Robert Lane Smith

Postdoctoral Advisees

• Riku Sakimura

Industry Relationships

Stanford is committed to ethical and transparent interactions with our industry partners. It is our policy to disclose payments of $5,000 or more, equity valued at $5,000 or more in a publicly traded company, or any equity in a privately held company, to physicians and scientists employed by Stanford University from companies or other commercial entities with which they interact as part of their professional activities. 

• Consulting: Histogenics

Research Interests

Our group is interested in the molecular and cell biology underlying bone and cartilage metabolism in health and disease. Normal daily activities are linked to the ability of the articular cartilage to withstand normal joint forces that may reach 5-7 times body weight and bone homeostasis depends on daily mechanical loading histories. The phenotypic stability of cartilage and bone depends on a complex interplay between stimuli influencing cell metabolism, physical forces, cytokines, hormones and growth factors, and the genetic expression determining the material properties of the tissue. Our lab applies modern biochemical techniques to analyze:

1. Mechanisms of cartilage degradation in inflammation and sepsis;
2. Stimulation of cartilage growth and repair by growth factors and hormones in serum-free culture;
3. Effects of adherence and deposition of glycocalyx on bacterial resistance to antibiotic treatment;
4. Effects of mechanical stresses and strains on cartilage and bone cell gene expression and matrix
syntheses;
5. Analysis of metal particles on bone resorption and prosthetic loosening in total joint arthroplasty.

The experimental techniques include development of primary cultures of human chondrocytes, quantification of proteoglycan and collagen synthesis and degradation, zymogen and kinetic analysis of neutral metalloproteinases, western analysis of protein expression, northern and slot blot analysis of mRNA levels and cloning of connective tissue and bacterial genes.

Publications

• Ultrahigh molecular weight polyethylene wear debris inhibits osteoprogenitor proliferation and differentiation in vitro. Chiu R,  Ma T, Smith RL, Goodman SB.  J Biomed Mater Res A.  2009; 89 (1): 242-7
• Efficacy of a p38 mitogen activated protein kinase inhibitor in mitigating an established inflammatory reaction to polyethylene particles in vivo. Ma T,  Ren PG, Larsen DM, Suenaga E, Zilber S, Genovese M, Smith RL, Goodman SB.  J Biomed Mater Res A.  2009; 89 (1): 117-23
• In vivo murine model of continuous intramedullary infusion of particles--a preliminary study. Ma T,  Ortiz SG, Huang Z, Ren P, Smith RL, Goodman SB.  J Biomed Mater Res B Appl Biomater.  2009; 88 (1): 250-3
• Biocompatibility of poly(ethylene glycol)/poly(acrylic acid) interpenetrating polymer network hydrogel particles in RAW 264.7 macrophage and MG-63 osteoblast cell lines. Yim ES,  Zhao B, Myung D, Kourtis LC, Frank CW, Carter D, Smith RL, Goodman SB.  J Biomed Mater Res A.  2009; 91 (3): 894-902
• Continuous intramedullary polymer particle infusion using a murine femoral explant model. Ortiz SG,  Ma T, Regula D, Smith RL, Goodman SB.  J Biomed Mater Res B Appl Biomater.  2008; 87 (2): 440-6
