Richard M. Myers

Administrative Appointments

• Chairman, Department of Genetics, Stanford University School of Medicine , (2002– present )
• Stanford W. Ascherman Professor of Genetics, Department of Genetics, Stanford University School of Medicine , (2003– present )
• Director, Stanford Human Genome Center, Department of Genetics, Stanford University School of Medicine , (1993– present )

Honors and Awards

• Honorary Doctorate in Humane Letters, University of Alabama (December 2005)
• Wills Foundation Award, The Wills Foundation (1986-2005)
• Pritzker Foundation Award, Pritzker Foundation (April 2002)
• Blount Initiative Award, University of Alabama (October 2003)
• Searle Scholar, The Searle Scholar Program (1987-1990)
• Basil O'Connor Starter Scholar Research Award, March of Dimes (1988)
• Darden Lecture Award, University of Alabama (March, 2002)

Professional Education

• Ph.D., Univ California Berkeley Biochemistry (1982)
• B.S., University of Alabama Biochemistry (1977)

Graduate & Fellowship Program Affiliations

• Genetics

Community & International Work

• Stanford Genetics San Jose Tech Museum Partnership, San Jose Tech Museum of Innovation More »
• Education outreach, Department of Genetics and Stanford Human Genome Center More »
• Editor, Genome Research More »

Web Site Links

• Myers Lab Site

Research Interests

My laboratory studies the human genome, with interests in understanding how allelic variation and gene expression changes contribute to understanding human traits, including diseases, behaviors and other phenotypes. We use high-throughput genomic methods, including DNA sequencing, genotyping, chromatin immunoprecipitation, mRNA expression profiling, transcriptional promoter and methylation measurements, and computational and statistical tools to identify, characterize and understand the functional elements encoded in our genomes.

In our human genetics work, we study brain and cardiovascular phenotypes, including Huntington disease, Parkinson disease, bipolar disease, insulin resistance and atherosclerosis, as well as cancer and population genetics. With the Pritzker Consortium, we study mood disorders with genetic approaches and by assessing gene expression patterns in brains of people with the disease. We are part of The Cancer Genome Atlas (TCGA) Project, where we are using genome-wide genotyping to measure structural genomic variation associated with a variety of tumors. We are using similar approaches to measure genetic diversity in human populations, including 51 populations from around the world.

The Stanford Human Genome Center was established in 1990 as one of the first genome centers of the Human Genome Project. We collaborated with the Joint Genome Institute in Walnut Creek on the public effort to sequence the human genome. Our groups contributed 11% of the sequence (chromosomes 5, 16 and 19). We continue to work with the JGI and have sequenced the genomes of more than 40 organisms, mostly concerned with bioenergy, agricultural and environmental problems. We are engaged in other sequencing projects, including sequencing full-length cDNAs, projects with David Kingsley to use stickleback fish to study vertebrate diversity, and a variety of positional cloning projects.

Another major interest of our group is functional genomics. We use high-throughput methods, including ChIP, mRNA profiling, transcriptional promoter and methylation assays, and computational and statistical tools to study human biology. We are part of the ENCODE Consortium, which has the goal of identifying and understanding all the functional elements in the human genome. With Dr. Barbara Wold and her lab at Caltech, we developed ChIPSeq, a method that uses ultra-high throughput sequencing to identify sites in the genome bound by transcription factors in living cells. We are using a similar approach to measure the methylation status at almost every CpG island in the human genome. We collaborate with Dr. Wold’s lab on networks of factors to study interesting human biological problems, including NRSF, GABP, SRF and FoxP2.

In addition to research, I participate in a variety of teaching, educational outreach, and institutional and national service activities. I teach in several courses in genetics and genomics to undergraduate, medical and graduate students, and I have a special interest in teaching science to non-science majors. I helped established a partnership between the Department of Genetics and the San Jose Tech Museum (“Stanford at the Tech”), which develops exhibits and trains graduate students in the art of teaching to the public. I am particularly interested in increasing and nurturing diversity in the scientific community, and I am active in several programs involved with under-represented groups at the graduate school level and earlier. I am an Associate Editor of Genome Research and serve on advisory panels for the National Human Genome Research Institute and the US Department of Energy.

