Key Documents

David K. Stevenson, M.D.

Professor, Pediatrics - Neonatology
Professor (By courtesy), Obstetrics & Gynecology
Member, Bio-X

Contact Information

Clinical Offices

Neonatal Intensive Care Unit 725 Welch Rd 2 West Palo Alto, CA 94304
Telephone Work (650) 497-8800 Fax (650) 725-8351

Clinical Focus

Neonatal-Perinatal Medicine
Neonatology

Administrative Appointments

Vice Dean, Stanford University School of Medicine , (2006– present )
Senior Associate Dean for Academic Affairs, Stanford University School of Medicine , (2001– present )
Director, Charles B. and Ann L. Johnson Center for Pregnancy and Newborn Services, Lucile Packard Children's Hospital at Stanford , (1997– present )
Harold K. Faber Professor of Pediatrics, Stanford University School of Medicine , (1992– present )
Chief, Division of Neonatal and Developmental Medicine, Stanford University School of Medicine , (1989– 2007 )
Program Director, Training in Developmental and Neonatal Biology, Stanford University School of Medicine , (1989– present )
Associate Program Director, General Clinical Research Center; Head, Pediatric Component, Stanford University School of Medicine , (1993– present )

Honors and Awards

Virginia Apgar Award in Perinatal Pediatrics, American Academy of Pediatrics (2006)
MENTOR Award for Excellence in Research Training, The National Institute of Child Health and Human Development (2004)
The Neonatal Education Award in Perinatal Pediatrics, American Academy of Pediatrics (2004)
Advisor of Highest Distinction for Exemplary Contributions to Undergraduate Education, Stanford University (2004)
The Duane Alexander Award for Academic Leadership in Perinatal Medicine, The National Institute of Child Health and Human Development (2003)
American Academy of Pediatrics Award for Excellence in Pediatric Research, American Academy of Pediatrics (1991)
Ross Young Investigator Award, Western Society for Pediatric Research (1990)
Kaiser Award for Outstanding and Innovative Contributions to Medical Education, The Henry J. Kaiser Family Foundation (1983)

Professional Education

Board Certification: General Pediatrics, American Board of Pediatrics (1979)
Stanford University Medical Center (1979) CA
University of Washington School of Medicine-GME (1977) WA
University of Washington School of Medicine-GME (1976) WA
University of Washington School of Medicine-GME (1975) WA
B.A., Stanford University Philosophy (1971)
M.D., University of Washington School of Medicine Medicine (1975)

Research Interests

Our research is focused on the study of the ontogeny and control of heme catabolism and bilirubin production in the developing neonate. A better understanding of the role of increased bilirubin production in neonatal jaundice and the prevention of hemolytic jaundice has remained an overall objective of our program. To this end, we are actively investigating a more targeted, preventive approach to the diagnosis and treatment of newborns, who are high producers of the pigment and/or unable to efficiently eliminate bilirubin, thus leading to an accumulation of the pigment in circulation and tissues, which may lead to irreversible neurologic injury. Control of bilirubin production is a logical strategy, but has unexplored consequences for the immature mammal. Thus, we are studying the pivotal role of heme oxygenase (HO), the rate-limiting enzyme in the production of bilirubin, under a variety of commonly encountered pathological conditions, such as infection and hypoxia-ischemia, as well as in anti-oxidant defense, immune response and the regulation of hematopoiesis. In support of the above interests, studies are in progress, which are designed to screen a variety of metalloporphyrins and other compounds for maximum in vitro and in vivo efficacy with minimal side effects; to determine the ontogeny of the HO enzyme system in various murine tissues, focusing on perturbations resulting from treatment with HO inhibitors; and further to develop and test new technologies for noninvasive or minimally-invasive measurements of in vivo metabolism that could be used for diagnostic and monitoring purposes.

Clinical Trials

Late Hypothermia for Hypoxic-Ischemic Encephalopathy Recruiting
Inhaled PGE1 in Neonatal Hypoxemic Respiratory Failure Terminated
Continuous Positive Airway Pressure (CPAP) Versus Surfactant, and a Lower Versus a Higher Oxygen Saturation in 24 to 27 Week Preterm Infants No longer recruiting

