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Anthony Oro MD/PhD
Email:
Profile: http://med.stanford.edu/profiles/Anthony_Oro/
Alternate Contact: Academic Appointments
Appointment
Organization
Associate Professor
Member
Member
View Clinical Profile |
NIH Biosketch PDFPostdoctoral Advisees
Scott Atwood,
Maria Fernanda Lara Cabanas,
Wei Woo
Web Site Links
Research/Lab website:
Personal Web site
Research Interests
Our lab is interested in the role of Sonic hedgehog (Shh) signaling system in the pathogenesis of the most common human tumor, basal cell carcinoma (BCCs) of the skin. Induction of Shh target genes mediate normal hair follicle morphogenesis. However, ectopic Shh target gene induction result in BCC tumor development from normal skin. We are interested in
1)how tumor stroma regulates Shh signaling and BCC progression
2) identifying Shh target genes that mediate the dramatic histologic changes in epithelium. We are using transgenic and knockout mice, retroviral infections in primary human and mouse cells, and DNA microarrays to address this questions. Our ultimate goal is to understand the pathogenesis of epithelial cancer in order to develop novel anti-tumor therapeutics.
Most recently we have identified a Shh target gene called MIM that is an inducible actin cytoskeleton remodeling protein. MIM binds to the tumor suppressor Suppressor of Fused and the oncogene Gli to potentiate Gli transcription.
1)how tumor stroma regulates Shh signaling and BCC progression
2) identifying Shh target genes that mediate the dramatic histologic changes in epithelium. We are using transgenic and knockout mice, retroviral infections in primary human and mouse cells, and DNA microarrays to address this questions. Our ultimate goal is to understand the pathogenesis of epithelial cancer in order to develop novel anti-tumor therapeutics.
Most recently we have identified a Shh target gene called MIM that is an inducible actin cytoskeleton remodeling protein. MIM binds to the tumor suppressor Suppressor of Fused and the oncogene Gli to potentiate Gli transcription.
Publications
- Huntzicker EG, Estay IS, Zhen H, Lokteva LA, Jackson PK, Oro AE "Dual degradation signals control Gli protein stability and tumor formation." Genes Dev 2006; More »
- Oro AE, "Mammalian variations on a theme: a smo and sufu surprise." Dev Cell 2006; 10: 2: 156-8 More »
- Gonzalez-Quevedo R, Shoffer M, Horng L, Oro AE "Receptor tyrosine phosphatase-dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4." J Cell Biol 2005; 168: 3: 453-63 More »
- Sarin KY, Cheung P, Gilison D, Lee E, Tennen RI, Wang E, Artandi MK, Oro AE, Artandi SE "Conditional telomerase induction causes proliferation of hair follicle stem cells." Nature 2005; 436: 7053: 1048-52 More »
- Callahan CA, Ofstad T, Horng L, Wang JK, Zhen HH, Coulombe PA, Oro AE "MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription." Genes Dev 2004; 18: 22: 2724-9 More »
9 publications: view full list
