Key Documents

Aaron Hsueh

Professor, Obstetrics & Gynecology
Member, Bio-X

Contact Information

Clinical Offices
Academic Offices

Personal Information
Email Aaron.Hsueh@stanford.edu

Postdoctoral Advisees

Yuan Cheng, Joonho Cho, Jing Li, Qing Yang, Ai Yata

Web Site Links

Hsueh Lab Home Page

Research Interests

We have been investigating the molecular and cellular mechanisms underlying the hormonal regulation of ovarian follicle growth and differentiation. By expressing recombinant FSH, LH and hCG and producing their mutants, we have designed long-acting agonists as well as deglycosylated antagonists of gonadotropins. We have also cloned human LH and FSH receptors and the expression of these proteins allows analysis of gonadotropin bioactivity in vitro. The extracellular ligand-binding domain of these receptors have been generated and found to be functional antagonists. Clinical syndromes of gain-of-function mutations for the LH receptor have been found in patients with familial male precocious puberty whereas loss-of-function mutations have been found to be the basis of Leydig cell hypoplasia. We are using bioinformatic tools and DNA microarray to analyze polypeptide hormones andtheir receptors in terms of ligand-receptor matching and paracrine interactions.

Publications

Paracrine regulation of the resumption of oocyte meiosis by endothelin-1. Kawamura K, Ye Y, Liang CG, Kawamura N, Gelpke MS, Rauch R, Tanaka T, Hsueh AJ. Dev Biol. 2009; 327 (1): 62-70
Autocrine regulation of early embryonic development by the artemin-GFRA3 (GDNF family receptor-alpha 3) signaling system in mice. Li J, Klein C, Liang C, Rauch R, Kawamura K, Hsueh AJ. FEBS Lett. 2009; 583 (15): 2479-85
Neuronostatin encoded by the somatostatin gene regulates neuronal, cardiovascular, and metabolic functions. Samson WK, Zhang JV, Avsian-Kretchmer O, Cui K, Yosten GL, Klein C, Lyu RM, Wang YX, Chen XQ, Yang J, Price CJ, Hoyda TD, Ferguson AV, Yuan XB, Chang JK, Hsueh AJ. J Biol Chem. 2008; 283 (46): 31949-59
Obestatin induction of early-response gene expression in gastrointestinal and adipose tissues and the mediatory role of G protein-coupled receptor, GPR39. Zhang JV, Jahr H, Luo CW, Klein C, Van Kolen K, Ver Donck L, De A, Baart E, Li J, Moechars D, Hsueh AJ. Mol Endocrinol. 2008; 22 (6): 1464-75
Gonadotropin stimulation of ovarian fractalkine expression and fractalkine augmentation of progesterone biosynthesis by luteinizing granulosa cells. Zhao P, De A, Hu Z, Li J, Mulders SM, Sollewijn Gelpke MD, Duan EK, Hsueh AJ. Endocrinology. 2008; 149 (6): 2782-9
Completion of Meiosis I of preovulatory oocytes and facilitation of preimplantation embryo development by glial cell line-derived neurotrophic factor. Kawamura K, Ye Y, Kawamura N, Jing L, Groenen P, Gelpke MS, Rauch R, Hsueh AJ, Tanaka T. Dev Biol. 2008; 315 (1): 189-202
Regulation of preimplantation embryo development by brain-derived neurotrophic factor. Kawamura K, Kawamura N, Fukuda J, Kumagai J, Hsueh AJ, Tanaka T. Dev Biol. 2007; 311 (1): 147-58
Matching receptome genes with their ligands for surveying paracrine/autocrine signaling systems. Ben-Shlomo I, Rauch R, Avsian-Kretchmer O, Hsueh AJ. Mol Endocrinol. 2007; 21 (8): 2009-14
