Ricardo Dolmetsch

Honors and Awards

• Society for Neuroscience Young Investigator Award, Society for Neuroscience (2007)
• NIH Pioneer Award, National Institutes of Health (2008-2013)
• Searle Scholar, Searle Foundation (2004-2006)
• Career Award in the Biomedical Sciences, Burroughes Welcome Fund (2002-2007)
• McKnight Scholar, McKnight Endowment for Neurosciences (2004-2006)
• Helen Hay Whitney Fellow, Helen Hay Whitney Foundation (1999-2002)

Professional Education

• Postdoctoral Fellow, Harvard Medical School Neuroscience (2002)
• Ph.D., Stanford University Neuroscience (1997)
• B.Sc., Brown University Neuroscience (1990)

Postdoctoral Advisees

• Sergiu Pasca, Thomas Portmann, Oleksandr Shcheglovitov, Masayuki Yazawa

Graduate & Fellowship Program Affiliations

• Chemical and Systems Biology
• Neurosciences

Web Site Links

• Lab Web Site

Research Interests

Our lab studies the underlying neurobiology of autism and other neuro-developmental disorders. We are particularly interested in understanding how electrical activity and calcium signals control the development of the brain and how this is altered in children with autism spectrum disorders. We are also developing new tools to study and repair the developing brain.

Publications

• STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1. Park CY,  Hoover PJ, Mullins FM, Bachhawat P, Covington ED, Raunser S, Walz T, Garcia KC, Dolmetsch RE, Lewis RS.  Cell.  2009; 136 (5): 876-90
• PIKfyve regulates CaV1.2 degradation and prevents excitotoxic cell death. Tsuruta F,  Green EM, Rousset M, Dolmetsch RE.  J Cell Biol.  2009; 187 (2): 279-94
• STIM1 and calmodulin interact with Orai1 to induce Ca2+-dependent inactivation of CRAC channels. Mullins FM,  Park CY, Dolmetsch RE, Lewis RS.  Proc Natl Acad Sci U S A.  2009; 106 (36): 15495-500
• Induction of protein-protein interactions in live cells using light. Yazawa M,  Sadaghiani AM, Hsueh B, Dolmetsch RE.  Nat Biotechnol.  2009; 27 (10): 941-5
• The tumor suppressor eIF3e mediates calcium-dependent internalization of the L-type calcium channel CaV1.2. Green EM,  Barrett CF, Bultynck G, Shamah SM, Dolmetsch RE.  Neuron.  2007; 55 (4): 615-32
• Molecular mechanisms of autism: a possible role for Ca2+ signaling. Krey JF,  Dolmetsch RE.  Curr Opin Neurobiol.  2007; 17 (1): 112-9
• The C terminus of the L-type voltage-gated calcium channel Ca(V)1.2 encodes a transcription factor. Gomez-Ospina N,  Tsuruta F, Barreto-Chang O, Hu L, Dolmetsch R.  Cell.  2006; 127 (3): 591-606
• Cell signaling. The double life of a transcription factor takes it outside the nucleus. Park CY,  Dolmetsch R.  Science.  2006; 314 (5796): 64-5
• Calcium oscillations increase the efficiency and specificity of gene expression. Dolmetsch RE,  Xu K, Lewis RS.  Nature.  1998; 392 (6679): 933-6
• Differential activation of transcription factors induced by Ca2+ response amplitude and duration. Dolmetsch RE,  Lewis RS, Goodnow CC, Healy JI.  Nature.  1997; 386 (6627): 855-8
• Calcium imaging of cortical neurons using Fura-2 AM. Barreto-Chang OL,  Dolmetsch RE.  J Vis Exp.  2009; (23)
• Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Eroglu C,  Allen NJ, Susman MW, O'Rourke NA, Park CY, Ozkan E, Chakraborty C, Mulinyawe SB, Annis DS, Huberman AD, Green EM, Lawler J, Dolmetsch R, Garcia KC, Smith SJ, Luo ZD, Rosenthal A, Mosher DF, Barres BA.  Cell.  2009; 139 (2): 380-92
• TrpC3 regulates hypertrophy-associated gene expression without affecting myocyte beating or cell size. Brenner JS,  Dolmetsch RE.  PLoS One.  2007; 2 (8): e802
• Calcium channels light up. Green E,  Dolmetsch RE.  Nat Chem Biol.  2007; 3 (7): 369-70
• Excitation-transcription coupling: signaling by ion channels to the nucleus. Dolmetsch R,  Sci STKE.  2003; 2003 (166): PE4
• CREB transcriptional activity in neurons is regulated by multiple, calcium-specific phosphorylation events. Kornhauser JM,  Cowan CW, Shaywitz AJ, Dolmetsch RE, Griffith EC, Hu LS, Haddad C, Xia Z, Greenberg ME.  Neuron.  2002; 34 (2): 221-33
• Time-lapse imaging of a dynamic phosphorylation-dependent protein-protein interaction in mammalian cells. Spotts JM,  Dolmetsch RE, Greenberg ME.  Proc Natl Acad Sci U S A.  2002; 99 (23): 15142-7
• Calcium regulation of neuronal gene expression. West AE,  Chen WG, Dalva MB, Dolmetsch RE, Kornhauser JM, Shaywitz AJ, Takasu MA, Tao X, Greenberg ME.  Proc Natl Acad Sci U S A.  2001; 98 (20): 11024-31
• Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway. Dolmetsch RE,  Pajvani U, Fife K, Spotts JM, Greenberg ME.  Science.  2001; 294 (5541): 333-9
• Gene regulation mediated by calcium signals in T lymphocytes. Feske S,  Giltnane J, Dolmetsch R, Staudt LM, Rao A.  Nat Immunol.  2001; 2 (4): 316-24
• A fluorometric method for estimating the calcium content of internal stores. Bergling S,  Dolmetsch R, Lewis RS, Keizer J.  Cell Calcium.  1998; 23 (4): 251-9
• Quantitative and qualitative control of antigen receptor signalling in tolerant B lymphocytes. Healy JI,  Dolmetsch RE, Lewis RS, Goodnow CC.  Novartis Found Symp.  1998; 215 137-44; discussion 144-5, 186-90
• Different nuclear signals are activated by the B cell receptor during positive versus negative signaling. Healy JI,  Dolmetsch RE, Timmerman LA, Cyster JG, Thomas ML, Crabtree GR, Lewis RS, Goodnow CC.  Immunity.  1997; 6 (4): 419-28
• Positive and negative regulation of depletion-activated calcium channels by calcium. Lewis RS,  Dolmetsch RE, Zweifach A.  Soc Gen Physiol Ser.  1996; 51 241-54
• Signaling between intracellular Ca2+ stores and depletion-activated Ca2+ channels generates [Ca2+]i oscillations in T lymphocytes. Dolmetsch RE,  Lewis RS.  J Gen Physiol.  1994; 103 (3): 365-88