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Key Documents

David A. Spain, MD

Professor - Med Center Line, Surgery - General Surgery

Contact Information

Clinical Offices

Surgical Specialities Clinic 300 Pasteur Dr A160 MC 5313 Stanford, CA 94305
Telephone Work (650) 736-7102 Fax (650) 723-8378
Academic Offices

Personal Information
Tel (650) 736-7102

Administrative Contact
Clinic Referrals Tel Work 650-736-7102

Not for medical emergencies or patient use

Clinical Focus

General Surgery
Critical Care Medicine
Trauma Surgery

Administrative Appointments

Program Director, Surgical Critical Care , (2005– present )
Chief of Trauma and Critical Care Surgery, Stanford University , (2001– present )

Honors and Awards

Collins Teaching Award, General Surgery Residency Progran (2004-2005)
Teaching Award, Stanford/Kaiser Emergency Medicine Residency (2003-04 and 2007-08)

Professional Education

Board Certification: General Surgery, American Board of Surgery (1993)
Board Certification: Surgical Critical Care, American Board of Surgery (1996)
University of Louisville Hospital (1994) KY
Robert Wood Johnson University Hospital (1992) NJ
Wayne State University (1986) MI
MD, Wayne State University Medicine (1986)
BS/Honors, Michigan State University Biochemistry (1982)

Graduate & Fellowship Program Affiliations

Surgery

Research Interests

Our main areas of interest have been shock, sepsis and mutiple organ failure. We are also interested in the introduction, application and evaluation of new technology in teh care of critically ill and injured patients

