Key Documents

NIH Biosketch available Online

Marlene Rabinovitch

Professor, Pediatrics - Cardiology
Professor (By courtesy), Developmental Biology
Member, Bio-X

Contact Information

Clinical Offices

Pediatric Heart Center 725 Welch Rd MC 5912 Palo Alto, CA 94304-1601
Telephone Work (650) 721-2121 Fax
Academic Offices

Personal Information
Email marlener@stanford.edu

Administrative Contact
Administrative Associate Email mfox1@stanford.edu Tel Work 723-8239

Not for medical emergencies or patient use

Clinical Focus

Cardiology (Heart), Pediatric
Pediatric Cardiology

Administrative Appointments

Director of Research, Vera Moulton Wall Center for Pulmonary Vascular Disease , (2003– present )

Honors and Awards

Scientific Accomplishment Award, American Thoracic Society (2008)
Distinguished Scientist Award, American Heart Association (2006)
Dickinson Richards Lecture, American Heart Association (2005)
Basic Research Prize, American Heart Association (2004)
Leadership Award and Prize, CIHR-Institute of Circulatory & Respiratory Health (2004)
The Gill Award, University of Kentucky (2003)
Paul Dudley White Lectureship, American Heart Association (2002)
Dunlevie Endowed Research Chair, Stanford Univeristy (2002)
Distinguished Scientist Award, MRC (2000)
Award of Merit, Heart & Stroke Foundation of Canada (1999)
Endowed Research Chair, Heart & Stroke Foundation of Ontario (1997)
Julius Comroe Lectureship, American Physiological Society (1996)
Research Achievement Award, Canadian Cardiovascular Society (1994)
Cushing Memorial Award in Pediatrics, McGill University, Montreal, Canada (1971)

Professional Education

Board Certification: Pediatric Cardiology, American Board of Pediatrics (1979)
Children's Hospital, Harvard Medical School (1977) MA
Board Certification: General Pediatrics, American Board of Pediatrics (1976)
University of Colorado Health Science Center (1973) CO
University of Colorado Health Science Center (1972) CO
McGill University (1971) Canada
B.S., McGill Universtiy Physiology/Psychology (1967)
M.D., McGill University Medicine (1971)

Postdoctoral Advisees

Tero-Pekka Alastalo, Yu-Mee Kim, Ying-Ju Lai, Hirofumi Sawada

Graduate & Fellowship Program Affiliations

Community & International Work

National Heart, Lung, Blood Institute Advisory Council, NIH, Bethesda, MD More »
Executive Committee, Pulmonary Vascular Research Institute (PVRI) More »
Canadian Institutes of Health Research, Circulatory and Respiratory Institute Advisory Board More »
Burroughs Wellcome Fund, Translational Research Advisory Committee More »
Pulmonary Hypertension Association, Scientific Advisory Board More »

Web Site Links

Rabinovich/Bland Lab

Research Interests

Our research focuses on the regulation of genes associated with cardiovascular development and disease. We identified a novel smooth muscle cell elastase that has a pivotal role in the pathobiology of pulmonary hypertension, vein graft atherosclerosis, transplant arteriopathy and rejection, coronary artery disease, restenosis, myocardial ischemia and myocarditis. Inhibition of elastase prevents or reverses the pathology in experimental animals. We are now pursuing fundamental studies which address the transcriptional regulation of elastase by AML1 and how this relates to genetic mechanisms of disease, focusing on polymorphisms in the serotonin transporter, mutations in a bone morphogenetic protein receptor, and overexpression of a calcium binding protein, Mts1. These studies use cultured cells, transgenic mice, gene arrays and gene therapy and are aimed at developing new treatments.

In our studies related to regulation of cell motility, a key feature of vascular pathology, we identified a requisite increase in production of the microtubule-associated protein LC-3, which is highly conserved across species. This protein regulates the efficiency of mRNA translation of genes, including fibronectin and apolipoprotein D. We determined that LC3, through its triple arginine motif, engages an AU rich element in the 3’ untranslated region of fibronectin mRNA, to enhance efficiency of mRNA translation. We are now addressing whether this process is critical to the regulation of a constellation of transcripts necessary for cell motility in development and disease. We are pursuing evidence that LC3 is regulated by nitric oxide, and are currently investigating how this leads to its phosphorylation and binding to mRNA. In addition, we are relating LC-3 to the migration of other cell types, including neural crest cells which regulate cardiac development, as well as neuronal cells, where it is highly expressed in development, and in diseased tissues and cancer cells. We are utilizing transgenic mice, RNAi, and transcriptional profiling by DNA microarray approaches to investigate the impact of LC3-dependent mRNA translation on cell function.

We have also cloned a novel chymase that mediates enhanced experimental hypertension through processing angiotensin II, endothelin 1, and transforming growth factor beta.

Our research program harmonizes with that of Dr. Richard Bland who investigates the regulation, expression and function of genes that coordinate pulmonary alveolar and vascular development, and how they are perturbed by prematurity and mechanical ventilation, leading to chronic lung disease.