Genomic analyses facilitate identification of receptors and signalling pathways for growth differentiation factor 9 and related orphan bone morphogenetic protein/growth differentiation factor ligands. Mazerbourg S, Hsueh AJ. Hum Reprod Update. 2006 Jul-Aug; 12 (4): 373-83
Genomic analyses of the evolution of LGR genes. Luo CW, Hsueh AJ. Chang Gung Med J. 2006 Jan-Feb; 29 (1): 2-8
Intraovarian tumor necrosis factor-related weak inducer of apoptosis/fibroblast growth factor-inducible-14 ligand-receptor system limits ovarian preovulatory follicles from excessive luteinization. De A, Park JI, Kawamura K, Chen R, Klein C, Rauch R, Mulders SM, Sollewijn Gelpke MD, Hsueh AJ. Mol Endocrinol. 2006; 20 (10): 2528-38
Ovarian brain-derived neurotrophic factor (BDNF) promotes the development of oocytes into preimplantation embryos. Kawamura K, Kawamura N, Mulders SM, Sollewijn Gelpke MD, Hsueh AJ. Proc Natl Acad Sci U S A. 2005; 102 (26): 9206-11
Hormonology: a genomic perspective on hormonal research. Hsueh AJ, Bouchard P, Ben-Shlomo I. J Endocrinol. 2005; 187 (3): 333-8
Identification of a stanniocalcin paralog, stanniocalcin-2, in fish and the paracrine actions of stanniocalcin-2 in the mammalian ovary. Luo CW, Pisarska MD, Hsueh AJ. Endocrinology. 2005; 146 (1): 469-76
Three's company: two or more unrelated receptors pair with the same ligand. Ben-Shlomo I, Hsueh AJ. Mol Endocrinol. 2005; 19 (5): 1097-109
Bursicon, the insect cuticle-hardening hormone, is a heterodimeric cystine knot protein that activates G protein-coupled receptor LGR2. Luo CW, Dewey EM, Sudo S, Ewer J, Hsu SY, Honegger HW, Hsueh AJ. Proc Natl Acad Sci U S A. 2005; 102 (8): 2820-5
Heterodimeric fly glycoprotein hormone-alpha2 (GPA2) and glycoprotein hormone-beta5 (GPB5) activate fly leucine-rich repeat-containing G protein-coupled receptor-1 (DLGR1) and stimulation of human thyrotropin receptors by chimeric fly GPA2 and human GPB5. Sudo S, Kuwabara Y, Park JI, Hsu SY, Hsueh AJ. Endocrinology. 2005; 146 (8): 3596-604
Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses. Mazerbourg S, Sangkuhl K, Luo CW, Sudo S, Klein C, Hsueh AJ. J Biol Chem. 2005; 280 (37): 32122-32
Obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake. Zhang JV, Ren PG, Avsian-Kretchmer O, Luo CW, Rauch R, Klein C, Hsueh AJ. Science. 2005; 310 (5750): 996-9
Relaxin research in the postgenomic era. Kawamura K, Sudo S, Kumagai J, Pisarska M, Hsu SY, Bathgate R, Wade J, Hsueh AJ. Ann N Y Acad Sci. 2005; 1041 1-7
Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality. Mazerbourg S, Bouley DM, Sudo S, Klein CA, Zhang JV, Kawamura K, Goodrich LV, Rayburn H, Tessier-Lavigne M, Hsueh AJ. Mol Endocrinol. 2004; 18 (9): 2241-54
Paracrine regulation of ovarian granulosa cell differentiation by stanniocalcin (STC) 1: mediation through specific STC1 receptors. Luo CW, Kawamura K, Klein C, Hsueh AJ. Mol Endocrinol. 2004; 18 (8): 2085-96
Paracrine regulation of mammalian oocyte maturation and male germ cell survival. Kawamura K, Kumagai J, Sudo S, Chun SY, Pisarska M, Morita H, Toppari J, Fu P, Wade JD, Bathgate RA, Hsueh AJ. Proc Natl Acad Sci U S A. 2004; 101 (19): 7323-8