Publications

Demographic and Financial Analysis of EMTALA Hand Patient Transfers. Melkun ET, Ford C, Brundage SI, Spain DA, Chang J. Hand (N Y). 2009;
Commitment to COT verification improves patient outcomes and financial performance. Maggio PM, Brundage SI, Hernandez-Boussard T, Spain DA. J Trauma. 2009; 67 (1): 190-4; discussion 194-5
The impact of hypopituitarism on function and performance in subjects with recent history of traumatic brain injury and aneurysmal subarachnoid haemorrhage. Srinivasan L, Roberts B, Bushnik T, Englander J, Spain DA, Steinberg GK, Ren L, Sandel ME, Al-Lawati Z, Teraoka J, Hoffman AR, Katznelson L. Brain Inj. 2009; 23 (7): 639-48
Massive transfusion protocols: the role of aggressive resuscitation versus product ratio in mortality reduction. Riskin DJ, Tsai TC, Riskin L, Hernandez-Boussard T, Purtill M, Maggio PM, Spain DA, Brundage SI. J Am Coll Surg. 2009; 209 (2): 198-205
Validation of a prehospital trauma triage tool: a 10-year perspective. Purtill MA, Benedict K, Hernandez-Boussard T, Brundage SI, Kritayakirana K, Sherck JP, Garland A, Spain DA. J Trauma. 2008; 65 (6): 1253-7
Insulin increases the release of proinflammatory mediators. Brundage SI, Kirilcuk NN, Lam JC, Spain DA, Zautke NA. J Trauma. 2008; 65 (2): 367-72
CT angiography effectively evaluates extremity vascular trauma. Peng PD, Spain DA, Tataria M, Hellinger JC, Rubin GD, Brundage SI. Am Surg. 2008; 74 (2): 103-7
Requests for 692 transfers to an academic level I trauma center: implications of the emergency medical treatment and active labor act. Spain DA, Bellino M, Kopelman A, Chang J, Park J, Gregg DL, Brundage SI. J Trauma. 2007; 62 (1): 63-7; discussion 67-8
Venous air embolism and pressure infusion devices. Mendenhall ML, Spain DA. J Trauma. 2007; 63 (1): 246
Recruitment strategies for a fall prevention program: if we build it, will they really come? Shandro JR, Spain DA, Dicker RA. J Trauma. 2007; 63 (1): 142-6
Pediatric blunt abdominal injury: age is irrelevant and delayed operation is not detrimental. Tataria M, Nance ML, Holmes JH, Miller CC, Mattix KD, Brown RL, Mooney DP, Scherer LR, Groner JI, Scaife ER, Spain DA, Brundage SI. J Trauma. 2007; 63 (3): 608-14
Dramatic shift in the primary management of traumatic thoracic aortic rupture. Lebl DR, Dicker RA, Spain DA, Brundage SI. Arch Surg. 2006; 141 (2): 177-80
Early enteral nutrition after abdominal trauma: effects on septic morbidity and practicality. Weissenfluh GM, Brundage SI, Spain DA. Nutr Clin Pract. 2006; 21 (5): 479-84
Endovascular management of a gunshot wound to the thoracic aorta. Fang TD, Peterson DA, Kirilcuk NN, Dicker RA, Spain DA, Brundage SI. J Trauma. 2006; 60 (1): 204-8
Are temporary inferior vena cava filters really temporary? Kirilcuk NN, Herget EJ, Dicker RA, Spain DA, Hellinger JC, Brundage SI. Am J Surg. 2005; 190 (6): 858-63
Education and training of the future trauma surgeon in acute care surgery: trauma, critical care, and emergency surgery. Spain DA, Miller FB. Am J Surg. 2005; 190 (2): 212-7
Potential targets to encourage a surgical career. Brundage SI, Lucci A, Miller CC, Azizzadeh A, Spain DA, Kozar RA. J Am Coll Surg. 2005; 200 (6): 946-53
Spontaneous splenic rupture: the masquerade of minor trauma. Tataria M, Dicker RA, Melcher M, Spain DA, Brundage SI. J Trauma. 2005; 59 (5): 1228-30
Impairment of endothelium-dependent dilation response after resuscitation from hemorrhagic shock involved postreceptor mechanisms. Zakaria el R, Garrison RN, Spain DA, Harris PD. Shock. 2004; 21 (2): 175-81
