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Key Documents

Curriculum Vitae available Online

Allen Cooper

Professor, Medicine - Gastroenterology & Hepatology

Contact Information

Clinical Offices

Hepatology Clinic 300 Pasteur Dr A160 MC 5303 Stanford, CA 94305
Telephone Work (650) 723-6961 Fax (650) 725-8418

Liver Transplant Clinic 300 Pasteur Dr A160 MC 5309 Stanford, CA 94305-2200
Telephone Work (650) 723-6961 Fax (650) 725-8418
Academic Offices

Personal Information
Email adc@stanford.edu
Not for medical emergencies or patient use

Clinical Focus

Liver Transplantation
Gastroenterology

Professional Education

UCSF Medical Center (1972) CA
UCSF Medical Center (1971) CA
UCSF Medical Center (1970) CA
Boston City Hospital (1969) MA
Boston City Hospital (1968) MA
State University of New York (1967) NY

Research Interests

The liver is the central organ in the metabolism of cholesterol and other fats. Previously my basci research laboratory studied the hepatic maetaoblism of these substances in animal and cellular models. Currently my major focus is on clinical care of patients with liver disease and I am engaged in studies of the role of NAFLD (non-alcoholic liver disease) in patients with hepatits C and in post liver transplant patients.

Publications

Effectiveness of a screening program for hepatitis C. Cheung RC, Cunningham BA, Cooper AD. Dig Dis Sci. 2006; 51 (5): 976-81
LDL and cAMP cooperate to regulate the functional expression of the LRP in rat ovarian granulosa cells. Azhar S, Medicherla S, Shen WJ, Fujioka Y, Fong LG, Reaven E, Cooper AD. J Lipid Res. 2006; 47 (11): 2538-50
An apolipoprotein(a) peptide delays chylomicron remnant clearance and increases plasma remnant lipoproteins and atherosclerosis in vivo. Devlin CM, Lee SJ, Kuriakose G, Spencer C, Becker L, Grosskopf I, Ko C, Huang LS, Koschinsky ML, Cooper AD, Tabas I. Arterioscler Thromb Vasc Biol. 2005; 25 (8): 1704-10
Removal of chylomicron remnants in transgenic mice overexpressing normal and membrane-anchored hepatic lipase. Lee SJ, Kadambi S, Yu KC, David C, Azhar S, Cooper AD, Choi SY. J Lipid Res. 2005; 46 (1): 27-35
Apolipoprotein A-V deficiency results in marked hypertriglyceridemia attributable to decreased lipolysis of triglyceride-rich lipoproteins and removal of their remnants. Grosskopf I, Baroukh N, Lee SJ, Kamari Y, Harats D, Rubin EM, Pennacchio LA, Cooper AD. Arterioscler Thromb Vasc Biol. 2005; 25 (12): 2573-9
Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient mice. Ishida T, Choi SY, Kundu RK, Spin J, Yamashita T, Hirata K, Kojima Y, Yokoyama M, Cooper AD, Quertermous T. J Biol Chem. 2004; 279 (43): 45085-92
Endothelial lipase is synthesized by hepatic and aorta endothelial cells and its expression is altered in apoE-deficient mice. Yu KC, David C, Kadambi S, Stahl A, Hirata K, Ishida T, Quertermous T, Cooper AD, Choi SY. J Lipid Res. 2004; 45 (9): 1614-23
Association of hepatic lipase with proteoglycans stimulates the production of proteoglycans in vivo and in vitro. Lee SJ, Kadambi S, David C, Cooper AD, Choi SY. J Lipid Res. 2004; 45 (7): 1266-71
Chylomicron remnant uptake in the livers of mice expressing human apolipoproteins E3, E2 (Arg158-->Cys), and E3-Leiden. Lee SJ, Grosskopf I, Choi SY, Cooper AD. J Lipid Res. 2004; 45 (12): 2199-210
Endothelial lipase is a major determinant of HDL level. Ishida T, Choi S, Kundu RK, Hirata K, Rubin EM, Cooper AD, Quertermous T. J Clin Invest. 2003; 111 (3): 347-55
