Key Documents
Emmet B. Keeffe, MD
- Emeritus Faculty-Med Ctr Line, Medicine - Gastroenterology & Hepatology
Contact Information
- Clinical Offices
Gastroenterology & Hepatology 750 Welch Rd Ste 210 MC 5729 Palo Alto, CA 94304-1509 Telephone Work (650) 498-5691 Fax (650) 498-5692
- Academic Offices
Personal Information Email ekeeffe@stanford.edu Tel (650) 498-6080Administrative Contact Donna Medved Administrative Assistant Email dmedved@stanford.edu Tel Work 650-498-5691Not for medical emergencies or patient use
Clinical Focus
- Hepatology (Liver)
- Chronic Hepatitis B
- Chronic Hepatitis C
- Liver Transplantation
- Gastroenterology
Administrative Appointments
- Board of Directors, American Liver Foundation, Northern California Chapter , (2008– present )
- Board of Directors, Foundation for Digestive Health and Nutrition , (2004– present )
- Chief of Hepatology, Stanford University School of Medicine , (2000– 2007 )
- Co-Director, Liver Transplant Program, Stanford University Medical Center , (2000– 2007 )
- Chief of Clinical Gastroenterology, Stanford University School of Medicine , (1995– 2000 )
- Medical Director, Liver Transplant Program, Stanford University Medical Center , (1995– 2000 )
- Board of Directors, American Digestive Health Foundation , (1994– 2001 )
- Board of Directors, American Liver Foundation , (1991– 1998 )
Honors and Awards
- Honorary Fellow, Royal College of Physicians of Ireland (2006)
- Fellow, American Gastroenterological Association (2006)
- Fellow, American Society for Gastrointestinal Endoscopy (2006)
- Master, American College of Physicians (2006)
- Biographee, Who's Who in the World (2006)
- Biographee, Who's Who in America (2005-2008)
- Member, American Clinical and Climatological Association (2004)
- President, American Gastroenterological Association (2005)
- Honorary Member, Asociacion Mexicana de Gastroenterologia (2004)
- Alumni Merit Award, Creighton University (2003)
- Member, Alpha Omega Alpha (2001)
- Biographee, America's Top Doctors (2000-2005)
- Honoree, American Liver Foundation, Northern California Chapter (1999)
- President, American Society for Gastrointestinal Endoscopy (1995)
- Biographee, The Best Doctors in America (1992-2008)
- President, Western Gut Club (1991)
- Member, Pacific Interurban Clinical Club (1991-2002)
- Fellow, American College of Gastroenterology (1989)
- Fellow, American College of Physicians (1978)
Professional Education
- Board Certification: Gastroenterology, American Board of Internal Medicine (1975)
- UCSF Medical Center (1979) CA
- Oregon Health Sciences Univ (1974) OR
- Oregon Health Sciences Univ (1973) OR
- Board Certification: Internal Medicine, American Board of Internal Medicine (1972)
- Oregon Health Science University Hospital (1970) OR
- Creighton University (1969) NE
- Fellowship, UCSF Hepatology (1979)
- Fellowship, Oregon Health & Science Univ Gastroenterology (1974)
- Residency, Oregon Health & Science Univ Internal Medicine (1973)
- M.D., Creighton University Medicine (1969)
- B.S., University of San Francisco Biology (1964)
Graduate & Fellowship Program Affiliations
Industry Relationships
Stanford is committed to ethical and transparent interactions with our industry partners. It is our policy to disclose payments of $5,000 or more, equity valued at $5,000 or more in a publicly traded company, or any equity in a privately held company, to physicians and scientists employed by Stanford University from companies or other commercial entities with which they interact as part of their professional activities.
- Consulting: Bristol Myers Squibb
- Equity: Full-time employee, Romark Laboratories
Research Interests
My primary current clinical research interests are focused on treatment of chronic hepatitis C with nitazoxanide as well as treatment of chronic hepatitis B, application of hepatitis vaccination especially in patients with chronic liver disease, and selection and outcomes of liver transplantation. In the past, I and my colleagues have studied the role of standard interferon, interferon alfacon-1, and peginterferon alone or with ribavirin for the treatment of chronic hepatitis C. We have also documented the role of liver transplantation for fulminant hepatic failure associated with mushroom poisoning, reviewed the institutional results of new liver transplant programs, reported a variant of recurrent hepatitis B after liver transplantation called fibrosing cholestatic hepatitis, documented that the results of liver transplantation in Asian patients with chronic hepatitis B are the same as the transplant outcomes of non-Asians, assessed the quality of life following liver transplantation using a comprehensive profile of psychologic testing, reviewed selection criteria and outcomes of liver transplantation for controversial indications, defined criteria for liver transplantation and associated comorbidities in patients with alcoholic liver disease, proposed minimal listing criteria for liver transplantation, and wrote several textbook chapters on selection of patients for liver transplantation.
