Key Documents

David A. Relman

Professor, Medicine - Infectious Diseases
Professor, Microbiology & Immunology
Member, Cancer Center
Member, Bio-X

Contact Information

Clinical Offices

Infectious Disease 3801 Miranda Ave Ste 154T Palo Alto, CA 94304
Telephone Work (650) 852-3308 Fax (650) 852-3291
Academic Offices

Personal Information
Email relman@stanford.edu Tel (650) 852-3308
Not for medical emergencies or patient use

Clinical Focus

Infectious Disease
Infectious Diseases

Administrative Appointments

Forum on Microbial Threats, Chair (2007-), Institute of Medicine, NAS , (2005– present )
Physical and Life Sciences Directorate Review Committee, Lawrence Livermore National Laboratory , (2006– present )
National Science Advisory Board for Biosecurity, U.S. Department of Health and Human Services , (2005– present )
Chief, Infectious Diseases, VA Palo Alto Health Care System , (2002– present )
Chair, Administrative Panel on Biosafety, Stanford University , (2001– present )
Board of Scientific Counselors (Chair, 2007-2008), NIDCR, NIH , (2003– 2008 )

Honors and Awards

Thomas C. and Joan M. Merigan Professor, Stanford University (2009-)
Distinguished Clinical Scientist Award, Doris Duke Charitable Foundation (2006)
NIH Director's Pioneer Award, NIH (2006)
Kinyoun Lecturer, NIAID/NIH (2005)
Fellow, American Academy of Microbiology (2003)
Senior Scholar Award in Global Infectious Diseases, Ellison Medical Foundation (2002)
Squibb Award, Infectious Diseases Society of America (2001)

Professional Education

Massachusetts General Hospital (1986) MA
Massachusetts General Hospital (1986) MA
Massachusetts General Hospital (1985) MA
Board Certification: Infectious Disease, American Board of Internal Medicine (1988)
SUMC - Graduate Medical Education (1988) CA
Board Certification: Internal Medicine, American Board of Internal Medicine (1985)
Harvard Medical School (1982) MA
S.B., M.I.T. Biology (1977)
M.D., Harvard Medical School Medicine (1982)

Postdoctoral Advisees

Elizabeth Costello, Leslie Dethlefsen, Jennifer Dinalo, Eoghan Harrington, Muhammad Khan, Clara Long, Suenje Pamp, David Pride, Noga Qvit Raz, Joanna Schaenman

Graduate & Fellowship Program Affiliations

Community & International Work

Chief Medical Officer, Rock Medicine, Haight-Ashbury Medical Clinics More »

Web Site Links

http://relman.stanford.edu

Industry Relationships

Stanford is committed to ethical and transparent interactions with our industry partners. It is our policy to disclose payments of $5,000 or more, equity valued at $5,000 or more in a publicly traded company, or any equity in a privately held company, to physicians and scientists employed by Stanford University from companies or other commercial entities with which they interact as part of their professional activities.

Consulting: NanoBio Corporation, Novartis Vaccines
Equity: NanoBio Corporation

Research Interests

My investigative program focuses on human-microbe interactions and human microbial ecology, and is divided into two research areas:
1) Ecology of human indigenous microbial communities;
2) Classification of humans and non-human primates with systemic infectious diseases, based on features of genome-wide gene transcript abundance patterns.

Projects in these areas include the following:

1) Ecology of human indigenous microbial communities
• Molecular ecology of human oral cavity, including health and disease (chronic periodontitis)
• Molecular ecology of human intestinal tract, including health and disease (inflammatory bowel disease)
• Microbes associated with pre-term labor and delivery
• Patterns of bacterial diversity in marine mammals

2) Classification of humans and non-human primates with systemic infectious diseases, based on features of genome-wide gene transcript abundance patterns
• Classification of patients with fever and systemic infection, based on causative agent and clinical course
• Host response patterns to malaria and dengue fever
• Patterns of host transcript abundance in smallpox, monkeypox, and filovirus infections