Publications

Effect of heme oxygenase-1 deficiency on placental development. Zhao H, Wong RJ, Kalish FS, Nayak NR, Stevenson DK. Placenta. 2009; 30 (10): 861-8
Dermal carbon monoxide excretion in neonatal rats during light exposure. Vreman HJ, Knauer Y, Wong RJ, Chan ML, Stevenson DK. Pediatr Res. 2009; 66 (1): 66-9
Standardized bench method for evaluating the efficacy of phototherapy devices. Vreman HJ, Wong RJ, Murdock JR, Stevenson DK. Acta Paediatr. 2008; 97 (3): 308-16
Aggressive vs. conservative phototherapy for infants with extremely low birth weight. Morris BH, Oh W, Tyson JE, Stevenson DK, Phelps DL, O'Shea TM, McDavid GE, Perritt RL, Van Meurs KP, Vohr BR, Grisby C, Yao Q, Pedroza C, Das A, Poole WK, Carlo WA, Duara S, Laptook AR, Salhab WA, Shankaran S, Poindexter BB, Fanaroff AA, Walsh MC, Rasmussen MR, Stoll BJ, Cotten CM, Donovan EF, Ehrenkranz RA, Guillet R, Higgins RD. N Engl J Med. 2008; 359 (18): 1885-96
Inhibition of heme oxygenase activity in newborn mice by azalanstat. Morisawa T, Wong RJ, Bhutani VK, Vreman HJ, Stevenson DK. Can J Physiol Pharmacol. 2008; 86 (10): 651-9
Heme oxygenase-1 deficiency leads to disrupted response to acute stress in stem cells and progenitors. Cao YA, Wagers AJ, Karsunky H, Zhao H, Reeves R, Wong RJ, Stevenson DK, Weissman IL, Contag CH. Blood. 2008; 112 (12): 4494-502
Statin treatment increases formation of carbon monoxide and bilirubin in mice: a novel mechanism of in vivo antioxidant protection. Muchova L, Wong RJ, Hsu M, Morioka I, Vitek L, Zelenka J, Schröder H, Stevenson DK. Can J Physiol Pharmacol. 2007; 85 (8): 800-10
(TA)n UGT 1A1 promoter polymorphism: a crucial factor in the pathophysiology of jaundice in G-6-PD deficient neonates. Kaplan M, Renbaum P, Vreman HJ, Wong RJ, Levy-Lahad E, Hammerman C, Stevenson DK. Pediatr Res. 2007; 61 (6): 727-31
Concentration of carbon monoxide (CO) in postmortem human tissues: effect of environmental CO exposure. Vreman HJ, Wong RJ, Stevenson DK, Smialek JE, Fowler DR, Li L, Vigorito RD, Zielke HR. J Forensic Sci. 2006; 51 (5): 1182-90
American Pediatric Society Presidential Address 2006: science on the edge with life in the balance. Stevenson DK, Pediatr Res. 2006; 60 (5): 630-5
Tissue-specific effects of statins on the expression of heme oxygenase-1 in vivo. Hsu M, Muchova L, Morioka I, Wong RJ, Schröder H, Stevenson DK. Biochem Biophys Res Commun. 2006; 343 (3): 738-44
The effectiveness of oral tin mesoporphyrin prophylaxis in reducing bilirubin production after an oral heme load in a transgenic mouse model. DeSandre GH, Wong RJ, Morioka I, Contag CH, Stevenson DK. Biol Neonate. 2006; 89 (3): 139-46
Systemic effects of orally-administered zinc and tin (IV) metalloporphyrins on heme oxygenase expression in mice. Morioka I, Wong RJ, Abate A, Vreman HJ, Contag CH, Stevenson DK. Pediatr Res. 2006; 59 (5): 667-72
Inhaled nitric oxide for premature infants with severe respiratory failure. Van Meurs KP, Wright LL, Ehrenkranz RA, Lemons JA, Ball MB, Poole WK, Perritt R, Higgins RD, Oh W, Hudak ML, Laptook AR, Shankaran S, Finer NN, Carlo WA, Kennedy KA, Fridriksson JH, Steinhorn RH, Sokol GM, Konduri GG, Aschner JL, Stoll BJ, D'Angio CT, Stevenson DK. N Engl J Med. 2005; 353 (1): 13-22
Phototherapy: current methods and future directions. Vreman HJ, Wong RJ, Stevenson DK. Semin Perinatol. 2004; 28 (5): 326-33
A primer on neonatal jaundice. Stevenson DK, Wong RJ, DeSandre GH, Vreman HJ. Adv Pediatr. 2004; 51 263-88
Heme oxygenase-2 protects against lipid peroxidation-mediated cell loss and impaired motor recovery after traumatic brain injury. Chang EF, Wong RJ, Vreman HJ, Igarashi T, Galo E, Sharp FR, Stevenson DK, Noble-Haeusslein LJ. J Neurosci. 2003; 23 (9): 3689-96
Inhaled nitric oxide for preterm premature rupture of membranes, oligohydramnios, and pulmonary hypoplasia. Chock VY, Van Meurs KP, Hintz SR, Ehrenkranz RA, Lemons JA, Kendrick DE, Stevenson DK. Am J Perinatol. 2009; 26 (4): 317-22
Commentary on the bilirubin supplement. Stevenson DK, J Perinatol. 2009; 29 Suppl 1 S2-3
Neonatal brain structure on MRI and diffusion tensor imaging, sex, and neurodevelopment in very-low-birthweight preterm children. Rose J, Butler EE, Lamont LE, Barnes PD, Atlas SW, Stevenson DK. Dev Med Child Neurol. 2009; 51 (7): 526-35
Readmission for neonatal jaundice in California, 1991-2000: trends and implications. Burgos AE, Schmitt SK, Stevenson DK, Phibbs CS. Pediatrics. 2008; 121 (4): e864-9
The role of Bach1 in the induction of heme oxygenase by tin mesoporphyrin. Abate A, Zhao H, Wong RJ, Stevenson DK. Biochem Biophys Res Commun. 2007; 354 (3): 757-63
The potential Salmonella aroA- vaccine strain is safe and effective in young BALB/c mice. Burns-Guydish SM, Zhao H, Stevenson DK, Contag CH. Neonatology. 2007; 91 (2): 114-20
Interobserver reliability and accuracy of cranial ultrasound scanning interpretation in premature infants. Hintz SR, Slovis T, Bulas D, Van Meurs KP, Perritt R, Stevenson DK, Poole WK, Das A, Higgins RD. J Pediatr. 2007; 150 (6): 592-6, 596.e1-5
