Key Documents

Jeffrey Norton

Professor - Med Center Line, Surgery - General Surgery
Member, Cancer Center

Contact Information

Clinical Offices

Surgical Oncology 875 Blake Wilbur Dr Clinic F Stanford, CA 94305-5820
Telephone Work (650) 498-6000 Fax (650) 736-4167
Academic Offices

Personal Information

Administrative Contact
JoAnne Smithson Administrative Assistant Email smithson@stanford.edu Tel Work (650) 498-6606

Not for medical emergencies or patient use

Clinical Focus

Adrenal Cancer
Carcinoid Tumors
Carcinoid Tumors - Endocrinology
Carcinoid Tumors - Surgery
Endocrine - Surgery
Endocrinology Surgery
Esophageal Cancer
Esophageal Cancer - Thoracic Surgery
Gastrointestinal Cancers
Gastrointestinal Cancers - Surgical Oncology
Gastrointestinal Oncology Surgery
General Surgery
Liver Cancer
Liver Cancer - Surgery
Multiple Endocrine Neoplasias
Multiple Endocrine Neoplasias - Surgery
Osteosarcoma
Osteosarcoma - Surgery
Pancreas Surgery
Pancreatic Cancer
Pancreatic Cancer - Surgery
Parathyroid Disease
Parathyroid Disease - Surgery
Sarcomas - Soft Tissue
Sarcomas - Soft Tissue - Surgery
Sarcomas - Surgical Oncology
Stomach Cancer
Stomach Cancer - Surgery
Thyroid Cancers
Thyroid Cancers - Surgery

Department

Cancer > GI Oncology

Professional Education

Board Certification: General Surgery, American Board of Surgery (1983)
Duke University Medical Center (1982) NC
National Cancer Institute (1979) MD
Duke University Medical Center (1974) NC
SUNY Upstate Medical University (1973) NY

Postdoctoral Advisees

Lingbing Zhang

Research Interests

Interleukin-12 is a Th1 cytokine. It is important in the cell mediated immune response. We are investigating its role as an anti-tumor cytokine to augment the immune response against cancer. We are planning a human trial.

Clinical Trials

Identification of Key Blood Molecular Markers for Immunotherapy Recruiting
Evaluation of Preexisiting Immunity Markers in Human Tumor Tissue Sample No longer recruiting
Cyberknife Radiosurgery for Locally Advanced Pancreatic Cancer Completed
Investigate Role of Metabolic Imaging in Predicting Tumor Response/Outcome After Pancreatic CA Tx Completed
Phase I Dose Escalation of Stereotactic Radiosurgical Boost for Locally Advanced Esophageal Cancer No longer recruiting
Phase I/II PTK787/ZK 222584 and Gemcitabine in Advanced Pancreatic Cancer No longer recruiting
Trilogy Stereotactic Body Radiotherapy for Pancreatic Cancer Completed