Perioperative risk assessment in elderly and high-risk patients. Richardson JD, Cocanour CS, Kern JA, Garrison RN, Kirton OC, Cofer JB, Spain DA, Thomason MH. J Am Coll Surg. 2004; 199 (1): 133-46
Interleukin-6 infusion blunts proinflammatory cytokine production without causing systematic toxicity in a swine model of uncontrolled hemorrhagic shock. Brundage SI, Zautke NA, Holcomb JB, Spain DA, Lam JC, Mastrangelo MA, Macaitis JM, Tweardy DJ. J Trauma. 2004; 57 (5): 970-7; discussion 977-8
Management of acute complete tracheal transection caused by nonpenetrating trauma: report of a case and review of the literature. Chow JL, Coady MA, Varner J, Cannon W, Spain D, Brock-Utne JG. J Cardiothorac Vasc Anesth. 2004; 18 (4): 475-8
Achievement of steady state optimizes results when performing indirect calorimetry. McClave SA, Spain DA, Skolnick JL, Lowen CC, Kieber MJ, Wickerham PS, Vogt JR, Looney SW. JPEN J Parenter Enteral Nutr. 2003 Jan-Feb; 27 (1): 16-20
The continuing challenge of intra-abdominal infection. Cheadle WG, Spain DA. Am J Surg. 2003; 186 (5A): 15S-22S; discussion 31S-34S
Society of University Surgeons position statement on the volume-outcome relationship for surgical procedures. Berger DH, Ko CY, Spain DA. Surgery. 2003; 134 (1): 34-40
Intraperitoneal resuscitation improves intestinal blood flow following hemorrhagic shock. Zakaria el R, Garrison RN, Spain DA, Matheson PJ, Harris PD, Richardson JD. Ann Surg. 2003; 237 (5): 704-11; discussion 711-3
Immune-enhancing enteral diet increases blood flow and proinflammatory cytokines in the rat ileum. Matheson PJ, Hurt RT, Mittel OF, Wilson MA, Spain DA, Garrison RN. J Surg Res. 2003; 110 (2): 360-70
Generalized dilation of the visceral microvasculature by peritoneal dialysis solutions. Zakaria el R, Spain DA, Harris PD, Garrison RN. Perit Dial Int. 2002 Sep-Oct; 22 (5): 593-601
When is the seriously ill patient ready to be fed? Spain DA, JPEN J Parenter Enteral Nutr. 2002 Nov-Dec; 26 (6 Suppl): S62-5; discussion S65-8
Do facial fractures protect the brain or are they a marker for severe head injury? Martin RC, Spain DA, Richardson JD. Am Surg. 2002; 68 (5): 477-81
Handsewn versus stapled anastomosis in penetrating colon injuries requiring resection: a multicenter study. Demetriades D, Murray JA, Chan LS, Ordoñez C, Bowley D, Nagy KK, Cornwell EE, Velmahos GC, Muñoz N, Hatzitheofilou C, Schwab CW, Rodriguez A, Cornejo C, Davis KA, Namias N, Wisner DH, Ivatury RR, Moore EE, Acosta JA, Maull KI, Thomason MH, Spain DA. J Trauma. 2002; 52 (1): 117-21
Femoral vessel injuries. Carrillo EH, Spain DA, Miller FB, Richardson JD. Surg Clin North Am. 2002; 82 (1): 49-65
Ventilator-associated pneumonia and surgical patients. Spain DA, Chest. 2002; 121 (5): 1390-1
Abdominal seat belt marks in the era of focused abdominal sonography for trauma. Stassen NA, Lukan JK, Carrillo EH, Spain DA, Richardson JD. Arch Surg. 2002; 137 (6): 718-22; discussion 722-3
Risk factors for delirium tremens in trauma patients. Lukan JK, Reed DN, Looney SW, Spain DA, Blondell RD. J Trauma. 2002; 53 (5): 901-6
Examination of the role of abdominal computed tomography in the evaluation of victims of trauma with increased aspartate aminotransferase in the era of focused abdominal sonography for trauma. Stassen NA, Lukan JK, Carrillo EH, Spain DA, Norfleet LA, Miller FB, Polk HC. Surgery. 2002; 132 (4): 642-6; discussion 646-7
