Key Documents
Paul Utz
- Associate Professor, Medicine - Immunology & Rheumatology
- Member, Bio-X
Contact Information
- Clinical Offices
Immunology & Rheumatology Clinic 300 Pasteur Dr A175 MC 5309 Stanford, CA 94305 Telephone Work (650) 723-6961 Fax (650) 725-8418
- Academic Offices
Personal Information Email pjutz@stanford.edu Tel (650) 724-5421Administrative Contact Sharon Dickow Administrative Assistant Email sdickow@stanford.edu Tel Work 723-7038Not for medical emergencies or patient use
Clinical Focus
- Immunology and Rheumatology
- Rheumatology
Administrative Appointments
- Acting MSTP Associate Director, Medical Science Training Program, Stanford University School of Medicine , (2009– 2010 )
- Member, Committee on Professionalism, Performance, and Promotion, Stanford University School of Medicine , (2009– present )
- Member, Cardiovascular Institute Steering Committee, Stanford University School of Medicine , (2007– 2010 )
- Secretary/Treasurer, FOCIS, Federal of Clinical Immunology Societies , (2008– present )
- Board of Directors, Northern California Arthritis Foundation , (2008– present )
- Treasurer and Secretary, FOCIS, Federal of Clinical Immunology Societies , (2007– 2010 )
- Appointed Councillor, Clinical Immunology Society , (2003– 2006 )
- Chair of Education, FOCIS, Federal of Clinical Immunology Societies , (2003– 2007 )
- Member, MSTP (Medical Science Training Program), Stanford University School of Medicine , (2002– present )
- Member, Dean's Committee on Diversity, Stanford University School of Medicine , (2002– present )
- Member, Immunology Graduate program Predoctoral Committee, Stanford University School of Medicine , (2000– 2003 )
- Member, Faculty Senate, Stanford Hospital , (2000– 2002 )
- Member, Internship Selection Committee, Stanford University Hospital , (1999– 2005 )
Honors and Awards
- Elected Member, American Society for Clinical Investigation (2007)
- Elected Member, The Kunkel Society (2006)
- Divisional Teaching Award, Stanford University (2002)
- Department of Medicine Teaching Award, Stanford University School of Medicine (2008)
- Baxter Fellowship, Donald and Delia Baxter (2000)
- Faculty Fellows Program, Stanford University School of Medicine (2009)
- Immunology Graduate Program Teaching and Mentoring Award, Stanford University (2002)
- Proteomics Award Nominee, FOCIS (2000)
- Stanford Clinical Medicine Award, Stanford University (1991)
- Advanced Predoctoral Fellowship in Pharmacology and Toxicology, Pharmaceutical Mfg. Association (1988-1989)
- Merck Student Research Fellowship, American Heart Association (1988-1989)
- Delta Epsilon Delta, Stanford University (1988)
- Alpha Epsilon Delta, Vice President, Stanford University (1988)
- Stanford Medical Scholars Fellowship, Stanford University (1987)
- Regina Award for Biology, King's College (1986)
- Center for Independent Learning Achievement Award, King's College (1986)
- Aquinas Society, Aquinas Society (1985-1986)
- Sidney Farber Research Award, Roswell Park Memorial Institute (1985)
- CRC Chemistry Award, King's College (1983)
- Bausch and Lomb Science Award, Bausch and Lomb (1982)
- King's College Scholarship Committee Award, King's College (1982-1986)
- King's College Dean's List, summa cum laude, King's College (1982-1986)
Professional Education
- Brigham and Women's Hospital, Harvard Medical School (1996) MA
- Brigham and Women's Hospital, Harvard Medical School (1993) MA
- Brigham and Women's Hospital, Harvard Medical School (1992) MA
- Board Certification: Rheumatology, American Board of Internal Medicine (1996)
- Stanford University School of Medicine (1991) CA
- M.D., Stanford University Medicine (1991)
- B.S., King's College Biology (1986)
Postdoctoral Advisees
Graduate & Fellowship Program Affiliations
Community & International Work
Web Site Links
Industry Relationships
Stanford is committed to ethical and transparent interactions with our industry partners. It is our policy to disclose payments of $5,000 or more, equity valued at $5,000 or more in a publicly traded company, or any equity in a privately held company, to physicians and scientists employed by Stanford University from companies or other commercial entities with which they interact as part of their professional activities.