• New bone formation by murine osteoprogenitor cells cultured on corticocancellous allograft bone. Nelson ER,  Huang Z, Ma T, Lindsey D, Jacobs C, Smith RL, Goodman SB.  J Orthop Res.  2008; 26 (12): 1660-4
• Histomorphometric analysis of the intramedullary bone response to titanium particles in wild-type and IL-1R1 knock-out mice: a preliminary study. Bragg B,  Epstein NJ, Ma T, Goodman S, Smith RL.  J Biomed Mater Res B Appl Biomater.  2008; 84 (2): 559-70
• Bioactive sutures for tendon repair: assessment of a method of delivering pluripotential embryonic cells. Yao J,  Korotkova T, Riboh J, Chong A, Chang J, Smith RL.  J Hand Surg Am.  2008; 33 (9): 1558-64
• Validation and quantification of an in vitro model of continuous infusion of submicron-sized particles. Ortiz SG,  Ma T, Epstein NJ, Smith RL, Goodman SB.  J Biomed Mater Res B Appl Biomater.  2008; 84 (2): 328-33
• An in vivo murine model of continuous intramedullary infusion of polyethylene particles. Ma T,  Huang Z, Ren PG, McCally R, Lindsey D, Smith RL, Goodman SB.  Biomaterials.  2008; 29 (27): 3738-42
• Fluid shear stress magnitude, duration, and total applied load regulate gene expression and nitric oxide production in primary calvarial osteoblast cultures. González O,  Fong KD, Trindade MC, Warren SM, Longaker MT, Smith RL.  Plast Reconstr Surg.  2008; 122 (2): 419-28
• Hydrostatic pressure enhances chondrogenic differentiation of human bone marrow stromal cells in osteochondrogenic medium. Wagner DR,  Lindsey DP, Li KW, Tummala P, Chandran SE, Smith RL, Longaker MT, Carter DR, Beaupre GS.  Ann Biomed Eng.  2008; 36 (5): 813-20
• Polymethylmethacrylate particles inhibit osteoblastic differentiation of MC3T3-E1 osteoprogenitor cells. Chiu R,  Ma T, Smith RL, Goodman SB.  J Orthop Res.  2008; 26 (7): 932-6
• The sequential expression profiles of growth factors from osteoprogenitors [correction of osteroprogenitors] to osteoblasts in vitro. Huang Z,  Nelson ER, Smith RL, Goodman SB.  Tissue Eng.  2007; 13 (9): 2311-20
• Kinetics of polymethylmethacrylate particle-induced inhibition of osteoprogenitor differentiation and proliferation. Chiu R,  Ma T, Smith RL, Goodman SB.  J Orthop Res.  2007; 25 (4): 450-7
• Effects of a p38 MAP kinase inhibitor on bone ingrowth and tissue differentiation in rabbit chambers. Goodman SB,  Ma T, Spanogle J, Chiu R, Miyanishi K, Oh K, Plouhar P, Wadsworth S, Smith RL.  J Biomed Mater Res A.  2007; 81 (2): 310-6
• Modulation of allograft incorporation by continuous infusion of growth factors over a prolonged duration in vivo. Ma T,  Gutnick J, Salazar B, Larsen MD, Suenaga E, Zilber S, Huang Z, Huddleston J, Smith RL, Goodman S.  Bone.  2007; 41 (3): 386-92
• Effects of orthopaedic wear particles on osteoprogenitor cells. Goodman SB,  Ma T, Chiu R, Ramachandran R, Smith RL.  Biomaterials.  2006; 27 (36): 6096-101
• Effects of local infusion of OP-1 on particle-induced and NSAID-induced inhibition of bone ingrowth in vivo. Ma T,  Nelson ER, Mawatari T, Oh KJ, Larsen DM, Smith RL, Goodman SB.  J Biomed Mater Res A.  2006; 79 (3): 740-6
• Effects of hydrostatic pressure and transforming growth factor-beta 3 on adult human mesenchymal stem cell chondrogenesis in vitro. Miyanishi K,  Trindade MC, Lindsey DP, Beaupré GS, Carter DR, Goodman SB, Schurman DJ, Smith RL.  Tissue Eng.  2006; 12 (6): 1419-28
• Polymethylmethacrylate particles inhibit osteoblastic differentiation of bone marrow osteoprogenitor cells. Chiu R,  Ma T, Smith RL, Goodman SB.  J Biomed Mater Res A.  2006; 77 (4): 850-6