Publications

• Worldwide human relationships inferred from genome-wide patterns of variation. Li JZ,  Absher DM, Tang H, Southwick AM, Casto AM, Ramachandran S, Cann HM, Barsh GS, Feldman M, Cavalli-Sforza LL, Myers RM.  Science.  2008; 319 (5866): 1100-4
• Multiple transcription start sites for FOXP2 with varying cellular specificities. Schroeder DI,  Myers RM.  Gene.  2008; 413 (1-2): 42-8
• Recombinant DNA: Genes and Genomes, 3rd Edition. Watson, J. D.,  Caudy, A. A., Myers, R. M. and Witkowski, J. A..  W. H. Freeman Press. ISBN 0-7167-2866-4..  2007;
• Sample matching by inferred agonal stress in gene expression analyses of the brain. Li JZ,  Meng F, Tsavaler L, Evans SJ, Choudary PV, Tomita H, Vawter MP, Walsh D, Shokoohi V, Chung T, Bunney WE, Jones EG, Akil H, Watson SJ, Myers RM.  BMC Genomics.  2007; 8 336
• Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. The ENCODE Project Consortium,  Nature.  2007; 447 799-816
• Wild-type huntingtin participates in protein trafficking between the Golgi and the extracellular space. Strehlow AN,  Li JZ, Myers RM.  Hum Mol Genet.  2007; 16 (4): 391-409
• Genome-wide mapping of in vivo protein-DNA interactions. Johnson DS,  Mortazavi A, Myers RM, Wold B.  Science.  2007; 316 (5830): 1497-502
• A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease. Assimes TL,  Knowles JW, Priest JR, Basu A, Borchert A, Volcik KA, Grove ML, Tabor HK, Southwick A, Tabibiazar R, Sidney S, Boerwinkle E, Go AS, Iribarren C, Hlatky MA, Fortmann SP, Myers RM, Kuhn H, Risch N, Quertermous T.  Atherosclerosis.  2008; 198 (1): 136-44
• Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets. Johnson DS,  Li W, Gordon DB, Bhattacharjee A, Curry B, Ghosh J, Brizuela L, Carroll JS, Brown M, Flicek P, Koch CM, Dunham I, Bieda M, Xu X, Farnham PJ, Kapranov P, Nix DA, Gingeras TR, Zhang X, Holster H, Jiang N, Green RD, Song JS, McCuine SA, Anton E, Nguyen L, Trinklein ND, Ye Z, Ching K, Hawkins D, Ren B, Scacheri PC, Rozowsky J, Karpikov A, Euskirchen G, Weissman S, Gerstein M, Snyder M, Yang A, Moqtaderi Z, Hirsch H, Shulha HP, Fu Y, Weng Z, Struhl K, Myers RM, Lieb JD, Liu XS.  Genome Res.  2008; 18 (3): 393-403
• Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. Denoeud F,  Kapranov P, Ucla C, Frankish A, Castelo R, Drenkow J, Lagarde J, Alioto T, Manzano C, Chrast J, Dike S, Wyss C, Henrichsen CN, Holroyd N, Dickson MC, Taylor R, Hance Z, Foissac S, Myers RM, Rogers J, Hubbard T, Harrow J, Guigó R, Gingeras TR, Antonarakis SE, Reymond A.  Genome Res.  2007; 17 (6): 746-59
• Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease. Hlatky MA,  Quertermous T, Boothroyd DB, Priest JR, Glassford AJ, Myers RM, Fortmann SP, Iribarren C, Tabor HK, Assimes TL, Tibshirani RJ, Go AS.  Am Heart J.  2007; 154 (6): 1035-42
• Matrix metalloproteinase circulating levels, genetic polymorphisms, and susceptibility to acute myocardial infarction among patients with coronary artery disease. Hlatky MA,  Ashley E, Quertermous T, Boothroyd DB, Ridker P, Southwick A, Myers RM, Iribarren C, Fortmann SP, Go AS.  Am Heart J.  2007; 154 (6): 1043-51
• Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction. Knowles JW,  Wang H, Itakura H, Southwick A, Myers RM, Iribarren C, Fortmann SP, Go AS, Quertermous T, Hlatky MA.  Am Heart J.  2007; 154 (6): 1052-8
• Stress-induced changes in primate prefrontal profiles of gene expression. Karssen AM,  Her S, Li JZ, Patel PD, Meng F, Bunney WE, Jones EG, Watson SJ, Akil H, Myers RM, Schatzberg AF, Lyons DM.  Mol Psychiatry.  2007; 12 (12): 1089-102
• Serum response factor binding sites differ in three human cell types. Cooper SJ,  Trinklein ND, Nguyen L, Myers RM.  Genome Res.  2007; 17 (2): 136-44
• Transcription factor binding and histone modifications in human bidirectional promoters. Lin, J. M.,  Collins, P. J., Trinklein N. D., Fu, Y., Xi, H., Myers, R. M. and Weng, Z..  Genome Research.  2007; 17 (In press): 818-827
• Integrated analysis of experimental data sets reveals many novel promoters in 1% of the human genome. Trinklein ND,  Karaöz U, Wu J, Halees A, Force Aldred S, Collins PJ, Zheng D, Zhang ZD, Gerstein MB, Snyder M, Myers RM, Weng Z.  Genome Res.  2007; 17 (6): 720-31
• Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Birney E, Stamatoyannopoulos JA, Dutta A, Guigó R, Gingeras TR, Margulies EH, Weng Z, Snyder M, Dermitzakis ET, Thurman RE, Kuehn MS, Taylor CM, Neph S, Koch CM, Asthana S, Malhotra A, Adzhubei I, Greenbaum JA, Andrews RM, Flicek P, Boyle PJ, Cao H, Carter NP, Clelland GK, Davis S, Day N, Dhami P, Dillon SC, Dorschner MO, Fiegler H, Giresi PG, Goldy J, Hawrylycz M, Haydock A, Humbert R, James KD, Johnson BE, Johnson EM, Frum TT, Rosenzweig ER, Karnani N, Lee K, Lefebvre GC, Navas PA, Neri F, Parker SC, Sabo PJ, Sandstrom R, Shafer A, Vetrie D, Weaver M, Wilcox S, Yu M, Collins FS, Dekker J, Lieb JD, Tullius TD, Crawford GE, Sunyaev S, Noble WS, Dunham I, Denoeud F, Reymond A, Kapranov P, Rozowsky J, Zheng D, Castelo R, Frankish A, Harrow J, Ghosh S, Sandelin A, Hofacker IL, Baertsch R, Keefe D, Dike S, Cheng J, Hirsch HA, Sekinger EA, Lagarde J, Abril JF, Shahab A, Flamm C, Fried C, Hackermüller J, Hertel J, Lindemeyer M, Missal K, Tanzer A, Washietl S, Korbel J, Emanuelsson O, Pedersen JS, Holroyd N, Taylor R, Swarbreck D, Matthews N, Dickson MC, Thomas DJ, Weirauch MT, Gilbert J, Drenkow J, Bell I, Zhao X, Srinivasan KG, Sung WK, Ooi HS, Chiu KP, Foissac S, Alioto T, Brent M, Pachter L, Tress ML, Valencia A, Choo SW, Choo CY, Ucla C, Manzano C, Wyss C, Cheung E, Clark TG, Brown JB, Ganesh M, Patel S, Tammana H, Chrast J, Henrichsen CN, Kai C, Kawai J, Nagalakshmi U, Wu J, Lian Z, Lian J, Newburger P, Zhang X, Bickel P, Mattick JS, Carninci P, Hayashizaki Y, Weissman S, Hubbard T, Myers RM, Rogers J, Stadler PF, Lowe TM, Wei CL, Ruan Y, Struhl K, Gerstein M, Antonarakis SE, Fu Y, Green ED, Karaöz U, Siepel A, Taylor J, Liefer LA, Wetterstrand KA, Good PJ, Feingold EA, Guyer MS, Cooper GM, Asimenos G, Dewey CN, Hou M, Nikolaev S, Montoya-Burgos JI, Löytynoja A, Whelan S, Pardi F, Massingham T, Huang H, Zhang NR, Holmes I, Mullikin JC, Ureta-Vidal A, Paten B, Seringhaus M, Church D, Rosenbloom K, Kent WJ, Stone EA, Batzoglou S, Goldman N, Hardison RC, Haussler D, Miller W, Sidow A, Trinklein ND, Zhang ZD, Barrera L, Stuart R, King DC, Ameur A, Enroth S, Bieda MC, Kim J, Bhinge AA, Jiang N, Liu J, Yao F, Vega VB, Lee CW, Ng P, Shahab A, Yang A, Moqtaderi Z, Zhu Z, Xu X, Squazzo S, Oberley MJ, Inman D, Singer MA, Richmond TA, Munn KJ, Rada-Iglesias A, Wallerman O, Komorowski J, Fowler JC, Couttet P, Bruce AW, Dovey OM, Ellis PD, Langford CF, Nix DA, Euskirchen G, Hartman S, Urban AE, Kraus P, Van Calcar S, Heintzman N, Kim TH, Wang K, Qu C, Hon G, Luna R, Glass CK, Rosenfeld MG, Aldred SF, Cooper SJ, Halees A, Lin JM, Shulha HP, Zhang X, Xu M, Haidar JN, Yu Y, Ruan Y, Iyer VR, Green RD, Wadelius C, Farnham PJ, Ren B, Harte RA, Hinrichs AS, Trumbower H, Clawson H, Hillman-Jackson J, Zweig AS, Smith K, Thakkapallayil A, Barber G, Kuhn RM, Karolchik D, Armengol L, Bird CP, de Bakker PI, Kern AD, Lopez-Bigas N, Martin JD, Stranger BE, Woodroffe A, Davydov E, Dimas A, Eyras E, Hallgrímsdóttir IB, Huppert J, Zody MC, Abecasis GR, Estivill X, Bouffard GG,.  Nature.  2007; 447 (7146): 799-816
