Professional Snapshot
Administrative Appointments
- President, Society for Physical Regulation in Biology and Medicine (2006 - present)
- Co-Editor, Computer Methods in Biomechanics and Biomedical Engineering (2007 - present)
- Skeletal Biology Structure and Regeneration Study Section Member, NIH (2003 - present)
Honors and Awards
- Young Investigator Award, American Society of Biomechanics (1998)
- Research Award, European Society of Biomechanics (1998)
Graduate & Fellowship Program Affiliations
Web Site Links
Scientific Focus
Current Research Interests
Dr. Jacobs is primarily interested in cellular mechanics and molecular mechanisms of cellular mechanotransduction particularly in bone. His recent work is focused on how fluid flow due to mechanical loading is transduced by bone cells. He also investigates the mechanical influence on and regulation of stress-adaptive orthopaedic structures, tissues, and cells. He is also the director of the Palo Alto DVA Center for Bone and Joint Rehabilitation Research and Development.
Publications
- Time-dependent deformations in bone cells exposed to fluid flow in vitro: investigating the role of cellular deformation in fluid flow-induced signaling. J Biomech. 2007; (14): 3162-8
- The role of actin cytoskeleton in oscillatory fluid flow-induced signaling in MC3T3-E1 osteoblasts. Am J Physiol Cell Physiol. 2007; (5): C1830-6
- Oscillatory fluid flow-induced shear stress decreases osteoclastogenesis through RANKL and OPG signaling. Bone. 2006; (5): 1043-7
- Effects of short-term recovery periods on fluid-induced signaling in osteoblastic cells. J Biomech. 2005; (9): 1909-17
- Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation. J Orthop Res. 2004; (6): 1283-9
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