• Comparison of VEGF-producing cells in periprosthetic osteolysis. Spanogle JP,  Miyanishi K, Ma T, Epstein NJ, Smith RL, Goodman SB.  Biomaterials.  2006; 27 (21): 3882-7
• Dose- and time-dependent effects of cyclic hydrostatic pressure on transforming growth factor-beta3-induced chondrogenesis by adult human mesenchymal stem cells in vitro. Miyanishi K,  Trindade MC, Lindsey DP, Beaupré GS, Carter DR, Goodman SB, Schurman DJ, Smith RL.  Tissue Eng.  2006; 12 (8): 2253-62
• The effects of titanium and polymethylmethacrylate particles on osteoblast phenotypic stability. Ramachandran R,  Goodman SB, Smith RL.  J Biomed Mater Res A.  2006; 77 (3): 512-7
• UHMWPE wear debris upregulates mononuclear cell proinflammatory gene expression in a novel murine model of intramedullary particle disease. Epstein NJ,  Bragg WE, Ma T, Spanogle J, Smith RL, Goodman SB.  Acta Orthop.  2005; 76 (3): 412-20
• Pharmacologic modulation of periprosthetic osteolysis. Goodman SB,  Trindade M, Ma T, Genovese M, Smith RL.  Clin Orthop Relat Res.  2005; (430): 39-45
• Temporal effects of a COX-2-selective NSAID on bone ingrowth. Goodman SB,  Ma T, Mitsunaga L, Miyanishi K, Genovese MC, Smith RL.  J Biomed Mater Res A.  2005; 72 (3): 279-87
• Interleukin-1 modulates periprosthetic tissue formation in an intramedullary model of particle-induced inflammation. Epstein NJ,  Warme BA, Spanogle J, Ma T, Bragg B, Smith RL, Goodman SB.  J Orthop Res.  2005; 23 (3): 501-10
• Microarray analysis of mechanical shear effects on flexor tendon cells. Fong KD,  Trindade MC, Wang Z, Nacamuli RP, Pham H, Fang TD, Song HM, Smith RL, Longaker MT, Chang J.  Plast Reconstr Surg.  2005; 116 (5): 1393-404; discussion 1405-6
• Proinflammatory mediator expression in a novel murine model of titanium-particle-induced intramedullary inflammation. Warme BA,  Epstein NJ, Trindade MC, Miyanishi K, Ma T, Saket RR, Regula D, Goodman SB, Smith RL.  J Biomed Mater Res B Appl Biomater.  2004; 71 (2): 360-6
• Intermittent hydrostatic pressure inhibits matrix metalloproteinase and pro-inflammatory mediator release from human osteoarthritic chondrocytes in vitro. Trindade MC,  Shida J, Ikenoue T, Lee MS, Lin EY, Yaszay B, Yerby S, Goodman SB, Schurman DJ, Smith RL.  Osteoarthritis Cartilage.  2004; 12 (9): 729-35
• Human interleukin-1-induced murine osteoclastogenesis is dependent on RANKL, but independent of TNF-alpha. Ma T,  Miyanishi K, Suen A, Epstein NJ, Tomita T, Smith RL, Goodman SB.  Cytokine.  2004; 26 (3): 138-44
• A framework for the in vivo pathomechanics of osteoarthritis at the knee. Andriacchi TP,  Mündermann A, Smith RL, Alexander EJ, Dyrby CO, Koo S.  Ann Biomed Eng.  2004; 32 (3): 447-57
• Effects of interleukin-10 on titanium particle-induced macrophage transcription factor activation and cytokine expression in vitro. Wong N,  Trindade MC, Patel R, Yaszay B, Goodman SB, Smith RL.  J Biomed Mater Res A.  2004; 69 (1): 40-6
• Pressure and shear differentially alter human articular chondrocyte metabolism: a review. Smith RL,  Carter DR, Schurman DJ.  Clin Orthop Relat Res.  2004; (427 Suppl): S89-95
• The mechanobiology of articular cartilage development and degeneration. Carter DR,  Beaupré GS, Wong M, Smith RL, Andriacchi TP, Schurman DJ.  Clin Orthop Relat Res.  2004; (427 Suppl): S69-77