Publications

Natural-host animal models indicate functional interchangeability between the filamentous haemagglutinins of Bordetella pertussis and Bordetella bronchiseptica and reveal a role for the mature C-terminal domain, but not the RGD motif, during infection. Julio SM, Inatsuka CS, Mazar J, Dieterich C, Relman DA, Cotter PA. Mol Microbiol. 2009; 71 (6): 1574-90
Majority rules? Tallying the microbial census in an abscess by means of molecular methods. Digiulio DB, Relman DA. Clin Infect Dis. 2009; 48 (9): 1179-81
Gene transcript abundance profiles distinguish Kawasaki disease from adenovirus infection. Popper SJ, Watson VE, Shimizu C, Kanegaye JT, Burns JC, Relman DA. J Infect Dis. 2009; 200 (4): 657-66
Cross-talk in the gut. Dinalo JE, Relman DA. Genome Biol. 2009; 10 (1): 203
Comparative analysis of viral gene expression programs during poxvirus infection: a transcriptional map of the vaccinia and monkeypox genomes. Rubins KH, Hensley LE, Bell GW, Wang C, Lefkowitz EJ, Brown PO, Relman DA. PLoS One. 2008; 3 (7): e2628
Microbiology in the post-genomic era. Medini D, Serruto D, Parkhill J, Relman DA, Donati C, Moxon R, Falkow S, Rappuoli R. Nat Rev Microbiol. 2008; 6 (6): 419-30
Learning to appreciate our differences. Relman DA, J Infect Dis. 2008; 198 (1): 4-5
Linking microbial phylogeny to metabolic activity at the single-cell level by using enhanced element labeling-catalyzed reporter deposition fluorescence in situ hybridization (EL-FISH) and NanoSIMS. Behrens S, Lösekann T, Pett-Ridge J, Weber PK, Ng WO, Stevenson BS, Hutcheon ID, Relman DA, Spormann AM. Appl Environ Microbiol. 2008; 74 (10): 3143-50
Host transmission of Salmonella enterica serovar Typhimurium is controlled by virulence factors and indigenous intestinal microbiota. Lawley TD, Bouley DM, Hoy YE, Gerke C, Relman DA, Monack DM. Infect Immun. 2008; 76 (1): 403-16
Microbial prevalence, diversity and abundance in amniotic fluid during preterm labor: a molecular and culture-based investigation. DiGiulio DB, Romero R, Amogan HP, Kusanovic JP, Bik EM, Gotsch F, Kim CJ, Erez O, Edwin S, Relman DA. PLoS One. 2008; 3 (8): e3056
Exploring microbial diversity and taxonomy using SSU rRNA hypervariable tag sequencing. Huse SM, Dethlefsen L, Huber JA, Welch DM, Relman DA, Sogin ML. PLoS Genet. 2008; 4 (11): e1000255
Modulation of the NF-kappaB pathway by Bordetella pertussis filamentous hemagglutinin. Abramson T, Kedem H, Relman DA. PLoS One. 2008; 3 (11): e3825
'Til death do us part': coming to terms with symbiotic relationships. Forward. Relman DA, Nat Rev Microbiol. 2008; 6 (10): 721-4
The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. Dethlefsen L, Huse S, Sogin ML, Relman DA. PLoS Biol. 2008; 6 (11): e280
Patterns of host genome-wide gene transcript abundance in the peripheral blood of patients with acute dengue hemorrhagic fever. Simmons CP, Popper S, Dolocek C, Chau TN, Griffiths M, Dung NT, Long TH, Hoang DM, Chau NV, Thao le TT, Hien TT, Relman DA, Farrar J. J Infect Dis. 2007; 195 (8): 1097-107
Gene-expression patterns reveal underlying biological processes in Kawasaki disease. Popper SJ, Shimizu C, Shike H, Kanegaye JT, Newburger JW, Sundel RP, Brown PO, Burns JC, Relman DA. Genome Biol. 2007; 8 (12): R261
Building a better virus trap. Long CD, Turner-Shelef K, Relman DA. Trends Biotechnol. 2007; 25 (12): 535-8
An ecological and evolutionary perspective on human-microbe mutualism and disease. Dethlefsen L, McFall-Ngai M, Relman DA. Nature. 2007; 449 (7164): 811-8
The temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever. Rubins KH, Hensley LE, Wahl-Jensen V, Daddario DiCaprio KM, Young HA, Reed DS, Jahrling PB, Brown PO, Relman DA, Geisbert TW. Genome Biol. 2007; 8 (8): R174
