology , (1990– 1997 )
• Committee of Five, School of Medicine , (1994– 1995 )
• Departmental Senator, Medical School Faculty Senate , (1990– 1995 )

Honors and Awards

• Young Investigator Award, Society for Neuroscience (.)
• Lucille P. Markey Scholar, Lucile P. Markey Charitable Trust (.)

Professional Education

• Ph.D., Univ.of Calif. San Francisco Neurosciences (1984)
• B.S., University of California, Irvine Biological Sciences (1979)

Postdoctoral Advisees

• Ananya Mitra

Graduate & Fellowship Program Affiliations

• Molecular and Cellular Physiology
• Neurosciences

Community & International Work

• MBL Neurobiology Course, Woods Hole, MA More »

Web Site Links

• Madison Lab Home Page

Research Interests

Our laboratory uses electrophysiological techniques to study the mechanisms of synaptic transmission and plasticity in the mammalian hippocampus. One of the main focuses in the lab is in the study of synaptic long-term potentiation (LTP). LTP is the persistent increase in synaptic strength that occurs after a period of heavy activity in a synaptic connection. It is the most widely studied and compelling model for mechanisms underlying memory formation in the mammalian central nervous system. Most recently, we have been involved in studies of the intracellular messenger, nitric oxide. Nitric oxide appears to play a role both in inducing LTP and also in communicating LTP between groups of unconnected synapses, thus creating funcitonal domains of alterered synapses.

The other major focus of the lab is the study of the modulation and short term plasticity of inhibitory synaptic transmission in the hippocampus by different neurotransmitter systems. Projects under this focus include studies on the modulatory properties of norepinesphrine, acetylcholine and opiates on hippocampal inhibitory circuitry and transmitter release.

Studies in the lab are carried out using a full range of electrophysiological techniques including extracellular field potential recording, intracellular recording,whjole cell and single channel recording in hippocampal slices and cultured neurons.