Immune-enhancing enteral diet selectively augments ileal blood flow in the rat. Rhoden D, Matheson PJ, Carricato ND, Spain DA, Garrison RN. J Surg Res. 2002; 106 (1): 25-30
A comparison of alcohol-positive and alcohol-negative trauma patients. Blondell RD, Looney SW, Krieg CL, Spain DA. J Stud Alcohol. 2002; 63 (3): 380-3
Resuscitation regimens for hemorrhagic shock must contain blood. Zakaria el R, Spain DA, Harris PD, Garrison RN. Shock. 2002; 18 (6): 567-73
Progressive decrease in constrictor reactivity of the non-absorbing intestine during chronic sepsis. Zhao H, Spain DA, Matheson PJ, Harris PD, Garrison RN. Shock. 2001; 16 (1): 40-3
Sepsis increases NOS-2 activity and decreases non-NOS-mediated acetylcholine-induced dilation in rat aorta. Beach PK, Spain DA, Kawabe T, Harris PD, Garrison RN. J Surg Res. 2001; 96 (1): 17-22
Does cell-saver blood administration and free hemoglobin load cause renal dysfunction? Klodell CT, Richardson JD, Bergamini TM, Spain DA. Am Surg. 2001; 67 (1): 44-7
"Incidental" pericardial effusion during surgeon-performed ultrasonography in patients with blunt torso trauma. Lukan JK, Franklin GA, Spain DA, Carrillo EH. J Trauma. 2001; 50 (4): 743-5
Successful incorporation of the Severe Head Injury Guidelines into a phased-outcome clinical pathway. Mcilvoy L, Spain DA, Raque G, Vitaz T, Boaz P, Meyer K. J Neurosci Nurs. 2001; 33 (2): 72-8, 82
Delayed laparoscopy facilitates the management of biliary peritonitis in patients with complex liver injuries. Carrillo EH, Reed DN, Gordon L, Spain DA, Richardson JD. Surg Endosc. 2001; 15 (3): 319-22
Penetrating colon injuries requiring resection: diversion or primary anastomosis? An AAST prospective multicenter study. Demetriades D, Murray JA, Chan L, Ordoñez C, Bowley D, Nagy KK, Cornwell EE, Velmahos GC, Muñoz N, Hatzitheofilou C, Schwab CW, Rodriguez A, Cornejo C, Davis KA, Namias N, Wisner DH, Ivatury RR, Moore EE, Acosta JA, Maull KI, Thomason MH, Spain DA. J Trauma. 2001; 50 (5): 765-75
Development and implementation of a clinical pathway for spinal cord injuries. Vitaz TW, McIlvoy L, Raque GH, Spain DA, Shields CB. J Spinal Disord. 2001; 14 (3): 271-6
Impact of recent trends of noninvasive trauma evaluation and nonoperative management in surgical resident education. Lukan JK, Carrillo EH, Franklin GA, Spain DA, Miller FB, Richardson JD. J Trauma. 2001; 50 (6): 1015-9
A multicenter evaluation of whether gender dimorphism affects survival after trauma. Wohltmann CD, Franklin GA, Boaz PW, Luchette FA, Kearney PA, Richardson JD, Spain DA. Am J Surg. 2001; 181 (4): 297-300
Thermal injury in the elderly: when is comfort care the right choice? Stassen NA, Lukan JK, Mizuguchi NN, Spain DA, Carrillo EH, Polk HC. Am Surg. 2001; 67 (7): 704-8
Discussion Barie PS, Fabian TC, Barie D, Malangoni MA, Malangoni D, Rodriguez JL, Spain DA, Rodriguez D, Fabian D. Am J Surg. 2000; 179 (2A Suppl): 7
Practice Management Guidelines for Prophylactic Antibiotic Use in Tube Thoracostomy for Traumatic Hemopneumothorax: the EAST Practice Management Guidelines Work Group. Eastern Association for Trauma. Luchette FA, Barrie PS, Oswanski MF, Spain DA, Mullins CD, Palumbo F, Pasquale MD. J Trauma. 2000; 48 (4): 753-7
Evolution in the management of hepatic trauma: a 25-year perspective. David Richardson J, Franklin GA, Lukan JK, Carrillo EH, Spain DA, Miller FB, Wilson MA, Polk HC, Flint LM. Ann Surg. 2000; 232 (3): 324-30