Dissecting biological "dark matter" with single-cell genetic analysis of rare and uncultivated TM7 microbes from the human mouth. Marcy Y, Ouverney C, Bik EM, Lösekann T, Ivanova N, Martin HG, Szeto E, Platt D, Hugenholtz P, Relman DA, Quake SR. Proc Natl Acad Sci U S A. 2007; 104 (29): 11889-94
Development of the human infant intestinal microbiota. Palmer C, Bik EM, DiGiulio DB, Relman DA, Brown PO. PLoS Biol. 2007; 5 (7): e177
Phase variation and microevolution at homopolymeric tracts in Bordetella pertussis. Gogol EB, Cummings CA, Burns RC, Relman DA. BMC Genomics. 2007; 8 122
The importance of individuals and scale: moving towards single cell microbiology. Dethlefsen L, Relman DA. Environ Microbiol. 2007; 9 (1): 8-10
The role of microbes in Crohn's disease. Eckburg PB, Relman DA. Clin Infect Dis. 2007; 44 (2): 256-62
Metagenomic analysis of the human distal gut microbiome. Gill SR, Pop M, Deboy RT, Eckburg PB, Turnbaugh PJ, Samuel BS, Gordon JI, Relman DA, Fraser-Liggett CM, Nelson KE. Science. 2006; 312 (5778): 1355-9
Growth phase- and nutrient limitation-associated transcript abundance regulation in Bordetella pertussis. Nakamura MM, Liew SY, Cummings CA, Brinig MM, Dieterich C, Relman DA. Infect Immun. 2006; 74 (10): 5537-48
Characterization of a highly conserved island in the otherwise divergent Bordetella holmesii and Bordetella pertussis genomes. Diavatopoulos DA, Cummings CA, van der Heide HG, van Gent M, Liew S, Relman DA, Mooi FR. J Bacteriol. 2006; 188 (24): 8385-94
Species- and strain-specific control of a complex, flexible regulon by Bordetella BvgAS. Cummings CA, Bootsma HJ, Relman DA, Miller JF. J Bacteriol. 2006; 188 (5): 1775-85
How bacterial communities expand functional repertoires. Versalovic J, Relman D. PLoS Biol. 2006; 4 (12): e430
Genomic features of Bordetella parapertussis clades with distinct host species specificity. Brinig MM, Register KB, Ackermann MR, Relman DA. Genome Biol. 2006; 7 (9): R81
Early days: genomics and human responses to infection. Liu M, Popper SJ, Rubins KH, Relman DA. Curr Opin Microbiol. 2006; 9 (3): 312-9
In search of biosecurity. Relman DA, Choffnes E, Lemon SM. Science. 2006; 311 (5769): 1835
Significant gene order and expression differences in Bordetella pertussis despite limited gene content variation. Brinig MM, Cummings CA, Sanden GN, Stefanelli P, Lawrence A, Relman DA. J Bacteriol. 2006; 188 (7): 2375-82
Bioterrorism--preparing to fight the next war. Relman DA, N Engl J Med. 2006; 354 (2): 113-5
Rapid quantitative profiling of complex microbial populations. Palmer C, Bik EM, Eisen MB, Eckburg PB, Sana TR, Wolber PK, Relman DA, Brown PO. Nucleic Acids Res. 2006; 34 (1): e5
Assembly of the human intestinal microbiota. Dethlefsen L, Eckburg PB, Bik EM, Relman DA. Trends Ecol Evol. 2006; 21 (9): 517-23
Molecular analysis of the bacterial microbiota in the human stomach. Bik EM, Eckburg PB, Gill SR, Nelson KE, Purdom EA, Francois F, Perez-Perez G, Blaser MJ, Relman DA. Proc Natl Acad Sci U S A. 2006; 103 (3): 732-7
Genomewide analysis of the host response to malaria in Kenyan children. Griffiths MJ, Shafi MJ, Popper SJ, Hemingway CA, Kortok MM, Wathen A, Rockett KA, Mott R, Levin M, Newton CR, Marsh K, Relman DA, Kwiatkowski DP. J Infect Dis. 2005; 191 (10): 1599-611
Diversity of the human intestinal microbial flora. Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, Sargent M, Gill SR, Nelson KE, Relman DA. Science. 2005; 308 (5728): 1635-8
VCAM-1 expression on CD8+ cells correlates with enhanced anti-HIV suppressing activity. Diaz LS, Foster H, Stone MR, Fujimura S, Relman DA, Levy JA. J Immunol. 2005; 174 (3): 1574-9