Forkhead l2 is expressed in the ovary and represses the promoter activity of the steroidogenic acute regulatory gene. Pisarska MD, Bae J, Klein C, Hsueh AJ. Endocrinology. 2004; 145 (7): 3424-33
Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulation. Sudo S, Avsian-Kretchmer O, Wang LS, Hsueh AJ. J Biol Chem. 2004; 279 (22): 23134-41
Growth differentiation factor-9 signaling is mediated by the type I receptor, activin receptor-like kinase 5. Mazerbourg S, Klein C, Roh J, Kaivo-Oja N, Mottershead DG, Korchynskyi O, Ritvos O, Hsueh AJ. Mol Endocrinol. 2004; 18 (3): 653-65
Comparative genomic analysis of the eight-membered ring cystine knot-containing bone morphogenetic protein antagonists. Avsian-Kretchmer O, Hsueh AJ. Mol Endocrinol. 2004; 18 (1): 1-12
Neonatal lethality of LGR5 null mice is associated with ankyloglossia and gastrointestinal distension. Morita H, Mazerbourg S, Bouley DM, Luo CW, Kawamura K, Kuwabara Y, Baribault H, Tian H, Hsueh AJ. Mol Cell Biol. 2004; 24 (22): 9736-43
Lack of LGR8 gene mutation in Finnish patients with a family history of cryptorchidism. Roh J, Virtanen H, Kumagai J, Sudo S, Kaleva M, Toppari J, Hsueh AJ. Reprod Biomed Online. 2003 Oct-Nov; 7 (4): 400-6
Signaling receptome: a genomic and evolutionary perspective of plasma membrane receptors involved in signal transduction. Ben-Shlomo I, Yu Hsu S, Rauch R, Kowalski HW, Hsueh AJ. Sci STKE. 2003; 2003 (187): RE9
Activation of the luteinizing hormone receptor in the extracellular domain. Nakabayashi K, Kudo M, Hsueh AJ, Maruo T. Mol Cell Endocrinol. 2003; 202 (1-2): 139-44
Relaxin signaling in reproductive tissues. Hsu SY, Nakabayashi K, Nishi S, Kumagai J, Kudo M, Bathgate RA, Sherwood OD, Hsueh AJ. Mol Cell Endocrinol. 2003; 202 (1-2): 165-70
Tankyrase 1 interacts with Mcl-1 proteins and inhibits their regulation of apoptosis. Bae J, Donigian JR, Hsueh AJ. J Biol Chem. 2003; 278 (7): 5195-204
Growth differentiation factor-9 stimulates inhibin production and activates Smad2 in cultured rat granulosa cells. Roh JS, Bondestam J, Mazerbourg S, Kaivo-Oja N, Groome N, Ritvos O, Hsueh AJ. Endocrinology. 2003; 144 (1): 172-8
H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2. Sudo S, Kumagai J, Nishi S, Layfield S, Ferraro T, Bathgate RA, Hsueh AJ. J Biol Chem. 2003; 278 (10): 7855-62
Growth differentiation factor-9 signaling in the ovary. Mazerbourg S, Hsueh AJ. Mol Cell Endocrinol. 2003; 202 (1-2): 31-6
Bone morphogenetic protein receptor type II is a receptor for growth differentiation factor-9. Vitt UA, Mazerbourg S, Klein C, Hsueh AJ. Biol Reprod. 2002; 67 (2): 473-80
INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent. Kumagai J, Hsu SY, Matsumi H, Roh JS, Fu P, Wade JD, Bathgate RA, Hsueh AJ. J Biol Chem. 2002; 277 (35): 31283-6
Hormonal genomics. Leo CP, Hsu SY, Hsueh AJ. Endocr Rev. 2002; 23 (3): 369-81
The ectodomain of the luteinizing hormone receptor interacts with exoloop 2 to constrain the transmembrane region: studies using chimeric human and fly receptors. Nishi S, Nakabayashi K, Kobilka B, Hsueh AJ. J Biol Chem. 2002; 277 (6): 3958-64