Regulation of intestine-specific spatiotemporal expression by the rat lactase promoter. Lee SY, Wang Z, Lin CK, Contag CH, Olds LC, Cooper AD, Sibley E. J Biol Chem. 2002; 277 (15): 13099-105
Endothelial lipase: a new lipase on the block. Choi SY, Hirata K, Ishida T, Quertermous T, Cooper AD. J Lipid Res. 2002; 43 (11): 1763-9
Mice expressing the human CYP7A1 gene in the mouse CYP7A1 knock-out background lack induction of CYP7A1 expression by cholesterol feeding and have increased hypercholesterolemia when fed a high fat diet. Chen JY, Levy-Wilson B, Goodart S, Cooper AD. J Biol Chem. 2002; 277 (45): 42588-95
Postprandial lipoproteins and atherosclerosis. Yu KC, Cooper AD. Front Biosci. 2001; 6 D332-54
LDL receptor-related protein mediates cell-surface clustering and hepatic sequestration of chylomicron remnants in LDLR-deficient mice. Yu KC, Chen W, Cooper AD. J Clin Invest. 2001; 107 (11): 1387-94
Rapid initial removal of chylomicron remnants by the mouse liver does not require hepatically localized apolipoprotein E. Yu KC, Jiang Y, Chen W, Cooper AD. J Lipid Res. 2000; 41 (11): 1715-27
The nuclear matrix protein CDP represses hepatic transcription of the human cholesterol-7alpha hydroxylase gene. Antes TJ, Chen J, Cooper AD, Levy-Wilson B. J Biol Chem. 2000; 275 (34): 26649-60
Cloning of a unique lipase from endothelial cells extends the lipase gene family. Hirata K, Dichek HL, Cioffi JA, Choi SY, Leeper NJ, Quintana L, Kronmal GS, Cooper AD, Quertermous T. J Biol Chem. 1999; 274 (20): 14170-5
Expression of the human cholesterol 7alpha-hydroxylase gene in transgenic mice. Goodart SA, Huynh C, Chen W, Cooper AD, Levy-Wilson B. Biochem Biophys Res Commun. 1999; 266 (2): 454-9
Evaluation of the components of the chylomicron remnant removal mechanism by use of the isolated perfused mouse liver. Yu KC, Jiang Y, Chen W, Cooper AD. J Lipid Res. 1999; 40 (10): 1899-910
Hepatocyte nuclear factor 1 binds to and transactivates the human but not the rat CYP7A1 promoter. Chen J, Cooper AD, Levy-Wilson B. Biochem Biophys Res Commun. 1999; 260 (3): 829-34
Role of the enterohepatic circulation of bile salts in lipoprotein metabolism. Cooper AD, Gastroenterol Clin North Am. 1999; 28 (1): 211-29, viii
Interaction between ApoB and hepatic lipase mediates the uptake of ApoB-containing lipoproteins. Choi SY, Goldberg IJ, Curtiss LK, Cooper AD. J Biol Chem. 1998; 273 (32): 20456-62
Accelerated lipoprotein uptake by transplantable hepatomas that express hepatic lipase. Donner C, Choi S, Komaromy M, Cooper AD. J Lipid Res. 1998; 39 (9): 1805-15
Multiple processes are involved in the uptake of chylomicron remnants by mouse peritoneal macrophages. Fujioka Y, Cooper AD, Fong LG. J Lipid Res. 1998; 39 (12): 2339-49
Bile salt biosynthesis: an alternate synthetic pathway joins the mainstream. Cooper AD, Gastroenterology. 1997; 113 (6): 2005-8
Hepatic uptake of chylomicron remnants. Cooper AD, J Lipid Res. 1997; 38 (11): 2173-92
Palo Alto Medical Foundation, Research Institute. Krupp MA, Cooper AD. Mol Med. 1997; 3 (10): 633-5
Reducing saturated fat intake is associated with increased levels of LDL receptors on mononuclear cells in healthy men and women. Mustad VA, Etherton TD, Cooper AD, Mastro AM, Pearson TA, Jonnalagadda SS, Kris-Etherton PM. J Lipid Res. 1997; 38 (3): 459-68
Characterization of hepatic-specific regulatory elements in the promoter region of the human cholesterol 7alpha-hydroxylase gene. Cooper AD, Chen J, Botelho-Yetkinler MJ, Cao Y, Taniguchi T, Levy-Wilson B. J Biol Chem. 1997; 272 (6): 3444-52