Bordetella pertussis, the causative agent of whooping cough, evolved from a distinct, human-associated lineage of B. bronchiseptica. Diavatopoulos DA, Cummings CA, Schouls LM, Brinig MM, Relman DA, Mooi FR. PLoS Pathog. 2005; 1 (4): e45
Acquired predisposition to mycobacterial disease due to autoantibodies to IFN-gamma. Kampmann B, Hemingway C, Stephens A, Davidson R, Goodsall A, Anderson S, Nicol M, Schölvinck E, Relman D, Waddell S, Langford P, Sheehan B, Semple L, Wilkinson KA, Wilkinson RJ, Ress S, Hibberd M, Levin M. J Clin Invest. 2005; 115 (9): 2480-8
Methanogenic Archaea and human periodontal disease. Lepp PW, Brinig MM, Ouverney CC, Palm K, Armitage GC, Relman DA. Proc Natl Acad Sci U S A. 2004; 101 (16): 6176-81
Bordetella pertussis infection of primary human monocytes alters HLA-DR expression. Shumilla JA, Lacaille V, Hornell TM, Huang J, Narasimhan S, Relman DA, Mellins ED. Infect Immun. 2004; 72 (3): 1450-62
Bordetella species are distinguished by patterns of substantial gene loss and host adaptation. Cummings CA, Brinig MM, Lepp PW, van de Pas S, Relman DA. J Bacteriol. 2004; 186 (5): 1484-92
The host response to smallpox: analysis of the gene expression program in peripheral blood cells in a nonhuman primate model. Rubins KH, Hensley LE, Jahrling PB, Whitney AR, Geisbert TW, Huggins JW, Owen A, Leduc JW, Brown PO, Relman DA. Proc Natl Acad Sci U S A. 2004; 101 (42): 15190-5
Exploring the potential of variola virus infection of cynomolgus macaques as a model for human smallpox. Jahrling PB, Hensley LE, Martinez MJ, Leduc JW, Rubins KH, Relman DA, Huggins JW. Proc Natl Acad Sci U S A. 2004; 101 (42): 15196-200
Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock. Pathan N, Hemingway CA, Alizadeh AA, Stephens AC, Boldrick JC, Oragui EE, McCabe C, Welch SB, Whitney A, O'Gara P, Nadel S, Relman DA, Harding SE, Levin M. Lancet. 2004; 363 (9404): 203-9
Sequencing and analysis of the genome of the Whipple's disease bacterium Tropheryma whipplei. Bentley SD, Maiwald M, Murphy LD, Pallen MJ, Yeats CA, Dover LG, Norbertczak HT, Besra GS, Quail MA, Harris DE, von Herbay A, Goble A, Rutter S, Squares R, Squares S, Barrell BG, Parkhill J, Relman DA. Lancet. 2003; 361 (9358): 637-44
Lethal invasive cestodiasis in immunosuppressed patients. Olson PD, Yoder K, Fajardo L-G LF, Marty AM, van de Pas S, Olivier C, Relman DA. J Infect Dis. 2003; 187 (12): 1962-6
Public health. Understanding threats to scientific openness. Petro JB, Relman DA. Science. 2003; 302 (5652): 1898
Individuality and variation in gene expression patterns in human blood. Relman DA, Whitney AR, Diehn M, Popper SJ, Alizadeh AA, Boldrick JC, Brown PO.. Proc Natl Acad Sci (USA). 2003; (100): 1896-1901
Individuality and variation in gene expression patterns in human blood. Whitney AR, Diehn M, Popper SJ, Alizadeh AA, Boldrick JC, Relman DA, Brown PO. Proc Natl Acad Sci U S A. 2003; 100 (4): 1896-901
Images in clinical medicine. Progression of the lesion at the site of inoculation after smallpox vaccination. Rubins K, Relman DA. N Engl J Med. 2003; 348 (5): 414
Analysis of conserved non-rRNA genes of Tropheryma whipplei. Maiwald M, Lepp PW, Relman DA. Syst Appl Microbiol. 2003; 26 (1): 3-12
Cultivation of Tropheryma whipplei from cerebrospinal fluid. Maiwald M, von Herbay A, Fredricks DN, Ouverney CC, Kosek JC, Relman DA. J Infect Dis. 2003; 188 (6): 801-8
Single-cell enumeration of an uncultivated TM7 subgroup in the human subgingival crevice. Ouverney CC, Armitage GC, Relman DA. Appl Environ Microbiol. 2003; 69 (10): 6294-8
Shedding light on microbial detection. Relman DA, N Engl J Med. 2003; 349 (22): 2162-3