- Consulting: Bayhill Therapeutics, Genentech, Goodman, Allen and Filetti, Morrison and Foerster, UCB, Inc
- Royalty Payments: Bayhill Therapeutics
- Equity: Bayhill Therapeutics
Research Interests
We are part of the Department of Medicine, Division of Immunology at Stanford University School of Medicine. Our lab is located in the brand new CCSR building, room 2215. We are interested in autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), scleroderma, myositis, primary biliary chirosis (PBC), Sjogren's disease, insulin dependent diabetes (type I diabetes or IDDM), multiple sclerosis (MS) and mixed connective tissue disease (MCTD). The Utz lab is comprised of approximately 12 scientists, including Postdoctoral Fellows, Research Assistants, Undergraduate Students and Graduate Students. The focus of our research centers on serum autoantibodies produced in a variety of autoimmune diseases. In addition to trying to better understand the pathogenic mechanisms involved in autoimmunity, we are interested in developing bench-to-bedside technologies, including diagnostics and therapeutics, for human autoimmune diseases.
The four major goals of our studies are:
(1) To understand the mechanisms by which highly-conserved, diverse molecules and complexes such as histones and splicing particles are targeted by T and B lymphocytes and to determine how an immune response directed against ubiquitous antigens leads to organ-specific autoimmune disease.
(2) To use autoimmune sera as molecular probes to study basic cellular processes, particularly apoptosis signaling pathways, alternative RNA splicing, and endoplasmic reticulum protein transport.
(3) To invent and validate novel technologies for high-throughput, multiplex proteomics signaling molecules and studies. We are currently focusing on proteomics analysis of proteins secreted by immune cells, including cytokines and autoantibodies.
(4) To take advantage of the information provided by autoantibody profiling methods to develop antigen-specific tolerizing therapies for common autoimmune diseases. We collaborate closely with the Stanford laboratory of Dr. Larry Steinman, the principle discoverer of DNA tolerizing technology. Our long-term goal is to develop patient-specific, individualized therapeutics.
Clinical Trials
- Imatinib in Systemic Sclerosis Recruiting
Publications
- J Immunol. 2009; (10): 5919-28
- Autoimmunity. 2009;
- J Cell Biochem. 2009; (2): 433-46
- Arthritis Rheum. 2008; (7): 2098-104
- Arthritis Rheum. 2008; (6): 1619-29
- Clin Chem. 2008; (6): 937-9
- J Clin Invest. 2008; (4): 1417-26
- Biosens Bioelectron. 2008; (10): 1413-21
- Arthritis Rheum. 2008; (10): 3192-204
- Nat Biotechnol. 2008; (11): 1285-92
- Nat Med. 2008; (11): 1284-9
- Proteomics. 2008; (17): 3443-9
- J Biol Chem. 2007; (4): 2450-5
- Nat Clin Pract Rheumatol. 2007; (2): 96-103
- Blood. 2007; (1): 278-86
- Arch Neurol. 2007; (10): 1407-15
- Anal Chem. 2007; (21): 8316-22
- J Clin Invest. 2006; (10): 2633-42
- Nat Methods. 2006; (9): 745-51
- Journal of Immunology. 2006;
- Annu. Rev. Immunol.. 2006; 391-418
- Cytometry A. 2006; (2): 59-65
- Proteomics. 2006; (21): 5720-4
- Immunol Rev. 2005; 264-82
- Curr Opin Rheumatol. 2005; (5): 513-7
- Modern Rheumatology. 2005; 315-322.
- Ann N Y Acad Sci. 2005; 61-8
- Clin Exp Immunol. 2005; (1): 148-54
- Curr Top Microbiol Immunol. 2005; 55-63
- Arthritis Rheum. 2005; (9): 2645-55
- Nature. 2005; (7042): 605-11
- Arthritis Rheum. 2005; (6): 1684-93
- Nat Med. 2004; (12): 1390-6
- J Virol. 2004; (12): 6313-21
- Lupus. 2004; (5): 304-11
- J Immunol. 2004; (8): 4994-5001
- Eur J Immunol. 2004; (6): 1654-62
- Arthritis Rheum. 2004; (10): 3239-49
- Ann Rheum Dis. 2004; (4): 330-2
- Clin Immunol. 2004; (2): 153-4
- Autoimmunity. 2004; (4): 269-72
- Curr Rheumatol Rep. 2004; (2): 156-63
- Clin Exp Rheumatol. 2003 Sep-Oct; (5 Suppl 31): S59-64
- Arthritis Res Ther. 2003; (5): 246-8
- Nat Biotechnol. 2003; (9): 1033-9
- Proc Natl Acad Sci U S A. 2003; (9): 4984-9
- Anal Chem. 2003; (5): 1180-7
- Proteomics. 2003; (11): 2077-84
- Nat Med. 2002; (3): 295-301
- Arthritis Rheum. 2002; (4): 885-93
- Biotechniques. 2002; 66-9
- J Exp Med. 2002; (9): 1213-25
- Clin Immunol. 2002; (1): 7-12
- Arthritis Res. 2001; (4): 237-40
- Cell Death Differ. 2000; (7): 589-602
- Blood. 1989; (8): 2733-42