Brent Tan
Academic Appointments
- Clinical Assistant Professor, Pathology
Key Documents
Contact Information
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Clinical Offices
Department of Pathology 300 Pasteur Dr L235 MC 5324 Stanford, CA 94305 Tel Work (650) 723-5252 Fax (650) 725-6902Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
- Academic Offices
Personal Information EmailNot for medical emergencies or patient use
Professional Overview
Clinical Focus
- Pathology
- Anatomic Pathology
Administrative Appointments
- Associate Medical Director, Quality for Informatics (2009 - present)
- Associate Medical Director, Laboratory Hematology (2007 - present)
Scientific Focus
Current Research Interests
My research interest is in the use of molecular methods to understand and characterize hematopoietic neoplasms. My current work focuses on the use of PCR-based assays for clonal rearrangements in the immunoglobulin heavy chain gene (IGH) and T-cell receptor gene (TCR) for the diagnosis of mature T-cell lymphomas. We recently demonstrated that two of the most common subtypes of PTCL, peripheral T-cell lymphoma, unspecified, and angioimmunoblastic T-cell lymphoma, exhibit clonal rearrangements both TCR and IGH relatively frequently. Our studies suggest that this unexpected result is due to the presence of B-cell proliferations that often complicate these subtypes of PTCL. We hypothesize that immune dysfunction in the locale of PTCL allows for uncontrolled B-cell proliferation, which is a model is similar to that of post-transplant lymphoproliferative disorder. Our current studies are aimed at providing further support for this theory.
We are also evaluating the use of PCR for the TCR gamma chain gene (TCRG) versus the TCR beta chain gene (TCRB) as a target for T-cell clonality for peripheral blood specimens. A canonical TCRG rearrangement that occurs in 1-3% of normal peripheral blood T cells raises the possibility of false positive clonality. Our studies are aimed at determining whether TCRB offers a more specific target for clonality studies.
Publications
- Evaluation of the Beckman Coulter UniCel DxH 800 and Abbott Diagnostics Cell-Dyn Sapphire hematology analyzers on pediatric and neonatal specimens in a tertiary care hospital. Am J Clin Pathol. 2011; (6): 929-38
- Evaluation of the Beckman Coulter UniCel DxH 800, Beckman Coulter LH 780, and Abbott Diagnostics Cell-Dyn Sapphire hematology analyzers on adult specimens in a tertiary care hospital. Am J Clin Pathol. 2011; (6): 939-51
- Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma. Cell. 2010; (5): 699-713
- The frequency of immunoglobulin heavy chain gene and T-cell receptor gamma-chain gene rearrangements and Epstein-Barr virus in ALK+ and ALK- anaplastic large cell lymphoma and other peripheral T-cell lymphomas. J Mol Diagn. 2008; (6): 502-12
- The Wilms' tumor gene WT1-GFP knock-in mouse reveals the dynamic regulation of WT1 expression in normal and leukemic hematopoiesis. Leukemia. 2007; (8): 1783-91
- The cancer stem cell hypothesis: a work in progress. Lab Invest. 2006; (12): 1203-7
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