Archaea and their potential role in human disease. Eckburg PB, Lepp PW, Relman DA. Infect Immun. 2003; 71 (2): 591-6
Prevalence of bacteria of division TM7 in human subgingival plaque and their association with disease. Brinig MM, Lepp PW, Ouverney CC, Armitage GC, Relman DA. Appl Environ Microbiol. 2003; 69 (3): 1687-94
Surveillance for unexplained deaths and critical illnesses due to possibly infectious causes, United States, 1995-1998. Hajjeh RA, Relman D, Cieslak PR, Sofair AN, Passaro D, Flood J, Johnson J, Hacker JK, Shieh WJ, Hendry RM, Nikkari S, Ladd-Wilson S, Hadler J, Rainbow J, Tappero JW, Woods CW, Conn L, Reagan S, Zaki S, Perkins BA. Emerg Infect Dis. 2002; 8 (2): 145-53
Identification of Cardiobacterium hominis by broad-range bacterial polymerase chain reaction analysis in a case of culture-negative endocarditis. Nikkari S, Gotoff R, Bourbeau PP, Brown RE, Kamal NR, Relman DA. Arch Intern Med. 2002; 162 (4): 477-9
The human body as microbial observatory. Relman DA, Nat Genet. 2002; 30 (2): 131-3
Human herpesvirus 8 and sarcoidosis. Fredricks DN, Martin TM, Edwards AO, Rosenbaum JT, Relman DA. Clin Infect Dis. 2002; 34 (4): 559-60
Stereotyped and specific gene expression programs in human innate immune responses to bacteria. Boldrick JC, Alizadeh AA, Diehn M, Dudoit S, Liu CL, Belcher CE, Botstein D, Staudt LM, Brown PO, Relman DA. Proc Natl Acad Sci U S A. 2002; 99 (2): 972-7
Smallpox research activities: U.S. interagency collaboration, 2001. LeDuc JW, Damon I, Relman DA, Huggins J, Jahrling PB. Emerg Infect Dis. 2002; 8 (7): 743-5
Genomics and microbiology. Microbial forensics--"cross-examining pathogens". Cummings CA, Relman DA. Science. 2002; 296 (5575): 1976-9
Genome-wide responses of a pathogenic bacterium to its host. Relman DA, J Clin Invest. 2002; 110 (8): 1071-3
New technologies, human-microbe interactions, and the search for previously unrecognized pathogens. Relman DA, J Infect Dis. 2002; 186 Suppl 2 S254-8
Molecular identification of cyanobacteria associated with stromatolites from distinct geographical locations. Neilan BA, Burns BP, Relman DA, Lowe DR. Astrobiology. 2002; 2 (3): 271-80
Mining the natural world for new pathogens. Relman DA, Am J Trop Med Hyg. 2002; 67 (2): 133-4
Role of phosphatidylinositol 3-kinase in the binding of Bordetella pertussis to human monocytes. Ishibashi Y, Yoshimura K, Nishikawa A, Claus S, Laudanna C, Relman DA. Cell Microbiol. 2002; 4 (12): 825-33
Broad-range bacterial detection and the analysis of unexplained death and critical illness. Nikkari S, Lopez FA, Lepp PW, Cieslak PR, Ladd-Wilson S, Passaro D, Danila R, Relman DA. Emerg Infect Dis. 2002; 8 (2): 188-94
Comparing functional genomic datasets: lessons from DNA microarray analyses of host-pathogen interactions. Diehn M, Relman DA. Curr Opin Microbiol. 2001; 4 (1): 95-101
Proinflammatory and proapoptotic activities associated with Bordetella pertussis filamentous hemagglutinin. Abramson T, Kedem H, Relman DA. Infect Immun. 2001; 69 (4): 2650-8
Localization of Tropheryma whippelii rRNA in tissues from patients with Whipple's disease. Fredricks DN, Relman DA. J Infect Dis. 2001; 183 (8): 1229-37
Does blood of healthy subjects contain bacterial ribosomal DNA? Nikkari S, McLaughlin IJ, Bi W, Dodge DE, Relman DA. J Clin Microbiol. 2001; 39 (5): 1956-9
The meaning and impact of the human genome sequence for microbiology. Relman DA, Falkow S. Trends Microbiol. 2001; 9 (5): 206-8
Sequence variability in the first internal transcribed spacer region within and among Cyclospora species is consistent with polyparasitism. Olivier C, van de Pas S, Lepp PW, Yoder K, Relman DA. Int J Parasitol. 2001; 31 (13): 1475-87