I have been a principle investigator in multiple clinical trials using various interferons, combined interferon or peginterferon plus ribavirin, and nitazoxanide for the treatment of chronic hepatitis C, antiviral trials using lamivudine and famciclovir for the treatment of chronic hepatitis B, optimal management of hepatitis B patients after liver transplantation, and trials of hepatitis B and hepatitis A vaccines. I reported that hepatitis A and B is more severe in patients with chronic liver disease, and demonstrated in an international trial the safety and efficacy of hepatitis A and B vaccine in patients with chronic liver disease.
Publications
- Dig Dis Sci. 2009; (1): 1-4
- Gastroenterology. 2009; (3): 856-62
- Aliment Pharmacol Ther. 2009; (7): 755-64
- Minerva Gastroenterol Dietol. 2009; (1): 5-22
- J Viral Hepat. 2009; (3): 149-55
- Am J Gastroenterol. 2009; (9): 2206-13
- Am J Gastroenterol. 2009;
- Hepatol Int. 2009;
- Biologics. 2009; 141-50
- World J Gastroenterol. 2009; (15): 1805-8
- Am J Transplant. 2009; (5): 1158-68
- Liver Transpl. 2009; (9): 1010-20
- Expert Rev Anti Infect Ther. 2009; (9): 1053-62
- Liver Transpl. 2009; (8): 894-906
- Clin Gastroenterol Hepatol. 2008; (3): 268-74
- Hepatology. 2008; (5): 1788-90
- Aliment Pharmacol Ther. 2008; (2): 167-77
- Rev Gastroenterol Disord. 2008; (1): 58-70
- Am J Gastroenterol. 2008; (5): 1131-5
- Med Clin North Am. 2008; (4): 839-60, ix
- Int J STD AIDS. 2008; (11): 780-1
- Clin Infect Dis. 2008; (10): 1312-4
- Clin Gastroenterol Hepatol. 2008; (12): 1315-41; quiz 1286
- Aliment Pharmacol Ther. 2008; (5): 574-80
- Clin Gastroenterol Hepatol. 2008; (5): 569-74
- Dig Dis Sci. 2008; (9): 2330-3
- Future Microbiol. 2008; 539-45
- Clin Gastroenterol Hepatol. 2007; (3): 285-94
- J Am Geriatr Soc. 2007; (1): 142
- Minerva Gastroenterol Dietol. 2007; (1): 25-41
- Clin Liver Dis. 2007; (2): 227-47
- Rev Gastroenterol Disord. 2007; (2): 63-73
- Clin Gastroenterol Hepatol. 2007; (8): 890-7
- Clin Gastroenterol Hepatol. 2007; (2): 142-51
- Aliment Pharmacol Ther. 2007; (6): 839-46
- Clin Liver Dis. 2007; (4): 965-91, x
- Antivir Ther. 2007; (7): 1015-25
- Gastroenterology. 2007; (5): 1718-21
- Rev Gastroenterol Disord. 2007; (1): 1-21
- Liver Transpl. 2007; (3): 334-42
- Transplantation. 2007; (2): 166-72
- Clin Gastroenterol Hepatol. 2006; (3): 288-92
- J Vasc Interv Radiol. 2006; (4): 737-9
- Clin Gastroenterol Hepatol. 2006; (8): 936-62
- Aliment Pharmacol Ther. 2006; (7): 1003-16
- Clin Liver Dis. 2006; (3): 513-34, viii
- Clin Gastroenterol Hepatol. 2006; (2): 233-48
- J Am Geriatr Soc. 2006; (4): 680-4
- Trans Am Clin Climatol Assoc. 2006; 227-37; discussion 237-8
- Rev Gastroenterol Disord. 2006; (3): 153-89
- Infect Dis Clin North Am. 2006; (1): 27-45
- Rev Gastroenterol Disord. 2006; (2): 112-6
- Rev Gastroenterol Mex. 2005 Jan-Mar; (1): 56-62
- Am J Gastroenterol. 2005; (2): 299-307
- J Clin Gastroenterol. 2005; (1 Suppl): S1-2
- Rev Gastroenterol Disord. 2005; (2): 107-10
- Clin Liver Dis. 2005; (3): 411-26, vi
- Clin Liver Dis. 2005; (3): xi-xiii
- Semin Liver Dis. 2005; 1
- Gastroenterology. 2005; (3): 885-93
- Ann Clin Microbiol Antimicrob. 2005; 13