Clinical Trials

Insulin Resistance in Pulmonary Arterial Hypertension Recruiting

Publications

S100A4 and bone morphogenetic protein-2 codependently induce vascular smooth muscle cell migration via phospho-extracellular signal-regulated kinase and chloride intracellular channel 4. Spiekerkoetter E, Guignabert C, de Jesus Perez V, Alastalo TP, Powers JM, Wang L, Lawrie A, Ambartsumian N, Schmidt AM, Berryman M, Ashley RH, Rabinovitch M. Circ Res. 2009; 105 (7): 639-47, 13 p following 647
Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways. de Jesus Perez VA, Alastalo TP, Wu JC, Axelrod JD, Cooke JP, Amieva M, Rabinovitch M. J Cell Biol. 2009; 184 (1): 83-99
Tie2-Mediated Loss of Peroxisome Proliferator-Activated Receptor-{gamma} in Mice Causes PDGF-Receptor {beta}-Dependant Pulmonary Arterial Muscularization. Guignabert C, Alvira CM, Alastalo TP, Sawada H, Hansmann G, Zhao M, Wang L, El-Bizri N, Rabinovitch M. Am J Physiol Lung Cell Mol Physiol. 2009;
An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension. Hansmann G, de Jesus Perez VA, Alastalo TP, Alvira CM, Guignabert C, Bekker JM, Schellong S, Urashima T, Wang L, Morrell NW, Rabinovitch M. J Clin Invest. 2008; 118 (5): 1846-57
SM22alpha-targeted deletion of bone morphogenetic protein receptor 1A in mice impairs cardiac and vascular development, and influences organogenesis. El-Bizri N, Guignabert C, Wang L, Cheng A, Stankunas K, Chang CP, Mishina Y, Rabinovitch M. Development. 2008; 135 (17): 2981-91
Prolonged Mechanical Ventilation with Air Induces Apoptosis and Causes Failure of Alveolar Septation and Angiogenesis in Lungs of Newborn Mice. Mokres LM, Parai K, Hilgendorff A, Ertsey R, Alvira CM, Rabinovitch M, Bland RD. Am J Physiol Lung Cell Mol Physiol. 2009;
Cholinergic modulation of angiogenesis: Role of the 7 nicotinic acetylcholine receptor. Wu JC, Chruscinski A, De Jesus Perez VA, Singh H, Pitsiouni M, Rabinovitch M, Utz PJ, Cooke JP. J Cell Biochem. 2009; 108 (2): 433-46
Balloon occlusion pulmonary wedge angiography and lung biopsy assessment in the child with a congenital cardiac defect. Rabinovitch M, Haworth SG. Cardiol Young. 2009; 19 Suppl 1 13-5
Insulin resistance in pulmonary arterial hypertension. Zamanian RT, Hansmann G, Snook S, Lilienfeld D, Rappaport KM, Reaven GM, Rabinovitch M, Doyle RL. Eur Respir J. 2009; 33 (2): 318-24
Molecular pathogenesis of pulmonary arterial hypertension. Rabinovitch M, J Clin Invest. 2008; 118 (7): 2372-9
Pulmonary arterial remodeling induced by a Th2 immune response. Daley E, Emson C, Guignabert C, de Waal Malefyt R, Louten J, Kurup VP, Hogaboam C, Taraseviciene-Stewart L, Voelkel NF, Rabinovitch M, Grunig E, Grunig G. J Exp Med. 2008; 205 (2): 361-72
Developmental expression of LC3alpha and beta: absence of fibronectin or autophagy phenotype in LC3beta knockout mice. Cann GM, Guignabert C, Ying L, Deshpande N, Bekker JM, Wang L, Zhou B, Rabinovitch M. Dev Dyn. 2008; 237 (1): 187-95
Smooth muscle protein 22alpha-mediated patchy deletion of Bmpr1a impairs cardiac contractility but protects against pulmonary vascular remodeling. El-Bizri N, Wang L, Merklinger SL, Guignabert C, Desai T, Urashima T, Sheikh AY, Knutsen RH, Mecham RP, Mishina Y, Rabinovitch M. Circ Res. 2008; 102 (3): 380-8
Reactivation of gammaHV68 induces neointimal lesions in pulmonary arteries of S100A4/Mts1-overexpressing mice in association with degradation of elastin. Spiekerkoetter E, Alvira CM, Kim YM, Bruneau A, Pricola KL, Wang L, Ambartsumian N, Rabinovitch M. Am J Physiol Lung Cell Mol Physiol. 2008; 294 (2): L276-89
Mechanical ventilation uncouples synthesis and assembly of elastin and increases apoptosis in lungs of newborn mice. Prelude to defective alveolar septation during lung development? Bland RD, Ertsey R, Mokres LM, Xu L, Jacobson BE, Jiang S, Alvira CM, Rabinovitch M, Shinwell ES, Dixit A. Am J Physiol Lung Cell Mol Physiol. 2008; 294 (1): L3-14
VEGF blockade inhibits angiogenesis and reepithelialization of endometrium. Fan X, Krieg S, Kuo CJ, Wiegand SJ, Rabinovitch M, Druzin ML, Brenner RM, Giudice LC, Nayak NR. FASEB J. 2008; 22 (10): 3571-80
Point:Counterpoint: Chronic hypoxia-induced pulmonary hypertension does/does not lead to loss of pulmonary vasculature. Rabinovitch M, Chesler N, Molthen RC. J Appl Physiol. 2007; 103 (4): 1449-51
Mechanical ventilation with 40% oxygen reduces pulmonary expression of genes that regulate lung development and impairs alveolar septation in newborn mice. Bland RD, Mokres LM, Ertsey R, Jacobson BE, Jiang S, Rabinovitch M, Xu L, Shinwell ES, Zhang F, Beasley MA. Am J Physiol Lung Cell Mol Physiol. 2007; 293 (5): L1099-110
Pathobiology of pulmonary hypertension. Rabinovitch M, Annu Rev Pathol. 2007; 2 369-99
Nuclear factor-kappaB activation in neonatal mouse lung protects against lipopolysaccharide-induced inflammation. Alvira CM, Abate A, Yang G, Dennery PA, Rabinovitch M. Am J Respir Crit Care Med. 2007; 175 (8): 805-15
Dysregulation of pulmonary elastin synthesis and assembly in preterm lambs with chronic lung disease. Bland RD, Xu L, Ertsey R, Rabinovitch M, Albertine KH, Wynn KA, Kumar VH, Ryan RM, Swartz DD, Csiszar K, Fong KS. Am J Physiol Lung Cell Mol Physiol. 2007; 292 (6): L1370-84
Pulmonary arterial hypertension is linked to insulin resistance and reversed by peroxisome proliferator-activated receptor-gamma activation. Hansmann G, Wagner RA, Schellong S, Perez VA, Urashima T, Wang L, Sheikh AY, Suen RS, Stewart DJ, Rabinovitch M. Circulation. 2007; 115 (10): 1275-84
Subversion of cellular autophagosomal machinery by RNA viruses. Jackson WT, Giddings TH, Taylor MP, Mulinyawe S, Rabinovitch M, Kopito RR, Kirkegaard K. PLoS Biol. 2005; 3 (5): e156
Increased fibulin-5 and elastin in S100A4/Mts1 mice with pulmonary hypertension. Merklinger SL, Wagner RA, Spiekerkoetter E, Hinek A, Knutsen RH, Kabir MG, Desai K, Hacker S, Wang L, Cann GM, Ambartsumian NS, Lukanidin E, Bernstein D, Husain M, Mecham RP, Starcher B, Yanagisawa H, Rabinovitch M. Circ Res. 2005; 97 (6): 596-604
Interdependent serotonin transporter and receptor pathways regulate S100A4/Mts1, a gene associated with pulmonary vascular disease. Lawrie A, Spiekerkoetter E, Martinez EC, Ambartsumian N, Sheward WJ, MacLean MR, Harmar AJ, Schmidt AM, Lukanidin E, Rabinovitch M. Circ Res. 2005; 97 (3): 227-35
Gene transfer of prostaglandin synthase maintains patency of the newborn lamb arterial duct. Humpl T, Zaidi SH, Coe JY, Russell J, Kaneda Y, Massaeli H, Benson LN, Rabinovitch M. Pediatr Res. 2005; 58 (5): 976-80
Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension. Merklinger SL, Jones PL, Martinez EC, Rabinovitch M. Circulation. 2005; 112 (3): 423-31
Caspases from apoptotic myocytes degrade extracellular matrix: a novel remodeling paradigm. Cowan KN, Leung WC, Mar C, Bhattacharjee R, Zhu Y, Rabinovitch M. FASEB J. 2005; 19 (13): 1848-50