Discussion Polk HC, Fabian TC, Polk D, Fabian D, Livingston DH, Rodriguez JL, Rodriguez D, Malangoni MA, Malangoni D, Spain DA, Boucher BA, Cheadle WG, Boucher D, Croce D. Am J Surg. 2000; 179 (2A Suppl): 24-5
Discussion Spain DA, Croce MA, Rodriguez JL, Croce D, Rodriguez D, Livingston DH, Spain D, Barie PS, Malangoni MA, Barie D. Am J Surg. 2000; 179 (2A Suppl): 30
Discussion Barie PS, Croce MA, Spain DA, Polk HC, Barie D, Polk D, Livingston DH, Croce D, Spain D, Rodriguez JL, Rodriguez D, Boucher BA, Boucher D. Am J Surg. 2000; 179 (2A Suppl): 39-40
Should trauma surgeons do general surgery? Spain DA, Richardson JD, Carrillo EH, Miller FB, Wilson MA, Polk HC. J Trauma. 2000; 48 (3): 433-7; discussion 437-8
Routine intragastric feeding following traumatic brain injury is safe and well tolerated. Klodell CT, Carroll M, Carrillo EH, Spain DA. Am J Surg. 2000; 179 (3): 168-71
Prehospital hypotension as a valid indicator of trauma team activation. Franklin GA, Boaz PW, Spain DA, Lukan JK, Carrillo EH, Richardson JD. J Trauma. 2000; 48 (6): 1034-7; discussion 1037-9
Lazaroid and pentoxifylline suppress sepsis-induced increases in renal vascular resistance via altered arachidonic acid metabolism. Krysztopik RJ, Matheson PJ, Spain DA, Garrison RN, Wilson MA. J Surg Res. 2000; 93 (1): 75-81
Empyema and restrictive pleural processes after blunt trauma: an under-recognized cause of respiratory failure. Watkins JA, Spain DA, Richardson JD, Polk HC. Am Surg. 2000; 66 (2): 210-4
Sustained infection induces 2 distinct microvascular mechanisms in the splanchnic circulation. Zhao H, Spain DA, Matheson PJ, Vaughn C, Harris PD, Garrison RN. Surgery. 2000; 128 (4): 513-9
Blunt hemopericardium detected by surgeon-performed sonography. Carrillo EH, Schirmer TP, Sideman MJ, Wallace JM, Spain DA. J Trauma. 2000; 48 (5): 971-4
Infusion protocol improves delivery of enteral tube feeding in the critical care unit. Spain DA, McClave SA, Sexton LK, Adams JL, Blanford BS, Sullins ME, Owens NA, Snider HL. JPEN J Parenter Enteral Nutr. 1999 Sep-Oct; 23 (5): 288-92
Common and external iliac artery injuries associated with pelvic fractures. Carrillo EH, Wohltmann CD, Spain DA, Schmieg RE, Miller FB, Richardson JD. J Orthop Trauma. 1999 Jun-Jul; 13 (5): 351-5
Decreased alpha-adrenergic response in the intestinal microcirculation after "two-hit" hemorrhage/resuscitation and bacteremia. Spain DA, Kawabe T, Keelan PC, Wilson MA, Harris PD, Garrison RN. J Surg Res. 1999; 84 (2): 180-5
Blunt carotid artery injuries: difficulties with the diagnosis prior to neurologic event. Carrillo EH, Osborne DL, Spain DA, Miller FB, Senler SO, Richardson JD. J Trauma. 1999; 46 (6): 1120-5
Enteral tube feeding in the intensive care unit: factors impeding adequate delivery. McClave SA, Sexton LK, Spain DA, Adams JL, Owens NA, Sullins MB, Blandford BS, Snider HL. Crit Care Med. 1999; 27 (7): 1252-6
Glucose and glutamine gavage increase portal vein nitric oxide metabolite levels via adenosine A2b activation. Matheson PJ, Spain DA, Harris PD, Garrison RN, Wilson MA. J Surg Res. 1999; 84 (1): 57-63
Interventional techniques are useful adjuncts in nonoperative management of hepatic injuries. Carrillo EH, Spain DA, Wohltmann CD, Schmieg RE, Boaz PW, Miller FB, Richardson JD. J Trauma. 1999; 46 (4): 619-22; discussion 622-4
Preoperative issues in clinical nutrition. McClave SA, Snider HL, Spain DA. Chest. 1999; 115 (5 Suppl): 64S-70S