Activation of orphan receptors by the hormone relaxin. Hsu SY, Nakabayashi K, Nishi S, Kumagai J, Kudo M, Sherwood OD, Hsueh AJ. Science. 2002; 295 (5555): 671-4
Perspective: the ovarian kaleidoscope database-II. Functional genomic analysis of an organ-specific database. Ben-Shlomo I, Vitt UA, Hsueh AJ. Endocrinology. 2002; 143 (6): 2041-4
Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor. Nakabayashi K, Matsumi H, Bhalla A, Bae J, Mosselman S, Hsu SY, Hsueh AJ. J Clin Invest. 2002; 109 (11): 1445-52
Ovarian gene database. Wasson KM, Hsueh AJ. J Soc Gynecol Investig. 2001 Jan-Feb; 8 (1 Suppl Proceedings): S37-9
Evolution and classification of cystine knot-containing hormones and related extracellular signaling molecules. Vitt UA, Hsu SY, Hsueh AJ. Mol Endocrinol. 2001; 15 (5): 681-94
Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor. Hsu SY, Hsueh AJ. Nat Med. 2001; 7 (5): 605-11
DNA array analysis of changes in preovulatory gene expression in the rat ovary. Leo CP, Pisarska MD, Hsueh AJ. Biol Reprod. 2001; 65 (1): 269-76
Stage-dependent role of growth differentiation factor-9 in ovarian follicle development. Vitt UA, Hsueh AJ. Mol Cell Endocrinol. 2001; 183 (1-2): 171-7
Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis. Bae J, Hsu SY, Leo CP, Zell K, Hsueh AJ. Apoptosis. 2001; 6 (5): 319-30
Müllerian inhibitory substance induces growth of rat preantral ovarian follicles. McGee EA, Smith R, Spears N, Nachtigal MW, Ingraham H, Hsueh AJ. Biol Reprod. 2001; 64 (1): 293-8
Characterization of two fly LGR (leucine-rich repeat-containing, G protein-coupled receptor) proteins homologous to vertebrate glycoprotein hormone receptors: constitutive activation of wild-type fly LGR1 but not LGR2 in transfected mammalian cells. Nishi S, Hsu SY, Zell K, Hsueh AJ. Endocrinology. 2000; 141 (11): 4081-90
In vivo treatment with GDF-9 stimulates primordial and primary follicle progression and theca cell marker CYP17 in ovaries of immature rats. Vitt UA, McGee EA, Hayashi M, Hsueh AJ. Endocrinology. 2000; 141 (10): 3814-20
The Ovarian Kaleidoscope database: an online resource for the ovarian research community. Leo CP, Vitt UA, Hsueh AJ. Endocrinology. 2000; 141 (9): 3052-4
Hormonal regulation of early follicle development in the rat ovary. Hsueh AJ, McGee EA, Hayashi M, Hsu SY. Mol Cell Endocrinol. 2000; 163 (1-2): 95-100
The three subfamilies of leucine-rich repeat-containing G protein-coupled receptors (LGR): identification of LGR6 and LGR7 and the signaling mechanism for LGR7. Hsu SY, Kudo M, Chen T, Nakabayashi K, Bhalla A, van der Spek PJ, van Duin M, Hsueh AJ. Mol Endocrinol. 2000; 14 (8): 1257-71
Growth differentiation factor-9 stimulates proliferation but suppresses the follicle-stimulating hormone-induced differentiation of cultured granulosa cells from small antral and preovulatory rat follicles. Vitt UA, Hayashi M, Klein C, Hsueh AJ. Biol Reprod. 2000; 62 (2): 370-7
MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain. Bae J, Leo CP, Hsu SY, Hsueh AJ. J Biol Chem. 2000; 275 (33): 25255-61
Discovering new hormones, receptors, and signaling mediators in the genomic era. Hsu SY, Hsueh AJ. Mol Endocrinol. 2000; 14 (5): 594-604