Cellular and molecular pathobiology of pulmonary hypertension conference summary. Rabinovitch M, Chest. 2005; 128 (6 Suppl): 642S-646S
Mts1/S100A4 stimulates human pulmonary artery smooth muscle cell migration through multiple signaling pathways. Spiekerkoetter E, Lawrie A, Merklinger S, Ambartsumian N, Lukanidin E, Schmidt AM, Rabinovitch M. Chest. 2005; 128 (6 Suppl): 577S
S100A4/Mts1 produces murine pulmonary artery changes resembling plexogenic arteriopathy and is increased in human plexogenic arteriopathy Greenway S, van Suylen R J, Du Marchie Sarvaas G, Kwan E, Ambartsumian N, Lukanidin E, Rabinovitch M.. Am J Pathol. 2004; 164 253-262
Cellular and molecular pathobiology of pulmonary arterial hypertension. Humbert M, Morrell NW, Archer SL, Stenmark KR, MacLean MR, Lang IM, Christman BW, Weir EK, Eickelberg O, Voelkel NF, Rabinovitch M. J Am Coll Cardiol. 2004; 43 (12 Suppl S): 13S-24S
Pulmonary arterial hypertension: future directions: report of a National Heart, Lung and Blood Institute/Office of Rare Diseases workshop. Newman JH, Fanburg BL, Archer SL, Badesch DB, Barst RJ, Garcia JG, Kao PN, Knowles JA, Loyd JE, McGoon MD, Morse JH, Nichols WC, Rabinovitch M, Rodman DM, Stevens T, Tuder RM, Voelkel NF, Gail DB. Circulation. 2004; 109 (24): 2947-52
Apolipoprotein D and platelet-derived growth factor-BB synergism mediates vascular smooth muscle cell migration. Leung WC, Lawrie A, Demaries S, Massaeli H, Burry A, Yablonsky S, Sarjeant JM, Fera E, Rassart E, Pickering JG, Rabinovitch M. Circ Res. 2004; 95 (2): 179-86
The mouse through the looking glass: a new door into the pathophysiology of pulmonary hypertension. Rabinovitch M, Circ Res. 2004; 94 (8): 1001-4
S100A4/Mts1 produces murine pulmonary artery changes resembling plexogenic arteriopathy and is increased in human plexogenic arteriopathy. Greenway S, van Suylen RJ, Du Marchie Sarvaas G, Kwan E, Ambartsumian N, Lukanidin E, Rabinovitch M. Am J Pathol. 2004; 164 (1): 253-62
Elafin-overexpressing mice have improved cardiac function after myocardial infarction. Ohta K, Nakajima T, Cheah AY, Zaidi SH, Kaviani N, Dawood F, You XM, Liu P, Husain M, Rabinovitch M. Am J Physiol Heart Circ Physiol. 2004; 287 (1): H286-92
Apolipoprotein D and PDGF-BB synergism mediates vascular smooth muscle cell migration. Leung W, Demaries S, Burry A, Yablonsky S, Sarjeant J, Fera E, Rassart E, Pickering JG, Rabinovitch M.. Circ Res. 2004; 95 (2): 179-86
Apolipoprotein D inhibits PDGF induced vascular smooth muscle cell proliferation by preventing translocation of P-ERK 1/2 to the nucleus. Sarjeant JM, Kinnear C, Yablonsky S, Leung W, Maesseli, Rassart E, Rabinovitch M.. Arterioscler Thromb Vasc Biol. 2003; 23 2172-2177
Low molecular weight heparin and unfractionated heparin are both effective at accelerating pulmonary vascular maturation in neonatal rabbits. O'Blenes SB, Merklinger SL, Jegatheeswaran A, Campbell A, Rabinovitch M, Rebeyka I, Van Arsdell G. Circulation. 2003; 108 Suppl 1 II161-6
Apolipoprotein D inhibits platelet-derived growth factor-BB-induced vascular smooth muscle cell proliferated by preventing translocation of phosphorylated extracellular signal regulated kinase 1/2 to the nucleus. Sarjeant JM, Lawrie A, Kinnear C, Yablonsky S, Leung W, Massaeli H, Prichett W, Veinot JP, Rassart E, Rabinovitch M. Arterioscler Thromb Vasc Biol. 2003; 23 (12): 2172-7
Temporal response and localization of integrins beta1 and beta3 in the heart after myocardial infarction: regulation by cytokines. Sun M, Opavsky MA, Stewart DJ, Rabinovitch M, Dawood F, Wen WH, Liu PP. Circulation. 2003; 107 (7): 1046-52
Elafin overexpressing mice have improved cardiac function after myocardial infarction. Kunio O, Nakajima T, Cheah, AYL, Zaidi S, Kaviani N, Dawood, F, You, X, Liu, P, Husain, M, Rabinovitch M.. Am J Physiol Heart Circ Physiol. 2003; 287 H286-H292
Understanding and treating vein graft atherosclerosis. Sarjeant JM, Rabinovitch M. Cardiovasc Pathol. 2002 Sep-Oct; 11 (5): 263-71
Novel notions on newborn lung disease. Rabinovitch M, Bland R. Nat Med. 2002; 8 (7): 664-6
Enhanced ERK-1/2 activation in mice susceptible to coxsackievirus-induced myocarditis. Opavsky MA, Martino T, Rabinovitch M, Penninger J, Richardson C, Petric M, Trinidad C, Butcher L, Chan J, Liu PP. J Clin Invest. 2002; 109 (12): 1561-9
Fetal pulmonary artery diameters and their association with lung hypoplasia and postnatal outcome in congenital diaphragmatic hernia. Sokol J, Bohn D, Lacro RV, Ryan G, Stephens D, Rabinovitch M, Smallhorn J, Hornberger LK. Am J Obstet Gynecol. 2002; 186 (5): 1085-90
Dexfenfluramine protects against pulmonary hypertension in rats. Mitani Y, Mutlu A, Russell JC, Brindley DN, DeAlmeida J, Rabinovitch M. J Appl Physiol. 2002; 93 (5): 1770-8
Overexpression of the serine elastase inhibitor elafin protects transgenic mice from hypoxic pulmonary hypertension. Zaidi SH, You XM, Ciura S, Husain M, Rabinovitch M. Circulation. 2002; 105 (4): 516-21
Pulmonary arterial hypertension in congenital heart disease. Granton JT, Rabinovitch M. Cardiol Clin. 2002; 20 (3): 441-57, vii
A novel vascular smooth muscle chymase is upregulated in hypertensive rats. Guo C, Ju H, Leung D, Massaeli H, Shi M, Rabinovitch M. J Clin Invest. 2001; 107 (6): 703-15
Tumor necrosis factor-alpha induces fibronectin synthesis in coronary artery smooth muscle cells by a nitric oxide-dependent posttranscriptional mechanism. O'Blenes CA, Kinnear C, Rabinovitch M. Circ Res. 2001; 89 (1): 26-32
Arterial elastase activity after balloon angioplasty and effects of elafin, an elastase inhibitor. Barolet AW, Nili N, Cheema A, Robinson R, Natarajan MK, O'Blenes S, Li J, Eskandarian MR, Sparkes J, Rabinovitch M, Strauss BH. Arterioscler Thromb Vasc Biol. 2001; 21 (8): 1269-74
Pathobiology of pulmonary hypertension. Extracellular matrix. Rabinovitch M, Clin Chest Med. 2001; 22 (3): 433-49, viii
Linking a serotonin transporter polymorphism to vascular smooth muscle proliferation in patients with primary pulmonary hypertension. Rabinovitch M, J Clin Invest. 2001; 108 (8): 1109-11
Conditional and targeted overexpression of vascular chymase causes hypertension in transgenic mice. Ju H, Gros R, You X, Tsang S, Husain M, Rabinovitch M. Proc Natl Acad Sci U S A. 2001; 98 (13): 7469-74
Hemodynamic unloading leads to regression of pulmonary vascular disease in rats. O'Blenes SB, Fischer S, McIntyre B, Keshavjee S, Rabinovitch M. J Thorac Cardiovasc Surg. 2001; 121 (2): 279-89
Isolated ductus arteriosus aneurysm in the fetus and infant: a multi-institutional experience. Dyamenahalli U, Smallhorn JF, Geva T, Fouron JC, Cairns P, Jutras L, Hughes V, Rabinovitch M, Mason CA, Hornberger LK. J Am Coll Cardiol. 2000; 36 (1): 262-9
