Professional Education
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Doctor of Philosophy, Johannes Gutenberg Universitat Mainz
(2008)
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M.S., University of Goettingen, Germany
Developmental Biology (2004)
Publications
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alpha-secretase mediated conversion of the amyloid precursor protein derived membrane stub C99 to C83 limits Abeta generation.
Jäger S,
Leuchtenberger S, Martin A, Czirr E, Wesselowski J, Dieckmann M, Waldron E, Korth C, Koo EH, Heneka M, Weggen S, Pietrzik CU.
J Neurochem.
2009;
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Nonsteroidal anti-inflammatory drugs and ectodomain shedding of the amyloid precursor protein.
Leuchtenberger S,
Maler J, Czirr E, Ness J, Lichtenthaler SF, Esselmann H, Pietrzik CU, Wiltfang J, Weggen S.
Neurodegener Dis.
2009;
6
(1-2):
1-8
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Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase.
Czirr E,
Cottrell BA, Leuchtenberger S, Kukar T, Ladd TB, Esselmann H, Paul S, Schubenel R, Torpey JW, Pietrzik CU, Golde TE, Wiltfang J, Baumann K, Koo EH, Weggen S.
J Biol Chem.
2008;
283
(25):
17049-54
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Insensitivity to Abeta42-lowering nonsteroidal anti-inflammatory drugs and gamma-secretase inhibitors is common among aggressive presenilin-1 mutations.
Czirr E,
Leuchtenberger S, Dorner-Ciossek C, Schneider A, Jucker M, Koo EH, Pietrzik CU, Baumann K, Weggen S.
J Biol Chem.
2007;
282
(34):
24504-13
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Gamma-secretase modulation with Abeta42-lowering nonsteroidal anti-inflammatory drugs and derived compounds.
Czirr E,
Weggen S.
Neurodegener Dis.
2006;
3
(4-5):
298-304
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Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.
Leuchtenberger S,
Kummer MP, Kukar T, Czirr E, Teusch N, Sagi SA, Berdeaux R, Pietrzik CU, Ladd TB, Golde TE, Koo EH, Weggen S.
J Neurochem.
2006;
96
(2):
355-65
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Genetic variation in oocyte phenotype revealed through parthenogenesis and cloning: correlation with differences in pronuclear epigenetic modification.
Gao S,
Czirr E, Chung YG, Han Z, Latham KE.
Biol Reprod.
2004;
70
(4):
1162-70
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Localisation of histone macroH2A1.2 to the XY-body is not a response to the presence of asynapsed chromosome axes.
Hoyer-Fender S,
Czirr E, Radde R, Turner JM, Mahadevaiah SK, Pehrson JR, Burgoyne PS.
J Cell Sci.
2004;
117
(Pt 2):
189-98
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Outer dense fibre protein 2 (ODF2) is a self-interacting centrosomal protein with affinity for microtubules.
Donkor FF,
Mönnich M, Czirr E, Hollemann T, Hoyer-Fender S.
J Cell Sci.
2004;
117
(Pt 20):
4643-51