Initial and cyclic recruitment of ovarian follicles. McGee EA, Hsueh AJ. Endocr Rev. 2000; 21 (2): 200-14
Tissue-specific Bcl-2 protein partners in apoptosis: An ovarian paradigm. Hsu SY, Hsueh AJ. Physiol Rev. 2000; 80 (2): 593-614
The nematode leucine-rich repeat-containing, G protein-coupled receptor (LGR) protein homologous to vertebrate gonadotropin and thyrotropin receptors is constitutively active in mammalian cells. Kudo M, Chen T, Nakabayashi K, Hsu SY, Hsueh AJ. Mol Endocrinol. 2000; 14 (2): 272-84
Activation of the luteinizing hormone receptor following substitution of Ser-277 with selective hydrophobic residues in the ectodomain hinge region. Nakabayashi K, Kudo M, Kobilka B, Hsueh AJ. J Biol Chem. 2000; 275 (39): 30264-71
Characterization of the antiapoptotic Bcl-2 family member myeloid cell leukemia-1 (Mcl-1) and the stimulation of its message by gonadotropins in the rat ovary. Leo CP, Hsu SY, Chun SY, Bae HW, Hsueh AJ. Endocrinology. 1999; 140 (12): 5469-77
Restricted expression of WT1 messenger ribonucleic acid in immature ovarian follicles: uniformity in mammalian and avian species and maintenance during reproductive senescence. Chun SY, McGee EA, Hsu SY, Minami S, LaPolt PS, Yao HH, Bahr JM, Gougeon A, Schomberg DW, Hsueh AJ. Biol Reprod. 1999; 60 (2): 365-73
Keratinocyte growth factor promotes the survival, growth, and differentiation of preantral ovarian follicles. McGee EA, Chun SY, Lai S, He Y, Hsueh AJ. Fertil Steril. 1999; 71 (4): 732-8
Recombinant growth differentiation factor-9 (GDF-9) enhances growth and differentiation of cultured early ovarian follicles. Hayashi M, McGee EA, Min G, Klein C, Rose UM, van Duin M, Hsueh AJ. Endocrinology. 1999; 140 (3): 1236-44
BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. Hsu SY, Lin P, Hsueh AJ. Mol Endocrinol. 1998; 12 (9): 1432-40
Cell death and survival during ovarian follicle development. McGee EA, Hsu SY, Kaipia A, Hsueh AJ. Mol Cell Endocrinol. 1998; 140 (1-2): 15-8
A splicing variant of the Bcl-2 member Bok with a truncated BH3 domain induces apoptosis but does not dimerize with antiapoptotic Bcl-2 proteins in vitro. Hsu SY, Hsueh AJ. J Biol Chem. 1998; 273 (46): 30139-46
DEFT, a novel death effector domain-containing molecule predominantly expressed in testicular germ cells. Leo CP, Hsu SY, McGee EA, Salanova M, Hsueh AJ. Endocrinology. 1998; 139 (12): 4839-48
Soluble ecto-domain mutant of thyrotropin (TSH) receptor incapable of binding TSH neutralizes the action of thyroid-stimulating antibodies from Graves' patients. Osuga Y, Liang SG, Dallas JS, Wang C, Hsueh AJ. Endocrinology. 1998; 139 (2): 671-6
Intracellular mechanisms of ovarian cell apoptosis. Hsu SY, Hsueh AJ. Mol Cell Endocrinol. 1998; 145 (1-2): 21-5
Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repeats and a G protein-coupled, seven-transmembrane region. Hsu SY, Liang SG, Hsueh AJ. Mol Endocrinol. 1998; 12 (12): 1830-45
Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11. Hsu SY, Kaipia A, Zhu L, Hsueh AJ. Mol Endocrinol. 1997; 11 (12): 1858-67