Circulation research Editors' yearly report: 1999-2000 Marban E, Bolli R, Breitwieser G, Busse R, Dietz H, Endoh M, Finkel T, Kass D, Lowenstein C, Rabinovitch M, Tomaselli G. Circ Res. 2000; 87 (4): 261-3
Gene transfer of the serine elastase inhibitor elafin protects against vein graft degeneration. O'Blenes SB, Zaidi SH, Cheah AY, McIntyre B, Kaneda Y, Rabinovitch M. Circulation. 2000; 102 (19 Suppl 3): III289-95
Pathobiology of pulmonary hypertension: Impact on clinical management. Rabinovitch M, Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu. 2000; 3 63-81
Under new management: A six-month progress report on Circulation Research. Marbán E, Bolli R, Breitwieser G, Busse R, Dietz H, Endoh M, Finkel T, Kass D, Lowenstein C, Rabinovitch M, Tomaselli G. Circ Res. 2000; 86 (2): 111-3
Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor. Cowan KN, Heilbut A, Humpl T, Lam C, Ito S, Rabinovitch M. Nat Med. 2000; 6 (6): 698-702
Suppressed smooth muscle proliferation and inflammatory cell invasion after arterial injury in elafin-overexpressing mice. Zaidi SH, You XM, Ciura S, O'Blenes S, Husain M, Rabinovitch M. J Clin Invest. 2000; 105 (12): 1687-95
Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease. Cowan KN, Jones PL, Rabinovitch M. J Clin Invest. 2000; 105 (1): 21-34
Adventitial fibroblasts: defining a role in vessel wall remodeling. Strauss BH, Rabinovitch M. Am J Respir Cell Mol Biol. 2000; 22 (1): 1-3
Nitric oxide reduces vascular smooth muscle cell elastase activity through cGMP-mediated suppression of ERK phosphorylation and AML1B nuclear partitioning. Mitani Y, Zaidi SH, Dufourcq P, Thompson K, Rabinovitch M. FASEB J. 2000; 14 (5): 805-14
Induction of vascular smooth muscle cell tenascin-C gene expression by denatured type I collagen is dependent upon a beta3 integrin-mediated mitogen-activated protein kinase pathway and a 122-base pair promoter element. Jones PL, Jones FS, Zhou B, Rabinovitch M. J Cell Sci. 1999; 112 ( Pt 4) 435-45
Targeted overexpression of elafin protects mice against cardiac dysfunction and mortality following viral myocarditis. Zaidi SH, Hui CC, Cheah AY, You XM, Husain M, Rabinovitch M. J Clin Invest. 1999; 103 (8): 1211-9
Regression of hypertrophied rat pulmonary arteries in organ culture is associated with suppression of proteolytic activity, inhibition of tenascin-C, and smooth muscle cell apoptosis. Cowan KN, Jones PL, Rabinovitch M. Circ Res. 1999; 84 (10): 1223-33
Survival of Mycobacterium avium and Mycobacterium tuberculosis in acidified vacuoles of murine macrophages. Gomes MS, Paul S, Moreira AL, Appelberg R, Rabinovitch M, Kaplan G. Infect Immun. 1999; 67 (7): 3199-206
EVE and beyond, retro and prospective insights. Rabinovitch M, Am J Physiol. 1999; 277 (1 Pt 1): L5-12
Nitric oxide mediates LC-3-dependent regulation of fibronectin in ductus arteriosus intimal cushion formation. Mason CA, Chang P, Fallery C, Rabinovitch M. FASEB J. 1999; 13 (11): 1423-34
Functional and antigenic concentrations of alpha-1-proteinase inhibitor after administration for the prevention of chronic lung disease of prematurity. Stiskal JA, Ito S, Cox DW, Shennan AT, O'Brien KK, Kelly EN, Longley TB, Rabinovitch M, Dunn MS. Biol Neonate. 1999; 76 (3): 134-43
Pulmonary hypertension: pathophysiology as a basis for clinical decision making. Rabinovitch M, J Heart Lung Transplant. 1999; 18 (11): 1041-53
Gene transfer in utero biologically engineers a patent ductus arteriosus in lambs by arresting fibronectin-dependent neointimal formation. Mason CA, Bigras JL, O'Blenes SB, Zhou B, McIntyre B, Nakamura N, Kaneda Y, Rabinovitch M. Nat Med. 1999; 5 (2): 176-82
Mechanisms of proliferative and obliterative vascular diseases. Insights from the pulmonary and systemic circulations. NHLBI Workshop summary. Fishman AP, Fishman MC, Freeman BA, Gimbrone MA, Rabinovitch M, Robinson D, Gail DB. Am J Respir Crit Care Med. 1998; 158 (2): 670-4
AML1-like transcription factor induces serine elastase activity in ovine pulmonary artery smooth muscle cells. Wigle DA, Thompson KE, Yablonsky S, Zaidi SH, Coulber C, Jones PL, Rabinovitch M. Circ Res. 1998; 83 (3): 252-63
Microtubule involvement in translational regulation of fibronectin expression by light chain 3 of microtubule-associated protein 1 in vascular smooth muscle cells. Zhou B, Rabinovitch M. Circ Res. 1998; 83 (5): 481-9
Elastase and the pathobiology of unexplained pulmonary hypertension. Rabinovitch M, Chest. 1998; 114 (3 Suppl): 213S-224S
A serine elastase inhibitor reduces inflammation and fibrosis and preserves cardiac function after experimentally-induced murine myocarditis. Lee JK, Zaidi SH, Liu P, Dawood F, Cheah AY, Wen WH, Saiki Y, Rabinovitch M. Nat Med. 1998; 4 (12): 1383-91
Tissue-specific and developmental regulation of transforming growth factor-beta1 expression in fetal lamb ductus arteriosus endothelial cells. Zhou B, Coulber C, Rabinovitch M. Pediatr Res. 1998; 44 (6): 865-72
Endothelial and serum factors which include apolipoprotein A1 tether elastin to smooth muscle cells inducing serine elastase activity via tyrosine kinase-mediated transcription and translation. Thompson K, Kobayashi J, Childs T, Wigle D, Rabinovitch M. J Cell Physiol. 1998; 174 (1): 78-89
Microtubule-associated protein 1 light chain 3 is a fibronectin mRNA-binding protein linked to mRNA translation in lamb vascular smooth muscle cells. Zhou B, Boudreau N, Coulber C, Hammarback J, Rabinovitch M. J Clin Invest. 1997; 100 (12): 3070-82
Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alpha v beta 3 integrin to promote epidermal growth factor receptor phosphorylation and growth. Jones PL, Crack J, Rabinovitch M. J Cell Biol. 1997; 139 (1): 279-93
New insights and therapeutic strategies for postcardiac transplantation coronary artery disease. Rabinovitch M, Transplant Proc. 1997; 29 (6): 2585-6
Pulmonary hypertension: updating a mysterious disease. Rabinovitch M, Cardiovasc Res. 1997; 34 (2): 268-72
The committed vascular smooth muscle cell: a question of "timing" or "response to pressure" or both. Rabinovitch M, Am J Respir Cell Mol Biol. 1997; 16 (4): 364-5
Tenascin-C, proliferation and subendothelial fibronectin in progressive pulmonary vascular disease. Jones PL, Cowan KN, Rabinovitch M. Am J Pathol. 1997; 150 (4): 1349-60
Carbon monoxide formation in the ductus arteriosus in the lamb: implications for the regulation of muscle tone. Coceani F, Kelsey L, Seidlitz E, Marks GS, McLaughlin BE, Vreman HJ, Stevenson DK, Rabinovitch M, Ackerley C. Br J Pharmacol. 1997; 120 (4): 599-608
Cell-extracellular matrix interactions in the ductus arteriosus and perinatal pulmonary circulation. Rabinovitch M, Semin Perinatol. 1996; 20 (6): 531-41
It all begins with EVE (endogenous vascular elastase). Rabinovitch M, Isr J Med Sci. 1996; 32 (10): 803-8; discussion 809-10