Whipple's disease and Tropheryma whippelii: secrets slowly revealed. Maiwald M, Relman D. Clin Infect Dis. 2001; 32 (3): 457-63
Tropheryma whippelii DNA is rare in the intestinal mucosa of patients without other evidence of Whipple disease. Maiwald M, von Herbay A, Persing DH, Mitchell PP, Abdelmalek MF, Thorvilson JN, Fredricks DN, Relman DA. Ann Intern Med. 2001; 134 (2): 115-9
Invasion of human respiratory epithelial cells by Bordetella pertussis: possible role for a filamentous hemagglutinin Arg-Gly-Asp sequence and alpha5beta1 integrin. Ishibashi Y, Relman DA, Nishikawa A. Microb Pathog. 2001; 30 (5): 279-88
Using DNA microarrays to study host-microbe interactions. Cummings CA, Relman DA. Emerg Infect Dis. 2000 Sep-Oct; 6 (5): 513-25
Rhinosporidium seeberi: a human pathogen from a novel group of aquatic protistan parasites. Fredricks DN, Jolley JA, Lepp PW, Kosek JC, Relman DA. Emerg Infect Dis. 2000 May-Jun; 6 (3): 273-82
Collaborative multidisciplinary workshop report: detection, culture, serology, and antimicrobial susceptibility testing of Chlamydia pneumoniae. Tompkins LS, Schachter J, Boman J, Chernesky MA, Dowell S, Gaydos CA, Levison ME, Maass M, Madico G, Orfila J, Ouchi K, Peeling RW, Taylor-Robinson D, Stamm WE, Wang SP, Blasi F, Relman D. J Infect Dis. 2000; 181 Suppl 3 S460-1
The transcriptional responses of respiratory epithelial cells to Bordetella pertussis reveal host defensive and pathogen counter-defensive strategies. Belcher CE, Drenkow J, Kehoe B, Gingeras TR, McNamara N, Lemjabbar H, Basbaum C, Relman DA. Proc Natl Acad Sci U S A. 2000; 97 (25): 13847-52
Molecular characterization of Bordetella bronchiseptica filamentous haemagglutinin and its secretion machinery. Jacob-Dubuisson F, Kehoe B, Willery E, Reveneau N, Locht C, Relman DA. Microbiology. 2000; 146 ( Pt 5) 1211-21
Organization, structure, and variability of the rRNA operon of the Whipple's disease bacterium (Tropheryma whippelii). Maiwald M, von Herbay A, Lepp PW, Relman DA. J Bacteriol. 2000; 182 (11): 3292-7
How the host 'sees' pathogens: global gene expression responses to infection. Manger ID, Relman DA. Curr Opin Immunol. 2000; 12 (2): 215-8
Application of polymerase chain reaction to the diagnosis of infectious diseases. Fredricks DN, Relman DA. Clin Infect Dis. 1999; 29 (3): 475-86; quiz 487-8
Absence of Kaposi's sarcoma-associated herpesvirus DNA in bacillary angiomatosis-peliosis lesions. Relman DA, Fredricks DN, Yoder KE, Mirowski G, Berger T, Koehler JE. J Infect Dis. 1999; 180 (4): 1386-9
Bacterial diversity within the human subgingival crevice. Kroes I, Lepp PW, Relman DA. Proc Natl Acad Sci U S A. 1999; 96 (25): 14547-52
Molecular characterization of Cyclospora-like organisms from baboons. Lopez FA, Manglicmot J, Schmidt TM, Yeh C, Smith HV, Relman DA. J Infect Dis. 1999; 179 (3): 670-6
The search for unrecognized pathogens. Relman DA, Science. 1999; 284 (5418): 1308-10
Molecular approaches for identification of infectious agents in Wegener's granulomatosis and other vasculitides. Nikkari S, Relman DA. Curr Opin Rheumatol. 1999; 11 (1): 11-6
Paraffin removal from tissue sections for digestion and PCR analysis. Fredricks DN, Relman DA. Biotechniques. 1999; 26 (2): 198-200
Detection and identification of previously unrecognized microbial pathogens. Relman DA, Emerg Infect Dis. 1998 Jul-Sep; 4 (3): 382-9
Explaining the unexplained in clinical infectious diseases: looking forward. Perkins BA, Relman D. Emerg Infect Dis. 1998 Jul-Sep; 4 (3): 395-7