Chinese hamster ovary cells expressing a cell surface-anchored form of hepatic lipase. Characterization of low density lipoprotein and chylomicron remnant uptake and selective uptake of high density lipoprotein-cholesteryl ester. Komaromy M, Azhar S, Cooper AD. J Biol Chem. 1996; 271 (28): 16906-14
Relative roles of the LDL receptor, the LDL receptor-like protein, and hepatic lipase in chylomicron remnant removal by the liver. de Faria E, Fong LG, Komaromy M, Cooper AD. J Lipid Res. 1996; 37 (1): 197-209
A scavenger that really scavenges is better in the liver than in the artery. Cooper AD, Hepatology. 1996; 23 (4): 929-30
Activation of LDL receptor gene expression in HepG2 cells by hepatocyte growth factor. Pak YK, Kanuck MP, Berrios D, Briggs MR, Cooper AD, Ellsworth JL. J Lipid Res. 1996; 37 (5): 985-98
Dietary linoleic acid increases and palmitic acid decreases hepatic LDL receptor protein and mRNA abundance in young pigs. Mustad VA, Ellsworth JL, Cooper AD, Kris-Etherton PM, Etherton TD. J Lipid Res. 1996; 37 (11): 2310-23
Development of multi-residue methodology for the HPLC determination of veterinary drugs in animal tissues. Cooper AD, Creaser CS, Farrington WH, Tarbin JA, Shearer G. Food Addit Contam. 1995 Mar-Apr; 12 (2): 167-76
Hepatic lipoprotein metabolism: recent molecular insights. Cooper AD, Prog Liver Dis. 1995; 13 173-200
Location and regulation of low-density lipoprotein receptors in intestinal epithelium. Fong LG, Fujishima SE, Komaromy MC, Pak YK, Ellsworth JL, Cooper AD. Am J Physiol. 1995; 269 (1 Pt 1): G60-72
Low density lipoprotein receptors in rat adipose cells: subcellular localization and regulation by insulin. Kraemer FB, Sather SA, Park B, Sztalryd C, Natu V, May K, Nishimura H, Simpson I, Cooper AD, Cushman SW. J Lipid Res. 1994; 35 (10): 1760-72
Enhanced expression of granulosa cell low density lipoprotein receptor activity in response to in vitro culture conditions. Reaven E, Tsai L, Spicher M, Shilo L, Philip M, Cooper AD, Azhar S. J Cell Physiol. 1994; 161 (3): 449-62
Characteristics and regulation of bile salt synthesis and secretion by human hepatoma HepG2 cells. Cooper AD, Craig WY, Taniguchi T, Everson GT. Hepatology. 1994; 20 (6): 1522-31
Regulation of cholesterol 7 alpha-hydroxylase gene expression in Hep-G2 cells. Effect of serum, bile salts, and coordinate and noncoordinate regulation with other sterol-responsive genes. Taniguchi T, Chen J, Cooper AD. J Biol Chem. 1994; 269 (13): 10071-8
Acceleration of uptake of LDL but not chylomicrons or chylomicron remnants by cells that secrete apoE and hepatic lipase. Choi SY, Komaromy MC, Chen J, Fong LG, Cooper AD. J Lipid Res. 1994; 35 (5): 848-59
Pain assessment in accident and emergency. Cooper AD, Accid Emerg Nurs. 1994; 2 (2): 103-7
A comparison of the roles of the low density lipoprotein (LDL) receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor in chylomicron remnant removal in the mouse in vivo. Choi SY, Cooper AD. J Biol Chem. 1993; 268 (21): 15804-11
Early induction of LDL receptor gene during rat liver regeneration. Bocchetta M, Bruscalupi G, Castellano F, Trentalance A, Komaromy M, Fong LG, Cooper AD. J Cell Physiol. 1993; 156 (3): 601-9
Inhibition of debrisoquin clearance in perfused rat livers and inhibition of dextromethorphan metabolism in human liver microsomes by 4-hydroxydebrisoquin or other metabolites of debrisoquin. Jaruratanasirikul S, Cooper AD, Blaschke TF. Drug Metab Dispos. 1992 May-Jun; 20 (3): 379-82