Altered vasoconstrictor and dilator responses after a "two-hit" model of sequential hemorrhage and bacteremia. Price SA, Spain DA, Wilson MA, Harris PD, Garrison RN. J Surg Res. 1999; 81 (1): 59-64
Complement activation mediates intestinal injury after resuscitation from hemorrhagic shock. Spain DA, Fruchterman TM, Matheson PJ, Wilson MA, Martin AW, Garrison RN. J Trauma. 1999; 46 (2): 224-33
Subacute sepsis impairs vascular smooth muscle contractile machinery and alters vasoconstrictor and dilator mechanisms. Price SA, Spain DA, Wilson MA, Harris PD, Garrison RN. J Surg Res. 1999; 83 (1): 75-80
The continuing challenge of Fournier's gangrene in the 1990s. Olsofka JN, Carrillo EH, Spain DA, Polk HC. Am Surg. 1999; 65 (12): 1156-9
Selective microvascular endothelial cell dysfunction in the small intestine following resuscitated hemorrhagic shock. Fruchterman TM, Spain DA, Wilson MA, Harris PD, Garrison RN. Shock. 1998; 10 (6): 417-22
Small intestinal production of nitric oxide is decreased following resuscitated hemorrhage. Fruchterman TM, Spain DA, Matheson PJ, Martin AW, Wilson MA, Harris PD, Garrison RN. J Surg Res. 1998; 80 (1): 102-9
Complement inhibition prevents gut ischemia and endothelial cell dysfunction after hemorrhage/resuscitation. Fruchterman TM, Spain DA, Wilson MA, Harris PD, Garrison RN. Surgery. 1998; 124 (4): 782-91; discussion 791-2
Effect of a clinical pathway for severe traumatic brain injury on resource utilization. Spain DA, McIlvoy LH, Fix SE, Carrillo EH, Boaz PW, Harpring JE, Raque GH, Miller FB. J Trauma. 1998; 45 (1): 101-4; discussion 104-5
Impact of trauma attending surgeon case volume on outcome: is more better? Richardson JD, Schmieg R, Boaz P, Spain DA, Wohltmann C, Wilson MA, Carrillo EH, Miller FB, Fulton RL. J Trauma. 1998; 44 (2): 266-71; discussion 271-2
Comparison of sequential compression devices and foot pumps for prophylaxis of deep venous thrombosis in high-risk trauma patients. Spain DA, Bergamini TM, Hoffmann JF, Carrillo EH, Richardson JD. Am Surg. 1998; 64 (6): 522-5; discussion 525-6
Thoracoscopy in the management of posttraumatic persistent pneumothorax. Carrillo EH, Schmacht DC, Gable DR, Spain DA, Richardson JD. J Am Coll Surg. 1998; 186 (6): 636-9; discussion 639-40
Alternatives in the management of penetrating injuries to the iliac vessels. Carrillo EH, Spain DA, Wilson MA, Miller FB, Richardson JD. J Trauma. 1998; 44 (6): 1024-9; discussion 1029-30
Microvascular changes explain the "two-hit" theory of multiple organ failure. Garrison RN, Spain DA, Wilson MA, Keelen PA, Harris PD. Ann Surg. 1998; 227 (6): 851-60
Nutritional management in acute and chronic pancreatitis. McClave SA, Spain DA, Snider HL. Gastroenterol Clin North Am. 1998; 27 (2): 421-34
Intrahepatic vascular clamping in complex hepatic vein injuries. Carrillo EH, Spain DA, Miller FB, Richardson JD. J Trauma. 1997; 43 (1): 131-3
Heme oxygenase-dependent carbon monoxide production is a hepatic adaptive response to sepsis. Downard PJ, Wilson MA, Spain DA, Matheson PJ, Siow Y, Garrison RN. J Surg Res. 1997; 71 (1): 7-12
Risk-taking behaviors among adolescent trauma patients. Spain DA, Boaz PW, Davidson DJ, Miller FB, Carrillo EH, Richardson JD. J Trauma. 1997; 43 (3): 423-6
Bedside percutaneous endoscopic gastrostomy. A safe alternative for early nutritional support in critically ill trauma patients. Carrillo EH, Heniford BT, Osborne DL, Spain DA, Miller FB, Richardson JD. Surg Endosc. 1997; 11 (11): 1068-71