• Application of microarray technology in primate behavioral neuroscience research. Karssen AM,  Li JZ, Her S, Patel PD, Meng F, Evans SJ, Vawter MP, Tomita H, Choudary PV, Bunney WE, Jones EG, Watson SJ, Akil H, Myers RM, Schatzberg AF, Lyons DM.  Methods.  2006; 38 (3): 227-34
• Comprehensive analysis of transcriptional promoter structure and function in 1% of the human genome Cooper SJ,  Trinklein ND, Anton ED, Nguyen L, Myers RM.  Genome Res.  2006; 16 1-10
• Comparative genomics modeling of the NRSF/REST repressor network: from single conserved sites to genome-wide repertoire. Mortazavi A,  Leeper Thompson EC, Garcia ST, Myers RM, Wold B.  Genome Res.  2006; 16 (10): 1208-21
• Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study. Elbaz A,  Nelson LM, Payami H, Ioannidis JP, Fiske BK, Annesi G, Carmine Belin A, Factor SA, Ferrarese C, Hadjigeorgiou GM, Higgins DS, Kawakami H, Krüger R, Marder KS, Mayeux RP, Mellick GD, Nutt JG, Ritz B, Samii A, Tanner CM, Van Broeckhoven C, Van Den Eeden SK, Wirdefeldt K, Zabetian CP, Dehem M, Montimurro JS, Southwick A, Myers RM, Trikalinos TA.  Lancet Neurol.  2006; 5 (11): 917-23
• Sequencing and analysis of 10,967 full-length cDNA clones from Xenopus laevis and Xenopus tropicalis reveals post-tetraploidization transcriptome remodeling. Morin RD,  Chang E, Petrescu A, Liao N, Griffith M, Chow W, Kirkpatrick R, Butterfield YS, Young AC, Stott J, Barber S, Babakaiff R, Dickson MC, Matsuo C, Wong D, Yang GS, Smailus DE, Wetherby KD, Kwong PN, Grimwood J, Brinkley CP, Brown-John M, Reddix-Dugue ND, Mayo M, Schmutz J, Beland J, Park M, Gibson S, Olson T, Bouffard GG, Tsai M, Featherstone R, Chand S, Siddiqui AS, Jang W, Lee E, Klein SL, Blakesley RW, Zeeberg BR, Narasimhan S, Weinstein JN, Pennacchio CP, Myers RM, Green ED, Wagner L, Gerhard DS, Marra MA, Jones SJ, Holt RA.  Genome Res.  2006; 16 (6): 796-803
• Widespread parallel evolution in sticklebacks by repeated fixation of Ectodysplasin alleles. Colosimo PF,  Hosemann KE, Balabhadra S, Villarreal G, Dickson M, Grimwood J, Schmutz J, Myers RM, Schluter D, Kingsley DM.  Science.  2005; 307 (5717): 1928-33
• Direct isolation and identification of promoters in the human genome. Kim TH,  Barrera LO, Qu C, Van Calcar S, Trinklein ND, Cooper SJ, Luna RM, Glass CK, Rosenfeld MG, Myers RM, Ren B.  Genome Res.  2005; 15 (6): 830-9
• Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels. Carlson CS,  Aldred SF, Lee PK, Tracy RP, Schwartz SM, Rieder M, Liu K, Williams OD, Iribarren C, Lewis EC, Fornage M, Boerwinkle E, Gross M, Jaquish C, Nickerson DA, Myers RM, Siscovick DS, Reiner AP.  Am J Hum Genet.  2005; 77 (1): 64-77
• Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Hillier LW,  Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, Wagner-McPherson C, Layman D, Wylie K, Sekhon M, Becker MC, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Kremitzki C, Oddy L, Du H, Sun H, Bradshaw-Cordum H, Ali J, Carter J, Cordes M, Harris A, Isak A, van Brunt A, Nguyen C, Du F, Courtney L, Kalicki J, Ozersky P, Abbott S, Armstrong J, Belter EA, Caruso L, Cedroni M, Cotton M, Davidson T, Desai A, Elliott G, Erb T, Fronick C, Gaige T, Haakenson W, Haglund K, Holmes A, Harkins R, Kim K, Kruchowski SS, Strong CM, Grewal N, Goyea E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Shah N, Swearengen-Shahid S, Snider J, Strong JT, Thompson J, Yoakum M, Leonard S, Pearman C, Trani L, Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson JO, Osborne J, Ding L, Meyer R, Sabo A, Shotland Y, Sinha P, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Jones TA, She X, Ciccarelli FD, Izaurralde E, Taylor J, Schmutz J, Myers RM, Cox DR, Huang X, McPherson JD, Mardis ER, Clifton SW, Warren WC, Chinwalla AT, Eddy SR, Marra MA, Ovcharenko I, Furey TS, Miller W, Eichler EE, Bork P, Suyama M, Torrents D, Waterston RH, Wilson RK.  Nature.  2005; 434 (7034): 724-31
• Sensitization of stefin B-deficient thymocytes towards staurosporin-induced apoptosis is independent of cysteine cathepsins. Kopitar-Jerala N,  Schweiger A, Myers RM, Turk V, Turk B.  FEBS Lett.  2005; 579 (10): 2149-55
• Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data. Dai M,  Wang P, Boyd AD, Kostov G, Athey B, Jones EG, Bunney WE, Myers RM, Speed TP, Akil H, Watson SJ, Meng F.  Nucleic Acids Res.  2005; 33 (20): e175
• Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression. Choudary PV,  Molnar M, Evans SJ, Tomita H, Li JZ, Vawter MP, Myers RM, Bunney WE, Akil H, Watson SJ, Jones EG.  Proc Natl Acad Sci U S A.  2005; 102 (43): 15653-8
• Coelacanth genome sequence reveals the evolutionary history of vertebrate genes. Noonan JP,  Grimwood J, Danke J, Schmutz J, Dickson M, Amemiya CT, Myers RM.  Genome Res.  2004; 14 (12): 2397-405
• Dysregulation of the fibroblast growth factor system in major depression. Evans SJ,  Choudary PV, Neal CR, Li JZ, Vawter MP, Tomita H, Lopez JF, Thompson RC, Meng F, Stead JD, Walsh DM, Myers RM, Bunney WE, Watson SJ, Jones EG, Akil H.  Proc Natl Acad Sci U S A.  2004; 101 (43): 15506-11
• The ENCODE (ENCyclopedia Of DNA Elements) Project ENCODE Project Consortium,  Science.  2004; 306 636-640
• Finishing the euchromatic sequence of the human genome Collins, F. S.,  International Human Genome Sequencing Consortium.  Nature.  2004; 431 931-945
• Quality assessment of the human genome sequence. Schmutz J,  Wheeler J, Grimwood J, Dickson M, Yang J, Caoile C, Bajorek E, Black S, Chan YM, Denys M, Escobar J, Flowers D, Fotopulos D, Garcia C, Gomez M, Gonzales E, Haydu L, Lopez F, Ramirez L, Retterer J, Rodriguez A, Rogers S, Salazar A, Tsai M, Myers RM.  Nature.  2004; 429 (6990): 365-8