- Clin Gastroenterol Hepatol. 2005; (10 Suppl 2): S97-S101
- Clin Gastroenterol Hepatol. 2005; (10 Suppl 2): S102-5
- Rev Gastroenterol Disord. 2005; (4): 223-7
- Rev Gastroenterol Disord. 2005; (4): 195-205
- Am J Med. 2005; 21S-27S
- Rev Gastroenterol Disord. 2005; 26-35
- Clin Gastroenterol Hepatol. 2005; (12): 1167-79
- Gastroenterology. 2005; (6): 2096-100
- J Hepatol. 2005; (6): 937-43
- Gastroenterology. 2005; (2): 494-503
- J Clin Gastroenterol. 2005; (4): 339-43
- Autoimmun Rev. 2005; (2): 82-95
- Best Pract Res Clin Gastroenterol. 2005; (1): 161-74
- J Vasc Interv Radiol. 2005; (2 Pt 1): 281-5
- J Clin Gastroenterol. 2004 May-Jun; (5): 440-8
- Liver Transpl. 2004; (8): 957-67
- Liver Transpl. 2004; (10 Suppl 2): S31-8
- Rev Gastroenterol Disord. 2004; (3): 97-103
- Rev Gastroenterol Disord. 2004; S14-21
- Gastroenterology. 2004; (5): 1409-15
- Rev Gastroenterol Disord. 2004; (1): 46-8
- Aliment Pharmacol Ther. 2004; (7): 715-27
- Clin Gastroenterol Hepatol. 2004; (2): 87-106
- Minerva Gastroenterol Dietol. 2004; (4): 289-303
- Clin Liver Dis. 2004; (2): 283-300
- Clin Gastroenterol Hepatol. 2004; (9): 820-4
- Rev Gastroenterol Mex. 2004; 160-70
- Antivir Ther. 2004; (5): 679-93
- Aliment Pharmacol Ther. 2004; (11): 1159-72
- J Clin Gastroenterol. 2004; (3): 264-71
- J Clin Gastroenterol. 2004; (2): 135-6
- Am J Gastroenterol. 2003; (5): 955-6
- Compr Ther. 2003; (4): 224-32
- Proc Natl Acad Sci U S A. 2003; (10): 6063-8
- Rev Gastroenterol Disord. 2003; (1): 8-24
- J Clin Gastroenterol. 2003; (1): 47-53
- J Hepatol. 2003; (1): 67-75
- Gastroenterology. 2003; (2): 444-51
- Hepatology. 2003; (3): 619-28
- J Clin Gastroenterol. 2003; (4): 349-50
- Aliment Pharmacol Ther. 2003; (7): 661-70
- Clin Liver Dis. 2003; (4): 821-39
- Semin Liver Dis. 2003; 1-2
- Rev Gastroenterol Disord. 2003; (3): 125-34
- Clin Liver Dis. 2003; (3): 551-72
- Minerva Chir. 2003; (5): 635-48
- J Clin Gastroenterol. 2003; (1): 68-71
- J Clin Gastroenterol. 2002 Nov-Dec; (5 Suppl 2): S86-91
- Hepatology. 2002; (3): 673-9
- Rev Gastroenterol Disord. 2002; (1): 34-40
- Rev Gastroenterol Disord. 2002; (4): 202-4
- Hepatology. 2002; (2): 410-7
- J Clin Gastroenterol. 2002; (1): 94-5
- Liver Transpl. 2002; (5): 433-9
- Semin Liver Dis. 2002; (3): 291-302
- Rev Gastroenterol Disord. 2002; (1): 11-9
- J Clin Gastroenterol. 2002; (4): 476-80
- Transplant Proc. 2001 Feb-Mar; (1-2): 1490-1
- Rev Gastroenterol Disord. 2001; (1): 42-7
- Annu Rev Med. 2001; 29-49
- Gastrointest Endosc Clin N Am. 2001; (1): 15-44
- Gastroenterology. 2001; (3): 749-62
- Blood. 2001; (10): 3171-6
- J Infect Dis. 2001; (7): 827-35
- Liver Transpl. 2001; (9): 755-61
- Hepatology. 2001; (4 Pt 1): 842-3
- Clin Liver Dis. 2001; (4): 1073-90
- Liver Transpl. 2001; (11 Suppl 1): S119-23
- Can J Gastroenterol. 2001; (11): 729-38
- Am J Gastroenterol. 2001; (11): 3053-5
- Hepatology. 2001; (1): 126-32
- J Hepatol. 2001; (2): 215-21
- Am J Gastroenterol. 2001; (1): 233-7
- Liver Transpl. 2001; (3): 191-203
- Clin Exp Med. 2001; (4): 165-78
- Med Sci Monit. 2000 Jan-Feb; (1): 181-93
- South Med J. 2000; (3): 261-4
- Hepatology. 2000; (6): 1396-8
- Manag Care Interface. 2000; (9): 77-9