Tenascin-C is induced with progressive pulmonary vascular disease in rats and is functionally related to increased smooth muscle cell proliferation. Jones PL, Rabinovitch M. Circ Res. 1996; 79 (6): 1131-42
Gerbode's defect associated with acute sinus node dysfunction as a complication of infective endocarditis. Michel C, Rabinovitch MA, Huynh T. Heart. 1996; 76 (4): 379
Exogenous leukocyte and endogenous elastases can mediate mitogenic activity in pulmonary artery smooth muscle cells by release of extracellular-matrix bound basic fibroblast growth factor. Thompson K, Rabinovitch M. J Cell Physiol. 1996; 166 (3): 495-505
Fusion of Leishmania amazonensis parasitophorous vacuoles with phagosomes containing zymosan particles: cinemicrographic and ultrastructural observations. Veras PS, Topilko A, Gouhier N, Moreau MF, Rabinovitch M, Pouchelet M. Braz J Med Biol Res. 1996; 29 (8): 1009-18
Elafin, a serine elastase inhibitor, attenuates post-cardiac transplant coronary arteriopathy and reduces myocardial necrosis in rabbits afer heterotopic cardiac transplantation. Cowan B, Baron O, Crack J, Coulber C, Wilson GJ, Rabinovitch M. J Clin Invest. 1996; 97 (11): 2452-68
Functional interplay between interleukin-1 receptor and elastin binding protein regulates fibronectin production in coronary artery smooth muscle cells. Hinek A, Molossi S, Rabinovitch M. Exp Cell Res. 1996; 225 (1): 122-31
Cohabitation of Leishmania amazonensis and Coxiella burnetii. Rabinovitch M, Veras PS. Trends Microbiol. 1996; 4 (4): 158-61
Cytokine-mediated fibronectin production and transendothelial migration of lymphocytes in the mechanism of cardiac allograft vascular disease: efficacy of novel therapeutic approaches. Rabinovitch M, Molossi S, Clausell N. J Heart Lung Transplant. 1995 Nov-Dec; 14 (6 Pt 2): S116-23
Increased elastin-degrading activity and neointimal formation in porcine aortic organ culture. Reduction of both features with a serine proteinase inhibitor. Oho S, Daley SJ, Koo EW, Childs T, Gotlieb AI, Rabinovitch M. Arterioscler Thromb Vasc Biol. 1995; 15 (12): 2200-6
Elastase and cell matrix interactions in the pathobiology of vascular disease. Rabinovitch M, Acta Paediatr Jpn. 1995; 37 (6): 657-66
Increased respiratory system resistance and bronchial smooth muscle hypertrophy in children with acute postoperative pulmonary hypertension. Schindler MB, Bohn DJ, Bryan AC, Cutz E, Rabinovitch M. Am J Respir Crit Care Med. 1995; 152 (4 Pt 1): 1347-52
VLA-4 and lymphocyte trafficking in immune-inflammatory states: novel therapeutic approaches in allograft arteriopathy. Molossi S, Rabinovitch M. Springer Semin Immunopathol. 1995; 16 (4): 443-65
Reciprocal induction of tumor necrosis factor-alpha and interleukin-1 beta activity mediates fibronectin synthesis in coronary artery smooth muscle cells. Molossi S, Clausell N, Rabinovitch M. J Cell Physiol. 1995; 163 (1): 19-29
Blockade of very late antigen-4 integrin binding to fibronectin with connecting segment-1 peptide reduces accelerated coronary arteriopathy in rabbit cardiac allografts. Molossi S, Elices M, Arrhenius T, Diaz R, Coulber C, Rabinovitch M. J Clin Invest. 1995; 95 (6): 2601-10
ICAM-1 and VCAM-1 expression in accelerated cardiac allograft arteriopathy and myocardial rejection are influenced differently by cyclosporine A and tumour necrosis factor-alpha blockade. Molossi S, Clausell N, Sett S, Rabinovitch M. J Pathol. 1995; 176 (2): 175-82
Expression of tumour necrosis factor alpha and accumulation of fibronectin in coronary artery restenotic lesions retrieved by atherectomy. Clausell N, de Lima VC, Molossi S, Liu P, Turley E, Gotlieb AI, Adelman AG, Rabinovitch M. Br Heart J. 1995; 73 (6): 534-9
Abnormalities in intramyocardial arteries detected in cardiac transplant biopsy specimens and lack of correlation with abnormal intracoronary ultrasound or endothelial dysfunction in large epicardial coronary arteries. Clausell N, Butany J, Molossi S, Lonn E, Gladstone P, Rabinovitch M, Daly PA. J Am Coll Cardiol. 1995; 26 (1): 110-9
Lymphocyte transendothelial migration toward smooth muscle cells in interleukin-1 beta-stimulated co-cultures is related to fibronectin interactions with alpha 4 beta 1 and alpha 5 beta 1 integrins. Molossi S, Elices M, Arrhenius T, Rabinovitch M. J Cell Physiol. 1995; 164 (3): 620-33
Experience with repair of congenital heart defects using adjunctive endovascular devices. Coles JG, Yemets I, Najm HK, Lukanich JM, Perron J, Wilson GJ, Rabinovitch M, Nykanen DG, Benson LN, Rebeyka IM. J Thorac Cardiovasc Surg. 1995; 110 (5): 1513-9; discussion 1519-20
In vivo blockade of tumor necrosis factor-alpha in cholesterol-fed rabbits after cardiac transplant inhibits acute coronary artery neointimal formation. Clausell N, Molossi S, Sett S, Rabinovitch M. Circulation. 1994; 89 (6): 2768-79
Serum-induced vascular smooth muscle cell elastolytic activity through tyrosine kinase intracellular signalling. Kobayashi J, Wigle D, Childs T, Zhu L, Keeley FW, Rabinovitch M. J Cell Physiol. 1994; 160 (1): 121-31
Post-cardiac transplant arteriopathy in piglets is associated with fragmentation of elastin and increased activity of a serine elastase. Oho S, Rabinovitch M. Am J Pathol. 1994; 145 (1): 202-10
67-kD elastin-binding protein is a protective "companion" of extracellular insoluble elastin and intracellular tropoelastin. Hinek A, Rabinovitch M. J Cell Biol. 1994; 126 (2): 563-74
Gas bubble emboli detected by transcranial Doppler sonography in patients with prosthetic heart valves: a preliminary report. Dauzat M, Deklunder G, Aldis A, Rabinovitch M, Burte F, Bret PM. J Ultrasound Med. 1994; 13 (2): 129-35
Alpha 1-antitrypsin protects neonatal rats from pulmonary vascular and parenchymal effects of oxygen toxicity. Koppel R, Han RN, Cox D, Tanswell AK, Rabinovitch M. Pediatr Res. 1994; 36 (6): 763-70
Cytochrome P450 during ontogenic development: occurrence in the ductus arteriosus and other tissues. Coceani F, Kelsey L, Ackerley C, Rabinovitch M, Gelboin H. Can J Physiol Pharmacol. 1994; 72 (3): 217-26
Pulmonary hypertension and vascular remodeling in fetal sheep. Belik J, Keeley FW, Baldwin F, Rabinovitch M. Am J Physiol. 1994; 266 (6 Pt 2): H2303-9
The endogenous vascular elastase that governs development and progression of monocrotaline-induced pulmonary hypertension in rats is a novel enzyme related to the serine proteinase adipsin. Zhu L, Wigle D, Hinek A, Kobayashi J, Ye C, Zuker M, Dodo H, Keeley FW, Rabinovitch M. J Clin Invest. 1994; 94 (3): 1163-71
Hyperplasia of pulmonary arterial media in infantile familial pulmonary hypertension associated with severe metabolic acidosis. Cullinane C, Clarke JT, Rabinovitch M, Bohn D, Silver MM. Mod Pathol. 1993; 6 (6): 699-706