Glucose-induced intestinal hyperemia is mediated by nitric oxide. Matheson PJ, Wilson MA, Spain DA, Harris PD, Anderson GL, Garrison RN. J Surg Res. 1997; 72 (2): 146-54
Twelfth rib resection. Preferred therapy for subphrenic abscess in selected surgical patients. Spain DA, Martin RC, Carrillo EH, Polk HC. Arch Surg. 1997; 132 (11): 1203-6
Percutaneous dilational tracheostomy for airway control. Carrillo EH, Spain DA, Bumpous JM, Schmieg RE, Miller FB, Richardson JD. Am J Surg. 1997; 174 (5): 469-73
Quality assessment of intraoperative blood salvage and autotransfusion. Spain DA, Miller FB, Bergamini TM, Montgomery RC, Richardson JD. Am Surg. 1997; 63 (12): 1059-63; discussion 1063-4
Lazaroid improves intestinal blood flow in the rat during hyperdynamic bacteraemia. Krysztopik RJ, Bentley FR, Spain DA, Wilson MA, Garrison RN. Br J Surg. 1997; 84 (12): 1717-21
Lazaroids prevent acute cyclosporine-induced renal vasoconstriction. Krysztopik RJ, Bentley FR, Spain DA, Wilson MA, Garrison RN. Transplantation. 1997; 63 (9): 1215-20
Differential intestinal microvascular dysfunction occurs during bacteremia. Spain DA, Wilson MA, Krysztopik RJ, Matheson PJ, Garrison RN. J Surg Res. 1997; 67 (1): 67-71
Blunt popliteal artery trauma: a challenging injury. Harrell DJ, Spain DA, Bergamini TM, Miller FB, Richardson JD. Am Surg. 1997; 63 (3): 228-31; discussion 231-2
Venous thromboembolism in the high-risk trauma patient: do risks justify aggressive screening and prophylaxis? Spain DA, Richardson JD, Polk HC, Bergamini TM, Wilson MA, Miller FB. J Trauma. 1997; 42 (3): 463-7; discussion 467-9
The role of thoracoscopy in the management of retained thoracic collections after trauma. Heniford BT, Carrillo EH, Spain DA, Sosa JL, Fulton RL, Richardson JD. Ann Thorac Surg. 1997; 63 (4): 940-3
Complex thoracic injuries. Richardson JD, Miller FB, Carrillo EH, Spain DA. Surg Clin North Am. 1996; 76 (4): 725-48
Fluid resuscitation attenuates early cytokine mRNA expression after peritonitis. Wilson MA, Chou MC, Spain DA, Downard PJ, Qian Q, Cheadle WG, Garrison RN. J Trauma. 1996; 41 (4): 622-7
Free radical scavenging by lazaroids improves renal blood flow during sepsis. Krysztopik RJ, Bentley FR, Spain DA, Wilson MA, Garrison RN. Surgery. 1996; 120 (4): 657-62
Operative strategies for management of abdominal aortic gunshot wounds. Richardson JD, Bergamini TM, Spain DA, Wilson MA, Carrillo EH, Garrison RN, Fulton RL, Miller FB. Surgery. 1996; 120 (4): 667-71
Heparan preserves intestinal perfusion after hemorrhage and resuscitation. Watkins JM, Spain DA, Krysztopik RJ, Downard PJ, Wilson MA, Garrison RN. J Surg Res. 1996; 66 (2): 154-8
Vasomotor response to pentoxifylline mediates improved renal blood flow to bacteremia. Krysztopik RJ, Bentley FR, Wilson MA, Spain DA, Garrison RN. J Surg Res. 1996; 63 (1): 17-22
Predicting the need to pack early for severe intra-abdominal hemorrhage. Garrison JR, Richardson JD, Hilakos AS, Spain DA, Wilson MA, Miller FB, Fulton RL. J Trauma. 1996; 40 (6): 923-7; discussion 927-9
Preoperative saline loading improves outcome after elective, noncardiac surgical procedures. Garrison RN, Wilson MA, Matheson PJ, Spain DA. Am Surg. 1996; 62 (3): 223-31
Alpha-adrenergic receptor antagonism prevents intestinal vasoconstriction but not hypoperfusion following resuscitated hemorrhage. Theuer CJ, Wilson MA, Spain DA, Edwards MJ, Garrison RN. J Surg Res. 1995; 59 (2): 292-8
