NIH Biosketch available OnlineSamuel Strober
- Professor, Medicine - Immunology & Rheumatology
- Member, Cancer Center
Contact Information
- Clinical Offices
Immunology & Rheumatology Clinic 300 Pasteur Dr A175 MC 5309 Stanford, CA 94305 Telephone Work (650) 723-6961 Fax (650) 725-8418
- Academic Offices
Personal InformationAdministrative Contact Glenna Letsinger Administrative Associate Email glenna@stanford.edu Tel Work 650 723-6500Not for medical emergencies or patient use
Clinical Focus
- Immunology and Rheumatology
- Rheumatology
Professional Education
- SUMC - Graduate Medical Education (1971) CA
- Massachusetts General Hospital/Joslin Diabetes Center (1967) MA
- Massachusetts General Hospital (1967) MA
- Harvard Medical School (1966) MA
- Oxford University Medical School (1965) UK
Postdoctoral Advisees
Web Site Links
Industry Relationships
Stanford is committed to ethical and transparent interactions with our industry partners. It is our policy to disclose payments of $5,000 or more, equity valued at $5,000 or more in a publicly traded company, or any equity in a privately held company, to physicians and scientists employed by Stanford University from companies or other commercial entities with which they interact as part of their professional activities.
- Equity: Innate Immune inc.
Research Interests
Our interests are in the area of cellular immunology, and the regulatory interactions between subpopulations of immune cells. In particular, we are interested in the identification, function, and molecular mechanisms by which some subpopulations of lymphocytes amplify the immune response and some suppress it. Investigation into interactions of the cells during the immune response to organ and bone marrow transplants and in autoimmune disease is a major focus of the laboratory research. Developing therapeutic strategies for organ transplantation and autoimmunity based on these principles is a major goal. Specific areas of research are as follows: (i) Immune tolerance to organ and bone marrow transplants: Immune tolerance is recognized to be the paralysis of the immune system in its response to a given antigen, the development of anergy, or antigen-specific suppressor cells. Our research programs are studying these mechanisms at the cellular and molecular levels in laboratory animals and humans that are made tolerant to foreign organ or bone marrow transplants. (ii) Mechanisms of autoimmunity: Many autoimmune diseases represent a breakdown of immune tolerance to self-antigens. The mechanisms by which 1) animals develop tolerance to self during ontogeny, 2) tolerance is broken in adult life resulting in autoimmune diseases, and 3) tolerance can be reestablished after the development of autoimmune disease are the subjects of investigation. Our laboratory is involved in identifying those cells involved in the induction and maintenance of immune tolerance with regard to their surface receptors, effector functions, and the nature of secreted molecules which mediate their function.
Clinical Trials
Publications
- Eur J Immunol. 2009; (3): 763-75
- J Immunol. 2009; (11): 7196-7203
- Blood. 2009; (18): 4458-67
- Blood. 2009; (5): 1099-109
- Clin Immunol. 2009; (3): 321-33
- Blood Cells Mol Dis. 2008 Jan-Feb; (1): 48-54
- N Engl J Med. 2008; (4): 362-8
- Transplantation. 2008; (4): 607-14
- Eur J Immunol. 2008; (1): 156-65
- Transplantation. 2007; (5): 619-28