• The DNA sequence and biology of human chromosome 19. Grimwood J,  Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM.  Nature.  2004; 428 (6982): 529-35
• Lack of evidence for an association between WNT2 and RELN polymorphisms and autism. Li J,  Nguyen L, Gleason C, Lotspeich L, Spiker D, Risch N, Myers RM.  Am J Med Genet B Neuropsychiatr Genet.  2004; 126B (1): 51-7
• Quality assessment of finished BAC sequences. Schmutz J,  Grimwood J, Myers RM.  Methods Mol Biol.  2004; 255 343-9
• Sequence finishing. Schmutz J,  Grimwood J, Myers RM.  Methods Mol Biol.  2004; 255 333-42
• Assembly of DNA sequencing data. Schmutz J,  Grimwood J, Myers RM.  Methods Mol Biol.  2004; 255 319-32
• Diverse and specific gene expression responses to stresses in cultured human cells. Murray JI,  Whitfield ML, Trinklein ND, Myers RM, Brown PO, Botstein D.  Mol Biol Cell.  2004; 15 (5): 2361-74
• Gene conversion and the evolution of protocadherin gene cluster diversity. Noonan JP,  Grimwood J, Schmutz J, Dickson M, Myers RM.  Genome Res.  2004; 14 (3): 354-66
• Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions. Li JZ,  Vawter MP, Walsh DM, Tomita H, Evans SJ, Choudary PV, Lopez JF, Avelar A, Shokoohi V, Chung T, Mesarwi O, Jones EG, Watson SJ, Akil H, Bunney WE, Myers RM.  Hum Mol Genet.  2004; 13 (6): 609-16
• An abundance of bidirectional promoters in the human genome. Trinklein ND,  Aldred SF, Hartman SJ, Schroeder DI, Otillar RP, Myers RM.  Genome Res.  2004; 14 (1): 62-6
• The role of heat shock transcription factor 1 in the genome-wide regulation of the mammalian heat shock response. Trinklein ND,  Murray JI, Hartman SJ, Botstein D, Myers RM.  Mol Biol Cell.  2004; 15 (3): 1254-61
• The Status, Quality and Expansion of the NIH Full-length cDNA project: The Mammalian Gene Collection (MGC) The MGC Project Team,  Genome Research.  2004; 14 2121-2127
• The sequence and analysis of duplication-rich human chromosome 16. Martin J,  Han C, Gordon LA, Terry A, Prabhakar S, She X, Xie G, Hellsten U, Chan YM, Altherr M, Couronne O, Aerts A, Bajorek E, Black S, Blumer H, Branscomb E, Brown NC, Bruno WJ, Buckingham JM, Callen DF, Campbell CS, Campbell ML, Campbell EW, Caoile C, Challacombe JF, Chasteen LA, Chertkov O, Chi HC, Christensen M, Clark LM, Cohn JD, Denys M, Detter JC, Dickson M, Dimitrijevic-Bussod M, Escobar J, Fawcett JJ, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Goodwin LA, Grady DL, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Hildebrand CE, Huang W, Israni S, Jett J, Jewett PB, Kadner K, Kimball H, Kobayashi A, Krawczyk MC, Leyba T, Longmire JL, Lopez F, Lou Y, Lowry S, Ludeman T, Manohar CF, Mark GA, McMurray KL, Meincke LJ, Morgan J, Moyzis RK, Mundt MO, Munk AC, Nandkeshwar RD, Pitluck S, Pollard M, Predki P, Parson-Quintana B, Ramirez L, Rash S, Retterer J, Ricke DO, Robinson DL, Rodriguez A, Salamov A, Saunders EH, Scott D, Shough T, Stallings RL, Stalvey M, Sutherland RD, Tapia R, Tesmer JG, Thayer N, Thompson LS, Tice H, Torney DC, Tran-Gyamfi M, Tsai M, Ulanovsky LE, Ustaszewska A, Vo N, White PS, Williams AL, Wills PL, Wu JR, Wu K, Yang J, Dejong P, Bruce D, Doggett NA, Deaven L, Schmutz J, Grimwood J, Richardson P, Rokhsar DS, Eichler EE, Gilna P, Lucas SM, Myers RM, Rubin EM, Pennacchio LA.  Nature.  2004; 432 (7020): 988-94
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS,  Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Morrin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J.  Genome Res.  2004; 14 (10B): 2121-7
• Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain. Tomita H,  Vawter MP, Walsh DM, Evans SJ, Choudary PV, Li J, Overman KM, Atz ME, Myers RM, Jones EG, Watson SJ, Akil H, Bunney WE.  Biol Psychiatry.  2004; 55 (4): 346-52
• The DNA sequence and comparative analysis of human chromosome 5. Schmutz J,  Martin J, Terry A, Couronne O, Grimwood J, Lowry S, Gordon LA, Scott D, Xie G, Huang W, Hellsten U, Tran-Gyamfi M, She X, Prabhakar S, Aerts A, Altherr M, Bajorek E, Black S, Branscomb E, Caoile C, Challacombe JF, Chan YM, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Glavina T, Gomez M, Gonzales E, Goodstein D, Grigoriev I, Groza M, Hammon N, Hawkins T, Haydu L, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Lopez F, Lou Y, Martinez D, Medina C, Morgan J, Nandkeshwar R, Noonan JP, Pitluck S, Pollard M, Predki P, Priest J, Ramirez L, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wheeler J, Wu K, Yang J, Dickson M, Cheng JF, Eichler EE, Olsen A, Pennacchio LA, Rokhsar DS, Richardson P, Lucas SM, Myers RM, Rubin EM.  Nature.  2004; 431 (7006): 268-74
• Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins. Cirman T,  Oresi? K, Mazovec GD, Turk V, Reed JC, Myers RM, Salvesen GS, Turk B.  J Biol Chem.  2004; 279 (5): 3578-87
• Transcriptional regulation and binding of heat shock factor 1 and heat shock factor 2 to 32 human heat shock genes during thermal stress and differentiation. Trinklein ND,  Chen WC, Kingston RE, Myers RM.  Cell Stress Chaperones.  2004; 9 (1): 21-8
• The master sex-determination locus in threespine sticklebacks is on a nascent Y chromosome. Peichel CL,  Ross JA, Matson CK, Dickson M, Grimwood J, Schmutz J, Myers RM, Mori S, Schluter D, Kingsley DM.  Curr Biol.  2004; 14 (16): 1416-24
• Coding potential of laboratory and clinical strains of human cytomegalovirus. Murphy E,  Yu D, Grimwood J, Schmutz J, Dickson M, Jarvis MA, Hahn G, Nelson JA, Myers RM, Shenk TE.  Proc Natl Acad Sci U S A.  2003; 100 (25): 14976-81
• Assessing the quality of finished genomic sequence. Schmutz J,  Wheeler J, Grimwood J, Dickson M, Myers RM.  Cold Spring Harb Symp Quant Biol.  2003; 68 31-7
• DNA microarray analysis of functionally discrete human brain regions reveals divergent transcriptional profiles. Evans SJ,  Choudary PV, Vawter MP, Li J, Meador-Woodruff JH, Lopez JF, Burke SM, Thompson RC, Myers RM, Jones EG, Bunney WE, Watson SJ, Akil H.  Neurobiol Dis.  2003; 14 (2): 240-50
• Microarray technology: a review of new strategies to discover candidate vulnerability genes in psychiatric disorders. Bunney WE,  Bunney BG, Vawter MP, Tomita H, Li J, Evans SJ, Choudary PV, Myers RM, Jones EG, Watson SJ, Akil H.  Am J Psychiatry.  2003; 160 (4): 657-66