Hepatic clearance of plasma chylomicron remnants. Cooper AD, Semin Liver Dis. 1992; 12 (4): 386-96
Effect of cutaneous permeability barrier disruption on HMG-CoA reductase, LDL receptor, and apolipoprotein E mRNA levels in the epidermis of hairless mice. Jackson SM, Wood LC, Lauer S, Taylor JM, Cooper AD, Elias PM, Feingold KR. J Lipid Res. 1992; 33 (9): 1307-14
Use of an anti-low density lipoprotein receptor antibody to quantify the role of the LDL receptor in the removal of chylomicron remnants in the mouse in vivo. Choi SY, Fong LG, Kirven MJ, Cooper AD. J Clin Invest. 1991; 88 (4): 1173-81
Metabolic basis of cholesterol gallstone disease. Cooper AD, Gastroenterol Clin North Am. 1991; 20 (1): 21-46
Evidence for sterol-independent regulation of low-density lipoprotein receptor activity in Hep-G2 cells. Ellsworth JL, Chandrasekaran C, Cooper AD. Biochem J. 1991; 279 ( Pt 1) 175-87
Inhibition of lipopolysaccharide-induced interleukin-1 beta mRNA expression in mouse macrophages by oxidized low density lipoprotein. Fong LG, Fong TA, Cooper AD. J Lipid Res. 1991; 32 (12): 1899-910
Inhibition of mouse macrophage degradation of acetyl-low density lipoprotein by interferon-gamma. Fong LG, Fong TA, Cooper AD. J Biol Chem. 1990; 265 (20): 11751-60
ELISA measurement of LDL receptors. May K, Kraemer FB, Chen J, Cooper AD. J Lipid Res. 1990; 31 (9): 1683-91
On-line recovery of trimeprazine enantiomers following chiral separation by reversed-phase high-performance liquid chromatography using a beta-cyclodextrin-containing mobile phase. Cooper AD, Jefferies TM. J Pharm Biomed Anal. 1990; 8 (8-12): 847-51
The effect of perfluorochemical artificial blood on lipoprotein metabolism in rats. Nagata Y, Mondon CE, Cooper AD. Metabolism. 1990; 39 (7): 682-9
Differences in the processing of chylomicron remnants and beta-VLDL by macrophages. Ellsworth JL, Fong LG, Kraemer FB, Cooper AD. J Lipid Res. 1990; 31 (8): 1399-411
Reduced binding and removal of chylomicron remnants by ethionine-induced premalignant liver. Barnard GF, Erickson SK, Nagata Y, Cooper AD. Hepatology. 1989; 9 (5): 731-9
Pathophysiology and treatment of gallstones. Cooper AD, Young HS. Med Clin North Am. 1989; 73 (4): 753-74
Mechanisms responsible for inhibition of vein-graft arteriosclerosis by fish oil. Sarris GE, Fann JI, Sokoloff MH, Smith DL, Loveday M, Kosek JC, Stephens RJ, Cooper AD, May K, Willis AL. Circulation. 1989; 80 (3 Pt 1): I109-23
Refractory ascites due to POEMS syndrome. Loeb JM, Hauger PH, Carney JD, Cooper AD. Gastroenterology. 1989; 96 (1): 247-9
Immunohistochemical localization of low density lipoprotein receptors in adrenal gland, liver, and intestine. Fong LG, Bonney E, Kosek JC, Cooper AD. J Clin Invest. 1989; 84 (3): 847-56
Regulation of cholesterol metabolism in a slow-growing hepatoma in vivo. Erickson SK, Cooper AD, Barnard GF, Havel CM, Watson JA, Feingold KR, Moser AH, Hughes-Fulford M, Siperstein MD. Biochim Biophys Acta. 1988; 960 (2): 131-8
Stimulation of LDL receptor activity in Hep-G2 cells by a serum factor(s). Ellsworth JL, Brown C, Cooper AD. J Cell Physiol. 1988; 135 (2): 213-23
Regulation of apoprotein synthesis and secretion in the human hepatoma Hep G2. The effect of exogenous lipoprotein. Craig WY, Nutik R, Cooper AD. J Biol Chem. 1988; 263 (27): 13880-90
Effects of chylomicron remnants and beta-VLDL on the class and composition of newly secreted lipoproteins by HepG2 cells. Craig WY, Cooper AD. J Lipid Res. 1988; 29 (3): 299-308
