Joseph Mcguire
Academic Appointments
- Emeritus Faculty, Acad Council, Dermatology
- Emeritus Faculty, Acad Council, Pediatrics
Key Documents
Contact Information
- Academic Offices
Personal Information Email Tel (650) 725-5269
Scientific Focus
Current Research Interests
Biology of the keratinocyte in inherited blistering diseases.
1. Studies include cytokine production and production of cytokine receptor antagonists (IL-1Ra)
2. Keratinocytes produce metalloproteinases in response to cytokines. These responses in keratinocytes from normal and diseases skin are studied at the protein level by zymography and at the mRNA level by RT PCR.
3. An uncommon recessively inherited blistering disease associated with premature aging of the skin is the subject of linkage studies in two U.S. families and 5 Egyptian families. These linkages studies do no show linkage to either Type I and Type II keratins. Keratinocytes from these subjects show enhanced sensitivity to UV-C.
Publications
- Recessive dystrophic epidermolysis bullosa associated with mesangioproliferative glomerulonephritis and multifocal necrotizing leucoencephalopathy of the pons. Br J Dermatol. 2004; (6): 1266-9
- Five cases of calciphylaxis and a review of the literature. J Am Acad Dermatol. 1999; (6 Pt 1): 979-87
- Prenatal diagnosis for recessive dystrophic epidermolysis bullosa in 10 families by mutation and haplotype analysis in the type VII collagen gene (COL7A1). Mol Med. 1996; (1): 59-76
- Gonadal steroids modulate interleukin-1 receptor antagonist mRNA expression in cultured human monocytes. Biochem Biophys Res Commun. 1995; (1): 279-85
- Kindler's Syndrome: a study on genetic linkage to candidate genes coding for connective tissue components J. Invest. Dermatol. 1995
- Histamine mobilizes calcium in cultured human keratinocytes through H-1 receptors. Biology of the Epidermis Tokyo. 1992
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