• Osteoarthritis: current treatment and future prospects for surgical, medical, and biologic intervention. Schurman DJ,  Smith RL.  Clin Orthop Relat Res.  2004; (427 Suppl): S183-9
• Regulation of nitric oxide and bcl-2 expression by shear stress in human osteoarthritic chondrocytes in vitro. Lee MS,  Trindade MC, Ikenoue T, Goodman SB, Schurman DJ, Smith RL.  J Cell Biochem.  2003; 90 (1): 80-6
• Periprosthetic osteolysis: induction of vascular endothelial growth factor from human monocyte/macrophages by orthopaedic biomaterial particles. Miyanishi K,  Trindade MC, Ma T, Goodman SB, Schurman DJ, Smith RL.  J Bone Miner Res.  2003; 18 (9): 1573-83
• Interleukin 1 receptor antagonist inhibits localized bone formation in vivo. Ma T,  Miyanishi K, Trindade MC, Genovese M, Regula D, Smith RL, Goodman SB.  J Rheumatol.  2003; 30 (12): 2547-52
• Expression of nitric oxide, peroxynitrite, and apoptosis in loose total hip replacements. Puskas BL,  Menke NE, Huie P, Song Y, Ecklund K, Trindade MC, Smith RL, Goodman SB.  J Biomed Mater Res A.  2003; 66 (3): 541-9
• Local infusion of FGF-2 enhances bone ingrowth in rabbit chambers in the presence of polyethylene particles. Goodman SB,  Song Y, Yoo JY, Fox N, Trindade MC, Kajiyama G, Ma T, Regula D, Brown J, Smith RL.  J Biomed Mater Res A.  2003; 65 (4): 454-61
• Human serum opsonization of orthopedic biomaterial particles: protein-binding and monocyte/macrophage activation in vitro. Sun DH,  Trindade MC, Nakashima Y, Maloney WJ, Goodman SB, Schurman DJ, Smith RL.  J Biomed Mater Res A.  2003; 65 (2): 290-8
• Modulation of bone ingrowth and tissue differentiation by local infusion of interleukin-10 in the presence of ultra-high molecular weight polyethylene (UHMWPE) wear particles. Goodman S,  Trindade M, Ma T, Lee M, Wang N, Ikenou T, Matsuura I, Miyanishi K, Fox N, Regula D, Genovese M, Klein J, Bloch D, Smith RL.  J Biomed Mater Res A.  2003; 65 (1): 43-50
• Intermittent hydrostatic pressure inhibits shear stress-induced nitric oxide release in human osteoarthritic chondrocytes in vitro. Lee MS,  Trindade MC, Ikenoue T, Schurman DJ, Goodman SB, Smith RL.  J Rheumatol.  2003; 30 (2): 326-8
• The role of the TH1 and TH2 immune responses in loosening and osteolysis of cemented total hip replacements. Arora A,  Song Y, Chun L, Huie P, Trindade M, Smith RL, Goodman S.  J Biomed Mater Res A.  2003; 64 (4): 693-7
• COX-2 selective NSAID decreases bone ingrowth in vivo. Goodman S,  Ma T, Trindade M, Ikenoue T, Matsuura I, Wong N, Fox N, Genovese M, Regula D, Smith RL.  J Orthop Res.  2002; 20 (6): 1164-9
• Interleukin-10 inhibits polymethylmethacrylate particle induced interleukin-6 and tumor necrosis factor-alpha release by human monocyte/macrophages in vitro. Trindade MC,  Lind M, Nakashima Y, Sun D, Goodman SB, Schurman DJ, Smith RL.  Biomaterials.  2001; 22 (15): 2067-73
• Fibroblast expression of C-C chemokines in response to orthopaedic biomaterial particle challenge in vitro. Yaszay B,  Trindade MC, Lind M, Goodman SB, Smith RL.  J Orthop Res.  2001; 19 (5): 970-6
• In vitro reaction to orthopaedic biomaterials by macrophages and lymphocytes isolated from patients undergoing revision surgery. Trindade MC,  Lind M, Sun D, Schurman DJ, Goodman SB, Smith RL.  Biomaterials.  2001; 22 (3): 253-9
