Guowei Fang
Academic Appointments
- Member, Cancer Center
Contact Information
- Academic
Offices
Personal Information Email Tel (650) 725-2762 Tel (650) 725-7813
Professional Snapshot
Honors and Awards
- Searle Scholar Award, Kinship Foundation (2001)
- Beckman Young Investigator Award, Beckman Foundation (2001)
- Sidney Kimmel Award in Cancer Research, Sidney Kimmel Foundation (2001)
- Burroughs-Welcome Career Awards in Biomedical Research, Burroughs-Welcome Fund (1998)
Professional Education
| Ph.D.: | University of Colorado, Boulder, Biochemistry (1993) |
| B.S.: | Nanjing University, PR China, Biochemistry (1987) |
Graduate & Fellowship Program Affiliations
Web Site Links
Scientific Focus
Research Interests
We study the molecular and cellular mechanisms that control mitosis and cytokinesis in normal cells and their dysregulations that lead to aneuploidy and genomic instability in tumor cells. The current focus is on the cell cycle regulatory circuits consisting of kinases and ubiquitin ligases. In addition, we investigate the assembly, dynamics and function of mitotic structures. We use a combination of genomics, cell biology, biochemistry, and molecular genetics in mammalian cells.
Publications
- RCS1, a substrate of APC/C, controls the metaphase to anaphase transition. Proc Natl Acad Sci U S A. 2008; (36): 13415-20
- DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement. J Cell Biol. 2008; (2): 255-67
- Plk1- and beta-TrCP-dependent degradation of Bora controls mitotic progression. J Cell Biol. 2008; (1): 65-78
- Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry. Science. 2008; (5883): 1655-8
- Cdk1 phosphorylation of BubR1 controls spindle checkpoint arrest and Plk1-mediated formation of the 3F3/2 epitope. J Cell Biol. 2007; (4): 611-7
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