Neurodevelopmental outcomes of premature infants with severe respiratory failure enrolled in a randomized controlled trial of inhaled nitric oxide. Hintz SR, Van Meurs KP, Perritt R, Poole WK, Das A, Stevenson DK, Ehrenkranz RA, Lemons JA, Vohr BR, Heyne R, Childers DO, Peralta-Carcelen M, Dusick A, Johnson YR, Morris B, Dillard R, Vaucher Y, Steichen J, Adams-Chapman I, Konduri G, Myers GJ, de Ungria M, Tyson JE, Higgins RD. J Pediatr. 2007; 151 (1): 16-22, 22.e1-3
Beware of the weaker sex: don't get too close to your twin brother. Stevenson DK, Tyson JE. Pediatrics. 2007; 120 (3): 638-9
Inhaled nitric oxide in infants >1500 g and <34 weeks gestation with severe respiratory failure. Van Meurs KP, Hintz SR, Ehrenkranz RA, Lemons JA, Ball MB, Poole WK, Perritt R, Das A, Higgins RD, Stevenson DK. J Perinatol. 2007; 27 (6): 347-52
Neonatal microstructural development of the internal capsule on diffusion tensor imaging correlates with severity of gait and motor deficits. Rose J, Mirmiran M, Butler EE, Lin CY, Barnes PD, Kermoian R, Stevenson DK. Dev Med Child Neurol. 2007; 49 (10): 745-50
Expression and regulation of heme oxygenase isozymes in the developing mouse cortex. Zhao H, Wong RJ, Nguyen X, Kalish F, Mizobuchi M, Vreman HJ, Stevenson DK, Contag CH. Pediatr Res. 2006; 60 (5): 518-23
Transcutaneous bilirubinometry: a noninvasive tool for studying newborn jaundiced rats before and after exposure to light. Vreman HJ, Wong RJ, Chan ML, Young BW, Stevenson DK. Pediatr Res. 2006; 59 (2): 203-9
Determination of carbon monoxide (CO) in rodent tissue: effect of heme administration and environmental CO exposure. Vreman HJ, Wong RJ, Kadotani T, Stevenson DK. Anal Biochem. 2005; 341 (2): 280-9
Monitoring age-related susceptibility of young mice to oral Salmonella enterica serovar Typhimurium infection using an in vivo murine model. Burns-Guydish SM, Olomu IN, Zhao H, Wong RJ, Stevenson DK, Contag CH. Pediatr Res. 2005; 58 (1): 153-8
Apigenin decreases hemin-mediated heme oxygenase-1 induction. Abate A, Yang G, Wong RJ, Schroder H, Stevenson DK, Dennery PA. Free Radic Biol Med. 2005; 39 (6): 711-8
End tidal carbon monoxide levels are lower in women with gestational hypertension and pre-eclampsia. Kreiser D, Baum M, Seidman DS, Fanaroff A, Shah D, Hendler I, Stevenson DK, Schiff E, Druzin ML. J Perinatol. 2004; 24 (4): 213-7
NICHD Conference on Kernicterus: Research on Prevention of Bilirubin-Induced Brain Injury and Kernicterus: Bench-to-Bedside--Diagnostic Methods and Prevention and Treatment Strategies. Stevenson DK, Wong RJ, Vreman HJ, McDonagh AF, Maisels MJ, Lightner DA. J Perinatol. 2004; 24 (8): 521-5
Characterization of coelenterazine analogs for measurements of Renilla luciferase activity in live cells and living animals. Zhao H, Doyle TC, Wong RJ, Cao Y, Stevenson DK, Piwnica-Worms D, Contag CH. Mol Imaging. 2004; 3 (1): 43-54
Cesarean delivery rates and neonatal morbidity in a low-risk population. Gould JB, Danielsen B, Korst LM, Phibbs R, Chance K, Main E, Wirtschafter DD, Stevenson DK. Obstet Gynecol. 2004; 104 (1): 11-9
Continuous, noninvasive, and localized microvascular tissue oximetry using visible light spectroscopy. Benaron DA, Parachikov IH, Friedland S, Soetikno R, Brock-Utne J, van der Starre PJ, Nezhat C, Terris MK, Maxim PG, Carson JJ, Razavi MK, Gladstone HB, Fincher EF, Hsu CP, Clark FL, Cheong WF, Duckworth JL, Stevenson DK. Anesthesiology. 2004; 100 (6): 1469-75
Effects of metalloporphyrins on heme oxygenase-1 transcription: correlative cell culture assays guide in vivo imaging. Hajdena-Dawson M, Zhang W, Contag PR, Wong RJ, Vreman HJ, Stevenson DK, Contag CH. Mol Imaging. 2003; 2 (3): 138-49
Gestational pattern of heme oxygenase expression in the rat. Kreiser D, Kelly DK, Seidman DS, Stevenson DK, Baum M, Dennery PA. Pediatr Res. 2003; 54 (2): 172-8
Heme oxygenase-1 modulates fetal growth in the rat. Kreiser D, Nguyen X, Wong R, Seidman D, Stevenson D, Quan S, Abraham N, Dennery PA. Lab Invest. 2002; 82 (6): 687-92
The jaundiced newborn. Understanding and managing transitional hyperbilirubinemia. Stevenson DK, Wong RJ, Hintz SR, Vreman HJ. Minerva Pediatr. 2002; 54 (5): 373-82
Selection of potential therapeutics based on in vivo spatiotemporal transcription patterns of heme oxygenase-1. Zhang W, Contag PR, Hardy J, Zhao H, Vreman HJ, Hajdena-Dawson M, Wong RJ, Stevenson DK, Contag CH. J Mol Med. 2002; 80 (10): 655-64
Ethical considerations in neuroimaging and its impact on decision-making for neonates. Stevenson DK, Goldworth A. Brain Cogn. 2002; 50 (3): 449-54
Neonatal hyperbilirubinemia. Dennery PA, Seidman DS, Stevenson DK. N Engl J Med. 2001; 344 (8): 581-90
Unique effects of zinc protoporphyrin on HO-1 induction and apoptosis. Yang G, Nguyen X, Ou J, Rekulapelli P, Stevenson DK, Dennery PA. Blood. 2001; 97 (5): 1306-13
