Bill Burkholder
Academic Appointments
- Assistant Professor, Biology (School of Humanities and Sciences)
- Member, Bio-X
Contact Information
-
Academic Offices
Personal Information Email Tel (650) 724-1504
Scientific Focus
Research Interests
Our lab is interested in how bacteria monitor and coordinate cell cycle events. We are focused on identifying and characterizing signal transduction pathways used by the bacterium Bacillus subtilis to regulate cell cycle progression and development in response to chromosome status. Our goal is to understand how these pathways work mechanistically and how they contribute to normal growth, development, and genome stability.
Publications
- The histidine kinase inhibitor Sda binds near the site of autophosphorylation and may sterically hinder autophosphorylation and phosphotransfer to Spo0F. Mol Microbiol. 2009; (3): 659-77
- Proteolysis of the replication checkpoint protein Sda is necessary for the efficient initiation of sporulation after transient replication stress in Bacillus subtilis. Mol Microbiol. 2006; (6): 1490-508
- Structure and mechanism of action of Sda, an inhibitor of the histidine kinases that regulate initiation of sporulation in Bacillus subtilis. Mol Cell. 2004; (5): 689-701
- Replication initiation proteins regulate a developmental checkpoint in Bacillus subtilis. Cell. 2001; (2): 269-79
Help