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Mark A. Kay, M.D., Ph.D.
Email:
Phone:(650) 498-6531 Profile: http://med.stanford.edu/profiles/Mark_Kay/
Alternate Contact: Academic Appointments
Appointment
Organization
Professor
Professor
Member
Genetics ;
Pediatrics ;
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Curriculum Vitae PDF
Honors & Awards
Title
Organization
Date(s)
Researcher of the Year
National Hemophilia Foundation
2000
Pediatric Researcher of the Year
E. Mead Johnson Award
2000
Elected Member
American Society for Clinical Investigation
1997
Arosenius Swedish Honorary Lectureship
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1997
Young Investigator Award
Western Society for Clinical Investigation
1996
Administrative Appointments
Title
Organization
Start Year
End Year
President
American Society of Gene Therapy
2005
2006
President Elect
American Society of Gene Therapy
2004
2005
Chair of Organizing Committee
Gordon Conference on Viral Vectors for Gene Therapy
2003
2004
Vice President
ASGT
2003
2004
Chief Scientific Advisor
Benitec, LLC
2003
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7 appointments: view full list
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
B.S.
Michigan State University
Physical Sciences
1980
Ph.D.
Case Western Reserve University
Developmental Genetics
1986
M.D.
Case Western Reserve University
1987
Postdoctoral Advisees
Dan Cao,
Shuo Gu,
Dirk Haussecker,
Lan Jin,
Hak Kyun Kim,
Leszek Lisowski,
Jiamiao Lu,
Jyoti Mathur,
Neil Phillips
Web Site Links
Research/Lab website:
Gene Therapy
Research Interests
The goal of the Program in Human Gene Therapy is to develop gene transfer technologies and use them for hepatic gene therapy for the treatment of genetic and acquired diseases. The general approach is to develop new vector systems and delivery methods, test them in the appropriate animal models, uncover the mechanisms involved in vector transduction, and use the most promising approaches in clinical trials. Specifically, we work on a variety of viral and non-viral vector systems. Our major disease models are hemophilia, hepatitis C and B viral infections, and diabetes. The second major focus includes the role that small RNAs play in mammalian gene regulation.
Publications
- Chen ZY, Riu E, He CY, Xu H, Kay MA "Silencing of Episomal Transgene Expression in Liver by Plasmid Bacterial Backbone DNA Is Independent of CpG Methylation." Mol Ther 2008; More »
- Streetz KL, Doyonnas R, Grimm D, Jenkins DD, Fuess S, Perryman S, Lin J, Trautwein C, Shizuru J, Blau H, Sylvester KG, Kay MA "Hepatic parenchymal replacement in mice by transplanted allogeneic hepatocytes is facilitated by bone marrow transplantation and mediated by CD4 cells." Hepatology 2008; 47: 2: 706-18 More »
- Grimm D, Lee JS, Wang L, Desai T, Akache B, Storm TA, Kay MA "In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and re-targeting of adeno-associated viruses." J Virol 2008; More »
- Giering JC, Grimm D, Storm TA, Kay MA "Expression of shRNA From a Tissue-specific pol II Promoter Is an Effective and Safe RNAi Therapeutic." Mol Ther 2008; More »
- Haussecker D, Cao D, Huang Y, Parameswaran P, Fire AZ, Kay MA "Capped small RNAs and MOV10 in human hepatitis delta virus replication." Nat Struct Mol Biol 2008; More »
91 publications: view full list