Serum bilirubin levels at 72 hours by selected characteristics in breastfed and formula-fed term infants delivered by cesarean section. Hintz SR, Gaylord TD, Oh W, Fanaroff AA, Mele L, Stevenson DK, Nichd FT. Acta Paediatr. 2001; 90 (7): 776-81
Prediction of hyperbilirubinemia in near-term and term infants. Stevenson DK, Fanaroff AA, Maisels MJ, Young BW, Wong RJ, Vreman HJ, MacMahon JR, Yeung CY, Seidman DS, Gale R, Oh W, Bhutani VK, Johnson LH, Kaplan M, Hammerman C, Nakamura H. Pediatrics. 2001; 108 (1): 31-9
Carbon monoxide and bilirubin production in neonates. Stevenson DK, Vreman HJ, Wong RJ, Contag CH. Semin Perinatol. 2001; 25 (2): 85-93
In vivo patterns of heme oxygenase-1 transcription. Contag CH, Stevenson DK. J Perinatol. 2001; 21 Suppl 1 S119-24; discussion S125-7
Alternative metalloporphyrins for the treatment of neonatal jaundice. Vreman HJ, Wong RJ, Stevenson DK. J Perinatol. 2001; 21 Suppl 1 S108-13; discussion S125-7
Prediction of hyperbilirubinemia in near-term and term infants. Stevenson DK, Fanaroff AA, Maisels MJ, Young BW, Wong RJ, Vreman HJ, MacMahon JR, Yeung CY, Seidman DS, Gale R, Oh W, Bhutani VK, Johnson LH, Kaplan M, Hammerman C, Nakamura H. J Perinatol. 2001; 21 Suppl 1 S63-72; discussion S83-7
Understanding newborn jaundice. Stevenson DK, Dennery PA, Hintz SR. J Perinatol. 2001; 21 Suppl 1 S21-4; discussion S35-9
The biology of bilirubin production. Dennery PA, Weng YH, Stevenson DK, Yang G. J Perinatol. 2001; 21 Suppl 1 S17-20; discussion S35-9
Just when you thought it was safe. Hintz SR, Stevenson DK. Pediatr Res. 2001; 50 (6): 676-7
Rapid in vivo functional analysis of transgenes in mice using whole body imaging of luciferase expression. Zhang W, Feng JQ, Harris SE, Contag PR, Stevenson DK, Contag CH. Transgenic Res. 2001; 10 (5): 423-34
Bedside functional imaging of the premature infant brain during passive motor activation. Hintz SR, Benaron DA, Siegel AM, Zourabian A, Stevenson DK, Boas DA. J Perinat Med. 2001; 29 (4): 335-43
Reduction of the NO-mediated response in the rat aorta by metalloporphyrins. Vreman HJ, Haenen GR, Stevenson DK, Bast A. Can J Physiol Pharmacol. 2000; 78 (6): 457-61
Carbon monoxide detection and biological investigations. Stevenson DK, Vreman HJ, Wong RJ, Dennery PA, Contag CH. Trans Am Clin Climatol Assoc. 2000; 111 61-75
Haem oxygenase activity in human umbilical cord and rat vascular tissues. Vreman HJ, Wong RJ, Kim EC, Nabseth DC, Marks GS, Stevenson DK. Placenta. 2000; 21 (4): 337-44
Noninvasive functional imaging of human brain using light. Benaron DA, Hintz SR, Villringer A, Boas D, Kleinschmidt A, Frahm J, Hirth C, Obrig H, van Houten JC, Kermit EL, Cheong WF, Stevenson DK. J Cereb Blood Flow Metab. 2000; 20 (3): 469-77
Sex differences in outcomes of very low birthweight infants: the newborn male disadvantage. Stevenson DK, Verter J, Fanaroff AA, Oh W, Ehrenkranz RA, Shankaran S, Donovan EF, Wright LL, Lemons JA, Tyson JE, Korones SB, Bauer CR, Stoll BJ, Papile LA. Arch Dis Child Fetal Neonatal Ed. 2000; 83 (3): F182-5
Bilirubin toxicity and differentiation of cultured astrocytes. Rhine WD, Schmitter SP, Yu AC, Eng LF, Stevenson DK. J Perinatol. 1999 Apr-May; 19 (3): 206-11
Validation of the Natus CO-Stat End Tidal Breath Analyzer in children and adults. Vreman HJ, Wong RJ, Harmatz P, Fanaroff AA, Berman B, Stevenson DK. J Clin Monit Comput. 1999; 15 (7-8): 421-7
Effects of skin-to-skin holding on general movements of preterm infants. Constantinou JC, Adamson-Macedo EN, Stevenson DK, Mirmiran M, Fleisher BE. Clin Pediatr (Phila). 1999; 38 (8): 467-71
Bedside imaging of intracranial hemorrhage in the neonate using light: comparison with ultrasound, computed tomography, and magnetic resonance imaging. Hintz SR, Cheong WF, van Houten JP, Stevenson DK, Benaron DA. Pediatr Res. 1999; 45 (1): 54-9
Bioluminescence for biological sensing in living mammals. Zhang W, Contag PR, Madan A, Stevenson DK, Contag CH. Adv Exp Med Biol. 1999; 471 775-84
Diffusion and perfusion magnetic resonance imaging of the evolution of hypoxic ischemic encephalopathy in the neonatal rabbit. D'Arceuil HE, de Crespigny AJ, Röther J, Seri S, Moseley ME, Stevenson DK, Rhine W. J Magn Reson Imaging. 1998 Jul-Aug; 8 (4): 820-8
Stationary headband for clinical time-of-flight optical imaging at the bedside. Hintz SR, Benaron DA, van Houten JP, Duckworth JL, Liu FW, Spilman SD, Stevenson DK, Cheong WF. Photochem Photobiol. 1998; 68 (3): 361-9
Strategy for lipid suppression in lactate imaging using STIR-DQCT: a study of hypoxic-ischemic brain injury. Nakai T, Rhine WD, Okada T, Stevenson DK, Spielman DM. Magn Reson Med. 1998; 40 (4): 629-32
Ethical dilemmas in the delivery room. Stevenson DK, Goldworth A. Semin Perinatol. 1998; 22 (3): 198-206
Light-emitting diodes: a novel light source for phototherapy. Vreman HJ, Wong RJ, Stevenson DK, Route RK, Reader SD, Fejer MM, Gale R, Seidman DS. Pediatr Res. 1998; 44 (5): 804-9