Radiologic features of a fatal platyhelminth (tapeworm) infection in an AIDS patient. Stark P, Relman DA, Santamaria-Fries M, Fajardo LF. AJR Am J Roentgenol. 1998; 170 (1): 136-8
The 'emergence' of Bartonella and the development of molecular discovery methods for microbial pathogens. Relman DA, Neth J Med. 1998; 52 (6): 249-55
Improved amplification of microbial DNA from blood cultures by removal of the PCR inhibitor sodium polyanetholesulfonate. Fredricks DN, Relman DA. J Clin Microbiol. 1998; 36 (10): 2810-6
Infectious agents and the etiology of chronic idiopathic diseases. Fredricks DN, Relman DA. Curr Clin Top Infect Dis. 1998; 18 180-200
Molecular and cellular microbiology: new tools of the trade. Relman DA, Wright A. Curr Opin Microbiol. 1998; 1 (3): 337-339
Culture-negative endocarditis caused by Bartonella henselae. Baorto E, Payne RM, Slater LN, Lopez F, Relman DA, Min KW, St Geme JW. J Pediatr. 1998; 132 (6): 1051-4
Are all Bartonella henselae strains created equal? Relman DA, Clin Infect Dis. 1998; 26 (6): 1300-1
Cyclospora. Soave R, Herwaldt BL, Relman DA. Infect Dis Clin North Am. 1998; 12 (1): 1-12
Diagnostic utility of the polymerase chain reaction in 2 cases of suspected Whipple disease. Taskén K, Schulz T, Elgjo K, Skullerud K, Relman D, Brubakk O. Arch Intern Med. 1998; 158 (7): 801-3
PCR analysis of T. whippelii DNA in a case of Whipple's disease: effect of antibiotics and correlation with histology. Petrides PE, Müller-Höcker J, Fredricks DN, Relman DA. Am J Gastroenterol. 1998; 93 (9): 1579-82
Filamentous hemagglutinin of Bordetella bronchiseptica is required for efficient establishment of tracheal colonization. Cotter PA, Yuk MH, Mattoo S, Akerley BJ, Boschwitz J, Relman DA, Miller JF. Infect Immun. 1998; 66 (12): 5921-9
The Whipple bacillus lives (ex vivo)! Relman DA, J Infect Dis. 1997; 176 (3): 752-4
Bordetella bronchiseptica expresses the fimbrial structural subunit gene fimA. Boschwitz JS, van der Heide HG, Mooi FR, Relman DA. J Bacteriol. 1997; 179 (24): 7882-5
Cultivation of Whipple bacillus: the irony and the ecstasy. Fredricks DN, Relman DA. Lancet. 1997; 350 (9087): 1262-3
Bordetella pertussis infection of human monocytes inhibits antigen-dependent CD4 T cell proliferation. Boschwitz JS, Batanghari JW, Kedem H, Relman DA. J Infect Dis. 1997; 176 (3): 678-86
Polymerase chain reaction-based detection of Tropheryma whippelii in central nervous system Whipple's disease. Lynch T, Odel J, Fredericks DN, Louis ED, Forman S, Rotterdam H, Fahn S, Relman DA. Ann Neurol. 1997; 42 (1): 120-4
Emerging infections and newly-recognised pathogens. Relman DA, Neth J Med. 1997; 50 (5): 216-20
Diagnosis and monitoring of Whipple disease by polymerase chain reaction. Ramzan NN, Loftus E, Burgart LJ, Rooney M, Batts KP, Wiesner RH, Fredricks DN, Relman DA, Persing DH. Ann Intern Med. 1997; 126 (7): 520-7
Molecular phylogenetic analysis of Cyclospora, the human intestinal pathogen, suggests that it is closely related to Eimeria species. Relman DA, Schmidt TM, Gajadhar A, Sogin M, Cross J, Yoder K, Sethabutr O, Echeverria P. J Infect Dis. 1996; 173 (2): 440-5
Sequence-based identification of microbial pathogens: a reconsideration of Koch's postulates. Fredericks DN, Relman DA. Clin Microbiol Rev. 1996; 9 (1): 18-33
Limited role for PCR-based diagnosis of Whipple's disease from peripheral blood mononuclear cells. Marth T, Fredericks D, Strober W, Relman DA. Lancet. 1996; 348 (9019): 66-7
Lethal infection by a previously unrecognised metazoan parasite. Santamaría-Fríes M, Fajardo LF, Sogin ML, Olson PD, Relman DA. Lancet. 1996; 347 (9018): 1797-801
Brief report: uveitis caused by Tropheryma whippelii (Whipple's bacillus) Rickman LS, Freeman WR, Green WR, Feldman ST, Sullivan J, Russack V, Relman DA. N Engl J Med. 1995; 332 (6): 363-6
