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David Prince
Academic Appointments
Appointment
Organization
Professor
Graduate & Fellowship Program Affiliations
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Honors & Awards
Title
Organization
Date(s)
Special Lecturer
Society for Neuroscience
2008
Lothman Lecturer
University of Virginia
2007
The Larry Benardo Research and Education Fund Lecturer .
SUNY Downstate Medical Center, New York
2006
Servier Lecturer
University of Montreal
2002
Bronte Lecturer
University of California, Davis
2001
Administrative Appointments
Title
Organization
Start Year
End Year
Chairman, Department of Neurology and Neurological Sciences
Stanford Univ. School of Medicine
1970
1989
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
B.S.
Univ. of Vermont
Psychology
1953
M.D.
Univ. of Pennsylvania
Medicine
1956
Research Interests
My work deals with regulation of excitability in neurons of mammalian cerebral cortex and thalamus and mechanisms underlying development of epilepsy. Long-term goals are to understand how injury produces changes in structure and function of neurons and neuronal networks that lead to hyperexcitability and epileptogenesis, and approaches to prevention of epilepsy after cortical injury. Areas of interest include regulation of voltage dependent membrane properties, neuropharmacology of transmitters and modulators including neuropeptides, synaptic mechanisms, and intrinsic properties of single, anatomically identified neurons. Techniques include use of in vivo mammalian preparations as well as in vitro slices and acutely dissociated neurons for recordings of synaptic activities and membrane properties, using patch-clamp techniques to study whole cell currents and membrane channels. Electrophysiological approaches are combined with intracellular labeling and immunocytochemistry to identify types of neurons and responses to injury.
Current studies include:
i) Reorganization of neocortical neuronal synaptic activities,and intrinsic neuronal properties after cortical trauma.
ii) Electrophysiologic and neuroanatomic studies of axonal sprouting following chronic neocortical injury.
iii) Anatomy and pathophysiology of neocortical developmental malformations.
iv) Effects of neuropeptides and GABAergic inhibition on intrinsic, synaptic and network properties of thalamic neurons; and generation of normal and pathophysiologic rhythms.
v) Modulation of neocortical inhibitory interneuronal activities by neurotransmitters and injury.
Publications
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Sun QQ,
Huguenard JR, Prince DA
"Barrel cortex microcircuits: thalamocortical feedforward inhibition in spiny stellate cells is mediated by a small number of fast-spiking interneurons."
J Neurosci
2006;
26:
4:
1219-30
More »
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Jin X,
Prince DA, Huguenard JR
"Enhanced excitatory synaptic connectivity in layer v pyramidal neurons of chronically injured epileptogenic neocortex in rats."
J Neurosci
2006;
26:
18:
4891-900
More »
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Halabisky B,
Shen F, Huguenard JR, Prince DA
"Electrophysiological classification of somatostatin-positive interneurons in mouse sensorimotor cortex."
J Neurophysiol
2006;
96:
2:
834-45
More »
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Tani H,
Bandrowski AE, Parada I, Wynn M, Huguenard JR, Prince DA, Reimer RJ
"Modulation of epileptiform activity by glutamine and system A transport in a model of post-traumatic epilepsy."
Neurobiol Dis
2006;
More »
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Li H,
Bandrowski AE, Prince DA
"Cortical injury affects short-term plasticity of evoked excitatory synaptic currents."
J Neurophysiol
2005;
93:
1:
146-56
More »
