Key Documents
Curriculum Vitae available Online
Tobias Meyer
- Professor, Chemical and Systems Biology
- Member, Bio-X
Contact Information
- Academic Offices
Personal Information Email tobias.meyer@stanford.edu
Postdoctoral Advisees
Web Site Links
Research Interests
UNDERSTANDING SIGNAL TRANSDUCTION NETWORKS The fundamental problem in signal transduction research is to understand how different receptor-stimuli and other cellular inputs control particular cell functions with a high degree of specificity. Similar to the regulation of organ function by complex hormonal feedback mechanisms, it is believed that interactions between several hundred intracellular signaling proteins and many types of second messengers guarantee the specificity of particular cellular responses. The goal of the research is our laboratory is to identify the fundamental properties of such intracellular Signal Transduction Networks and to determine how perturbations in networks can cause disease. In particular, we are currently using three mammalian model systems to understand and model the signaling systems that control neuronal plasticity, chemotaxis and regulated secretion. Many signaling events for these and other cell functions occur as oscillations or all-or-none responses and the precise timing and localization between parallel signaling events is essential for the induction of downstream functions. Therefore, single cell measurements of signaling responses are essential to develop models of signal transduction networks. Over the last years, we have developed several new strategies to monitor signaling events in single cells using different fluorescent microscopy techniques and fluorescent probes and we are now in a unique position to be able to monitor in the same experiment signaling responses in each of many thousands of cells. By combining such imaging techniques with quantitative single cell perturbation strategies, we are pursuing a strategy for a genome-wide exploration on how signaling networks are wired in health and disease.
Publications
- Proc Natl Acad Sci U S A. 2007; (22): 9301-6
- Curr Biol. 2007; (1): 85-91
- Cell Cycle. 2007; (18): 2276-83
- J Cell Biol. 2007; (3): 263-8
- Science. 2006; (5804): 1458-61
- Science. 2006; (5804): 1454-7
- Nat Methods. 2005; (6): 415-8
- Curr Opin Chem Biol. 2005; (1): 82-7
- Dev Cell. 2005; (2): 215-27
- J Cell Biol. 2005; (3): 429-41
- J Cell Biol. 2005; (7): 1147-58
- Science. 2005; (5747): 496-8
- Chem Biol. 2004; (9): 1261-7
- Proc Natl Acad Sci U S A. 2004; (12): 4036-40
- Curr Drug Discov Technol. 2004; (1): 1-11
- J Biol Chem. 2004; (16): 15831-40
- Nat Biotechnol. 2004; (3): 306-12
- Proc Natl Acad Sci U S A. 2003; (18): 10512-7
- Neuron. 2003; (2): 283-97
- Cell. 2003; (3): 315-28
- Nat Biotechnol. 2003; (3): 324-8
- Trends Cell Biol. 2003; (2): 101-6
- Neuron. 2003; (2): 319-30
- Curr Opin Neurobiol. 2002; (3): 293-9
- Science. 2002; (5561): 1910-2
- Curr Biol. 2002; (21): 1871-6
- Nat Cell Biol. 2002; (10): 766-73
- J Cell Biol. 2001; (7): 1369-80
- Curr Biol. 2001; (14): 1089-97
- Curr Biol. 2000; (2): 86-94
- Trends Cell Biol. 2000; (6): 238-44
- J Cell Biol. 2000; (7): 1353-68
- Cell. 2000; (2): 181-4
- Methods Enzymol. 2000; 500-13
- Nat Neurosci. 2000; (9): 881-6
- J Cell Biol. 2000; (6): 1269-80
- Cell. 2000; (2): 221-8
- Science. 1999; (5411): 162-6
- Cell Calcium. 1999; (1): 1-7
- Proc Natl Acad Sci U S A. 1999; (8): 4686-91
- J Neurosci Methods. 1999; (1): 37-48
- J Neurochem. 1998; (1): 96-104
- Curr Biol. 1998; (6): 343-6
- J Cell Biol. 1998; (3): 485-98
- J Biol Chem. 1998; (17): 10755-62
- Cell. 1998; (3): 307-18
- Mol Cell Biol. 1998; (7): 4131-40
- Neuron. 1998; (3): 593-606
- J Cell Biol. 1997; (6): 1447-54
- Biophys J. 1997; (4): 1785-96
- J Biol Chem. 1997; (48): 30362-70
- Cell. 1997; (6): 963-71
- Biochemistry. 1997; (31): 9388-94
- Mol Pharmacol. 1997; (2): 177-84
- J Neurosci. 1997; (11): 4129-35
- Science. 1997; (5319): 1690-3
- J Biol Chem. 1996; (29): 17253-60
- Nat Biotechnol. 1996; (10): 1252-6
- Biochemistry. 1995; (39): 12738-46
- Dev Biol. 1995; (1): 50-61
- Ciba Found Symp. 1995; 252-62; discussion 262-6
- Neuron. 1994; (5): 943-56
- Proc Natl Acad Sci U S A. 1994; (26): 12458-62
- Cell Calcium. 1993; (10): 691-7
- Biochemistry. 1993; (5): 1270-7
- Cell Calcium. 1992 Jun-Jul; (6-7): 401-11
- Cell Motil Cytoskeleton. 1992; (4): 250-6
- Science. 1992; (5089): 1812-5
- Science. 1992; (5060): 1199-202
- Cell. 1991; (4): 675-8
- Annu Rev Biophys Biophys Chem. 1991; 153-74
- Biochemistry. 1990; (1): 32-7
- Proc Natl Acad Sci U S A. 1990; (10): 3841-5
- Biophys J. 1988; (6): 983-93
- Proc Natl Acad Sci U S A. 1988; (14): 5051-5
- Science. 1988; (4852): 653-6