Expression and function of a proapoptotic Bcl-2 family member Bcl-XL/Bcl-2-associated death promoter (BAD) in rat ovary. Kaipia A, Hsu SY, Hsueh AJ. Endocrinology. 1997; 138 (12): 5497-504
Follicle-stimulating hormone enhances the development of preantral follicles in juvenile rats. McGee EA, Perlas E, LaPolt PS, Tsafriri A, Hsueh AJ. Biol Reprod. 1997; 57 (5): 990-8
Regulation of ovarian follicle atresia. Kaipia A, Hsueh AJ. Annu Rev Physiol. 1997; 59 349-63
Telomerase activity in female and male rat germ cells undergoing meiosis and in early embryos. Eisenhauer KM, Gerstein RM, Chiu CP, Conti M, Hsueh AJ. Biol Reprod. 1997; 56 (5): 1120-5
Preantral ovarian follicles in serum-free culture: suppression of apoptosis after activation of the cyclic guanosine 3',5'-monophosphate pathway and stimulation of growth and differentiation by follicle-stimulating hormone. McGee E, Spears N, Minami S, Hsu SY, Chun SY, Billig H, Hsueh AJ. Endocrinology. 1997; 138 (6): 2417-24
Co-expression of defective luteinizing hormone receptor fragments partially reconstitutes ligand-induced signal generation. Osuga Y, Hayashi M, Kudo M, Conti M, Kobilka B, Hsueh AJ. J Biol Chem. 1997; 272 (40): 25006-12
Derivation of functional antagonists using N-terminal extracellular domain of gonadotropin and thyrotropin receptors. Osuga Y, Kudo M, Kaipia A, Kobilka B, Hsueh AJ. Mol Endocrinol. 1997; 11 (11): 1659-68
Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Hsu SY, Kaipia A, McGee E, Lomeli M, Hsueh AJ. Proc Natl Acad Sci U S A. 1997; 94 (23): 12401-6
Hormonal regulation of apoptosis in early antral follicles: follicle-stimulating hormone as a major survival factor. Chun SY, Eisenhauer KM, Minami S, Billig H, Perlas E, Hsueh AJ. Endocrinology. 1996; 137 (4): 1447-56
The C-terminal third of the human luteinizing hormone (LH) receptor is important for inositol phosphate release: analysis using chimeric human LH/follicle-stimulating hormone receptors. Hirsch B, Kudo M, Naro F, Conti M, Hsueh AJ. Mol Endocrinol. 1996; 10 (9): 1127-37
Transmembrane regions V and VI of the human luteinizing hormone receptor are required for constitutive activation by a mutation in the third intracellular loop. Kudo M, Osuga Y, Kobilka BK, Hsueh AJ. J Biol Chem. 1996; 271 (37): 22470-8
Oocyte maturation involves compartmentalization and opposing changes of cAMP levels in follicular somatic and germ cells: studies using selective phosphodiesterase inhibitors. Tsafriri A, Chun SY, Zhang R, Hsueh AJ, Conti M. Dev Biol. 1996; 178 (2): 393-402
Targeted overexpression of Bcl-2 in ovaries of transgenic mice leads to decreased follicle apoptosis, enhanced folliculogenesis, and increased germ cell tumorigenesis. Hsu SY, Lai RJ, Finegold M, Hsueh AJ. Endocrinology. 1996; 137 (11): 4837-43
Tumor necrosis factor-alpha and its second messenger, ceramide, stimulate apoptosis in cultured ovarian follicles. Kaipia A, Chun SY, Eisenhauer K, Hsueh AJ. Endocrinology. 1996; 137 (11): 4864-70
Gonadal cell apoptosis. Hsueh AJ, Eisenhauer K, Chun SY, Hsu SY, Billig H. Recent Prog Horm Res. 1996; 51 433-55; discussion 455-6
Different 5'-flanking regions of the inhibin-alpha gene target transgenes to the gonad and adrenal in an age-dependent manner in transgenic mice. Hsu SY, Lai RJ, Nanuel D, Hsueh AJ. Endocrinology. 1995; 136 (12): 5577-86