Inhibition of vein graft intimal thickening by eicosapentanoic acid: reduced thromboxane production without change in lipoprotein levels or low-density lipoprotein receptor density. Cahill PD, Sarris GE, Cooper AD, Wood PD, Kosek JC, Mitchell RS, Miller DC. J Vasc Surg. 1988; 7 (1): 108-18
Role of low density lipoprotein receptor-dependent and -independent sites in binding and uptake of chylomicron remnants in rat liver. Nagata Y, Chen J, Cooper AD. J Biol Chem. 1988; 263 (29): 15151-8
Regulation of rat hepatic cholesterol metabolism. Effects of lipoprotein composition on acyl coenzyme A:cholesterol acyltransferase in vivo and in the perfused liver and on hepatic cholesterol secretion. Van Zuiden PE, Cooper AD, Erickson SK. J Lipid Res. 1987; 28 (8): 930-40
Transport of beta-very low density lipoproteins and chylomicron remnants by macrophages is mediated by the low density lipoprotein receptor pathway. Ellsworth JL, Kraemer FB, Cooper AD. J Biol Chem. 1987; 262 (5): 2316-25
Characterization of the estrogen-induced lipoprotein receptor of rat liver. Cooper AD, Nutik R, Chen J. J Lipid Res. 1987; 28 (1): 59-68
The sequence of a sea urchin muscle actin gene suggests a gene conversion with a cytoskeletal actin gene. Crain WR, Boshar MF, Cooper AD, Durica DS, Nagy A, Steffen D. J Mol Evol. 1987; 25 (1): 37-45
Evidence that chylomicron remnants and beta-VLDL are transported by the same receptor pathway in J774 murine macrophage-derived cells. Ellsworth JL, Cooper AD, Kraemer FB. J Lipid Res. 1986; 27 (10): 1062-72
Regulation of lipoprotein receptors on rat hepatomas in vivo. Barnard GF, Erickson SK, Cooper AD. Biochim Biophys Acta. 1986; 879 (3): 301-12
Very low and low density lipoprotein synthesis and secretion by the human hepatoma cell line Hep-G2: effects of free fatty acid. Ellsworth JL, Erickson SK, Cooper AD. J Lipid Res. 1986; 27 (8): 858-74
Role of the liver in the degradation of lipoproteins. Cooper AD, Gastroenterology. 1985; 88 (1 Pt 1): 192-205
Regulation of rat biliary cholesterol secretion by agents that alter intrahepatic cholesterol metabolism. Evidence for a distinct biliary precursor pool. Stone BG, Erickson SK, Craig WY, Cooper AD. J Clin Invest. 1985; 76 (5): 1773-81
Chylomicron remnant and asialoglycoprotein metabolism are independent. Cooper AD, Coleman D. Lipids. 1985; 20 (10): 664-7
The indirect costs of sponsored research. Cooper AD, Clin Res. 1984; 32 (2): 99-105
Lipoprotein metabolism by rat hepatomas. Studies on the etiology of defective dietary feedback inhibition of cholesterol synthesis. Barnard GF, Erickson SK, Cooper AD. J Clin Invest. 1984; 74 (1): 173-84
Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and cholesterol synthesis and esterification during the first cell cycle of liver regeneration. Trentalance A, Leoni S, Mangiantini MT, Spagnuolo S, Feingold K, Hughes-Fulford M, Siperstein M, Cooper AD, Erickson SK. Biochim Biophys Acta. 1984; 794 (1): 142-51
Effect of removal of lipoproteins of different composition on hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and hepatic very low density lipoprotein secretion. Van Zuiden PE, Erickson SK, Cooper AD. J Lipid Res. 1983; 24 (4): 418-28
Regulation of rabbit intestinal acyl coenzyme A-cholesterol acyltransferase in vivo and in vitro. Field FJ, Cooper AD, Erickson SK. Gastroenterology. 1982; 83 (4): 873-80