Very low birth weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, January 1993 through December 1994. Stevenson DK, Wright LL, Lemons JA, Oh W, Korones SB, Papile LA, Bauer CR, Stoll BJ, Tyson JE, Shankaran S, Fanaroff AA, Donovan EF, Ehrenkranz RA, Verter J. Am J Obstet Gynecol. 1998; 179 (6 Pt 1): 1632-9
Simultaneous production of carbon monoxide and thiobarbituric acid reactive substances in rat tissue preparations by an iron-ascorbate system. Vreman HJ, Wong RJ, Sanesi CA, Dennery PA, Stevenson DK. Can J Physiol Pharmacol. 1998; 76 (12): 1057-65
Neonatal hypoglycemia, part II: pathophysiology and therapy. Halamek LP, Stevenson DK. Clin Pediatr (Phila). 1998; 37 (1): 11-6
Bioluminescent indicators in living mammals. Contag PR, Olomu IN, Stevenson DK, Contag CH. Nat Med. 1998; 4 (2): 245-7
Supplemental oxygen may decrease progression of prethreshold disease to threshold retinopathy of prematurity. Gaynon MW, Stevenson DK, Sunshine P, Fleisher BE, Landers MB. J Perinatol. 1997 Nov-Dec; 17 (6): 434-8
Neonatal hypoglycemia, Part I: Background and definition. Halamek LP, Benaron DA, Stevenson DK. Clin Pediatr (Phila). 1997; 36 (12): 675-80
Visualizing gene expression in living mammals using a bioluminescent reporter. Contag CH, Spilman SD, Contag PR, Oshiro M, Eames B, Dennery P, Stevenson DK, Benaron DA. Photochem Photobiol. 1997; 66 (4): 523-31
Carbon monoxide and bilirubin production in neonates. Stevenson DK, Vreman HJ. Pediatrics. 1997; 100 (2 Pt 1): 252-4
Tissue optics. Benaron DA, Cheong WF, Stevenson DK. Science. 1997; 276 (5321): 2002-3
Development of jaundice in Korean neonates after cesarean section. Lee CS, Vreman HJ, Choi JH, Yun CK, Stevenson DK. Acta Paediatr Jpn. 1997; 39 (3): 309-11
The value of neurophysiologic approaches in the anticipation and evaluation of neonatal hypoglycemia. Halamek LP, Benaron DA, Stevenson DK. Acta Paediatr Jpn. 1997; 39 Suppl 1 S33-43
Neonatal severity of illness scoring systems: a comparison. Fleisher BE, Murthy L, Lee S, Constantinou JC, Benitz WE, Stevenson DK. Clin Pediatr (Phila). 1997; 36 (4): 223-7
Nitrovasodilator therapy for severe respiratory distress syndrome. Benitz WE, Rhine WD, Van Meurs KP, Stevenson DK. J Perinatol. 1996 Nov-Dec; 16 (6): 443-8
A model for detecting early metabolic changes in neonatal asphyxia by 1H-MRS. Nakai T, Rhine WD, Enzmann DR, Stevenson DK, Spielman DM. J Magn Reson Imaging. 1996 May-Jun; 6 (3): 445-52
Evaluation of neonatal jaundice: monitoring the transition in bilirubin metabolism. Stevenson DK, Vreman HJ, Benaron DA. J Perinatol. 1996 May-Jun; 16 (3 Pt 2): S62-7
Duration of action and tissue distribution of zinc protoporphyrin in neonatal rats. Rodgers PA, Seidman DS, Wei PL, Dennery PA, Stevenson DK. Pediatr Res. 1996; 39 (6): 1041-9
Evaluation of a fully automated end-tidal carbon monoxide instrument for breath analysis. Vreman HJ, Baxter LM, Stone RT, Stevenson DK. Clin Chem. 1996; 42 (1): 50-6
Neonatal intracranial ischemia and hemorrhage: diagnosis with US, CT, and MR imaging. Blankenberg FG, Norbash AM, Lane B, Stevenson DK, Bracci PM, Enzmann DR. Radiology. 1996; 199 (1): 253-9
Imaging brain injury using time-resolved near infrared light scanning. Van Houten JP, Benaron DA, Spilman S, Stevenson DK. Pediatr Res. 1996; 39 (3): 470-6
Characterization of porphyrin heme oxygenase inhibitors. Vreman HJ, Cipkala DA, Stevenson DK. Can J Physiol Pharmacol. 1996; 74 (3): 278-85
Hepatic heme oxygenase is inducible in neonatal rats during the early postnatal period. Tom DJ, Rodgers PA, Shokoohi V, Stevenson DK, Dennery PA. Pediatr Res. 1996; 40 (2): 288-93
The risk of carbon monoxide poisoning after prolonged laparoscopic surgery. Nezhat C, Seidman DS, Vreman HJ, Stevenson DK, Nezhat F, Nezhat C. Obstet Gynecol. 1996; 88 (5): 771-4
Is Carbon Monoxide Poisoning a Risk During Prolonged Laparoscopic Surgery? Seidman DS, Nezhat CR, Vreman HJ, Stevenson DK, Brock-Une JG. J Am Assoc Gynecol Laparosc. 1996; 3 (4, Supplement): S45
Interlaboratory variability of bilirubin measurements. Vreman HJ, Verter J, Oh W, Fanaroff AA, Wright LL, Lemons JA, Shankaran S, Tyson JE, Korones SB, Bauer CR, Stoll BJ, Papile LA, Donovan EF, Ehrenkranz RA, Stevenson DK. Clin Chem. 1996; 42 (6 Pt 1): 869-73
Hyperbilirubinemia results in reduced oxidative injury in neonatal Gunn rats exposed to hyperoxia. Dennery PA, McDonagh AF, Spitz DR, Rodgers PA, Stevenson DK. Free Radic Biol Med. 1995; 19 (4): 395-404
Individualized developmental care for very-low-birth-weight premature infants. Fleisher BE, VandenBerg K, Constantinou J, Heller C, Benitz WE, Johnson A, Rosenthal A, Stevenson DK. Clin Pediatr (Phila). 1995; 34 (10): 523-9
Photonic detection of bacterial pathogens in living hosts. Contag CH, Contag PR, Mullins JI, Spilman SD, Stevenson DK, Benaron DA. Mol Microbiol. 1995; 18 (4): 593-603
Hospital readmission due to neonatal hyperbilirubinemia. Seidman DS, Stevenson DK, Ergaz Z, Gale R. Pediatrics. 1995; 96 (4 Pt 1): 727-9
