Jacob E. Kuperstock
Academic Appointments
- MD Student, expected graduation Spring 2013
- NBIO Tutor, Dean's Office - Educational Programs and Services (EPS), Office of Medical Education (OME)
Key Documents
Contact Information
- Contact Information
Personal Information Email
Professional Overview
Stanford Advisors
| Terrence Blaschke: | Academic Advising Dean |
| Paula Hillard: | E4C Mentor |
| Alan Cheng: | Med Scholar Project Advisor |
Lab Affiliations
- Alan Cheng, Cheng Lab - Otolaryngology (3/1/2010 - 6/1/2013)
Clerkships
| Calendar Year | Quarter | List of Clerkships |
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| 2013 | Winter |
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| 2012 | Autumn |
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| Summer |
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| 2011 | Autumn |
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Honors and Awards
- Medical Scholars Research Grant, Stanford University School of Medicine (June 2010-Current)
- William G. Guy Prize in Chemistry, College of William and Mary (June 2009)
- Phi Beta Kappa Inductee, Alpha Chapter - PBK (November 2008)
- Howard Hughes Research Grant, HHMI (September 2005-May 2006)
Work Experience
- GlaxoSmithKline - Molecular Drug Discovery, GlaxoSmithKline (5/17/2008 - 7/1/2009)
Service, Volunteer, and Community Work
- Arbor Free Clinic - Medical Student Volunteer , Stanford University School of Medicine (9/1/2009)
- Hospital Volunteer - Sentara Community Hospital , Sentara Williamsburg Hospital (8/1/2006 - 6/1/2008)
Scientific Focus
Current Research Interests
Hearing loss is one of the most common sensory disorders, affecting
both the pediatric and adult populations. In the United States alone 30
million people suffer from this disability. The pathology underlying
sensory hearing loss is the irreversible loss of the inner ear sensory
hair cells. These cells are highly specialized and function to transform
sound pressure waves to electrical neural signals. Since mammals are
unable to regenerate lost sensory hair cells, there is much interest in
investigating the potential of endogenous progenitor cells in the
cochlear and vestibular systems of mice.
Past experiments have demonstrated that Wnt-responsive Axin2-
positive cells show signs of proliferation after Wnt activation. These
findings draw similarities between the inner ear to other systems
including skin, mammary glands, central nervous system, eyes and
prostate where Wnt signals also play a critical role in modulating their
respective endogenous stem/progenitor cells. However, we are
interested in understanding the mechanism by which we can modulate
proliferation among progenitor cell population in the cochlea by
controlling the Wnt pathway, and have therefore designed many experiments interrogating Wnt agonists and antagonists.
Research Projects
- Characterization of Wnt-responsive Cells in the Cochlea (Scholarly Concentration project, MedScholars project)
Presentations
Publications
- Efficacy and predictors of success of noninvasive ventilation for prevention of extubation failure in critically ill children with heart disease. Pediatr Cardiol. 2013; (4): 964-77
- Network formation and photoluminescence in copper(I) halide complexes with substituted piperazine ligands. Dalton Trans. 2012; (38): 11663-74
- Perioperative care following complex laryngotracheal reconstruction in infants and children Saudi J Anaesth. 2010; (3): 186-96
- Piperazinium Chlorocuprates(I) Journal of Chemical Crystallography. 2009: 131
Student Life and Personal Pursuits
Membership Organizations
- Otolaryngology Interest Group, Medical Student Member
- Arbor Free Clinic, Medical Student Volunteer
- Pediatrics Interest Group, Medical Student - Group Officer
- SWEAT: Stanford Wilderness Experience Active Orientation Trip, Group Leader
- SIG: Surgery Interest Group, Medical Student Member
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