Ting-Ting Huang

Professional Education

• B.S., Taipei Medical College Medical Technology (1981)
• M.S., University of Oklahoma HSC Microbiol. and Immunol. (1985)
• Ph.D., University of Oklahoma HSC Microbial Genetics (1988)

Postdoctoral Advisees

• Sayanti Bhattacharya, Victor Chu, Yani Zou

Graduate & Fellowship Program Affiliations

• Neurology and Neurol Sciences
• Neurosciences

Research Interests

We study the role of oxygen free radicals in oxidative tissue damage and degeneration. Our research tools include transgenic and knockout mice and tissue culture cells for in vitro gene expression.

Publications

• Lack of extracellular superoxide dismutase (EC-SOD) in the microenvironment impacts radiation-induced changes in neurogenesis. Rola R,  Zou Y, Huang TT, Fishman K, Baure J, Rosi S, Milliken H, Limoli CL, Fike JR.  Free Radic Biol Med.  2007; 42 (8): 1133-45; discussion 1131-2
• Identification of biomarkers associated with the development of hepatocellular carcinoma in CuZn superoxide dismutase deficient mice. Elchuri S,  Naeemuddin M, Sharpe O, Robinson WH, Huang TT.  Proteomics.  2007; 7 (12): 2121-9
• Genetic modifiers of the phenotype of mice deficient in mitochondrial superoxide dismutase. Huang TT,  Naeemuddin M, Elchuri S, Yamaguchi M, Kozy HM, Carlson EJ, Epstein CJ.  Hum Mol Genet.  2006; 15 (7): 1187-94
• CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life. Elchuri S,  Oberley TD, Qi W, Eisenstein RS, Jackson Roberts L, Van Remmen H, Epstein CJ, Huang TT.  Oncogene.  2005; 24 (3): 367-80
• Selective neuronal vulnerability and inadequate stress response in superoxide dismutase mutant mice. Lynn S,  Huang EJ, Elchuri S, Naeemuddin M, Nishinaka Y, Yodoi J, Ferriero DM, Epstein CJ, Huang TT.  Free Radic Biol Med.  2005; 38 (6): 817-28
• Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Van Remmen H,  Ikeno Y, Hamilton M, Pahlavani M, Wolf N, Thorpe SR, Alderson NL, Baynes JW, Epstein CJ, Huang TT, Nelson J, Strong R, Richardson A.  Physiol Genomics.  2003; 16 (1): 29-37
• Increased sensitivity of homozygous Sod2 mutant mice to oxygen toxicity. Asikainen TM,  Huang TT, Taskinen E, Levonen AL, Carlson E, Lapatto R, Epstein CJ, Raivio KO.  Free Radic Biol Med.  2002; 32 (2): 175-86
• Transgenic and mutant mice for oxygen free radical studies. Huang TT,  Raineri I, Eggerding F, Epstein CJ.  Methods Enzymol.  2002; 349 191-213
• Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Kops GJ,  Dansen TB, Polderman PE, Saarloos I, Wirtz KW, Coffer PJ, Huang TT, Bos JL, Medema RH, Burgering BM.  Nature.  2002; 419 (6904): 316-21
• Genetic modification of prenatal lethality and dilated cardiomyopathy in Mn superoxide dismutase mutant mice. Huang TT,  Carlson EJ, Kozy HM, Mantha S, Goodman SI, Ursell PC, Epstein CJ.  Free Radic Biol Med.  2001; 31 (9): 1101-10
• Regional vulnerability after traumatic brain injury: gender differences in mice that overexpress human copper, zinc superoxide dismutase. Igarashi T,  Huang TT, Noble LJ.  Exp Neurol.  2001; 172 (2): 332-41
• Ubiquitous overexpression of CuZn superoxide dismutase does not extend life span in mice. Huang TT,  Carlson EJ, Gillespie AM, Shi Y, Epstein CJ.  J Gerontol A Biol Sci Med Sci.  2000; 55 (1): B5-9
• The use of transgenic and mutant mice to study oxygen free radical metabolism. Huang TT,  Carlson EJ, Raineri I, Gillespie AM, Kozy H, Epstein CJ.  Ann N Y Acad Sci.  1999; 893 95-112
• Ts1Cje, a partial trisomy 16 mouse model for Down syndrome, exhibits learning and behavioral abnormalities. Sago H,  Carlson EJ, Smith DJ, Kilbridge J, Rubin EM, Mobley WC, Epstein CJ, Huang TT.  Proc Natl Acad Sci U S A.  1998; 95 (11): 6256-61
• Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Li Y,  Huang TT, Carlson EJ, Melov S, Ursell PC, Olson JL, Noble LJ, Yoshimura MP, Berger C, Chan PH, Wallace DC, Epstein CJ.  Nat Genet.  1995; 11 (4): 376-81