Carbon monoxide and carboxyhemoglobin. Vreman HJ, Mahoney JJ, Stevenson DK. Adv Pediatr. 1995; 42 303-34
Neonatal jaundice--what now? Dennery PA, Rhine WD, Stevenson DK. Clin Pediatr (Phila). 1995; 34 (2): 103-7
Recombinant human erythropoietin (r-HuEPO) increases total bilirubin production in premature infants. Baxter LM, Vreman HJ, Ball B, Stevenson DK. Clin Pediatr (Phila). 1995; 34 (4): 213-6
Advances in the diagnosis and treatment of neonatal hyperbilirubinemia. Yao TC, Stevenson DK. Clin Perinatol. 1995; 22 (3): 741-58
Effect of phototherapy for neonatal jaundice on cognitive performance. Seidman DS, Paz I, Stevenson DK, Laor A, Danon YL, Gale R. J Perinatol. 1994 Jan-Feb; 14 (1): 23-8
Semiportable electrochemical instrument for determining carbon monoxide in breath. Vreman HJ, Stevenson DK, Oh W, Fanaroff AA, Wright LL, Lemons JA, Wright E, Shankaran S, Tyson JE, Korones SB. Clin Chem. 1994; 40 (10): 1927-33
Maternal transmission of human immunodeficiency virus-1. Paz I, Seidman DS, Mashiach S, Stevenson DK. Obstet Gynecol Surv. 1994; 49 (8): 577-84
Carboxyhemoglobin determined in neonatal blood with a CO-oximeter unaffected by fetal oxyhemoglobin. Vreman HJ, Stevenson DK. Clin Chem. 1994; 40 (8): 1522-7
Kernicterus in a full term infant. Penn AA, Enzmann DR, Hahn JS, Stevenson DK. Pediatrics. 1994; 93 (6 Pt 1): 1003-6
Tomographic time-of-flight optical imaging device. Benaron DA, Ho DC, Spilman S, Van Houten JP, Stevenson DK. Adv Exp Med Biol. 1994; 361 207-14
Non-recursive linear algorithms for optical imaging in diffusive media. Benaron DA, Ho DC, Spilman S, Van Houten JP, Stevenson DK. Adv Exp Med Biol. 1994; 361 215-22
Resolution of near infrared time-of-flight brain oxygenation imaging. Benaron DA, Stevenson DK. Adv Exp Med Biol. 1994; 345 609-17
Bilirubin production in healthy term infants as measured by carbon monoxide in breath. Stevenson DK, Vreman HJ, Oh W, Fanaroff AA, Wright LL, Lemons JA, Verter J, Shankaran S, Tyson JE, Korones SB. Clin Chem. 1994; 40 (10): 1934-9
Sources of carbon monoxide (CO) in biological systems and applications of CO detection technologies. Rodgers PA, Vreman HJ, Dennery PA, Stevenson DK. Semin Perinatol. 1994; 18 (1): 2-10
Gd-DTPA MR detection of blood-brain barrier opening in rats after hyperosmotic shock. Rhine WD, Benaron DA, Enzmann DR, Chung C, Gonzales-Mendez R, Sayre JR, Stevenson DK. J Comput Assist Tomogr. 1993 Jul-Aug; 17 (4): 563-6
Measurement of carboxyhemoglobin and total hemoglobin by five specialized spectrophotometers (CO-oximeters) in comparison with reference methods. Mahoney JJ, Vreman HJ, Stevenson DK, Van Kessel AL. Clin Chem. 1993; 39 (8): 1693-700
Role of lipid peroxidation in metalloporphyrin-mediated phototoxic reactions in neonatal rats. Dennery PA, Vreman HJ, Rodgers PA, Stevenson DK. Pediatr Res. 1993; 33 (1): 87-91
Inhibition of heme oxygenase after oral vs intraperitoneal administration of chromium porphyrins. Vallier HA, Rodgers PA, Stevenson DK. Life Sci. 1993; 52 (10): PL79-84
Selection of metalloporphyrin heme oxygenase inhibitors based on potency and photoreactivity. Vreman HJ, Ekstrand BC, Stevenson DK. Pediatr Res. 1993; 33 (2): 195-200
Optical time-of-flight and absorbance imaging of biologic media. Benaron DA, Stevenson DK. Science. 1993; 259 (5100): 1463-6
Prediction of the development of low birth weight preterm infants by a new neonatal medical index. Korner AF, Stevenson DK, Kraemer HC, Spiker D, Scott DT, Constantinou J, Dimiceli S. J Dev Behav Pediatr. 1993; 14 (2): 106-11
Maturation of jejunoileal gradients in rat intestine: the role of intraluminal nutrients. Castillo RO, Feng JJ, Stevenson DK, Kwong LK. Biol Neonate. 1992; 62 (5): 351-62
Effects of microwave radiation on anti-infective factors in human milk. Quan R, Yang C, Rubinstein S, Lewiston NJ, Sunshine P, Stevenson DK, Kerner JA. Pediatrics. 1992; 89 (4 Pt 1): 667-9
Noninvasive methods for estimating in vivo oxygenation. Benaron DA, Benitz WE, Ariagno RL, Stevenson DK. Clin Pediatr (Phila). 1992; 31 (5): 258-73
Race, ethnicity, and the propensity for neonatal jaundice. Introduction. Stevenson DK, Brown AK. Clin Pediatr (Phila). 1992; 31 (12): 706-7
The carboxyhemoglobin method for estimating bilirubin production in neonates. Japanese studies. Stevenson DK, Clin Pediatr (Phila). 1992; 31 (12): 708-11
Delayed compliance increase in infants with respiratory distress syndrome following synthetic surfactant. Armsby DH, Bellon G, Carlisle K, Rector D, Baldwin R, Long W, Stevenson DK, Ariagno RL. Pediatr Pulmonol. 1992; 14 (4): 206-13
Altered maturation of small intestinal function in the absence of intraluminal nutrients: rapid normalization with refeeding. Castillo RO, Feng JJ, Stevenson DK, Kwong LK. Am J Clin Nutr. 1991; 53 (2): 558-61
A study of nephrotoxin-induced acute tubular necrosis with 31P magnetic resonance spectroscopy. Schutz T, González-Méndez R, Nabseth DC, Tune BM, Jardetzky O, Stevenson DK. Magn Reson Med. 1991; 18 (1): 159-68
