Miriam B. Goodman

Honors and Awards

• Klingenstein Fellow in Neuroscience, The Klingenstein Fund (2005-2008)
• McKnight Scholar Award, McKnight Endowment (2005-2008)
• Prize in Neurobiology, Eppendorf & Science (2004)
• Alfred P. Sloan Fellow, Alfred P. Sloan Foundation (2002-2004)
• Terman Fellow, Stanford University (2002-2005)
• Baxter Fellow, Donald B. and Delia E. Baxter Foundation (2002)

Professional Education

• Ph.D., The University of Chicago Neurobiology (1995)
• Sc.B., Brown University Biochemistry (1986)

Postdoctoral Advisees

• Amy Eastwood, Shana Geffeney, Dominique Glauser, Dong Wang

Graduate & Fellowship Program Affiliations

• Biophysics
• Molecular and Cellular Physiology
• Neurosciences

Web Site Links

• Goodman Lab Site

Research Interests

We study the molecular events that give rise to the sensation of touch and temperature using C. elegans nematodes as a model system. To do this, we use a combination of quantitative behavioral analysis, genetics, in vivo electrophysiology, and heterologous expression of ion channels. We also collaborate with Pruitt's group in Mechanical Engineering (http://microsystems.stanford.edu) to develop and fabricate novel devices for the study of sensory transduction.

Publications

• Bidirectional temperature-sensing by a single thermosensory neuron in C. elegans. Ramot D,  MacInnis BL, Goodman MB.  Nat Neurosci.  2008; 11 (8): 908-15
• Thermotaxis is a robust mechanism for thermoregulation in Caenorhabditis elegans nematodes. Ramot D,  MacInnis BL, Lee HC, Goodman MB.  J Neurosci.  2008; 28 (47): 12546-57
• Nanoscale organization of the MEC-4 DEG/ENaC sensory mechanotransduction channel in Caenorhabditis elegans touch receptor neurons. Cueva JG,  Mulholland A, Goodman MB.  J Neurosci.  2007; 27 (51): 14089-98
• Gain-of-function mutations in the MEC-4 DEG/ENaC sensory mechanotransduction channel alter gating and drug blockade. Brown AL,  Fernandez-Illescas SM, Liao Z, Goodman MB.  J Gen Physiol.  2007; 129 (2): 161-73
• Analysis of nematode mechanics by piezoresistive displacement clamp. Park SJ,  Goodman MB, Pruitt BL.  Proc Natl Acad Sci U S A.  2007; 104 (44): 17376-81
• The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals. O'Hagan R,  Chalfie M, Goodman MB.  Nat Neurosci.  2005; 8 (1): 43-50
• SU-8 force sensing pillar arrays for biological measurements. Doll JC,  Harjee N, Klejwa N, Kwon R, Coulthard SM, Petzold B, Goodman MB, Pruitt BL.  Lab Chip.  2009; 9 (10): 1449-54
• Pressure-polishing pipettes for improved patch-clamp recording. Johnson BE,  Brown AL, Goodman MB.  J Vis Exp.  2008; (20)
• MEC-2 and MEC-6 in the Caenorhabditis elegans sensory mechanotransduction complex: auxiliary subunits that enable channel activity. Brown AL,  Liao Z, Goodman MB.  J Gen Physiol.  2008; 131 (6): 605-16
• The Parallel Worm Tracker: a platform for measuring average speed and drug-induced paralysis in nematodes. Ramot D,  Johnson BE, Berry TL, Carnell L, Goodman MB.  PLoS One.  2008; 3 (5): e2208
• Dissecting a circuit for olfactory behaviour in Caenorhabditis elegans. Chalasani SH,  Chronis N, Tsunozaki M, Gray JM, Ramot D, Goodman MB, Bargmann CI.  Nature.  2007; 450 (7166): 63-70
• Mechanosensation. Goodman MB,  WormBook.  2006; 1-14
• Eppendorf essay winner. Deconstructing C. elegans sensory mechanotransduction. Goodman MB,  Science.  2004; 306 (5695): 427-8
• Molecules and mechanisms of mechanotransduction. Goodman MB,  Lumpkin EA, Ricci A, Tracey WD, Kernan M, Nicolson T.  J Neurosci.  2004; 24 (42): 9220-2
• Sensation is painless. Goodman MB,  Trends Neurosci.  2003; 26 (12): 643-5
• Transducing touch in Caenorhabditis elegans. Goodman MB,  Schwarz EM.  Annu Rev Physiol.  2003; 65 429-52
• The mechanosensory protein MEC-6 is a subunit of the C. elegans touch-cell degenerin channel. Chelur DS,  Ernstrom GG, Goodman MB, Yao CA, Chen L, O' Hagan R, Chalfie M.  Nature.  2002; 420 (6916): 669-73
• MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation. Goodman MB,  Ernstrom GG, Chelur DS, O'Hagan R, Yao CA, Chalfie M.  Nature.  2002; 415 (6875): 1039-42
• Pressure polishing: a method for re-shaping patch pipettes during fire polishing. Goodman MB,  Lockery SR.  J Neurosci Methods.  2000; 100 (1-2): 13-5
• Tight-seal whole-cell patch clamping of Caenorhabditis elegans neurons. Lockery SR,  Goodman MB.  Methods Enzymol.  1998; 293 201-17
• Active currents regulate sensitivity and dynamic range in C. elegans neurons. Goodman MB,  Hall DH, Avery L, Lockery SR.  Neuron.  1998; 20 (4): 763-72
• Positive feedback by a potassium-selective inward rectifier enhances tuning in vertebrate hair cells. Goodman MB,  Art JJ.  Biophys J.  1996; 71 (1): 430-42
• Ionic conductances and hair cell tuning in the turtle cochlea. Art JJ,  Goodman MB.  Ann N Y Acad Sci.  1996; 781 103-22
• Variations in the ensemble of potassium currents underlying resonance in turtle hair cells. Goodman MB,  Art JJ.  J Physiol.  1996; 497 ( Pt 2) 395-412
• A kinetic description of the calcium-activated potassium channel and its application to electrical tuning of hair cells. Wu YC,  Art JJ, Goodman MB, Fettiplace R.  Prog Biophys Mol Biol.  1995; 63 (2): 131-58
• Rapid scanning confocal microscopy. Art JJ,  Goodman MB.  Methods Cell Biol.  1993; 38 47-77
• Activation of the inositol trisphosphate second messenger system by cAMP in a mouse fibroblast cell line. Horn VJ,  Sheehy PA, Goodman MB, Ambudkar IS.  Mol Cell Biochem.  1991; 101 (1): 43-9
• Inositol trisphosphate mediates cloned muscarinic receptor-activated conductances in transfected mouse fibroblast A9 L cells. Jones SV,  Barker JL, Goodman MB, Brann MR.  J Physiol.  1990; 421 499-519
• Calcium currents and fura-2 signals in fluorescence-activated cell sorted lactotrophs and somatotrophs of rat anterior pituitary. Lewis DL,  Goodman MB, St John PA, Barker JL.  Endocrinology.  1988; 123 (1): 611-21