- Bone Marrow Transplant. 2007; (5): 487-97
- J Immunol. 2007; (10): 6242-51
- J Immunol. 2007; (10): 6547-54
- N Engl J Med. 2005; (13): 1321-31
- Blood. 2005; (12): 4009-15
- J Immunol. 2005; (7): 4363-73
- Am J Transplant. 2004; (9): 1543-8
- Eur J Immunol. 2004; (6): 1654-62
- Nat Med. 2004; (5): 510-7
- Transplantation. 2004; (6): 932-6
- Transplantation. 2004; (1 Suppl): S9-S11
- Arthritis Rheum. 2004; (10): 3239-49
- Cell Immunol. 2003; (1): 6-14
- Biol Blood Marrow Transplant. 2003; (6): 355-63
- J Immunol. 2003; (3): 1207-15
- Nat Med. 2003; (9): 1144-50
- J Clin Invest. 2003; (8): 1211-22
- Arthritis Rheum. 2002; (4): 1014-8
- Nat Med. 2002; (5): 500-8
- Transplantation. 2002; (9): 1386-91
- J Exp Med. 2002; (3): 389-99
- J Immunol. 2002; (10): 5564-70
- Blood. 2002; (4): 1449-57
- J Immunol. 2001; (4): 2087-96
- Arthritis Rheum. 2001; (7): 1525-8
- Cancer. 2001; (12): 2205-13
- Proc Natl Acad Sci U S A. 2001; (13): 7455-60
- Blood. 2001; (11): 3458-65
- Biol Blood Marrow Transplant. 2000; (5): 506-12
- J Allergy Clin Immunol. 2000; (1 Pt 2): S113-4
- Transplantation. 2000; (8): 1549-54
- J Immunol. 2000; (10): 5000-4
- Transplantation. 2000; (4): 649-55
- J Immunol. 1999; (10): 5338-45
- Proc Natl Acad Sci U S A. 1999; (25): 14493-8
- Transplantation. 1999; (7): 1036-44
- Transplant Proc. 1999; (3B Suppl): 25S-26S
- J Exp Med. 1999; (7): 1073-81
- Transplantation. 1998; (10): 1285-91
- Transplantation. 1998; (5): 585-93
- J Exp Med. 1998; (4): 525-36
- J Exp Med. 1998; (11): 1813-23
- J Immunol. 1998; (4): 1710-7
- Immunol Rev. 1997; 13-40
- Blood. 1997; (1): 453-63
- Int J Radiat Oncol Biol Phys. 1997; (5): 953-60
- Blood. 1997; (7): 2586-95
- J Am Geriatr Soc. 1996; (9): 1038-42
- Immunol Rev. 1996; 217-30
- Bone Marrow Transplant. 1996; S31-3
- J Immunol. 1996; (10): 3591-601
- Transplantation. 1996; (4): 510-7
- J Immunol. 1995; (7): 3338-44
- Transplantation. 1995; (4): 355-61
- Exp Hematol. 1995; (9): 1024-9
- J Exp Med. 1995; (6): 2201-11
- Transplantation. 1993; (6): 1443-7
- J Immunol. 1993; (10): 5348-53
- J Immunol. 1992; (3): 808-17
- Blood. 1992; (12): 3242-50
- J Immunol. 1992; (10): 3319-26
- J Immunol. 1992; (2): 373-80
- Cell Immunol. 1991; (2): 316-28
- Cell Immunol. 1991; (2): 326-40
- Cell Immunol. 1991; (1): 1-15
- Transplant Proc. 1991; (1 Pt 1): 200-2
- Transplant Proc. 1991; (1 Pt 1): 34-5
- Transplantation. 1991; (4): 905-9
- Am J Physiol. 1991; (5 Pt 2): F717-27
- Arthritis Rheum. 1991; (6): 679-86
- Arthritis Rheum. 1990; (4): 553-62
- Arthritis Rheum. 1990; (5): 702-10
- Immunol Rev. 1990; 233-55
- Autoimmunity. 1990; (2): 115-23
- Cell Immunol. 1990; (1): 129-42
- Cell Immunol. 1989; (2): 423-32
- Nature. 1989; (6221): 226-9
- Transplantation. 1989; (4): 587-91
- Transplantation. 1989; (1): 107-10
- N Engl J Med. 1989; (1): 28-33
- J Immunol. 1989; (4): 1118-22
- J Clin Invest. 1989; (3): 922-30
- J Exp Med. 1989; (5): 1495-511
- J Immunol. 1989; (5): 1500-5
- Arthritis Rheum. 1988; (12): 1481-91
- Proc Natl Acad Sci U S A. 1988; (19): 7312-6
- Arthritis Rheum. 1988; (7): 850-8
- J Immunol. 1988; (10): 3373-9
- J Immunol. 1988; (8): 2633-8
- Transplantation. 1988; (3): 540-6
- Arthritis Rheum. 1988; (1): 21-30
- J Exp Med. 1987; (4): 1168-73
- Ann Intern Med. 1987; (5): 689-90
- Transplant Proc. 1987; (6 Suppl 7): 88-94
- J Pediatr. 1987; (6 Pt 2): 1051-5
- J Allergy Clin Immunol. 1987; (6): 798-802
- Transplant Proc. 1987; (1 Pt 1): 533-5