Key Documents

David I. Bellovin

Student of the Year, Department of Molecular and Cellular Biology, University of Arizona (2000)
B.S., Magna Cum Laude with Honors, University of Arizona (2000)
BCRP Predoctoral Fellow, US Dept. of Defense (2003-2006)
NRSA Postdoctoral Fellow, NIH/NCI (2008)

Currently investigating the origin, development, and treatment of MYC-induced hepatocellular carcinoma using a conditional transgenic mouse model.

Low-level shRNA Cytotoxicity Can Contribute to MYC-induced Hepatocellular Carcinoma in Adult Mice. Beer S, Bellovin DI, Lee JS, Komatsubara K, Wang LS, Koh H, Börner K, Storm TA, Davis CR, Kay MA, Felsher DW, Grimm D. Mol Ther. 2009;
Hepatotoxin-induced changes in the adult murine liver promote MYC-induced tumorigenesis. Beer S, Komatsubara K, Bellovin DI, Kurobe M, Sylvester K, Felsher DW. PLoS One. 2008; 3 (6): e2493
Combined Inactivation of MYC and K-Ras oncogenes reverses tumorigenesis in lung adenocarcinomas and lymphomas. Tran PT, Fan AC, Bendapudi PK, Koh S, Komatsubara K, Chen J, Horng G, Bellovin DI, Giuriato S, Wang CS, Whitsett JA, Felsher DW. PLoS One. 2008; 3 (5): e2125
Reciprocal regulation of RhoA and RhoC characterizes the EMT and identifies RhoC as a prognostic marker of colon carcinoma. Bellovin DI, Simpson KJ, Danilov T, Maynard E, Rimm DL, Oettgen P, Mercurio AM. Oncogene. 2006; 25 (52): 6959-67
Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. Bates RC, Bellovin DI, Brown C, Maynard E, Wu B, Kawakatsu H, Sheppard D, Oettgen P, Mercurio AM. J Clin Invest. 2005; 115 (2): 339-47
Altered localization of p120 catenin during epithelial to mesenchymal transition of colon carcinoma is prognostic for aggressive disease. Bellovin DI, Bates RC, Muzikansky A, Rimm DL, Mercurio AM. Cancer Res. 2005; 65 (23): 10938-45