Wilms' tumor protein WT1 as an ovarian transcription factor: decreases in expression during follicle development and repression of inhibin-alpha gene promoter. Hsu SY, Kubo M, Chun SY, Haluska FG, Housman DE, Hsueh AJ. Mol Endocrinol. 1995; 9 (10): 1356-66
Apoptosis in testis germ cells: developmental changes in gonadotropin dependence and localization to selective tubule stages. Billig H, Furuta I, Rivier C, Tapanainen J, Parvinen M, Hsueh AJ. Endocrinology. 1995; 136 (1): 5-12
Genetic basis of human reproductive endocrine disorders. Fauser BC, Hsueh AJ. Hum Reprod. 1995; 10 (4): 826-46
Interleukin-1 beta suppresses apoptosis in rat ovarian follicles by increasing nitric oxide production. Chun SY, Eisenhauer KM, Kubo M, Hsueh AJ. Endocrinology. 1995; 136 (7): 3120-7
Growth hormone suppression of apoptosis in preovulatory rat follicles and partial neutralization by insulin-like growth factor binding protein. Eisenhauer KM, Chun SY, Billig H, Hsueh AJ. Biol Reprod. 1995; 53 (1): 13-20
Designer contraceptive pills. Hsueh AJ, Hum Reprod. 1995; 10 (8): 1997-2000
Gonadotropin suppression of apoptosis in cultured preovulatory follicles: mediatory role of endogenous insulin-like growth factor I. Chun SY, Billig H, Tilly JL, Furuta I, Tsafriri A, Hsueh AJ. Endocrinology. 1994; 135 (5): 1845-53
Experimentally induced cryptorchidism increases apoptosis in rat testis. Shikone T, Billig H, Hsueh AJ. Biol Reprod. 1994; 51 (5): 865-72
Ovarian follicle atresia: a hormonally controlled apoptotic process. Hsueh AJ, Billig H, Tsafriri A. Endocr Rev. 1994; 15 (6): 707-24
Photoperiod regulates testis cell apoptosis in Djungarian hamsters. Furuta I, Porkka-Heiskanen T, Scarbrough K, Tapanainen J, Turek FW, Hsueh AJ. Biol Reprod. 1994; 51 (6): 1315-21
Characterization of gonadal sex cord-stromal tumor cell lines from inhibin-alpha and p53-deficient mice: the role of activin as an autocrine growth factor. Shikone T, Matzuk MM, Perlas E, Finegold MJ, Lewis KA, Vale W, Bradley A, Hsueh AJ. Mol Endocrinol. 1994; 8 (8): 983-95
Follicle-stimulating hormone receptor expression in the rat ovary: increases during prepubertal development and regulation by the opposing actions of transforming growth factors beta and alpha. Dunkel L, Tilly JL, Shikone T, Nishimori K, Hsueh AJ. Biol Reprod. 1994; 50 (4): 940-8
Gonadotropin-releasing hormone directly induces apoptotic cell death in the rat ovary: biochemical and in situ detection of deoxyribonucleic acid fragmentation in granulosa cells. Billig H, Furuta I, Hsueh AJ. Endocrinology. 1994; 134 (1): 245-52
Hormonal control of apoptotic cell death in the testis: gonadotropins and androgens as testicular cell survival factors. Tapanainen JS, Tilly JL, Vihko KK, Hsueh AJ. Mol Endocrinol. 1993; 7 (5): 643-50
Estrogens inhibit and androgens enhance ovarian granulosa cell apoptosis. Billig H, Furuta I, Hsueh AJ. Endocrinology. 1993; 133 (5): 2204-12
Induction of ovarian follicle luteinization by recombinant follicle-stimulating hormone. Tapanainen JS, Lapolt PS, Perlas E, Hsueh AJ. Endocrinology. 1993; 133 (6): 2875-80