• Effects of local infusion of TGFbeta on bone ingrowth in rabbit chambers. Goodman S,  Song Y, Chun L, Aspenberg P, Plouhar P, Glancy T, Regula D, Smith RL.  J Biomed Mater Res.  2000; 53 (5): 475-9
• G-protein activity requirement for polymethylmethacrylate and titanium particle-induced fibroblast interleukin-6 and monocyte chemoattractant protein-1 release in vitro. Trindade MC,  Schurman DJ, Maloney WJ, Goodman SB, Smith RL.  J Biomed Mater Res.  2000; 51 (3): 360-8
• Induction of interleukin-6 release in human osteoblast-like cells exposed to titanium particles in vitro. Shida J,  Trindade MC, Goodman SB, Schurman DJ, Smith RL.  Calcif Tissue Int.  2000; 67 (2): 151-5
• Interleukin-4 inhibits granulocyte-macrophage colony-stimulating factor, interleukin-6, and tumor necrosis factor-alpha expression by human monocytes in response to polymethylmethacrylate particle challenge in vitro. Trindade MC,  Nakashima Y, Lind M, Sun DH, Goodman SB, Maloney WJ, Schurman DJ, Smith RL.  J Orthop Res.  1999; 17 (6): 797-802
• Degradative enzymes in osteoarthritis. Smith RL,  Front Biosci.  1999; 4 D704-12
• Proinflammatory mediator release in response to particle challenge: studies using the bone harvest chamber. Trindade MC,  Song Y, Aspenberg P, Smith RL, Goodman SB.  J Biomed Mater Res.  1999; 48 (4): 434-9
• Interferon-gamma exacerbates polymethylmethacrylate particle-induced interleukin-6 release by human monocyte/macrophages in vitro. Trindade MC,  Lind M, Goodman SB, Maloney WJ, Schurman DJ, Smith RL.  J Biomed Mater Res.  1999; 47 (1): 1-7
• Signaling pathways for tumor necrosis factor-alpha and interleukin-6 expression in human macrophages exposed to titanium-alloy particulate debris in vitro. Nakashima Y,  Sun DH, Trindade MC, Maloney WJ, Goodman SB, Schurman DJ, Smith RL.  J Bone Joint Surg Am.  1999; 81 (5): 603-15
• Induction of macrophage C-C chemokine expression by titanium alloy and bone cement particles. Nakashima Y,  Sun DH, Trindade MC, Chun LE, Song Y, Goodman SB, Schurman DJ, Maloney WJ, Smith RL.  J Bone Joint Surg Br.  1999; 81 (1): 155-62
• Joint infection. Schurman DJ,  Smith RL.  Acta Orthop Scand Suppl.  1998; 281 14-6
• Effects of particulate debris on macrophage-dependent fibroblast stimulation in coculture. Lind M,  Trindade MC, Yaszay B, Goodman SB, Smith RL.  J Bone Joint Surg Br.  1998; 80 (5): 924-30
• Induction of matrix metalloproteinase expression in human macrophages by orthopaedic particulate debris in vitro. Nakashima Y,  Sun DH, Maloney WJ, Goodman SB, Schurman DJ, Smith RL.  J Bone Joint Surg Br.  1998; 80 (4): 694-700
• Effects of serum protein opsonization on cytokine release by titanium-alloy particles. Maloney WJ,  Sun DH, Nakashima Y, James R, Smith RL.  J Biomed Mater Res.  1998; 41 (3): 371-6
• In vitro, in vivo, and tissue retrieval studies on particulate debris. Goodman SB,  Lind M, Song Y, Smith RL.  Clin Orthop Relat Res.  1998; (352): 25-34
• Effects of polyethylene particles on tissue surrounding knee arthroplasties in rabbits. Sacomen D,  Smith RL, Song Y, Fornasier V, Goodman SB.  J Biomed Mater Res.  1998; 43 (2): 123-30
• Osteoarthritis: differential expression of matrix metalloproteinase-9 mRNA in nonfibrillated and fibrillated cartilage. Tsuchiya K,  Maloney WJ, Vu T, Hoffman AR, Huie P, Sibley R, Schurman DJ, Smith RL.  J Orthop Res.  1997; 15 (1): 94-100