Fetal hemoglobin of transfused neonates and spectrophotometric measurements of oxyhemoglobin and carboxyhemoglobin. Mahoney JJ, Wong RJ, Vreman HJ, Stevenson DK. J Clin Monit. 1991; 7 (2): 154-60
Observations on neonatal hyperbilirubinemia. Stevenson DK, Brown AK. N Y State J Med. 1991; 91 (11): 477-8
In vitro and in vivo characteristics of a heme oxygenase inhibitor: ZnBG. Vreman HJ, Lee OK, Stevenson DK. Am J Med Sci. 1991; 302 (6): 335-41
Anthropometry and bilirubin production. Stevenson DK, Ochikubo CG, Rodgers PA, Kerner JA. J Perinatol. 1991; 11 (4): 340-2
Oral administration of zinc deuteroporphyrin IX 2,4 bis glycol inhibits heme oxygenase in neonatal rats. Vallier HA, Rodgers PA, Stevenson DK. Dev Pharmacol Ther. 1991; 17 (3-4): 220-2
Absorption of zinc deuteroporphyrin IX 2,4-bis-glycol by the neonatal rat small intestine in vivo. Vallier HA, Rodgers PA, Castillo RO, Stevenson DK. Dev Pharmacol Ther. 1991; 17 (1-2): 109-15
Zinc protoporphyrin administration for suppression of increased bilirubin production by iatrogenic hemolysis in rhesus neonates. Vreman HJ, Rodgers PA, Stevenson DK. J Pediatr. 1990; 117 (2 Pt 1): 292-7
A comparison of tocolysis with nifedipine or ritodrine: analysis of efficacy and maternal, fetal, and neonatal outcome. Ferguson JE, Dyson DC, Schutz T, Stevenson DK. Am J Obstet Gynecol. 1990; 163 (1 Pt 1): 105-11
Developmental biology of heme oxygenase. Rodgers PA, Stevenson DK. Clin Perinatol. 1990; 17 (2): 275-91
Metalloporphyrin-enhanced photodegradation of bilirubin in vitro. Vreman HJ, Stevenson DK. Am J Dis Child. 1990; 144 (5): 590-4
Limiting treatment for extremely premature, low-birth-weight infants (500 to 750 g). Young EW, Stevenson DK. Am J Dis Child. 1990; 144 (5): 549-52
In vitro generation of carbon monoxide from organic molecules and synthetic metalloporphyrins mediated by light. Vreman HJ, Gillman MJ, Downum KR, Stevenson DK. Dev Pharmacol Ther. 1990; 15 (2): 112-24
Mortality of metalloporphyrin-treated neonatal rats after light exposure. Hintz SR, Vreman HJ, Stevenson DK. Dev Pharmacol Ther. 1990; 14 (3): 187-92
Heme catabolism in rhesus neonates inhibited by zinc protoporphyrin. Rodgers PA, Vreman HJ, Stevenson DK. Dev Pharmacol Ther. 1990; 14 (4): 216-22
The use of antibiotics in neonates weighing less than 1200 grams. Prober CG, Stevenson DK, Benitz WE. Pediatr Infect Dis J. 1990; 9 (2): 111-21
Regulation of intestinal ontogeny by intraluminal nutrients. Castillo RO, Feng JJ, Stevenson DK, Kerner JA, Kwong LK. J Pediatr Gastroenterol Nutr. 1990; 10 (2): 199-205
Carbon monoxide production by nonbacterial sources after heme feeding of neonatal rats. Stevenson DK, Hamori CJ, Carlton RR, Castillo RO, Kerner JA, Vreman HJ. Biol Neonate. 1990; 57 (3-4): 238-42
Neonatal bilirubin production after preterm labor tocolysis with nifedipine. Ferguson JE, Schutz TE, Stevenson DK. Dev Pharmacol Ther. 1989; 12 (3): 113-7
Zinc protoporphyrin inhibits CO production in rats. Hamori CJ, Vreman HJ, Rodgers PA, Stevenson DK. J Pediatr Gastroenterol Nutr. 1989; 8 (1): 110-5
A concurrent epidemic of respiratory syncytial virus and echovirus 7 infections in an intensive care nursery. Wilson CW, Stevenson DK, Arvin AM. Pediatr Infect Dis J. 1989; 8 (1): 24-9
Interpreting the carboxyhaemoglobin concentration in fetal cord blood. Leonard MB, Vreman HJ, Ferguson JE, Smith DW, Stevenson DK. J Dev Physiol. 1989; 11 (2): 73-6
The use of metalloporphyrins for the chemoprevention of neonatal jaundice. Stevenson DK, Rodgers PA, Vreman HJ. Am J Dis Child. 1989; 143 (3): 353-6
The real challenge of "Baby Doe": considering the sanctity and quality of life. Goldworth A, Stevenson DK. Clin Pediatr (Phila). 1989; 28 (3): 119-22
Carbon monoxide excretion as an index of bilirubin production in rhesus monkeys. Vreman HJ, Rodgers PA, Gale R, Stevenson DK. J Med Primatol. 1989; 18 (6): 449-60
Nifedipine pharmacokinetics during preterm labor tocolysis. Ferguson JE, Schutz T, Pershe R, Stevenson DK, Blaschke T. Am J Obstet Gynecol. 1989; 161 (6 Pt 1): 1485-90
Stable individual differences in developmentally changing preterm infants: a replicated study. Korner AF, Brown BW, Dimiceli S, Forrest T, Stevenson DK, Lane NM, Constantinou J, Thom VA. Child Dev. 1989; 60 (2): 502-13
Vancomycin pharmacokinetics in very low birth weight neonates. Leonard MB, Koren G, Stevenson DK, Prober CG. Pediatr Infect Dis J. 1989; 8 (5): 282-6
In vitro inhibition of adult rat intestinal heme oxygenase by metalloporphyrins. Vreman HJ, Gillman MJ, Stevenson DK. Pediatr Res. 1989; 26 (4): 362-5
Continuous parenteral infusion of vitamin E pharmacokinetics and bilirubin production in premature neonates. Stevenson DK, Vreman HJ, Ferguson JE, Lenert LA, Leonard MB, Gale R. Ann N Y Acad Sci. 1989; 570 352-7
The education of scientific physicians. Stevenson DK, J Perinatol. 1989; 9 (4): 442-3
Effects of oral administration of tin and zinc protoporphyrin on neonatal and adult rat tissue heme oxygenase activity. Vreman HJ, Hintz SR, Kim CB, Castillo RO, Stevenson DK. J Pediatr Gastroenterol Nutr. 1988 Nov-Dec; 7 (6): 902-6