Complete nucleotide sequence of a sea urchin actin gene. Cooper AD, Crain WR. Nucleic Acids Res. 1982; 10 (13): 4081-92
Comparison of binding and removal of remnants of triglyceride-rich lipoproteins of intestinal and hepatic origin by rat liver in vitro. Cooper AD, Shrewsbury MA, Erickson SK. Am J Physiol. 1982; 243 (5): G389-95
Lipid hapten containing membrane targets can trigger specific immunoglobulin E-dependent degranulation of rat basophil leukemia cells. Balakrishnan K, Hsu FJ, Cooper AD, McConnell HM. J Biol Chem. 1982; 257 (11): 6427-33
Lymphomas involving the gastrointestinal tract. Gray GM, Rosenberg SA, Cooper AD, Gregory PB, Stein DT, Herzenberg H. Gastroenterology. 1982; 82 (1): 143-52
Characterization of chylomicron remnant binding to rat liver membranes. Cooper AD, Erickson SK, Nutik R, Shrewsbury MA. J Lipid Res. 1982; 23 (1): 42-52
3-hydroxy-3-methylglutaryl coenzyme A reductase from rat intestine: subcellular localization and in vitro regulation. Field FJ, Erickson SK, Shrewsbury MA, Cooper AD. J Lipid Res. 1982; 23 (1): 105-13
Mobile haptens in liposomes stimulate serotonin release by rat basophil leukemia cells in the presence of specific immunoglobulin E. Cooper AD, Balakrishnan K, McConnell HM. J Biol Chem. 1981; 256 (18): 9379-81
Acyl-coenzyme A:cholesterol acyltransferase in human liver. In vitro detection and some characteristics of the enzyme. Erickson SK, Cooper AD. Metabolism. 1980; 29 (10): 991-6
Studies on the mechanisms of the rapid modulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in intact liver by mevalonolactone and 25-hydroxycholesterol. Erickson SK, Shrewsbury MA, Gould RG, Cooper AD. Biochim Biophys Acta. 1980; 620 (1): 70-9
Studies on the etiology of the hyperlipemia in rats fed an atherogenic diet. Kris-Etherton PM, Cooper AD. J Lipid Res. 1980; 21 (4): 435-42
High affinity binding of chylomicron remnants to rat liver plasma membranes. Carrella M, Cooper AD. Proc Natl Acad Sci U S A. 1979; 76 (1): 338-42
Rates of removal and degradation of chylomicron remnants by isolated perfused rat liver. Cooper AD, Yu PY. J Lipid Res. 1978; 19 (5): 635-43
Effects of 25-hydroxycholesterol on rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in vivo, in perfused liver, and in hepatocytes. Erickson SK, Matsui SM, Shrewsbury MA, Cooper AD, Gould RG. J Biol Chem. 1978; 253 (12): 4159-64
Regulation of cholesterol synthesis in cultured canine intestinal mucosa. Gebhard RL, Cooper AD. J Biol Chem. 1978; 253 (8): 2790-6
The metabolism of chylomicron remnants by isolated perfused rat liver. Cooper AD, Biochim Biophys Acta. 1977; 488 (3): 464-74
7-Ketocholesterol. Its effects on hepatic cholesterogenesis and its hepatic metabolism in vivo and in vitro. Erickson SK, Cooper AD, Matsui SM, Gould RG. J Biol Chem. 1977; 252 (15): 5186-93
The regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the isolated perfused rat liver. Cooper AD, J Clin Invest. 1976; 57 (6): 1461-70
Liver disease in nonparenteral drug abusers. Cooper AD, Niejadlik D, Huston K. JAMA. 1975; 233 (9): 964-6
Letter: Gastrointestinal manifestations of adverse drug reactions: clindamycin. DeFord JW, Daly JJ, Cooper AD, Molinaro JR. Am J Dig Dis. 1974; 19 (6): 581
Studies of hepatic cholesterol synthesis in experimental acute biliary obstruction. Cooper AD, Ockner RK. Gastroenterology. 1974; 66 (4): 586-95
Selective biliary obstruction: a model for the study of lipid metabolism in cholestasis. Cooper AD, Jones AL, Koldinger RE, Ockner RK. Gastroenterology. 1974; 66 (4): 574-85