- Am J Gastroenterol. 2000; (12): 3552-65
- Manag Care Interface. 2000; (8): 62-4, 69
- West J Med. 2000; (1): 29-32
- Am Fam Physician. 2000; (6): 1673-80, 1687-8
- J Med Virol. 2000; (3): 403-8
- Arch Immunol Ther Exp (Warsz). 2000; (1): 1-10
- Clin Liver Dis. 2000; (1): 241-55
- J Viral Hepat. 2000; 15-7
- J Gastroenterol Hepatol. 1999; S37-41
- Liver Transpl Surg. 1999; (5): 369-74
- Gastrointest Endosc. 1999; (2): 279-81
- Clin Infect Dis. 1999; (1): 207-8
- Liver Transpl Surg. 1999; (4): 318-31
- Cytokines Cell Mol Ther. 1999; (4): 207-10
- Hepatology. 1999; (1): 338-9
- Cytokines Cell Mol Ther. 1999; (4): 211-6
- Clin Liver Dis. 1999; (4): 757-73
- J Gastroenterol Hepatol. 1999; S48-52
- J Gastroenterol Hepatol. 1999; S12-8
- Am J Gastroenterol. 1999; (1): 249-51
- Arch Surg. 1999; (1): 25-9
- J Clin Gastroenterol. 1999; (2): 212-3
- J Hepatol. 1999; (4): 664-71
- Am J Gastroenterol. 1999; (12): 3583-8
- J Gastroenterol Hepatol. 1999; S42-7
- J Viral Hepat. 1998; (4): 271-6
- Liver Transpl Surg. 1998; (5): 437-9
- Clin Transpl. 1998; 287-96
- Hepatology. 1998; (4): 1136-43
- Hepatology. 1998; (3): 881-6
- Annu Rev Med. 1998; 85-94
- Liver Transpl Surg. 1998; (3): 208-14
- Liver Transpl Surg. 1998; (5 Suppl 1): S108-14
- J Clin Invest. 1998; (10): 1831-40
- Clin Liver Dis. 1998; (1): 119-31, vii
- Am J Gastroenterol. 1998; (12): 2598-9
- Clin Liver Dis. 1997; (1): 77-84, xi
- Clin Liver Dis. 1997; (2): 305-21
- Hepatology. 1997; (1): 223-5
- Gastrointest Endosc Clin N Am. 1997; (2): 331-9
- West J Med. 1997; (1): 23-33
- Hepatology. 1997; (3 Suppl 1): 101S-107S
- Liver Transpl Surg. 1997; (3): 197-8
- Liver Transpl Surg. 1997; (3): 251-7
- Gastrointestinal and Liver Disease. 6th ed. Philadelphia:WB Saunders. 1997; 301-309
- Am J Gastroenterol. 1997; (1): 73-8
- J Pediatr Gastroenterol Nutr. 1997; (3): 366
- Hepatology. 1997; (3): 747-54
- Am J Gastroenterol. 1997; (11): 1957-9
- Liver Transpl Surg. 1997; (6): 628-37
- Surgery. 1996; (4): 698-704; discussion 704-5
- Liver Transpl Surg. 1996; (5 Suppl 1): 12-20
- Arch Surg. 1996; (9): 935-9; discussion 939-41
- Gastrointest Endosc. 1996; (4): 505-9
- Am J Gastroenterol. 1996; (10): 2135-8
- Gastrointest Endosc. 1996; (5): 524-8
- Hepatology. 1996; (1): 1-7
- Dig Dis. 1995 Sep-Oct; (5): 291-300
- Gastroenterol Clin North Am. 1995; (4): 991-1001
- J Hepatol. 1995; (3): 257-62
- Gastroenterology. 1995; (3): 932-4
- Liver Transpl Surg. 1995; (4): 237-41
- Liver Transpl Surg. 1995; (2): 99-102
- Am J Gastroenterol. 1995; (2): 201-5
- World J Surg. 1994 Nov-Dec; (6): 866-70; discussion 870-1
- Gastrointest Endosc. 1994 May-Jun; (3): 379-82
- Transplantation. 1994; (2): 309-11
- Chest. 1994; (1): 294-6
- Clin Transpl. 1994; 163-71
- Hepatology. 1994; (2): 404-10
- Transplantation. 1994; (4): 447-50
- Transplantation. 1994; (6): 732-4
- Dig Dis Sci. 1994; (10): 2255-9
- Am J Gastroenterol. 1994; (10): 1823-6
- Arch Surg. 1994; (10): 1018-23; discussion 1023-4
- Gastrointest Endosc. 1993 Nov-Dec; (6): 840-5
- Hepatology. 1993; (5): 1127-31
- Am J Gastroenterol. 1993; (11): 1966-8
- West J Med. 1993; (5): 586-93
- Am J Med. 1993; (6): 584-8
- Transplant Proc. 1993; (6): 3196-8