Publications

Surgical management of Zollinger-Ellison syndrome; state of the art. Morrow EH, Norton JA. Surg Clin North Am. 2009; 89 (5): 1091-103
A Novel PRKAR1A Mutation Associated with Primary Pigmented Nodular Adrenocortical Disease and the Carney Complex. Peck M, Visser BC, Norton JA, Pasche L, Katznelson L. Endocr Pract. 2009; 1-22
The value of surgery for retroperitoneal sarcoma. Gholami S, Jacobs CD, Kapp DS, Parast LM, Norton JA. Sarcoma. 2009; 2009 605840
Major blood vessel reconstruction during sarcoma surgery. Song TK, Harris EJ, Raghavan S, Norton JA. Arch Surg. 2009; 144 (9): 817-22
Appendiceal Mucinous Neoplasms: Clinicopathologic Study of 116 Cases With Analysis of Factors Predicting Recurrence. Pai RK, Beck AH, Norton JA, Longacre TA. Am J Surg Pathol. 2009;
Solid Pseudopapillary Tumor of the Pancreas: An Unexpected Finding After Minor Abdominal Trauma. Cisco R, Jeffrey RB, Norton JA. Dig Dis Sci. 2009;
Tissue effects after stereotactic body radiotherapy using cyberknife for patients with abdominal malignancies. Cupp JS, Koong AC, Fisher GA, Norton JA, Goodman KA. Clin Oncol (R Coll Radiol). 2008; 20 (1): 69-75
Hereditary diffuse gastric cancer: implications of genetic testing for screening and prophylactic surgery. Cisco RM, Ford JM, Norton JA. Cancer. 2008; 113 (7 Suppl): 1850-6
Hereditary diffuse gastric cancer: surgery, surveillance and unanswered questions. Cisco RM, Norton JA. Future Oncol. 2008; 4 (4): 553-9
Identifying and Preventing High-risk Gastric Cancer Individuals With CDH1 Mutations. Norton JA, Ford JM. Ann Surg. 2008; 247 (4): 715-716
Risk-reducing total gastrectomy for germline mutations in E-cadherin (CDH1): pathologic findings with clinical implications. Rogers WM, Dobo E, Norton JA, Van Dam J, Jeffrey RB, Huntsman DG, Kingham K, Chun N, Ford JM, Longacre TA. Am J Surg Pathol. 2008; 32 (6): 799-809
Intraoperative radiation therapy for locally advanced and recurrent soft-tissue sarcomas in adults. Tran PT, Hara W, Su Z, Lin HJ, Bendapudi PK, Norton J, Teng N, King CR, Kapp DS. Int J Radiat Oncol Biol Phys. 2008; 72 (4): 1146-53
Gemcitabine chemotherapy and single-fraction stereotactic body radiotherapy for locally advanced pancreatic cancer. Schellenberg D, Goodman KA, Lee F, Chang S, Kuo T, Ford JM, Fisher GA, Quon A, Desser TS, Norton J, Greco R, Yang GP, Koong AC. Int J Radiat Oncol Biol Phys. 2008; 72 (3): 678-86
Prospective study of surgery for primary hyperparathyroidism (HPT) in multiple endocrine neoplasia-type 1 and Zollinger-Ellison syndrome: long-term outcome of a more virulent form of HPT. Norton JA, Venzon DJ, Berna MJ, Alexander HR, Fraker DL, Libutti SK, Marx SJ, Gibril F, Jensen RT. Ann Surg. 2008; 247 (3): 501-10
Identifying and Preventing High-risk Gastric Cancer Individuals With CDH1 Mutations. Norton JA, Ford JM. Ann Surg. 2008; 247 (4): 715-6
CDH1 truncating mutations in the E-cadherin gene: an indication for total gastrectomy to treat hereditary diffuse gastric cancer. Norton JA, Ham CM, Van Dam J, Jeffrey RB, Longacre TA, Huntsman DG, Chun N, Kurian AW, Ford JM. Ann Surg. 2007; 245 (6): 873-9
Surgery for gastrinoma. Cisco RM, Norton JA. Adv Surg. 2007; 41 165-76
Role of surgery in Zollinger-Ellison syndrome. Norton JA, Jensen RT. J Am Coll Surg. 2007; 205 (4 Suppl): S34-7
Surgery increases survival in patients with gastrinoma. Norton JA, Fraker DL, Alexander HR, Gibril F, Liewehr DJ, Venzon DJ, Jensen RT. Ann Surg. 2006; 244 (3): 410-9
Inhibition of host signal transducer and activator of transcription factor 6 results in cure with cyclophosphamide and interleukin 12 immunotherapy. Norton JA, Li M, Lee NC, Tsung K. Ann Surg Oncol. 2006; 13 (1): 118-24
Surgery for gastrinoma and insulinoma in multiple endocrine neoplasia type 1. Norton JA, Fang TD, Jensen RT. J Natl Compr Canc Netw. 2006; 4 (2): 148-53
Surgery for primary pancreatic neuroendocrine tumors. Norton JA, J Gastrointest Surg. 2006; 10 (3): 327-31
Lessons from Coley's Toxin. Tsung K, Norton JA. Surg Oncol. 2006; 15 (1): 25-8
A national comparison of surgical versus percutaneous drainage of pancreatic pseudocysts: 1997-2001. Morton JM, Brown A, Galanko JA, Norton JA, Grimm IS, Behrns KE. J Gastrointest Surg. 2005; 9 (1): 15-20; discussion 20-1
Endocrine tumours of the gastrointestinal tract. Surgical treatment of neuroendocrine metastases. Norton JA, Best Pract Res Clin Gastroenterol. 2005; 19 (4): 577-83
Computed tomography, endoscopic, laparoscopic, and intra-operative sonography for assessing resectability of pancreatic cancer. Long EE, Van Dam J, Weinstein S, Jeffrey B, Desser T, Norton JA. Surg Oncol. 2005; 14 (2): 105-13
Phase II study to assess the efficacy of conventionally fractionated radiotherapy followed by a stereotactic radiosurgery boost in patients with locally advanced pancreatic cancer. Koong AC, Christofferson E, Le QT, Goodman KA, Ho A, Kuo T, Ford JM, Fisher GA, Greco R, Norton J, Yang GP. Int J Radiat Oncol Biol Phys. 2005; 63 (2): 320-3
Surgical treatment and prognosis of gastrinoma. Norton JA, Best Pract Res Clin Gastroenterol. 2005; 19 (5): 799-805
Surgery and prognosis of duodenal gastrinoma as a duodenal neuroendocrine tumor. Norton JA, Best Pract Res Clin Gastroenterol. 2005; 19 (5): 699-704
Gastric carcinoid tumors in multiple endocrine neoplasia-1 patients with Zollinger-Ellison syndrome can be symptomatic, demonstrate aggressive growth, and require surgical treatment. Norton JA, Melcher ML, Gibril F, Jensen RT. Surgery. 2004; 136 (6): 1267-74
Does the use of routine duodenotomy (DUODX) affect rate of cure, development of liver metastases, or survival in patients with Zollinger-Ellison syndrome? Norton JA, Alexander HR, Fraker DL, Venzon DJ, Gibril F, Jensen RT. Ann Surg. 2004; 239 (5): 617-25; discussion 626
Resolved and unresolved controversies in the surgical management of patients with Zollinger-Ellison syndrome. Norton JA, Jensen RT. Ann Surg. 2004; 240 (5): 757-73
A high-resolution radiation hybrid map of the human genome draft sequence. Olivier M, Aggarwal A, Allen J, Almendras AA, Bajorek ES, Beasley EM, Brady SD, Bushard JM, Bustos VI, Chu A, Chung TR, De Witte A, Denys ME, Dominguez R, Fang NY, Foster BD, Freudenberg RW, Hadley D, Hamilton LR, Jeffrey TJ, Kelly L, Lazzeroni L, Levy MR, Lewis SC, Liu X, Lopez FJ, Louie B, Marquis JP, Martinez RA, Matsuura MK, Misherghi NS, Norton JA, Olshen A, Perkins SM, Perou AJ, Piercy C, Piercy M, Qin F, Reif T, Sheppard K, Shokoohi V, Smick GA, Sun WL, Stewart EA, Fernando J, Tejeda, Tran NM, Trejo T, Vo NT, Yan SC, Zierten DL, Zhao S, Sachidanandam R, Trask BJ, Myers RM, Cox DR. Science. 2001; 291 (5507): 1298-302