Key Documents
Anthony Oro MD/PhD
Academic Appointments
- Associate Professor, Dermatology
- Member, Bio-X
- Member, Cancer Center
Contact Information
-
Clinical Offices
Adult Dermatology Clinic 450 Broadway Street, Pavilion B MC 5334 Redwood City, CA 94063 Tel Work (650) 723-6316 Fax (650) 725-7711
- Academic Offices
Personal Information EmailAdministrative Contact Ray Herrman administrative assistant Email Tel Work 650-725-7022Not for medical emergencies or patient use
Professional Snapshot
Clinical Focus
- Dermatology
- Skin Cancer
- Hair disorders
Professional Education
| Board Certification: | Dermatology, American Board of Dermatology (1998) |
| Residency: | Stanford University Medical Center, CA (1997) |
| Internship: | Stanford University Medical Center, CA (1994) |
| Medical Education: | UCSD School of Medicine, CA (1993) |
Postdoctoral Advisees
Scott Atwood , Marina Bershteyn , Mindy Hebert-Derouen , Wei Woo , Gozde Yucel
Graduate & Fellowship Program Affiliations
Web Site Links
Scientific Focus
Current Research Interests
Our lab is interested in the role of Sonic hedgehog (Shh) signaling system in the pathogenesis of the most common human tumor, basal cell carcinoma (BCCs) of the skin. Induction of Shh target genes mediate normal hair follicle morphogenesis. However, ectopic Shh target gene induction result in BCC tumor development from normal skin. We are interested in
1)how tumor stroma regulates Shh signaling and BCC progression
2) identifying Shh target genes that mediate the dramatic histologic changes in epithelium. We are using transgenic and knockout mice, retroviral infections in primary human and mouse cells, and DNA microarrays to address this questions. Our ultimate goal is to understand the pathogenesis of epithelial cancer in order to develop novel anti-tumor therapeutics.
Most recently we have identified a Shh target gene called MIM that is an inducible actin cytoskeleton remodeling protein. MIM binds to the tumor suppressor Suppressor of Fused and the oncogene Gli to potentiate Gli transcription.
Clinical Trials
- Phase II, Multi-Center, Single-Arm, Two-Cohort Trial of GDC-0449 for Advanced Basal Cell Carcinoma Recruiting
- Characteristics of Patients with Dystrophic Epidermolysis Bullosa Recruiting
- A Study of GDC-0449 (Hedgehog Pathway Inhibitor) in Patients Treated With GDC-0449 in a Previous Genentech-Sponsored Phase I or II Cancer Study Enrolling by Invitation
Publications
- A new role for an old friend: NFAT and stem cell quiescence. Cell Stem Cell. 2008; (2): 104-6
- Laminin-511 is an epithelial message promoting dermal papilla development and function during early hair morphogenesis. Genes Dev. 2008; (15): 2111-24
- The primary cilia, a 'Rab-id' transit system for hedgehog signaling. Curr Opin Cell Biol. 2007; (6): 691-6
- Dual degradation signals control Gli protein stability and tumor formation. Genes Dev. 2006; (3): 276-81
- Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation. Proc Natl Acad Sci U S A. 2006; (40): 14842-7
Help