Relative efficiency of incorporation of newly synthesized elastin and collagen into aorta, pulmonary artery and pulmonary vein of growing pigs. Johnson DJ, LaBourene J, Rabinovitch M, Keeley FW. Connect Tissue Res. 1993; 29 (3): 213-21
The ductus arteriosus migratory smooth muscle cell phenotype processes tropoelastin to a 52-kDa product associated with impaired assembly of elastic laminae. Hinek A, Rabinovitch M. J Biol Chem. 1993; 268 (2): 1405-13
Coronary arteriopathy postcardiac transplant in a heterotopic piglet model: the role of matrix-cytokine interaction. Clausell N, Coles J, Rabinovitch M. Transplant Proc. 1993; 25 (1 Pt 2): 859-60
A developmentally regulated program restricting insolubilization of elastin and formation of laminae in the fetal lamb ductus arteriosus. Zhu L, Dagher E, Johnson DJ, Bedell-Hogan D, Keeley FW, Kagan HM, Rabinovitch M. Lab Invest. 1993; 68 (3): 321-31
The 67-kD elastin/laminin-binding protein is related to an enzymatically inactive, alternatively spliced form of beta-galactosidase. Hinek A, Rabinovitch M, Keeley F, Okamura-Oho Y, Callahan J. J Clin Invest. 1993; 91 (3): 1198-205
Regulation of fetal lamb ductus arteriosus smooth muscle cell migration by indomethacin and dexamethasone. Koppel R, Rabinovitch M. Pediatr Res. 1993; 33 (4 Pt 1): 352-8
Increased interleukin-1 beta and fibronectin expression are early features of the development of the postcardiac transplant coronary arteriopathy in piglets. Clausell N, Molossi S, Rabinovitch M. Am J Pathol. 1993; 142 (6): 1772-86
Scimitar syndrome in infancy. Gao YA, Burrows PE, Benson LN, Rabinovitch M, Freedom RM. J Am Coll Cardiol. 1993; 22 (3): 873-82
Upregulation of fibronectin synthesis by interleukin-1 beta in coronary artery smooth muscle cells is associated with the development of the post-cardiac transplant arteriopathy in piglets. Clausell N, Rabinovitch M. J Clin Invest. 1993; 92 (4): 1850-8
Coronary artery endothelial interleukin-1 beta mediates enhanced fibronectin production related to post-cardiac transplant arteriopathy in piglets. Molossi S, Clausell N, Rabinovitch M. Circulation. 1993; 88 (5 Pt 2): II248-56
Pulmonary vascular obstructive disease. Collins-Nakai RL, Rabinovitch M. Cardiol Clin. 1993; 11 (4): 675-87
Profile of paediatric patients with pulmonary hypertension judged by responsiveness to vasodilators. Houde C, Bohn DJ, Freedom RM, Rabinovitch M. Br Heart J. 1993; 70 (5): 461-8
Autoimmune disease and unexplained pulmonary hypertension. Rabinovitch M, Circulation. 1992; 85 (1): 380-1
Vascular smooth muscle cell detachment from elastin and migration through elastic laminae is promoted by chondroitin sulfate-induced "shedding" of the 67-kDa cell surface elastin binding protein. Hinek A, Boyle J, Rabinovitch M. Exp Cell Res. 1992; 203 (2): 344-53
Transforming growth factor-beta regulates increased ductus arteriosus endothelial glycosaminoglycan synthesis and a post-transcriptional mechanism controls increased smooth muscle fibronectin, features associated with intimal proliferation. Boudreau N, Clausell N, Boyle J, Rabinovitch M. Lab Invest. 1992; 67 (3): 350-9
Increased pulmonary artery elastolytic activity in adult rats with monocrotaline-induced progressive hypertensive pulmonary vascular disease compared with infant rats with nonprogressive disease. Todorovich-Hunter L, Dodo H, Ye C, McCready L, Keeley FW, Rabinovitch M. Am Rev Respir Dis. 1992; 146 (1): 213-23
Factors influencing the idiopathic development of pulmonary hypertension in the fawn hooded rat. Sato K, Webb S, Tucker A, Rabinovitch M, O'Brien RF, McMurtry IF, Stelzner TJ. Am Rev Respir Dis. 1992; 145 (4 Pt 1): 793-7
Association of pulmonary hypertension with congenital portal hypertension in a child. Silver MM, Bohn D, Shawn DH, Shuckett B, Eich G, Rabinovitch M. J Pediatr. 1992; 120 (2 Pt 1): 321-9
Abnormalities in von Willebrand factor and antithrombin III after cardiopulmonary bypass operations for congenital heart disease. Turner-Gomes SO, Andrew M, Coles J, Trusler GA, Williams WG, Rabinovitch M. J Thorac Cardiovasc Surg. 1992; 103 (1): 87-97
New developments in the pulmonary circulation in children. Ye C, Rabinovitch M. Curr Opin Cardiol. 1992; 7 (1): 124-33
Investigational approaches to pulmonary hypertension. Rabinovitch M, Toxicol Pathol. 1991; 19 (4 Pt 1): 458-69
Chronic hypoxic pulmonary hypertension in rats and increased elastolytic activity. Maruyama K, Ye CL, Woo M, Venkatacharya H, Lines LD, Silver MM, Rabinovitch M. Am J Physiol. 1991; 261 (6 Pt 2): H1716-26
Impaired elastin fiber assembly related to reduced 67-kD elastin-binding protein in fetal lamb ductus arteriosus and in cultured aortic smooth muscle cells treated with chondroitin sulfate. Hinek A, Mecham RP, Keeley F, Rabinovitch M. J Clin Invest. 1991; 88 (6): 2083-94
Leishmania amazonensis: specific labeling of amastigote cysteine proteinases by radioiodinated N-benzyloxycarbonyl-tyrosyl-alanyl diazomethane. Alfieri SC, Pral EM, Shaw E, Ramazeilles C, Rabinovitch M. Exp Parasitol. 1991; 73 (4): 424-32
Fibronectin, hyaluronan, and a hyaluronan binding protein contribute to increased ductus arteriosus smooth muscle cell migration. Boudreau N, Turley E, Rabinovitch M. Dev Biol. 1991; 143 (2): 235-47
Developmentally regulated changes in extracellular matrix in endothelial and smooth muscle cells in the ductus arteriosus may be related to intimal proliferation. Boudreau N, Rabinovitch M. Lab Invest. 1991; 64 (2): 187-99
Effect of ambient oxygen changes on platelet activating factor production by fetal ovine endothelial cells. Turner-Gomes SO, Boudreau N, Rabinovitch M. Prostaglandins. 1991; 41 (5): 463-72
Inhibition of elastolysis by SC-37698 reduces development and progression of monocrotaline pulmonary hypertension. Ye CL, Rabinovitch M. Am J Physiol. 1991; 261 (4 Pt 2): H1255-67
Effective endothelialization of polyurethane surfaces. Response to shear stress and platelet adhesion. Zhu L, Williams WG, Bellhouse B, Pugh S, Rabinovitch M. ASAIO Trans. 1990 Oct-Dec; 36 (4): 811-6
Alterations in elastin and collagen related to the mechanism of progressive pulmonary venous obstruction in a piglet model. A hemodynamic, ultrastructural, and biochemical study. LaBourene JI, Coles JG, Johnson DJ, Mehra A, Keeley FW, Rabinovitch M. Circ Res. 1990; 66 (2): 438-56
William Glenn lecture. The cavopulmonary shunt. Evolution of a concept. Trusler GA, Williams WG, Cohen AJ, Rabinovitch M, Moes CA, Smallhorn JF, Coles JG, Lightfoot NE, Freedom RM. Circulation. 1990; 82 (5 Suppl): IV131-8
Pathophysiology of dynamic cardiomyoplasty: a clinico-pathological case study. Odim JN, Burgess JH, Williams BH, Blundell PE, Rabinovitch MA, Stewart JA, Lough JO, Chiu RC. J Card Surg. 1990; 5 (4): 336-46