Publications

• Presynaptic FMR1 genotype influences the degree of synaptic connectivity in a mosaic mouse model of fragile X syndrome. Hanson JE,  Madison DV.  J Neurosci.  2007; 27 (15): 4014-8
• The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome. Hanson JE,  Blank M, Valenzuela RA, Garner CC, Madison DV.  J Physiol.  2007; 579 (Pt 1): 53-67
• Blocking polysynaptic inhibition via opioid receptor activation isolates excitatory synaptic currents without triggering epileptiform activity in organotypic hippocampal slices. Hanson JE,  Emond MR, Madison DV.  J Neurosci Methods.  2006; 150 (1): 8-15
• Toward a unified hypothesis of interneuronal modulation. Madison DV,  McQuiston AR.  J Physiol.  2006; 570 (Pt 3): 435
• Dynamin-dependent NMDAR endocytosis during LTD and its dependence on synaptic state. Montgomery JM,  Selcher JC, Hanson JE, Madison DV.  BMC Neurosci.  2005; 6 48
• Discrete synaptic states define a major mechanism of synapse plasticity. Montgomery JM,  Madison DV.  Trends Neurosci.  2004; 27 (12): 744-50
• SNAP-25 Ser187 does not mediate phorbol ester enhancement of hippocampal synaptic transmission. Finley MF,  Scheller RH, Madison DV.  Neuropharmacology.  2003; 45 (6): 857-62
• The core membrane fusion complex governs the probability of synaptic vesicle fusion but not transmitter release kinetics. Finley MF,  Patel SM, Madison DV, Scheller RH.  J Neurosci.  2002; 22 (4): 1266-72
• State-dependent heterogeneity in synaptic depression between pyramidal cell pairs. Montgomery JM,  Madison DV.  Neuron.  2002; 33 (5): 765-77
• Pair recordings reveal all-silent synaptic connections and the postsynaptic expression of long-term potentiation. Montgomery JM,  Pavlidis P, Madison DV.  Neuron.  2001; 29 (3): 691-701
• Preparation of hippocampal brain slices. Madison DV,  Edson EB.  Curr Protoc Neurosci.  2001; Chapter 6 Unit 6.4
• The grass roots of synapse suppression. Montgomery JM,  Madison DV.  Neuron.  2001; 29 (3): 567-70
• A novel SNAP25-caveolin complex correlates with the onset of persistent synaptic potentiation. Braun JE,  Madison DV.  J Neurosci.  2000; 20 (16): 5997-6006
• Presynaptic protein kinase activity supports long-term potentiation at synapses between individual hippocampal neurons. Pavlidis P,  Montgomery J, Madison DV.  J Neurosci.  2000; 20 (12): 4497-505
• Nicotinic receptor activation excites distinct subtypes of interneurons in the rat hippocampus. McQuiston AR,  Madison DV.  J Neurosci.  1999; 19 (8): 2887-96
• Impaired synaptic plasticity in mice carrying the Huntington's disease mutation. Usdin MT,  Shelbourne PF, Myers RM, Madison DV.  Hum Mol Genet.  1999; 8 (5): 839-46
• Synaptic transmission in pair recordings from CA3 pyramidal cells in organotypic culture. Pavlidis P,  Madison DV.  J Neurophysiol.  1999; 81 (6): 2787-97
• Muscarinic receptor activity induces an afterdepolarization in a subpopulation of hippocampal CA1 interneurons. McQuiston AR,  Madison DV.  J Neurosci.  1999; 19 (14): 5703-10
• Muscarinic receptor activity has multiple effects on the resting membrane potentials of CA1 hippocampal interneurons. McQuiston AR,  Madison DV.  J Neurosci.  1999; 19 (14): 5693-702
• Excitatory actions of norepinephrine on multiple classes of hippocampal CA1 interneurons. Bergles DE,  Doze VA, Madison DV, Smith SJ.  J Neurosci.  1996; 16 (2): 572-85
• Calcium channel involvement in GABAB receptor-mediated inhibition of GABA release in area CA1 of the rat hippocampus. Doze VA,  Cohen GA, Madison DV.  J Neurophysiol.  1995; 74 (1): 43-53
• Diffusible messengers and intercellular signaling: locally distributed synaptic potentiation in the hippocampus. Madison DV,  Schuman EM.  Curr Top Microbiol Immunol.  1995; 196 5-6
• Communication of synaptic potentiation between synapses of the hippocampus. Schuman EM,  Madison DV.  Adv Second Messenger Phosphoprotein Res.  1994; 29 507-20
• Inhibition of hippocampal heme oxygenase, nitric oxide synthase, and long-term potentiation by metalloporphyrins. Meffert MK,  Haley JE, Schuman EM, Schulman H, Madison DV.  Neuron.  1994; 13 (5): 1225-33
• Nitric oxide and synaptic function. Schuman EM,  Madison DV.  Annu Rev Neurosci.  1994; 17 153-83