• Stabilized analogs of thymopentin. 3. Evaluation of ketomethylene pseudopeptides for antiarthritic properties. Smith RL,  Dousman L, Waud WR, DeGraw JI.  J Med Chem.  1997; 40 (15): 2407-11
• Staphylococcal septic arthritis: antibiotic and nonsteroidal anti-inflammatory drug treatment in a rabbit model. Smith RL,  Kajiyama G, Schurman DJ.  J Orthop Res.  1997; 15 (6): 919-26
• Nitric oxide and G proteins mediate the response of bovine articular chondrocytes to fluid-induced shear. Das P,  Schurman DJ, Smith RL.  J Orthop Res.  1997; 15 (1): 87-93
• RT-PCR analysis of MMP-9 expression in human articular cartilage chondrocytes and synovial fluid cells. Tsuchiya K,  Maloney WJ, Vu T, Hoffman AR, Schurman DJ, Smith RL.  Biotech Histochem.  1996; 71 (4): 208-13
• Osteoblast adhesion to orthopaedic implant alloys: effects of cell adhesion molecules and diamond-like carbon coating. Kornu R,  Maloney WJ, Kelly MA, Smith RL.  J Orthop Res.  1996; 14 (6): 871-7
• Anti-lipid A antibodies in childhood arthritis: methods of immobilization affect quantitation and crossreactivity measured by ELISA. Miller JJ,  Zhu S, Smith RL.  J Rheumatol.  1996; 23 (12): 2125-31
• In vitro activation of human fibroblasts by retrieved titanium alloy wear debris. Manlapaz M,  Maloney WJ, Smith RL.  J Orthop Res.  1996; 14 (3): 465-72
• Effect of size, concentration, surface area, and volume of polymethylmethacrylate particles on human macrophages in vitro. González O,  Smith RL, Goodman SB.  J Biomed Mater Res.  1996; 30 (4): 463-73
• Chondrocytes from osteoarthritic cartilage have increased expression of insulin-like growth factor I (IGF-I) and IGF-binding protein-3 (IGFBP-3) and -5, but not IGF-II or IGFBP-4. Olney RC,  Tsuchiya K, Wilson DM, Mohtai M, Maloney WJ, Schurman DJ, Smith RL.  J Clin Endocrinol Metab.  1996; 81 (3): 1096-103
• Human macrophage response to retrieved titanium alloy particles in vitro. Maloney WJ,  James RE, Smith RL.  Clin Orthop Relat Res.  1996; (322): 268-78
• In vitro stimulation of articular chondrocyte mRNA and extracellular matrix synthesis by hydrostatic pressure. Smith RL,  Rusk SF, Ellison BE, Wessells P, Tsuchiya K, Carter DR, Caler WE, Sandell LJ, Schurman DJ.  J Orthop Res.  1996; 14 (1): 53-60
• Isolation and characterization of wear particles generated in patients who have had failure of a hip arthroplasty without cement. Maloney WJ,  Smith RL, Schmalzried TP, Chiba J, Huene D, Rubash H.  J Bone Joint Surg Am.  1995; 77 (9): 1301-10
• Nonsteroidal antiinflammatory drugs: effects on normal and interleukin 1 treated human articular chondrocyte metabolism in vitro. Smith RL,  Kajiyama G, Lane NE.  J Rheumatol.  1995; 22 (6): 1130-7
• Interleukin-1 and tumor necrosis factor-alpha increase insulin-like growth factor-binding protein-3 (IGFBP-3) production and IGFBP-3 protease activity in human articular chondrocytes. Olney RC,  Wilson DM, Mohtai M, Fielder PJ, Smith RL.  J Endocrinol.  1995; 146 (2): 279-86
• Lysosomal enzyme production at the interface surrounding loose and well-fixed cemented tibial hemiarthroplasties in the rabbit knee. Goodman SB,  Kang T, Smith RL.  J Invest Surg.  1993 Sep-Oct; 6 (5): 413-8
• Expression of 92-kD type IV collagenase/gelatinase (gelatinase B) in osteoarthritic cartilage and its induction in normal human articular cartilage by interleukin 1. Mohtai M,  Smith RL, Schurman DJ, Tsuji Y, Torti FM, Hutchinson NI, Stetler-Stevenson WG, Goldberg GI.  J Clin Invest.  1993; 92 (1): 179-85