Relationship between breath and total body hydrogen excretion rates in neonates. Modler S, Kerner JA, Castillo RO, Vreman HJ, Stevenson DK. J Pediatr Gastroenterol Nutr. 1988 Jul-Aug; 7 (4): 554-8
Comparison of bilirubin production in Japanese and Caucasian infants. Fischer AF, Nakamura H, Uetani Y, Vreman HJ, Stevenson DK. J Pediatr Gastroenterol Nutr. 1988 Jan-Feb; 7 (1): 27-9
Lack of inhibition of intestinal heme oxygenase by antibiotics and tin-protoporphyrin. Hintz SR, Kim CB, Vreman HJ, Stevenson DK. Pediatr Res. 1988; 23 (1): 50-3
Heme oxygenase activity as measured by carbon monoxide production. Vreman HJ, Stevenson DK. Anal Biochem. 1988; 168 (1): 31-8
In vitro carbon monoxide production by the small intestine of suckling and adult Wistar rats: effect of parenteral tin-protoporphyrin. Kim CB, Hintz SR, Vreman HJ, Stevenson DK. Dev Pharmacol Ther. 1988; 11 (3): 166-72
Interference of fetal hemoglobin with the spectrophotometric measurement of carboxyhemoglobin. Vreman HJ, Ronquillo RB, Ariagno RL, Schwartz HC, Stevenson DK. Clin Chem. 1988; 34 (5): 975-7
Nephrolithiasis following in utero diuretic exposure: an unusual case. Fischer AF, Parker BR, Stevenson DK. Pediatrics. 1988; 81 (5): 712-4
Sn-protoporphyrin: a consideration of the first clinical trial in human neonates. Stevenson DK, Vreman HJ. Pediatrics. 1988; 81 (6): 881-2
End-stage periventricular leukomalacia: MR evaluation. Baker LL, Stevenson DK, Enzmann DR. Radiology. 1988; 168 (3): 809-15
Plasma prorenin and renin in childhood and adolescence. Wilson DM, Stevenson DK, Luetscher JA. Am J Dis Child. 1988; 142 (10): 1070-2
Suppression of carbon monoxide excretion by zinc mesoporphyrin in adult Wistar rats: evidence for potent in vivo inhibition of bilirubin production. Hamori CJ, Vreman HJ, Stevenson DK. Res Commun Chem Pathol Pharmacol. 1988; 62 (1): 41-8
Oxytocin-induced labor characteristics and uterine activity after preinduction cervical priming with prostaglandin E2 intracervical gel. Ferguson JE, Ueland FR, Stevenson DK, Ueland K. Obstet Gynecol. 1988; 72 (5): 739-45
Carboxyhemoglobin as measured by gas chromatography and with the IL 282 and 482 CO-Oximeters. Vreman HJ, Mahoney JJ, Van Kessel AL, Stevenson DK. Clin Chem. 1988; 34 (12): 2562-6
Correlation of carbon monoxide and bilirubin production by tissue homogenates. Vreman HJ, Stevenson DK, Henton D, Rosenthal P. J Chromatogr. 1988; 427 (2): 315-9
Outcome of neonates with birth weights of less than 801 grams. Stevenson DK, Petersen KR, Yates BL, Benitz WE, Gale R. J Perinatol. 1988; 8 (2): 82-7
Refractory neonatal hypoxemia: diagnostic evaluation and pharmacologic management. Benitz WE, Stevenson DK. Resuscitation. 1988; 16 (1): 49-64
Effect of bupivacaine hydrochloride on bilirubin production in neonatal rats. Gale R, Vreman HJ, Ferguson JE, Stevenson DK. Biol Neonate. 1988; 54 (1): 45-8
Tin-protoporphyrin inhibits carbon monoxide production in adult male Wistar rats with common bile duct ligation. McMillan JJ, Vreman HJ, Stevenson DK. J Pediatr Gastroenterol Nutr. 1987 Sep-Oct; 6 (5): 795-8
Carboxyhemoglobin concentration as an index of bilirubin production in neonates with birth weights less than 1,500 grams: a randomized double-blind comparison of supplemental oral vitamin E and placebo. Fischer AF, Inguillo D, Martin DM, Ochikubo CG, Vreman HJ, Stevenson DK. J Pediatr Gastroenterol Nutr. 1987 Sep-Oct; 6 (5): 748-51
Recovery of exogenous heme as carbon monoxide and biliary heme in adult rats after tin protoporphyrin treatment. Hintz SR, Kwong LK, Vreman HJ, Stevenson DK. J Pediatr Gastroenterol Nutr. 1987 Mar-Apr; 6 (2): 302-6
The consequences of uncertainty. An empirical approach to medical decision making in neonatal intensive care. Fischer AF, Stevenson DK. JAMA. 1987; 258 (14): 1929-31
Immediate management of the asphyxiated infant: facilitating the cardiorespiratory transition from fetus to newborn. Stevenson DK, Frankel LR, Benitz WE. J Perinatol. 1987; 7 (3): 221-5
Metabolic emergencies of the newborn: hypoxemia and hypoglycemia. Frankel L, Stevenson DK. Compr Ther. 1987; 13 (10): 14-9
Carbon monoxide generation from tin- and zinc-protoporphyrin by tissue homogenates. Vreman HJ, Stevenson DK. Biochem Biophys Res Commun. 1987; 148 (1): 417-21
Effect of epidural analgesia with bupivacaine hydrochloride on neonatal bilirubin production. Gale R, Ferguson JE, Stevenson DK. Obstet Gynecol. 1987; 70 (5): 692-5
A technique for the administration of ribavirin to mechanically ventilated infants with severe respiratory syncytial virus infection. Frankel LR, Wilson CW, Demers RR, Parker JR, Lewiston NJ, Stevenson DK, Smith DW. Crit Care Med. 1987; 15 (11): 1051-4
Carbon monoxide production in ventilated premature infants weighing less than 1500 g. Fischer AF, Ochikubo CG, Vreman HJ, Stevenson DK. Arch Dis Child. 1987; 62 (10): 1070-2