• An ADP-ribosyltransferase as a potential target for nitric oxide action in hippocampal long-term potentiation. Schuman EM,  Meffert MK, Schulman H, Madison DV.  Proc Natl Acad Sci U S A.  1994; 91 (25): 11958-62
• Enhancement of transmission at the developing retinogeniculate synapse. Mooney R,  Madison DV, Shatz CJ.  Neuron.  1993; 10 (5): 815-25
• Phorbol esters enhance synaptic transmission by a presynaptic, calcium-dependent mechanism in rat hippocampus. Parfitt KD,  Madison DV.  J Physiol.  1993; 471 245-68
• Pass the nitric oxide. Madison DV,  Proc Natl Acad Sci U S A.  1993; 90 (10): 4329-31
• Isoproterenol increases the phosphorylation of the synapsins and increases synaptic transmission in dentate gyrus, but not in area CA1, of the hippocampus. Parfitt KD,  Doze VA, Madison DV, Browning MD.  Hippocampus.  1992; 2 (1): 59-64
• Opioid inhibition of GABA release from presynaptic terminals of rat hippocampal interneurons. Cohen GA,  Doze VA, Madison DV.  Neuron.  1992; 9 (2): 325-35
• Long-term potentiation. Knocking out memory's door. Madison DV,  Nature.  1992; 358 (6388): 626-7
• Synaptic localization of adrenergic disinhibition in the rat hippocampus. Doze VA,  Cohen GA, Madison DV.  Neuron.  1991; 6 (6): 889-900
• LTP, post or pre? A look at the evidence for the locus of long-term potentiation. Madison DV,  Schuman EM.  New Biol.  1991; 3 (6): 549-57
• Mechanisms underlying long-term potentiation of synaptic transmission. Madison DV,  Malenka RC, Nicoll RA.  Annu Rev Neurosci.  1991; 14 379-97
• Protein kinases and long-term potentiation. Meffert MK,  Parfitt KD, Doze VA, Cohen GA, Madison DV.  Ann N Y Acad Sci.  1991; 627 2-9
• Norepinephrine decreases synaptic inhibition in the rat hippocampus. Madison DV,  Nicoll RA.  Brain Res.  1988; 442 (1): 131-8
• Spatial distribution of calcium channels and cytosolic calcium transients in growth cones and cell bodies of sympathetic neurons. Lipscombe D,  Madison DV, Poenie M, Reuter H, Tsien RY, Tsien RW.  Proc Natl Acad Sci U S A.  1988; 85 (7): 2398-402
• Enkephalin hyperpolarizes interneurones in the rat hippocampus. Madison DV,  Nicoll RA.  J Physiol.  1988; 398 123-30
• Imaging of cytosolic Ca2+ transients arising from Ca2+ stores and Ca2+ channels in sympathetic neurons. Lipscombe D,  Madison DV, Poenie M, Reuter H, Tsien RW, Tsien RY.  Neuron.  1988; 1 (5): 355-65
• Multiple types of neuronal calcium channels and their selective modulation. Tsien RW,  Lipscombe D, Madison DV, Bley KR, Fox AP.  Trends Neurosci.  1988; 11 (10): 431-8
• Persistent protein kinase activity underlying long-term potentiation. Malinow R,  Madison DV, Tsien RW.  Nature.  1988; 335 (6193): 820-4
• Voltage clamp analysis of cholinergic action in the hippocampus. Madison DV,  Lancaster B, Nicoll RA.  J Neurosci.  1987; 7 (3): 733-41
• Potentiation of synaptic transmission in the hippocampus by phorbol esters. Malenka RC,  Madison DV, Nicoll RA.  Nature.  1986 May 8-14; 321 (6066): 175-7
• Phorbol esters block a voltage-sensitive chloride current in hippocampal pyramidal cells. Madison DV,  Malenka RC, Nicoll RA.  Nature.  1986 Jun 12-18; 321 (6071): 695-7
• Cyclic adenosine 3',5'-monophosphate mediates beta-receptor actions of noradrenaline in rat hippocampal pyramidal cells. Madison DV,  Nicoll RA.  J Physiol.  1986; 372 245-59
• Actions of noradrenaline recorded intracellularly in rat hippocampal CA1 pyramidal neurones, in vitro. Madison DV,  Nicoll RA.  J Physiol.  1986; 372 221-44
• Phorbol esters mimic some cholinergic actions in hippocampal pyramidal neurons. Malenka RC,  Madison DV, Andrade R, Nicoll RA.  J Neurosci.  1986; 6 (2): 475-80
• Folic acid has a disinhibitory action in the rat hippocampal slice preparation. Otis LC,  Madison DV, Nicoll RA.  Brain Res.  1985; 346 (2): 281-6
• Control of the repetitive discharge of rat CA 1 pyramidal neurones in vitro. Madison DV,  Nicoll RA.  J Physiol.  1984; 354 319-31
• Noradrenaline blocks accommodation of pyramidal cell discharge in the hippocampus. Madison DV,  Nicoll RA.  Nature.  1982; 299 (5884): 636-8
• General anesthetics hyperpolarize neurons in the vertebrate central nervous system. Nicoll RA,  Madison DV.  Science.  1982; 217 (4564): 1055-7