Prediction of the left ventricular ejection fraction response to doxorubicin using a multiple linear regression model. Rabinovitch M, Suissa S, Stern J, Adam J, Mettauer B, Boileau G, Elstein J, Rouleau J. Can J Cardiol. 1989 Nov-Dec; 5 (8): 382-8
Structure and function of the pulmonary vascular bed: an update. Rabinovitch M, Cardiol Clin. 1989; 7 (4): 895-914
Oxygen-related prostaglandin synthesis in ductus arteriosus and other vascular cells. Rabinovitch M, Boudreau N, Vella G, Coceani F, Olley PM. Pediatr Res. 1989; 26 (4): 330-5
New developments in the pathogenesis of pulmonary hypertension in the newborn and child. Rabinovitch M, Acta Paediatr Jpn. 1989; 31 (6): 631-40
Structure and function of the pulmonary vascular bed: an update. Rabinovitch M, Cardiol Clin. 1989; 7 (2): 227-38
SC-39026, a serine elastase inhibitor, prevents muscularization of peripheral arteries, suggesting a mechanism of monocrotaline-induced pulmonary hypertension in rats. Ilkiw R, Todorovich-Hunter L, Maruyama K, Shin J, Rabinovitch M. Circ Res. 1989; 64 (4): 814-25
Platelet-endothelial factors. Rabinovitch M, Turner-Gomes SO. Adv Pediatr. 1989; 36 91-115
Proteinase inhibitors protect Leishmania amazonensis amastigotes from destruction by amino acid esters. Alfieri SC, Ramazeilles C, Zilberfarb V, Galpin I, Norman SE, Rabinovitch M. Mol Biochem Parasitol. 1988; 29 (2-3): 191-201
Qualitative and quantitative differences in protein synthesis comparing fetal lamb ductus arteriosus endothelium and smooth muscle with cells from adjacent vascular sites. Rabinovitch M, Beharry S, Bothwell T, Jackowski G. Dev Biol. 1988; 130 (1): 250-8
Intralipid effect on normal and hypoxic remodeled rat pulmonary vasculature. Ilkiw R, Maruyama K, Rabinovitch M. Am J Physiol. 1988; 255 (6 Pt 2): H1499-508
Endothelial injury and vascular reactivity in monocrotaline pulmonary hypertension. Rosenberg HC, Rabinovitch M. Am J Physiol. 1988; 255 (6 Pt 2): H1484-91
Repair of tricuspid atresia: utility of right ventricular incorporation. Coles JG, Leung M, Kielmanowicz S, Freedom RM, Benson LN, Rabinovitch M, Sherret H, Dasmahapatra H, Trusler GA, McLaughlin PR. Ann Thorac Surg. 1988; 45 (4): 384-9
Altered elastin and collagen synthesis associated with progressive pulmonary hypertension induced by monocrotaline. A biochemical and ultrastructural study. Todorovich-Hunter L, Johnson DJ, Ranger P, Keeley FW, Rabinovitch M. Lab Invest. 1988; 58 (2): 184-95
High-pressure pulsation of central and microvessel pulmonary artery endothelial cells. Rabinovitch M, Bothwell T, Mullen M, Hayakawa BN. Am J Physiol. 1988; 254 (2 Pt 1): C338-43
Problems of pulmonary hypertension in children with congenital cardiac defects. Rabinovitch M, Chest. 1988; 93 (3 Suppl): 119S-126S
Angiotensin II prevents hypoxic pulmonary hypertension and vascular changes in rat. Rabinovitch M, Mullen M, Rosenberg HC, Maruyama K, O'Brodovich H, Olley PM. Am J Physiol. 1988; 254 (3 Pt 2): H500-8
Metaiodobenzylguanidine [131I] scintigraphy detects impaired myocardial sympathetic neuronal transport function of canine mechanical-overload heart failure. Rabinovitch MA, Rose CP, Rouleau JL, Chartrand C, Wieland DM, Lepanto L, Legault F, Suissa S, Rosenthall L, Burgess JH. Circ Res. 1987; 61 (6): 797-804
Abnormal endothelial factor VIII associated with pulmonary hypertension and congenital heart defects. Rabinovitch M, Andrew M, Thom H, Trusler GA, Williams WG, Rowe RD, Olley PM. Circulation. 1987; 76 (5): 1043-52
Surgical experience with the modified Fontan procedure. Coles JG, Kielmanowicz S, Freedom RM, Benson LN, Moes F, Olley PM, Rabinovitch M, Rosenberg H, Sherret H, Rowe RD. Circulation. 1987; 76 (3 Pt 2): III61-6
Ventilatory predictors of pulmonary hypoplasia in congenital diaphragmatic hernia, confirmed by morphologic assessment. Bohn D, Tamura M, Perrin D, Barker G, Rabinovitch M. J Pediatr. 1987; 111 (3): 423-31
Prostaglandins and structural changes in pulmonary arteries. Rabinovitch M, Am Rev Respir Dis. 1987; 136 (3): 777-9
Structural composition of central pulmonary arteries. Growth potential after surgical shunts. Rosenberg HG, Williams WG, Trusler GA, Higa T, Rabinovitch M. J Thorac Cardiovasc Surg. 1987; 94 (4): 498-503
A pulmonary artery endothelial factor causes unidirectional alignment of smooth muscle cells. Wilson W, Bothwell T, Rabinovitch M. Tissue Cell. 1987; 19 (2): 177-82
Pulmonary hypertension in children: perioperative management. Burrows FA, Klinck JR, Rabinovitch M, Bohn DJ. Can Anaesth Soc J. 1986; 33 (5): 606-28
Sex-specific criteria for interpretation of thallium-201 myocardial uptake and washout studies. Rabinovitch M, Suissa S, Elstein J, Staniloff H, Tang A, Rush C, Aldis A, Tannous R, Turek M, Addas A. J Nucl Med. 1986; 27 (12): 1837-41
Pulmonary artery endothelial abnormalities in patients with congenital heart defects and pulmonary hypertension. A correlation of light with scanning electron microscopy and transmission electron microscopy. Rabinovitch M, Bothwell T, Hayakawa BN, Williams WG, Trusler GA, Rowe RD, Olley PM, Cutz E. Lab Invest. 1986; 55 (6): 632-53
Pulmonary arterial changes in patients with ventricular septal defects and severe pulmonary hypertension. Fried R, Falkovsky G, Newburger J, Gorchakova AI, Rabinovitch M, Gordonova MI, Fyler D, Reid L, Burakovsky V. Pediatr Cardiol. 1986; 7 (3): 147-54
Variations on calculating left-ventricular volume with the radionuclide count-based method. Koral KF, Rabinovitch MA, Kalff V, Chan W, Juni JE, Lerman B, Lampman R, Walton J, Vogel R, Pitt B. Med Phys. 1985 Jan-Feb; 12 (1): 93-8
Morphology of the developing pulmonary bed: pharmacologic implications. Rabinovitch M, Pediatr Pharmacol (New York). 1985; 5 (1): 31-48
The pulmonary circulation in children with congenital heart disease: morphologic and morphometric considerations. Burrows FA, Rabinovitch M. Can Anaesth Soc J. 1985; 32 (4): 364-73
Abnormal distribution of pulmonary blood flow after the Glenn shunt or Fontan procedure: risk of development of arteriovenous fistulae. Cloutier A, Ash JM, Smallhorn JF, Williams WG, Trusler GA, Rowe RD, Rabinovitch M. Circulation. 1985; 72 (3): 471-9
Hyperoxia-induced pulmonary vascular and lung abnormalities in young rats and potential for recovery. Wilson WL, Mullen M, Olley PM, Rabinovitch M. Pediatr Res. 1985; 19 (10): 1059-67
Pulmonary toxicity of monocrotaline differs at critical periods of lung development. Todd L, Mullen M, Olley PM, Rabinovitch M. Pediatr Res. 1985; 19 (7): 731-7
Vascular structure in lung tissue obtained at biopsy correlated with pulmonary hemodynamic findings after repair of congenital heart defects. Rabinovitch M, Keane JF, Norwood WI, Castaneda AR, Reid L. Circulation. 1984; 69 (4): 655-67
Congenital unilateral pulmonary vein stenosis complicating transposition of the great arteries. Vogel M, Ash J, Rowe RD, Trusler GA, Rabinovitch M. Am J Cardiol. 1984; 54 (1): 166-71
