James Trudell
Academic Appointments
- Professor, Anesthesia
- Member, Bio-X
Contact Information
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Academic Offices
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Professional Snapshot
Professional Education
| PhD: | Stanford University, Chemistry (1969) |
| B.S.: | University of Michigan, Chemistry (1963) |
Industry Relationships
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| Consulting: | Jazz Pharmaceuticals |
Scientific Focus
Research Interests
I use computational chemistry to develop molecular theories of anesthesia and alcohol intoxication. I collaborate with three groups that use molecular biology to make site-directed mutations in ligand-gated ion channels. Molecular modeling of these channels is used to visualize the effect of mutations and to predict new mutations that will further refine their structure. I also use quantum mechanics calculations to determine the kinds of interactions that are likely to provide binding energy for anesthetic molecules at their sites of action.
Publications
- Effect of cobratoxin binding on the normal mode vibration within acetylcholine binding protein. J Chem Inf Model. 2008; (4): 855-60
- Molecular modeling and mutagenesis reveals a tetradentate binding site for Zn2+ in GABA(A) alphabeta receptors and provides a structural basis for the modulating effect of the gamma subunit. J Chem Inf Model. 2008; (2): 344-9
- Normal-mode analysis of the glycine alpha1 receptor by three separate methods. J Chem Inf Model. 2007 Jul-Aug; (4): 1572-9
- The common chemical motifs within anesthetic binding sites. Anesth Analg. 2007; (2): 318-24
- Molecular mechanisms and binding site location for the noncompetitive antagonist crystal violet on nicotinic acetylcholine receptors. Biochemistry. 2006; (7): 2014-26
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