Luminescence luteinizing hormone/choriogonadotropin (LH/CG) bioassay: measurement of serum bioactive LH/CG during early pregnancy in human and macaque. Jia XC, Perlas E, Su JG, Moran F, Lasley BL, Ny T, Hsueh AJ. Biol Reprod. 1993; 49 (6): 1310-6
Microscale autoradiographic method for the qualitative and quantitative analysis of apoptotic DNA fragmentation. Tilly JL, Hsueh AJ. J Cell Physiol. 1993; 154 (3): 519-26
Deglycosylated human chorionic gonadotropin (hCG) antagonizes hCG stimulation of 3',5'-cyclic adenosine monophosphate accumulation through a noncompetitive interaction with recombinant human luteinizing hormone receptors. Dunkel L, Jia XC, Nishimori K, Boime I, Hsueh AJ. Endocrinology. 1993; 132 (2): 763-9
Characterization of mouse inhibin alpha gene and its promoter. Su JG, Hsueh AJ. Biochem Biophys Res Commun. 1992; 186 (1): 293-300
Epidermal growth factor and basic fibroblast growth factor suppress the spontaneous onset of apoptosis in cultured rat ovarian granulosa cells and follicles by a tyrosine kinase-dependent mechanism. Tilly JL, Billig H, Kowalski KI, Hsueh AJ. Mol Endocrinol. 1992; 6 (11): 1942-50
Apoptosis in atretic ovarian follicles is associated with selective decreases in messenger ribonucleic acid transcripts for gonadotropin receptors and cytochrome P450 aromatase. Tilly JL, Kowalski KI, Schomberg DW, Hsueh AJ. Endocrinology. 1992; 131 (4): 1670-6
Expression of recombinant human follicle-stimulating hormone receptor: species-specific ligand binding, signal transduction, and identification of multiple ovarian messenger ribonucleic acid transcripts. Tilly JL, Aihara T, Nishimori K, Jia XC, Billig H, Kowalski KI, Perlas EA, Hsueh AJ. Endocrinology. 1992; 131 (2): 799-806
Enhanced stimulation of follicle maturation and ovulatory potential by long acting follicle-stimulating hormone agonists with extended carboxyl-terminal peptides. LaPolt PS, Nishimori K, Fares FA, Perlas E, Boime I, Hsueh AJ. Endocrinology. 1992; 131 (6): 2514-20
Hormonal regulation of follicle-stimulating hormone receptor messenger ribonucleic acid levels in cultured rat granulosa cells. Tilly JL, LaPolt PS, Hsueh AJ. Endocrinology. 1992; 130 (3): 1296-302
Gonadotropin-induced up- and down-regulation of ovarian follicle-stimulating hormone (FSH) receptor gene expression in immature rats: effects of pregnant mare's serum gonadotropin, human chorionic gonadotropin, and recombinant FSH. LaPolt PS, Tilly JL, Aihara T, Nishimori K, Hsueh AJ. Endocrinology. 1992; 130 (3): 1289-95
Expression of testicular messenger ribonucleic acid for luteinizing hormone receptor in the rat: developmental regulation of multiple transcripts during postnatal life. Vihko KK, Nishimori K, LaPolt PS, Hsueh AJ. Biol Reprod. 1992; 46 (6): 1016-20
Stimulatory effects of recombinant follicle-stimulating hormone on Leydig cell function and spermatogenesis in immature hypophysectomized rats. Vihko KK, LaPolt PS, Nishimori K, Hsueh AJ. Endocrinology. 1991; 129 (4): 1926-32
Involvement of apoptosis in ovarian follicular atresia and postovulatory regression. Tilly JL, Kowalski KI, Johnson AL, Hsueh AJ. Endocrinology. 1991; 129 (5): 2799-801