Has trench fever returned? Relman DA, N Engl J Med. 1995; 332 (7): 463-4
Bacillary angiomatosis and Rochalimaea species. Relman DA, Curr Clin Top Infect Dis. 1994; 14 205-19
Haemophilus parainfluenzae endocarditis: application of a molecular approach for identification of pathogenic bacterial species. Hamed KA, Dormitzer PR, Su CK, Relman DA. Clin Infect Dis. 1994; 19 (4): 677-83
Bordetella pertussis filamentous hemagglutinin interacts with a leukocyte signal transduction complex and stimulates bacterial adherence to monocyte CR3 (CD11b/CD18). Ishibashi Y, Claus S, Relman DA. J Exp Med. 1994; 180 (4): 1225-33
Search for highly conserved viral and bacterial nucleic acid sequences corresponding to an etiologic agent of Kawasaki disease. Rowley AH, Wolinsky SM, Relman DA, Sambol SP, Sullivan J, Terai M, Shulman ST. Pediatr Res. 1994; 36 (5): 567-71
Phylogenetic identification of uncultured pathogens using ribosomal RNA sequences. Schmidt TM, Relman DA. Methods Enzymol. 1994; 235 205-22
The identification of uncultured microbial pathogens. Relman DA, J Infect Dis. 1993; 168 (1): 1-8
Isolation of Rochalimaea species. Relman DA, N Engl J Med. 1993; 328 (19): 1422-3
Phylogenetic relationships among the agent of bacillary angiomatosis, Bartonella bacilliformis, and other alpha-proteobacteria. Relman DA, Lepp PW, Sadler KN, Schmidt TM. Mol Microbiol. 1992; 6 (13): 1801-7
Identification of the uncultured bacillus of Whipple's disease. Relman DA, Schmidt TM, MacDermott RP, Falkow S. N Engl J Med. 1992; 327 (5): 293-301
Identification of uncultured microorganisms: expanding the spectrum of characterized microbial pathogens. Relman DA, Falkow S. Infect Agents Dis. 1992; 1 (5): 245-53
Localization of Mycobacterium avium-intracellulare within a skin lesion of bacillary angiomatosis in a patient with AIDS. Sagerman PM, Relman DA, Niroomand F, Niedt GW. Diagn Mol Pathol. 1992; 1 (3): 212-6
The organism causing bacillary angiomatosis, peliosis hepatis, and fever and bacteremia in immunocompromised patients. Relman DA, Falkow S, LeBoit PE, Perkocha LA, Min KW, Welch DF, Slater LN. N Engl J Med. 1991; 324 (21): 1514
The agent of bacillary angiomatosis. An approach to the identification of uncultured pathogens. Relman DA, Loutit JS, Schmidt TM, Falkow S, Tompkins LS. N Engl J Med. 1990; 323 (23): 1573-80
Recognition of a bacterial adhesion by an integrin: macrophage CR3 (alpha M beta 2, CD11b/CD18) binds filamentous hemagglutinin of Bordetella pertussis. Relman D, Tuomanen E, Falkow S, Golenbock DT, Saukkonen K, Wright SD. Cell. 1990; 61 (7): 1375-82
Bordetella pertussis filamentous hemagglutinin: evaluation as a protective antigen and colonization factor in a mouse respiratory infection model. Kimura A, Mountzouros KT, Relman DA, Falkow S, Cowell JL. Infect Immun. 1990; 58 (1): 7-16
Genetic characterization of Bordetella pertussis filamentous haemagglutinin: a protein processed from an unusually large precursor. Domenighini M, Relman D, Capiau C, Falkow S, Prugnola A, Scarlato V, Rappuoli R. Mol Microbiol. 1990; 4 (5): 787-800
Filamentous hemagglutinin of Bordetella pertussis: nucleotide sequence and crucial role in adherence. Relman DA, Domenighini M, Tuomanen E, Rappuoli R, Falkow S. Proc Natl Acad Sci U S A. 1989; 86 (8): 2637-41
Stomatococcus mucilaginosus endocarditis in an intravenous drug abuser. Relman DA, Ruoff K, Ferraro MJ. J Infect Dis. 1987; 155 (5): 1080-2
Mechanical instability of the oxy-form of sickle haemoglobin. Asakura T, Agarwal PL, Relman DA, McCray JA, Chance B, Schwartz E, Friedman S, Lubin B. Nature. 1973; 244 (5416): 437-8