• Production and hormonal regulation of insulin-like growth factor binding proteins in bovine chondrocytes. Olney RC,  Smith RL, Kee Y, Wilson DM.  Endocrinology.  1993; 133 (2): 563-70
• The effects of bone cement powder on human adherent monocytes/macrophages in vitro. Davis RG,  Goodman SB, Smith RL, Lerman JA, Williams RJ.  J Biomed Mater Res.  1993; 27 (8): 1039-46
• Fibroblast response to metallic debris in vitro. Enzyme induction cell proliferation, and toxicity. Maloney WJ,  Smith RL, Castro F, Schurman DJ.  J Bone Joint Surg Am.  1993; 75 (6): 835-44
• Inhibition of interleukin 1 induced chondrocyte protease activity by a corticosteroid and a nonsteroidal antiinflammatory drug. Lane NE,  Williams RJ, Schurman DJ, Smith RL.  J Rheumatol.  1992; 19 (1): 135-9
• Rabbit knee immobilization: bone remodeling precedes cartilage degradation. Smith RL,  Thomas KD, Schurman DJ, Carter DR, Wong M, van der Meulen MC.  J Orthop Res.  1992; 10 (1): 88-95
• Mechanical overload of a single compartment induces early degenerative changes in the rabbit knee: a preliminary study. Goodman SB,  Lee J, Smith RL, Csongradi JC, Fornasier VL.  J Invest Surg.  1991; 4 (2): 161-70
• Purified staphylococcal culture medium stimulates neutral metalloprotease secretion from human articular cartilage. Williams RJ,  Smith RL, Schurman DJ.  J Orthop Res.  1991; 9 (2): 258-65
• Septic arthritis. Staphylococcal induction of chondrocyte proteolytic activity. Williams RJ,  Smith RL, Schurman DJ.  Arthritis Rheum.  1990; 33 (4): 533-41
• Quantitation and relative distribution of extracellular matrix in Staphylococcus epidermidis biofilm. Van Pett K,  Schurman DJ, Smith RL.  J Orthop Res.  1990; 8 (3): 321-7
• Glucosaminidase, galactosaminidase, and glucuronidase in the growth plate. Gamble JG,  Haimson R, Smith RL.  J Orthop Res.  1990; 8 (5): 764-8
• Soluble mediators of articular cartilage degradation in juvenile rheumatoid arthritis. Smith RL,  Clin Orthop Relat Res.  1990; (259): 31-7
• Stimulation of adult chondrocyte metabolism by a thyroid-derived factor. Jones DG,  Smith RL.  J Orthop Res.  1990; 8 (2): 227-33
• Induction of articular cartilage degradation by recombinant interleukin 1 alpha and 1 beta. Smith RL,  Allison AC, Schurman DJ.  Connect Tissue Res.  1989; 18 (4): 307-16
• Growth hormone stimulates insulin-like growth factor I actions on adult articular chondrocytes. Smith RL,  Palathumpat MV, Ku CW, Hintz RL.  J Orthop Res.  1989; 7 (2): 198-207
• Quantitation of glycocalyx production in coagulase-negative Staphylococcus. Tsai CL,  Schurman DJ, Smith RL.  J Orthop Res.  1988; 6 (5): 666-70
• Time-varying magnetic fields: effects of orientation on chondrocyte proliferation. Elliott JP,  Smith RL, Block CA.  J Orthop Res.  1988; 6 (2): 259-64
• Biochemistry of fusion mass consolidation in the sheep spine. Slater R,  Nagel D, Smith RL.  J Orthop Res.  1988; 6 (1): 138-44
• The effect of antibiotics on the destruction of cartilage in experimental infectious arthritis. Smith RL,  Schurman DJ, Kajiyama G, Mell M, Gilkerson E.  J Bone Joint Surg Am.  1987; 69 (7): 1063-8
• Surgical approach to the management of septic arthritis. Schurman DJ,  Smith RL.  Orthop Rev.  1987; 16 (4): 241-5