• Apoptosis caused by cathepsins does not require Bid signaling in an in vivo model of progressive myoclonus epilepsy (EPM1). Houseweart MK,  Vilaythong A, Yin XM, Turk B, Noebels JL, Myers RM.  Cell Death Differ.  2003; 10 (12): 1329-35
• Extensive linkage disequilibrium, a common 16.7-kilobase deletion, and evidence of balancing selection in the human protocadherin alpha cluster. Noonan JP,  Li J, Nguyen L, Caoile C, Dickson M, Grimwood J, Schmutz J, Feldman MW, Myers RM.  Am J Hum Genet.  2003; 72 (3): 621-35
• Identification of promoter regions in the human genome by using a retroviral plasmid library-based functional reporter gene assay. Khambata-Ford S,  Liu Y, Gleason C, Dickson M, Altman RB, Batzoglou S, Myers RM.  Genome Res.  2003; 13 (7): 1765-74
• Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1). Houseweart MK,  Pennacchio LA, Vilaythong A, Peters C, Noebels JL, Myers RM.  J Neurobiol.  2003; 56 (4): 315-27
• Identification and functional analysis of human transcriptional promoters. Trinklein ND,  Aldred SJ, Saldanha AJ, Myers RM.  Genome Res.  2003; 13 (2): 308-12
• Lack of association between HoxA1 and HoxB1 gene variants and autism in 110 multiplex families. Li J,  Tabor HK, Nguyen L, Gleason C, Lotspeich LJ, Spiker D, Risch N, Myers RM.  Am J Med Genet.  2002; 114 (1): 24-30
• Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL,  Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA.  Proc Natl Acad Sci U S A.  2002; 99 (26): 16899-903
• Candidate-gene approaches for studying complex genetic traits: practical considerations. Tabor HK,  Risch NJ, Myers RM.  Nat Rev Genet.  2002; 3 (5): 391-7
• Rapid mapping of zebrafish mutations with SNPs and oligonucleotide microarrays. Stickney HL,  Schmutz J, Woods IG, Holtzer CC, Dickson MC, Kelly PD, Myers RM, Talbot WS.  Genome Res.  2002; 12 (12): 1929-34
• Behavioral phenotypic variation in autism multiplex families: evidence for a continuous severity gradient. Spiker D,  Lotspeich LJ, Dimiceli S, Myers RM, Risch N.  Am J Med Genet.  2002; 114 (2): 129-36
• Neuropathological changes in a mouse model of progressive myoclonus epilepsy: cystatin B deficiency and Unverricht-Lundborg disease. Shannon P,  Pennacchio LA, Houseweart MK, Minassian BA, Myers RM.  J Neuropathol Exp Neurol.  2002; 61 (12): 1085-91
• A high-resolution radiation hybrid map of the human genome draft sequence. Olivier M,  Aggarwal A, Allen J, Almendras AA, Bajorek ES, Beasley EM, Brady SD, Bushard JM, Bustos VI, Chu A, Chung TR, De Witte A, Denys ME, Dominguez R, Fang NY, Foster BD, Freudenberg RW, Hadley D, Hamilton LR, Jeffrey TJ, Kelly L, Lazzeroni L, Levy MR, Lewis SC, Liu X, Lopez FJ, Louie B, Marquis JP, Martinez RA, Matsuura MK, Misherghi NS, Norton JA, Olshen A, Perkins SM, Perou AJ, Piercy C, Piercy M, Qin F, Reif T, Sheppard K, Shokoohi V, Smick GA, Sun WL, Stewart EA, Fernando J, Tejeda, Tran NM, Trejo T, Vo NT, Yan SC, Zierten DL, Zhao S, Sachidanandam R, Trask BJ, Myers RM, Cox DR.  Science.  2001; 291 (5507): 1298-302
• Birth order effects on nonverbal IQ scores in autism multiplex families. Spiker D,  Lotspeich LJ, Dimiceli S, Szatmari P, Myers RM, Risch N.  J Autism Dev Disord.  2001; 31 (5): 449-60
• Cystatin B-deficient mice have increased expression of apoptosis and glial activation genes. Lieuallen K,  Pennacchio LA, Park M, Myers RM, Lennon GG.  Hum Mol Genet.  2001; 10 (18): 1867-71
• A physical map of the human genome. McPherson JD,  Marra M, Hillier L, Waterston RH, Chinwalla A, Wallis J, Sekhon M, Wylie K, Mardis ER, Wilson RK, Fulton R, Kucaba TA, Wagner-McPherson C, Barbazuk WB, Gregory SG, Humphray SJ, French L, Evans RS, Bethel G, Whittaker A, Holden JL, McCann OT, Dunham A, Soderlund C, Scott CE, Bentley DR, Schuler G, Chen HC, Jang W, Green ED, Idol JR, Maduro VV, Montgomery KT, Lee E, Miller A, Emerling S, Kucherlapati, Gibbs R, Scherer S, Gorrell JH, Sodergren E, Clerc-Blankenburg K, Tabor P, Naylor S, Garcia D, de Jong PJ, Catanese JJ, Nowak N, Osoegawa K, Qin S, Rowen L, Madan A, Dors M, Hood L, Trask B, Friedman C, Massa H, Cheung VG, Kirsch IR, Reid T, Yonescu R, Weissenbach J, Bruls T, Heilig R, Branscomb E, Olsen A, Doggett N, Cheng JF, Hawkins T, Myers RM, Shang J, Ramirez L, Schmutz J, Velasquez O, Dixon K, Stone NE, Cox DR, Haussler D, Kent WJ, Furey T, Rogic S, Kennedy S, Jones S, Rosenthal A, Wen G, Schilhabel M, Gloeckner G, Nyakatura G, Siebert R, Schlegelberger B, Korenberg J, Chen XN, Fujiyama A, Hattori M, Toyoda A, Yada T, Park HS, Sakaki Y, Shimizu N, Asakawa S, Kawasaki K, Sasaki T, Shintani A, Shimizu A, Shibuya K, Kudoh J, Minoshima S, Ramser J, Seranski P, Hoff C, Poustka A, Reinhardt R, Lehrach H.  Nature.  2001; 409 (6822): 934-41
• Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. Wu Q,  Zhang T, Cheng JF, Kim Y, Grimwood J, Schmutz J, Dickson M, Noonan JP, Zhang MQ, Myers RM, Maniatis T.  Genome Res.  2001; 11 (3): 389-404
• Initial sequencing and analysis of the human genome. Lander ES,  Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, Funke R, Gage D, Harris K, Heaford A, Howland J, Kann L, Lehoczky J, LeVine R, McEwan P, McKernan K, Meldrim J, Mesirov JP, Miranda C, Morris W, Naylor J, Raymond C, Rosetti M, Santos R, Sheridan A, Sougnez C, Stange-Thomann N, Stojanovic N, Subramanian A, Wyman D, Rogers J, Sulston J, Ainscough R, Beck S, Bentley D, Burton J, Clee C, Carter N, Coulson A, Deadman R, Deloukas P, Dunham A, Dunham I, Durbin R, French L, Grafham D, Gregory S, Hubbard T, Humphray S, Hunt A, Jones M, Lloyd C, McMurray A, Matthews L, Mercer S, Milne S, Mullikin JC, Mungall A, Plumb R, Ross M, Shownkeen R, Sims S, Waterston RH, Wilson RK, Hillier LW, McPherson JD, Marra MA, Mardis ER, Fulton LA, Chinwalla AT, Pepin KH, Gish WR, Chissoe SL, Wendl MC, Delehaunty KD, Miner TL, Delehaunty A, Kramer JB, Cook LL, Fulton RS, Johnson DL, Minx PJ, Clifton SW, Hawkins T, Branscomb E, Predki P, Richardson P, Wenning S, Slezak T, Doggett N, Cheng JF, Olsen A, Lucas S, Elkin C, Uberbacher E, Frazier M, Gibbs RA, Muzny DM, Scherer SE, Bouck JB, Sodergren EJ, Worley KC, Rives CM, Gorrell JH, Metzker ML, Naylor SL, Kucherlapati RS, Nelson DL, Weinstock GM, Sakaki Y, Fujiyama A, Hattori M, Yada T, Toyoda A, Itoh T, Kawagoe C, Watanabe H, Totoki Y, Taylor T, Weissenbach J, Heilig R, Saurin W, Artiguenave F, Brottier P, Bruls T, Pelletier E, Robert C, Wincker P, Smith DR, Doucette-Stamm L, Rubenfield M, Weinstock K, Lee HM, Dubois J, Rosenthal A, Platzer M, Nyakatura G, Taudien S, Rump A, Yang H, Yu J, Wang J, Huang G, Gu J, Hood