Tirin Moore

Honors and Awards

• Troland Research Award, National Academy of Sciences (2009)
• McKnight Scholar Award, McKnight Endowment Fund (2006-2009)
• CAREER Award, National Science Foundation (2006-2011)
• Sloan Fellow, Alfred P. Sloan Foundation (2004-2006)
• Pew Scholar, Pew Charitable Trust (2004-2008)

Professional Education

• Ph.D., Princeton, Neuroscience (1995)

Postdoctoral Advisees

• Katherine Armstrong, Behrad Noudoost

Graduate & Fellowship Program Affiliations

• Neurobiology
• Neurosciences

Web Site Links

• Tirin Moore Links

Research Interests

We study neural mechanisms of visual-motor integration and the neural basis of cognition (e.g. attention). We study the activity of single neurons in visual and motor structures within the brain, examine how perturbing that activity affects neurons in other brain structures, and also how it affects the perceptual and motor performance of behaving animals. Questions currently addressed by our group include:

(1) How are the signals conveyed by visual cortical neurons used to guide eye movements?

(2) How does oculomotor feedback affect processing in visual cortex?

(3) What is the impact of planned movements on visual perception?

(4) What are the neural circuits and neural computations that control selective attention?

Our laboratory is also driven to develop more powerful approaches to systems-level neurobiological questions.

Publications

• Dynamic sensitivity of area V4 neurons during saccade preparation. Han X,  Xian SX, Moore T.  Proc Natl Acad Sci U S A.  2009; 106 (31): 13046-51
• Attention governs action in the primate frontal eye field. Schafer RJ,  Moore T.  Neuron.  2007; 56 (3): 541-51
• Changes in visual receptive fields with microstimulation of frontal cortex. Armstrong KM,  Fitzgerald JK, Moore T.  Neuron.  2006; 50 (5): 791-8
• Representations of faces and body parts in macaque temporal cortex: a functional MRI study. Pinsk MA,  DeSimone K, Moore T, Gross CG, Kastner S.  Proc Natl Acad Sci U S A.  2005; 102 (19): 6996-7001
• Selective gating of visual signals by microstimulation of frontal cortex. Moore T,  Armstrong KM.  Nature.  2003; 421 (6921): 370-3
• Presaccadic discrimination of receptive field stimuli by area V4 neurons. Moore T,  Chang MH.  Vision Res.  2009; 49 (10): 1227-32
• Rapid enhancement of visual cortical response discriminability by microstimulation of the frontal eye field. Armstrong KM,  Moore T.  Proc Natl Acad Sci U S A.  2007; 104 (22): 9499-504
• Temporal patterning of saccadic eye movement signals. Kimmel DL,  Moore T.  J Neurosci.  2007; 27 (29): 7619-30
• Electrical signals propagate unbiased in cortex. Gilja V,  Moore T.  Neuron.  2007; 55 (5): 684-6
• The neurobiology of visual attention: finding sources. Moore T,  Curr Opin Neurobiol.  2006; 16 (2): 159-65
• Visual and oculomotor selection: links, causes and implications for spatial attention. Awh E,  Armstrong KM, Moore T.  Trends Cogn Sci.  2006; 10 (3): 124-30
• Methods for functional magnetic resonance imaging in normal and lesioned behaving monkeys. Pinsk MA,  Moore T, Richter MC, Gross CG, Kastner S.  J Neurosci Methods.  2005; 143 (2): 179-95
• Visually guided behavior after V1 lesions in young and adult monkeys and its relation to blindsight in humans. Gross CG,  Moore T, Rodman HR.  Prog Brain Res.  2004; 144 279-94
• Distribution of hand location in monkeys during spontaneous behavior. Graziano MS,  Cooke DF, Taylor CS, Moore T.  Exp Brain Res.  2004; 155 (1): 30-6
• Microstimulation of the frontal eye field and its effects on covert spatial attention. Moore T,  Fallah M.  J Neurophysiol.  2004; 91 (1): 152-62
• Homeland defense begins in precentral cortex. Focus on "Sensorimotor integration in the precentral gyrus: polysensory neurons and defensive movements". Moore T,  J Neurophysiol.  2004; 91 (4): 1456
• Complex movements evoked by microstimulation of the ventral intraparietal area. Cooke DF,  Taylor CS, Moore T, Graziano MS.  Proc Natl Acad Sci U S A.  2003; 100 (10): 6163-8
• Visuomotor origins of covert spatial attention. Moore T,  Armstrong KM, Fallah M.  Neuron.  2003; 40 (4): 671-83
• Probing cortical function with electrical stimulation. Graziano MS,  Taylor CS, Moore T.  Nat Neurosci.  2002; 5 (10): 921
• Complex movements evoked by microstimulation of precentral cortex. Graziano MS,  Taylor CS, Moore T.  Neuron.  2002; 34 (5): 841-51
• The cortical control of movement revisited. Graziano MS,  Taylor CS, Moore T, Cooke DF.  Neuron.  2002; 36 (3): 349-62
• Direction of motion discrimination after early lesions of striate cortex (V1) of the macaque monkey. Moore T,  Rodman HR, Gross CG.  Proc Natl Acad Sci U S A.  2001; 98 (1): 325-30
• Control of eye movements and spatial attention. Moore T,  Fallah M.  Proc Natl Acad Sci U S A.  2001; 98 (3): 1273-6
• Eye movements modulate visual receptive fields of V4 neurons. Tolias AS,  Moore T, Smirnakis SM, Tehovnik EJ, Siapas AG, Schiller PH.  Neuron.  2001; 29 (3): 757-67
• Shape representations and visual guidance of saccadic eye movements. Moore T,  Science.  1999; 285 (5435): 1914-7
• Visual representations during saccadic eye movements. Moore T,  Tolias AS, Schiller PH.  Proc Natl Acad Sci U S A.  1998; 95 (15): 8981-4
• Man, Monkey and Blindsight. Moore, T.,  Rodman, H.R., Gross, C.G..  The Neuroscientist.  1998; 4 227-230
• Greater residual vision in monkeys after striate cortex damage in infancy. Moore T,  Rodman HR, Repp AB, Gross CG, Mezrich RS.  J Neurophysiol.  1996; 76 (6): 3928-33
• Localization of visual stimuli after striate cortex damage in monkeys: parallels with human blindsight. Moore T,  Rodman HR, Repp AB, Gross CG.  Proc Natl Acad Sci U S A.  1995; 92 (18): 8215-8