Is the timing of fracture fixation important for the patient with multiple trauma? Reynolds MA, Richardson JD, Spain DA, Seligson D, Wilson MA, Miller FB. Ann Surg. 1995; 222 (4): 470-8; discussion 478-81
Haemophilus pneumonia is a common cause of early pulmonary dysfunction following trauma. Spain DA, Wilson MA, Boaz PW, Bar-Natan MF, Garrison RN. Arch Surg. 1995; 130 (11): 1228-31; discussion 1231-2
Transpyloric passage of feeding tubes in patients with head injuries does not decrease complications. Spain DA, DeWeese RC, Reynolds MA, Richardson JD. J Trauma. 1995; 39 (6): 1100-2
Endothelin-1 expression in the small intestine during chronic peritonitis. Chou MC, Wilson MA, Spain DA, Hadjiminas D, Anderson GL, Cheadle WG, Garrison RN. Shock. 1995; 4 (6): 411-4
Nitric oxide mediates redistribution of intrarenal blood flow during bacteremia. Garrison RN, Wilson MA, Matheson PJ, Spain DA. J Trauma. 1995; 39 (1): 90-6; discussion 96-7
Platelet-activating factor and sepsis-induced small intestinal microvascular hypoperfusion. Bar-Natan MF, Wilson MA, Spain DA, Garrison RN. J Surg Res. 1995; 58 (1): 38-45
The delirious ICU patient: often misdiagnosed and undertreated. Spain DA, Miller FB. J Ky Med Assoc. 1995; 93 (1): 10-4
An experimental study of altered nitric oxide metabolism as a mechanism of cyclosporin-induced renal vasoconstriction. Bloom IT, Bentley FR, Spain DA, Garrison RN. Br J Surg. 1995; 82 (2): 195-8
Differential microvascular response to cyclooxygenase blockade in the rat small intestine during acute bacteremia. Gosche JR, Spain DA, Garrison RN, Lübbe AS, Cryer HG. Shock. 1994; 2 (6): 408-12
Antibiotic overkill of trauma victims? Hadjiminas D, Cheadle WG, Spain DA, Wilson MA, Short A, Starko KM, Harris BJ, Livingston DH, Rodriguez JL. Am J Surg. 1994; 168 (3): 288-90
Nitric oxide synthase inhibition exacerbates sepsis-induced renal hypoperfusion. Spain DA, Wilson MA, Garrison RN. Surgery. 1994; 116 (2): 322-30; discussion 330-1
Role of nitric oxide in the small intestinal microcirculation during bacteremia. Spain DA, Wilson MA, Bar-Natan MF, Garrison RN. Shock. 1994; 2 (1): 41-6
Renal microvascular responses to sepsis are dependent on nitric oxide. Spain DA, Wilson MA, Bloom IT, Garrison RN. J Surg Res. 1994; 56 (6): 524-9
Tracheostomy and percutaneous endoscopic gastrostomy in the management of the head-injured trauma patient. D'Amelio LF, Hammond JS, Spain DA, Sutyak JP. Am Surg. 1994; 60 (3): 180-5
Nitric oxide synthase inhibition aggravates intestinal microvascular vasoconstriction and hypoperfusion of bacteremia. Spain DA, Wilson MA, Bar-Natan MF, Garrison RN. J Trauma. 1994; 36 (5): 720-5
Operative tube versus percutaneous cholecystostomy for acute cholecystitis. Spain DA, Bibbo C, Ecker T, Nosher JL, Brolin RE. Am J Surg. 1993; 166 (1): 28-31
Nonoperative management of bilateral shattered kidneys from blunt trauma. Spain DA, Berger Y, Boyarsky AH, Flancbaum LJ. Urology. 1993; 41 (6): 579-81
Peritoneal leukocyte response following placement of polyglycolic acid intestinal sling in patients with rectal carcinoma. Devereux DF, O'Connell SM, Spain DA, Robertson FM. Dis Colon Rectum. 1991; 34 (8): 670-4
Whipple operation revisited. Spain DA, Greco RS. N J Med. 1990; 87 (1): 41-4
The adequacy and cost effectiveness of routine resuscitation-area cervical-spine radiographs. Spain DA, Trooskin SZ, Flancbaum L, Boyarsky AH, Nosher JL. Ann Emerg Med. 1990; 19 (3): 276-8