L, Rowen L, Madan A, Qin S, Davis RW, Federspiel NA, Abola AP, Proctor MJ, Myers RM, Schmutz J, Dickson M, Grimwood J, Cox DR, Olson MV, Kaul R, Raymond C, Shimizu N, Kawasaki K, Minoshima S, Evans GA, Athanasiou M, Schultz R, Roe BA, Chen F, Pan H, Ramser J, Lehrach H, Reinhardt R, McCombie WR, de la Bastide M, Dedhia N, Blöcker H, Hornischer K, Nordsiek G, Agarwala R, Aravind L, Bailey JA, Bateman A, Batzoglou S, Birney E, Bork P, Brown DG, Burge CB, Cerutti L, Chen HC, Church D, Clamp M, Copley RR, Doerks T, Eddy SR, Eichler EE, Furey TS, Galagan J, Gilbert JG, Harmon C, Hayashizaki Y, Haussler D, Hermjakob H, Hokamp K, Jang W, Johnson LS, Jones TA, Kasif S, Kaspryzk A, Kennedy S, Kent WJ, Kitts P, Koonin EV, Korf I, Kulp D, Lancet D, Lowe TM, McLysaght A, Mikkelsen T, Moran JV, Mulder N, Pollara VJ, Ponting CP, Schuler G, Schultz J, Slater G, Smit AF, Stupka E, Szustakowski J, Thierry-Mieg D, Thierry-Mieg J, Wagner L, Wallis J, Wheeler R, Williams A, Wolf YI, Wolfe KH, Yang SP, Yeh RF, Collins F, Guyer MS, Peterson J, Felsenfeld A, Wetterstrand KA, Patrinos A, Morgan MJ, de Jong P, Catanese JJ, Osoegawa K, Shizuya H, Choi S, Chen YJ, Szustakowki J.  Nature.  2001; 409 (6822): 860-921
• Reductive cleavage of N-O bonds using Samarium(II) iodide in a traceless release strategy for solid-phase synthesis Myers RM,  Langston SP, Conway SP, Abell C.  Org Lett.  2000; 2 (10): 1349-52
• Impaired synaptic plasticity in mice carrying the Huntington's disease mutation. Usdin MT,  Shelbourne PF, Myers RM, Madison DV.  Hum Mol Genet.  1999; 8 (5): 839-46
• A putative Drosophila homolog of the Huntington's disease gene. Li Z,  Karlovich CA, Fish MP, Scott MP, Myers RM.  Hum Mol Genet.  1999; 8 (9): 1807-15
• A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice. Shelbourne PF,  Killeen N, Hevner RF, Johnston HM, Tecott L, Lewandoski M, Ennis M, Ramirez L, Li Z, Iannicola C, Littman DR, Myers RM.  Hum Mol Genet.  1999; 8 (5): 763-74
• Exclusion of linkage to the HLA region in ninety multiplex sibships with autism. Rogers T,  Kalaydjieva L, Hallmayer J, Petersen PB, Nicholas P, Pingree C, McMahon WM, Spiker D, Lotspeich L, Kraemer H, McCague P, Dimiceli S, Nouri N, Peachy T, Yang J, Hinds D, Risch N, Myers RM.  J Autism Dev Disord.  1999; 29 (3): 195-201
• Absence of linkage and linkage disequilibrium to chromosome 15q11-q13 markers in 139 multiplex families with autism. Salmon B,  Hallmayer J, Rogers T, Kalaydjieva L, Petersen PB, Nicholas P, Pingree C, McMahon W, Spiker D, Lotspeich L, Kraemer H, McCague P, Dimiceli S, Nouri N, Pitts T, Yang J, Hinds D, Myers RM, Risch N.  Am J Med Genet.  1999; 88 (5): 551-6
• The molecular genetic bases of the progressive myoclonus epilepsies. Serratosa JM,  Gardiner RM, Lehesjoki AE, Pennacchio LA, Myers RM.  Adv Neurol.  1999; 79 383-98
• A physical map of 30,000 human genes. Deloukas P,  Schuler GD, Gyapay G, Beasley EM, Soderlund C, Rodriguez-Tomé P, Hui L, Matise TC, McKusick KB, Beckmann JS, Bentolila S, Bihoreau M, Birren BB, Browne J, Butler A, Castle AB, Chiannilkulchai N, Clee C, Day PJ, Dehejia A, Dibling T, Drouot N, Duprat S, Fizames C, Fox S, Gelling S, Green L, Harrison P, Hocking R, Holloway E, Hunt S, Keil S, Lijnzaad P, Louis-Dit-Sully C, Ma J, Mendis A, Miller J, Morissette J, Muselet D, Nusbaum HC, Peck A, Rozen S, Simon D, Slonim DK, Staples R, Stein LD, Stewart EA, Suchard MA, Thangarajah T, Vega-Czarny N, Webber C, Wu X, Hudson J, Auffray C, Nomura N, Sikela JM, Polymeropoulos MH, James MR, Lander ES, Hudson TJ, Myers RM, Cox DR, Weissenbach J, Boguski MS, Bentley DR.  Science.  1998; 282 (5389): 744-6
• Progressive ataxia, myoclonic epilepsy and cerebellar apoptosis in cystatin B-deficient mice. Pennacchio LA,  Bouley DM, Higgins KM, Scott MP, Noebels JL, Myers RM.  Nat Genet.  1998; 20 (3): 251-8
• Characterization of the Huntington's disease (HD) gene homologue in the zebrafish Danio rerio. Karlovich CA,  John RM, Ramirez L, Stainier DY, Myers RM.  Gene.  1998; 217 (1-2): 117-25
• Gastrogenomic delights: a movable feast. Eisen JA,  Kaiser D, Myers RM.  Nat Med.  1997; 3 (10): 1076-8
• Identification and characterization of the human homologue of SH3BP2, an SH3 binding domain protein within a common region of deletion at 4p16.3 involved in bladder cancer. Bell SM,  Shaw M, Jou YS, Myers RM, Knowles MA.  Genomics.  1997; 44 (2): 163-70
• Unstable minisatellite expansion causing recessively inherited myoclonus epilepsy, EPM1. Virtaneva K,  D'Amato E, Miao J, Koskiniemi M, Norio R, Avanzini G, Franceschetti S, Michelucci R, Tassinari CA, Omer S, Pennacchio LA, Myers RM, Dieguez-Lucena JL, Krahe R, de la Chapelle A, Lehesjoki AE.  Nat Genet.  1997; 15 (4): 393-6
• Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Johnson RL,  Rothman AL, Xie J, Goodrich LV, Bare JW, Bonifas JM, Quinn AG, Myers RM, Cox DR, Epstein EH, Scott MP.  Science.  1996; 272 (5268): 1668-71
• Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1) Pennacchio LA,  Lehesjoki AE, Stone NE, Willour VL, Virtaneva K, Miao J, D'Amato E, Ramirez L, Faham M, Koskiniemi M, Warrington JA, Norio R, de la Chapelle A, Cox DR, Myers RM.  Science.  1996; 271 (5256): 1731-4
• Construction of a 750-kb bacterial clone contig and restriction map in the region of human chromosome 21 containing the progressive myoclonus epilepsy gene. Stone NE,  Fan JB, Willour V, Pennacchio LA, Warrington JA, Hu A, de la Chapelle A, Lehesjoki AE, Cox DR, Myers RM.  Genome Res.  1996; 6 (3): 218-25
• Genomes and evolution. Boguski MS,  Cox DR, Myers RM.  Curr Opin Genet Dev.  1996; 6 (6): 683-5
• Isolation and characterization of the mouse cystatin B gene. Pennacchio LA,  Myers RM.  Genome Res.  1996; 6 (11): 1103-9
• Mutation of the prion protein gene at codon 208 in familial Creutzfeldt-Jakob disease. Mastrianni JA,  Iannicola C, Myers RM, DeArmond S, Prusiner SB.  Neurology.  1996; 47 (5): 1305-12
