Professional Overview
Internet Links
Scientific Focus
Current Research Interests
We are investigating several interrelated phenomena in a primitive chordate, the ascidian Botryllus schlosseri. The lab is located at Stanfords Hopkins Marine Station on the Monterey Peninsula, where we are studying: 1) allorecognition and the evolutionary origins of different components of the vertebrate immune system; 2) pluripotent, parasitic stem cells; 3) the molecular mechanisms which underlie complete asexual regeneration in this organism.
Publications
- A conserved role of the VEGF pathway in angiogenesis of an ectodermally-derived vasculature. Dev Biol. 2008; (1): 243-55
- Striving for normality: whole body regeneration through a series of abnormal generations. FASEB J. 2007; (7): 1335-44
- Allorecognition polymorphism versus parasitic stem cells. Trends Genet. 2006; (9): 485-90
- fester, A candidate allorecognition receptor from a primitive chordate. Immunity. 2006; (1): 163-73
- Isolation and characterization of a protochordate histocompatibility locus. Nature. 2005; (7067): 454-9
- Predatory stem cells in the non-zebrafish chordate, Botryllus schlosseri. Zebrafish. 2005; (4): 357-61
Help