Measurement of left ventricular ejection fraction in pediatric patients using the nuclear stethoscope. Spicer RL, Rabinovitch M, Rosenthal A, Pitt B. Am J Cardiol. 1984; 53 (1): 211-4
The effect of dobutamine on exercise performance in patients with symptomatic ischemic heart disease. Rabinovitch MA, Kalff V, Chan W, Schork A, Gross MD, Vogel RA, Thrall JH, Pitt B. Am Heart J. 1984; 107 (1): 81-5
Bilateral ductus arteriosus (or remnant): an analysis of 27 patients. Freedom RM, Moes CA, Pelech A, Smallhorn J, Rabinovitch M, Olley PM, Williams WG, Trusler GA, Rowe RD. Am J Cardiol. 1984; 53 (7): 884-91
Computer analysis of cardiac radionuclide data. Froelich JW, Thrall JH, Kalff V, Rogers WL, Rabinovitch M. Prog Cardiovasc Dis. 1983 Jul-Aug; 26 (1): 43-74
Evaluation of cardiac function in the presence of frequent ventricular premature beats. Chan W, Kalff V, Rabinovitch MA, Clare JM, Thrall JH, Pitt B. Radiology. 1983; 146 (2): 551-2
Changes in pulmonary blood flow affect vascular response to chronic hypoxia in rats. Rabinovitch M, Konstam MA, Gamble WJ, Papanicolaou N, Aronovitz MJ, Treves S, Reid L. Circ Res. 1983; 52 (4): 432-41
Topography of preemptying ventricular segments in patients with Wolff-Parkinson-White syndrome using scintigraphic phase mapping and esophageal pacing. Chan WW, Kalff V, Dick M, Rabinovitch MA, Jenkins J, Thrall JH, Pitt B. Circulation. 1983; 67 (5): 1139-46
Aneurysm of the pulmonary artery as a cause of severe chest pain. Jaffin BW, Gundel WD, Capeless MA, Castaneda AR, Rabinovitch M, Wackers FJ. Arch Intern Med. 1983; 143 (7): 1484-5
Selective right ventricular dysfunction after coronary artery bypass grafting. Rabinovitch MA, Elstein J, Chiu RC, Rose CP, Arzoumanian A, Burgess JH. J Thorac Cardiovasc Surg. 1983; 86 (3): 444-6
Impact of radionuclide techniques on evaluation of patients with ischemic heart disease. Pitt B, Kalff V, Rabinovitch MA, Buda AJ, Colfer HT, Vogel RA, Thrall JH. J Am Coll Cardiol. 1983; 1 (1): 63-72
Polycythemia and the acute hypoxic response in awake rats following chronic hypoxia. Fried R, Meyrick B, Rabinovitch M, Reid L. J Appl Physiol. 1983; 55 (4): 1167-72
Transposition of the great arteries and ventricular septal defect: results with the Senning operation and closure of the ventricular septal defect in infants. Penkoske PA, Westerman GR, Marx GR, Rabinovitch M, Freed MD, Norwood WI, Castaneda AR. Ann Thorac Surg. 1983; 36 (3): 281-8
Baseline left-ventricular function during frequent ventricular or atrial ectopic beats: concise communication. Kalff V, Rabinovitch MA, Chan W, O'Neill W, Stewart J, Walton J, Pitt B, Thrall JH. J Nucl Med. 1982; 23 (12): 1076-9
Radionuclide angiocardiographic assessment of pulmonary vascular reactivity in patients with left to right shunt and pulmonary hypertension. Fujii AM, Rabinovitch M, Keane JF, Fyler DC, Treves S. Am J Cardiol. 1982; 49 (2): 356-61
Walk-through angina phenomenon demonstrated by graded exercise radionuclide ventriculography: possible coronary spasm mechanisms. Rizi HR, Kline RC, Besozzi MC, Kalf V, Rabinovitch M, Chan W, Thrall JH, Pitt B. Am Heart J. 1982; 103 (2): 292-5
Radionuclide evaluation of postextrasystolic potentiation of left ventricular function induced by atrial and ventricular stimulation. Kalff V, Chan W, Rabinovitch M, O'Neill W, Walton J, Stewart J, Thrall JH, Pitt B. Am J Cardiol. 1982; 50 (1): 106-11
Scintigraphic demonstration of ventriculo atrial conduction in the ventricular pacemaker syndrome. Rabinovitch MA, Stewart J, Chan W, Dunlap TE, Kalff V, Clare J, Thrall JH, Pitt B. J Nucl Med. 1982; 23 (9): 795-8
Compression of intrapulmonary bronchi by abnormally branching pulmonary arteries associated with absent pulmonary valves. Rabinovitch M, Grady S, David I, Van Praagh R, Sauer U, Buhlmeyer K, Castaneda AR, Reid L. Am J Cardiol. 1982; 50 (4): 804-13
Growth and development of the pulmonary vascular bed in patients with tetralogy of Fallot with or without pulmonary atresia. Rabinovitch M, Herrera-deLeon V, Castaneda AR, Reid L. Circulation. 1981; 64 (6): 1234-49
A case of spontaneous resolution of idiopathic pulmonary hypertension. Fujii A, Rabinovitch M, Matthews EC. Br Heart J. 1981; 46 (5): 574-7
The structural basis of persistent pulmonary hypertension of the newborn infant. Murphy JD, Rabinovitch M, Goldstein JD, Reid LM. J Pediatr. 1981; 98 (6): 962-7
Age and sex influence on pulmonary hypertension of chronic hypoxia and on recovery. Rabinovitch M, Gamble WJ, Miettinen OS, Reid L. Am J Physiol. 1981; 240 (1): H62-72
Quantitative structural analysis of the pulmonary vascular bed in congenital heart defects. Rabinovitch M, Reid LM. Cardiovasc Clin. 1981; 11 (2): 149-69
Lung biopsy with frozen section as a diagnostic aid in patients with congenital heart defects. Rabinovitch M, Castaneda AR, Reid L. Am J Cardiol. 1981; 47 (1): 77-84
Quantitative analysis of the pulmonary wedge angiogram in congenital heart defects. Correlation with hemodynamic data and morphometric findings in lung biopsy tissue. Rabinovitch M, Keane JF, Fellows KE, Castaneda AR, Reid L. Circulation. 1981; 63 (1): 152-64
Quantitative thallium-201 myocardial imaging in assessing right ventricular pressure in patients with congenital heart defects. Rabinovitch M, Fischer KC, Treves S. Br Heart J. 1981; 45 (2): 198-205
Early pulmonary vascular changes in congenital heart disease studied in biopsy tissue. Rabinovitch M, Haworth SG, Vance Z, Vawter G, Castaneda AR, Nadas AS, Reid LM. Hum Pathol. 1980; 11 (5 Suppl): 499-509
Rat pulmonary circulation after chronic hypoxia: hemodynamic and structural features. Rabinovitch M, Gamble W, Nadas AS, Miettinen OS, Reid L. Am J Physiol. 1979; 236 (6): H818-27
Unusual vascular anomalies causing persistent pulmonary hypertension in a newborn. Goldstein JD, Rabinovitch M, Van Praagh R, Reid L. Am J Cardiol. 1979; 43 (5): 962-8
Thallium 201 scintigraphy in patients with anomalous origin of the left coronary artery from the main pulmonary artery. Rabinovitch M, Rowland TW, Castaneda AR, Treves S. J Pediatr. 1979; 94 (2): 244-7
Thallium-201: quantitation of right ventricular hypertrophy in chronically hypoxic rats. Rabinovitch M, Fisher K, Gamble W, Reid L, Treves S. Radiology. 1979; 130 (1): 223-5
Lung biopsy in congenital heart disease: a morphometric approach to pulmonary vascular disease. Rabinovitch M, Haworth SG, Castaneda AR, Nadas AS, Reid LM. Circulation. 1978; 58 (6): 1107-22
Regional lung function studies and radionuclide angiography in D-transposition of the great arteries. Rabinovitch M, Rosenthal A, Sade RM, Castaneda AR, Treves S, Nadas AS. Pediatr Res. 1977; 11 (10 Pt 2): 1117-21
Intracardiac electrography in endocardial cushion defects. Jacobsen JR, Gillette PC, Corbett BN, Rabinovitch M, McNamara DG. Circulation. 1976; 54 (4): 599-603