• A gene map of the human genome. Schuler GD,  Boguski MS, Stewart EA, Stein LD, Gyapay G, Rice K, White RE, Rodriguez-Tomé P, Aggarwal A, Bajorek E, Bentolila S, Birren BB, Butler A, Castle AB, Chiannilkulchai N, Chu A, Clee C, Cowles S, Day PJ, Dibling T, Drouot N, Dunham I, Duprat S, East C, Edwards C, Fan JB, Fang N, Fizames C, Garrett C, Green L, Hadley D, Harris M, Harrison P, Brady S, Hicks A, Holloway E, Hui L, Hussain S, Louis-Dit-Sully C, Ma J, MacGilvery A, Mader C, Maratukulam A, Matise TC, McKusick KB, Morissette J, Mungall A, Muselet D, Nusbaum HC, Page DC, Peck A, Perkins S, Piercy M, Qin F, Quackenbush J, Ranby S, Reif T, Rozen S, Sanders C, She X, Silva J, Slonim DK, Soderlund C, Sun WL, Tabar P, Thangarajah T, Vega-Czarny N, Vollrath D, Voyticky S, Wilmer T, Wu X, Adams MD, Auffray C, Walter NA, Brandon R, Dehejia A, Goodfellow PN, Houlgatte R, Hudson JR, Ide SE, Iorio KR, Lee WY, Seki N, Nagase T, Ishikawa K, Nomura N, Phillips C, Polymeropoulos MH, Sandusky M, Schmitt K, Berry R, Swanson K, Torres R, Venter JC, Sikela JM, Beckmann JS, Weissenbach J, Myers RM, Cox DR, James MR, Bentley D, Deloukas P, Lander ES, Hudson TJ.  Science.  1996; 274 (5287): 540-6
• Fluorescence in situ hybridization deletion mapping at 4p16.3 in bladder cancer cell lines refines the localisation of the critical interval to 30 kb. Bell SM,  Zuo J, Myers RM, Knowles MA.  Genes Chromosomes Cancer.  1996; 17 (2): 108-17
• The end of the beginning: the race to begin human genome sequencing. Boguski M,  Chakravarti A, Gibbs R, Green E, Myers RM.  Genome Res.  1996; 6 (9): 771-2
• Progressive myoclonus epilepsy EPM1 locus maps to a 175-kb interval in distal 21q. Virtaneva K,  Miao J, Träskelin AL, Stone N, Warrington JA, Weissenbach J, Myers RM, Cox DR, Sistonen P, de la Chapelle A.  Am J Hum Genet.  1996; 58 (6): 1247-53
• Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH. Burke JR,  Enghild JJ, Martin ME, Jou YS, Myers RM, Roses AD, Vance JM, Strittmatter WJ.  Nat Med.  1996; 2 (3): 347-50
• A map to the future. Cox DR,  Myers RM.  Nat Genet.  1996; 12 (2): 117-8
• A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation. Patil N,  Cox DR, Bhat D, Faham M, Myers RM, Peterson AS.  Nat Genet.  1995; 11 (2): 126-9
• Summary of the 1993 ASHG ancillary meeting "recent research on chromosome 4p syndromes and genes". Estabrooks LL,  Breg WR, Hayden MR, Ledbetter DH, Myers RM, Wyandt HE, Yang-Feng TL, Hirschhorn K.  Am J Med Genet.  1995; 55 (4): 453-8
• Evidence from antibody studies that the CAG repeat in the Huntington disease gene is expressed in the protein. Jou YS,  Myers RM.  Hum Mol Genet.  1995; 4 (3): 465-9
• A transcript map of the Down syndrome critical region on chromosome 21. Peterson A,  Patil N, Robbins C, Wang L, Cox DR, Myers RM.  Hum Mol Genet.  1994; 3 (10): 1735-42
• Pituitary cell line GH3 expresses two somatostatin receptor subtypes that inhibit adenylyl cyclase: functional expression of rat somatostatin receptor subtypes 1 and 2 in human embryonic kidney 293 cells. Garcia PD,  Myers RM.  Mol Pharmacol.  1994; 45 (3): 402-9
• Identification of genes within CpG-enriched DNA from human chromosome 4p16.3. John RM,  Robbins CA, Myers RM.  Hum Mol Genet.  1994; 3 (9): 1611-6
• Report and abstracts of the Third International Workshop on Human Chromosome 4 Mapping. Palo Alto, California, July 10-11, 1993. Myers RM,  Goold RD, van Ommen GJ.  Cytogenet Cell Genet.  1994; 66 (4): 218-36
• Localization of the alpha 2-macroglobulin receptor-associated protein 1 gene (LRPAP1) and other gene fragments to human chromosome 4p16.3 by direct cDNA selection. Jou YS,  Goold RD, Myers RM.  Genomics.  1994; 24 (2): 410-3
• A high resolution physical map of 2.5 Mbp of the Down syndrome region on chromosome 21. Patil N,  Peterson A, Rothman A, de Jong PJ, Myers RM, Cox DR.  Hum Mol Genet.  1994; 3 (10): 1811-7
• Assessing mapping progress in the Human Genome Project. Cox DR,  Green ED, Lander ES, Cohen D, Myers RM.  Science.  1994; 265 (5181): 2031-2
• The pluses of subtraction. Myers RM,  Science.  1993; 259 (5097): 942-3
• Sensitivity of HincII to CpG methylation. Bull LN,  Hewitt JE, Cox DR, Myers RM.  Nucleic Acids Res.  1993; 21 (8): 2021
• A radiation hybrid map of the distal short arm of human chromosome 11, containing the Beckwith-Wiedemann and associated embryonal tumor disease loci. Richard CW,  Boehnke M, Berg DJ, Lichy JH, Meeker TC, Hauser E, Myers RM, Cox DR.  Am J Hum Genet.  1993; 52 (5): 915-21
• Identification and characterization of a beta-globin promoter-binding factor from murine erythroleukemia cells. Stuvé LL,  Myers RM.  Mol Cell Biol.  1993; 13 (7): 4311-22
• Construction of cosmid contigs and high-resolution restriction mapping of the Huntington disease region of human chromosome 4. Zuo J,  Robbins C, Baharloo S, Cox DR, Myers RM.  Hum Mol Genet.  1993; 2 (7): 889-99
• Discrimination among potential activators of the beta-globin CACCC element by correlation of binding and transcriptional properties. Hartzog GA,  Myers RM.  Mol Cell Biol.  1993; 13 (1): 44-56
• A simple and efficient method for attachment of a 40-base pair, GC-rich sequence to PCR-amplified DNA. Sheffield VC,  Beck JS, Stone EM, Myers RM.  Biotechniques.  1992; 12 (3): 386-8
• Genetic linkage analysis of bipolar affective disorder in an Old Order Amish pedigree. Law A,  Richard CW, Cottingham RW, Lathrop GM, Cox DR, Myers RM.  Hum Genet.  1992; 88 (5): 562-8
• Cloning of the Huntington disease region in yeast artificial chromosomes. Zuo J,  Robbins C, Taillon-Miller P, Cox DR, Myers RM.  Hum Mol Genet.  1992; 1 (3): 149-59
• Bridging the gaps. Cox DR,  Myers RM.  Curr Biol.  1992; 2 (6): 338-9
• Identification and molecular cloning of a neuropeptide Y homolog that produces prolonged inhibition in Aplysia neurons. Rajpara SM,  Garcia PD, Roberts R, Eliassen JC, Owens DF, Maltby D, Myers RM, Mayeri E.  Neuron.  1992; 9 (3): 505-13
• A radiation hybrid map of the region on human chromosome 22 containing the neurofibromatosis type 2 locus. Frazer KA,  Boehnke M, Budarf ML, Wolff RK, Emanuel BS, Myers RM, Cox DR.  Genomics.  1992; 14 (3): 574-84
• Improved sequencing of cosmids using new primers and linearized DNA. Dugaiczyk A,  Goold R, diSibio G, Myers RM.  Nucleic Acids Res.  1992; 20 (23): 6421-2
• Identification of polymorphisms by genomic denaturing gradient gel electrophoresis: application to the proximal region of human chromosome 21. Burmeister M,  diSibio G, Cox DR, Myers RM.  Nucleic Acids Res.  1991; 19 (7): 1475-81
• The end in sight for Huntington disease? Pritchard C,  Cox DR, Myers RM.  Am J Hum Genet.  1991; 49 (1): 1-6
• TaqI RFLP at D21S137. Burmeister M,  Cox DR, Myers RM.  Nucleic Acids Res.  1991; 19 (14): 4020
• Physical mapping of yeast artificial chromosomes containing sequences from the human beta-globin gene region. Gaensler KM,  Burmeister M, Brownstein BH, Taillon-Miller P, Myers RM.  Genomics.  1991; 10 (4): 976-84
• Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. Maricq AV,  Peterson AS, Brake AJ, Myers RM, Julius D.  Science.  1991; 254 (5030): 432-7
• Dinucleotide repeat polymorphism located at D4S169. Pritchard C,  Cox DR, Myers RM.  Nucleic Acids Res.  1991; 19 (22): 6347
• A map of the distal region of the long arm of human chromosome 21 constructed by radiation hybrid mapping and pulsed-field gel electrophoresis. Burmeister M,  Kim S, Price ER, de Lange T, Tantravahi U, Myers RM, Cox DR.  Genomics.  1991; 9 (1): 19-30
• A radiation hybrid map of the proximal long arm of human chromosome 11 containing the multiple endocrine neoplasia type 1 (MEN-1) and bcl-1 disease loci. Richard CW,  Withers DA, Meeker TC, Maurer S, Evans GA, Myers RM, Cox DR.  Am J Hum Genet.  1991; 49 (6): 1189-96
• Exon trapping: a genetic screen to identify candidate transcribed sequences in cloned mammalian genomic DNA. Duyk GM,  Kim SW, Myers RM, Cox DR.  Proc Natl Acad Sci U S A.  1990; 87 (22): 8995-9
• Structure and variability of human chromosome ends. de Lange T,  Shiue L, Myers RM, Cox DR, Naylor SL, Killery AM, Varmus HE.  Mol Cell Biol.  1990; 10 (2): 518-27
• Non-hydrophobic extracytoplasmic determinant of stop transfer in the prion protein. Yost CS,  Lopez CD, Prusiner SB, Myers RM, Lingappa VR.  Nature.  1990; 343 (6259): 669-72
• A directly repeated sequence in the beta-globin promoter regulates transcription in murine erythroleukemia cells. Stuve LL,  Myers RM.  Mol Cell Biol.  1990; 10 (3): 972-81
• Unusual topogenic sequence directs prion protein biogenesis. Lopez CD,  Yost CS, Prusiner SB, Myers RM, Lingappa VR.  Science.  1990; 248 (4952): 226-9
• Analysis of the site in CD4 that binds to the HIV envelope glycoprotein. Brodsky MH,  Warton M, Myers RM, Littman DR.  J Immunol.  1990; 144 (8): 3078-86
• Dinucleotide repeat polymorphism located at D21S120. Burmelster M,  Cox DR, Myers RM.  Nucleic Acids Res.  1990; 18 (16): 4969
• A cloned DNA segment from the telomeric region of human chromosome 4p is not detectably rearranged in Huntington disease patients. Pritchard C,  Casher D, Bull L, Cox DR, Myers RM.  Proc Natl Acad Sci U S A.  1990; 87 (18): 7309-13
• Radiation hybrid mapping: a somatic cell genetic method for constructing high-resolution maps of mammalian chromosomes. Cox DR,  Burmeister M, Price ER, Kim S, Myers RM.  Science.  1990; 250 (4978): 245-50
• Isolation and field-inversion gel electrophoresis analysis of DNA markers located close to the Huntington disease gene. Pritchard CA,  Casher D, Uglum E, Cox DR, Myers RM.  Genomics.  1989; 4 (3): 408-18
• Methylation at the Huntington disease-linked D4S95 locus. Pritchard CA,  Cox DR, Myers RM.  Am J Hum Genet.  1989; 45 (2): 335-6
• Segregation of the Huntington disease region of human chromosome 4 in a somatic cell hybrid. Cox DR,  Pritchard CA, Uglum E, Casher D, Kobori J, Myers RM.  Genomics.  1989; 4 (3): 397-407
• Attachment of a 40-base-pair G + C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes. Sheffield VC,  Cox DR, Lerman LS, Myers RM.  Proc Natl Acad Sci U S A.  1989; 86 (1): 232-6
• Genetic and biochemical analysis of the mouse beta-major globin promoter. Myers RM,  Cowie A, Stuve L, Hartzog G, Gaensler K.  Prog Clin Biol Res.  1989; 316A 117-27
• DNA sequences involved in transcriptional regulation of the mouse beta-globin promoter in murine erythroleukemia cells. Cowie A,  Myers RM.  Mol Cell Biol.  1988; 8 (8): 3122-8
• Alterations in DNA helix stability due to base modifications can be evaluated using denaturing gradient gel electrophoresis. Collins M,  Myers RM.  J Mol Biol.  1987; 198 (4): 737-44
• Detection and localization of single base changes by denaturing gradient gel electrophoresis. Myers RM,  Maniatis T, Lerman LS.  Methods Enzymol.  1987; 155 501-27
• In vitro mutagenesis and overexpression of the Escherichia coli trpA gene and the partial characterization of the resultant tryptophan synthase mutant alpha-subunits. Milton DL,  Napier ML, Myers RM, Hardman JK.  J Biol Chem.  1986; 261 (35): 16604-15
• Fine structure genetic analysis of a beta-globin promoter. Myers RM,  Tilly K, Maniatis T.  Science.  1986; 232 (4750): 613-8
• Recent advances in the development of methods for detecting single-base substitutions associated with human genetic diseases. Myers RM,  Maniatis T.  Cold Spring Harb Symp Quant Biol.  1986; 51 Pt 1 275-84
• Detection of single base substitutions in total genomic DNA. Myers RM,  Lumelsky N, Lerman LS, Maniatis T.  Nature.  1985 Feb 7-13; 313 (6002): 495-8
• Nearly all single base substitutions in DNA fragments joined to a GC-clamp can be detected by denaturing gradient gel electrophoresis. Myers RM,  Fischer SG, Lerman LS, Maniatis T.  Nucleic Acids Res.  1985; 13 (9): 3131-45
• A general method for saturation mutagenesis of cloned DNA fragments. Myers RM,  Lerman LS, Maniatis T.  Science.  1985; 229 (4710): 242-7
• Detection of single base substitutions by ribonuclease cleavage at mismatches in RNA:DNA duplexes. Myers RM,  Larin Z, Maniatis T.  Science.  1985; 230 (4731): 1242-6
• Modification of the melting properties of duplex DNA by attachment of a GC-rich DNA sequence as determined by denaturing gradient gel electrophoresis. Myers RM,  Fischer SG, Maniatis T, Lerman LS.  Nucleic Acids Res.  1985; 13 (9): 3111-29
• Mutational analysis of simian virus 40 large T antigen DNA binding sites. Jones KA,  Myers RM, Tjian R.  EMBO J.  1984; 3 (13): 3247-55
• Oligomeric structure of a simian virus 40 T antigen in free form and bound to DNA. Myers RM,  Williams RC, Tjian R.  J Mol Biol.  1981; 148 (4): 347-53
• SV40 gene expression is modulated by the cooperative binding of T antigen to DNA. Myers RM,  Rio DC, Robbins AK, Tjian R.  Cell.  1981; 25 (2): 373-84
• Does simian virus 40 T antigen unwind DNA? Myers RM,  Kligman M, Tjian R.  J Biol Chem.  1981; 256 (19): 10156-60
• Construction and analysis of simian virus 40 origins defective in tumor antigen binding and DNA replication. Myers RM,  Tjian R.  Proc Natl Acad Sci U S A.  1980; 77 (11): 6491-5
• Regulation of simian virus 40 early transcription in vitro by a purified tumor antigen. Rio D,  Robbins A, Myers R, Tjian R.  Proc Natl Acad Sci U S A.  1980; 77 (10): 5706-10
• Substrate interactions with the alpha-subunit of the Escherichia coli tryptophan synthase. A kinetic study of the wild-type alpha-subunit. Hodo HG,  Murphy J, Hardman JK, Myers R.  Arch Biochem Biophys.  1977; 181 (2): 419-27